Theflavanone homoeriodictyol increases SGLT-1-mediated glucose uptake but decreases serotonin release in differentiated Caco-2 cells

PLoS ONE

Volumn 12, Issue 2, 2017, Pages

  Lieder, Barbara ^a   Hoi, Julia Katharina ^a   Holik, Ann Katrin ^a   Geissler, Katrin ^b   Hans, Joachim ^b   Friedl, Barbara ^a   Liszt, Kathrin ^a   Krammer, Gerhard E ^b   Ley, Jakob P ^b   Somoza, Veronika ^a  

^a UNIVERSITY OF VIENNA   (Austria)

^b SYMRISE AG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC AMP; FLAVANONE; GLUCOSE TRANSPORTER; HOMOERIODICTYOL; PHLORETIN; PHLORIZIN; SEROTONIN; SODIUM GLUCOSE COTRANSPORTER 1; UNCLASSIFIED DRUG; FLAVONE DERIVATIVE; GLUCOSE; SLC5A1 PROTEIN, HUMAN;

ARTICLE; CACO-2 CELL LINE; CELL VIABILITY; CONTROLLED STUDY; DRUG MECHANISM; GENE EXPRESSION; GLUCOSE METABOLISM; GLUCOSE TRANSPORT; HUMAN; HUMAN CELL; SEROTONIN RELEASE; SIGNAL TRANSDUCTION; ADENOCARCINOMA; CELL DIFFERENTIATION; CELL SURVIVAL; COLON TUMOR; DRUG EFFECTS; EXTRACELLULAR SPACE; GENETICS; METABOLISM; PATHOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SECRETION (PROCESS); TRANSPORT AT THE CELLULAR LEVEL; TUMOR CELL LINE;

ADENOCARCINOMA; BIOLOGICAL TRANSPORT; CACO-2 CELLS; CELL DIFFERENTIATION; CELL LINE, TUMOR; CELL SURVIVAL; COLONIC NEOPLASMS; CYCLIC AMP; EXTRACELLULAR SPACE; FLAVONES; GENE EXPRESSION; GLUCOSE; HUMANS; PHLORHIZIN; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SEROTONIN; SIGNAL TRANSDUCTION; SODIUM-GLUCOSE TRANSPORTER 1;

EID: 85012112330     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0171580     Document Type: Article

References (24)

1. Gorboulev V, Schurmann A, Vallon V, Kipp H, Jaschke A, Klessen D, et al. Na+-d-glucose cotransporter SGLT1 is pivotal for intestinal glucose absorption and glucose-dependent incretin secretion. Diabetes. 2012;61(1):187-96. doi: 10.2337/db11-1029 PMID: 22124465
2. Mueckler M. Facilitative glucose transporters. Eur J Biochem. 1994;219(3):713-25. PMID: 8112322
3. Gouyon F, Caillaud L, Carriere V, Klein C, Dalet V, Citadelle D, et al. Simple-sugar meals target GLUT2 at enterocyte apical membranes to improve sugar absorption: a study in GLUT2-null mice. J Physiol. 2003;552(3):823-32.
4. Grefner N, Gromova L, Gruzdkov A, Komissarchik YY. Comparative analysis of SGLT1 and GLUT2 transporters distribution in rat small-intestine enterocytes and Caco-2 cells during hexose absorption. Cell and Tissue Biology. 2010;4(4):354-61.
5. Kellett GL, Brot-Laroche E, Mace OJ, Leturque A. Sugar absorption in the intestine: the role of GLUT2. Annu Rev Nutr. 2008;28:35-54. Epub 2008/04/09. doi: 10.1146/annurev. nutr.28.061807.155518 PMID: 18393659
6. Zheng Y, Scow JS, Duenes JA, Sarr MG. Mechanisms of glucose uptake in intestinal cell lines: role of GLUT2. Surgery. 2012;151(1):13-25. doi: 10.1016/j.surg.2011.07.010 PMID: 21943636
7. Grefner N, Gromova L, Gruzdkov A, Komissarchik YY. Caco2 cell culture as an intestinal epithelium model to study hexose transport. Cell and Tissue Biology. 2012;6(4):335-40.
8. Shirazi-Beechey S, Moran A, Batchelor D, Daly K, Al-Rammahi M. Glucose sensing and signalling; regulation of intestinal glucose transport. Proc Nutr Soc. 2011;70(02):185-93.
9. Kim M, Cooke HJ, Javed NH, Carey HV, Christofi F, Raybould HE. D-glucose releases 5-hydroxytryptamine from human BON cells as a model of enterochromaffin cells. Gastroenterology. 2001;121(6):1400-6. Epub 2001/12/01. PMID: 11729119
10. Hajduch E, Rencurel F, Balendran A, Batty IH, Downes CP, Hundal HS. Serotonin (5-Hydroxytryptamine), a novel regulator of glucose transport in rat skeletal muscle. J Biol Chem. 1999;274(19):13563-8. PMID: 10224126
11. Margolskee RF, Dyer J, Kokrashvili Z, Salmon KS, Ilegems E, Daly K, et al. T1R3 and gustducin in gut sense sugars to regulate expression of Na+-glucose cotransporter 1. Proc Natl Acad Sci. 2007;104(38):15075-80. doi: 10.1073/pnas.0706678104 PMID: 17724332
12. Alzaid F, Cheung HM, Preedy VR, Sharp PA. Regulation of glucose transporter expression in human intestinal Caco-2 cells following exposure to an anthocyanin-rich berry extract. PLoS One. 2013;8(11):e78932. PubMed Central PMCID: PMCPMC3827299. doi: 10.1371/journal.pone.0078932 PMID: 24236070
13. Johnston K, Sharp P, Clifford M, Morgan L. Dietary polyphenols decrease glucose uptake by human intestinal Caco-2 cells. FEBS Lett. 2005;579(7):1653-7. Epub 2005/03/11. doi: 10.1016/j.febslet.2004. 12.099 PMID: 15757656
14. Park JB. Flavonoids are potential inhibitors of glucose uptake in U937 cells. Biochem Biophys Res Co. 1999;260(2):568-74.
15. Yang Y, Wolfram J, Boom K, Fang X, Shen H, Ferrari M. Hesperetin impairs glucose uptake and inhibits proliferation of breast cancer cells. Cell Biochem Funct. 2013;31(5):374-9. doi: 10.1002/cbf.2905 PMID: 23042260
16. Ley JP, KrammerG, ReindersG, Gatfield IL, Bertram HJ. Evaluation of bitter masking flavanones from Herba Santa (Eriodictyon californicum (H. and A.) Torr., Hydrophyllaceae). J Agric Food Chem. 2005;53(15):6061-6. doi: 10.1021/jf0505170 PMID: 16028996
17. Doihara H, Nozawa K, Kojima R, Kawabata-Shoda E, YokoyamaT, Ito H. QGP-1 cells release 5-HT via TRPA1 activation; a model of human enterochromaffin cells. Mol Cell Biochem. 2009;331(1-2):239-45. doi: 10.1007/s11010-009-0165-7 PMID: 19507004
18. Yanai H, Tomono Y, Ito K, Hirowatari Y, Yoshida H, Tada N. A molecular mechanism for diacylglycerolmediated promotion of negative caloric balance. Diabetes Metab Syndr Obes. 2010;3:1-6. Epub 2010/01/01. PubMed Central PMCID: PMC3047988.
19. Tandy S, Williams M, Leggett A, Lopez-Jimenez M, Dedes M, Ramesh B, etal. Nramp2 expression is associated with pH-dependent iron uptake across the apical membrane of human intestinal Caco-2 cells. J Biol Chem. 2000;275(2):1023-9. PMID: 10625641
20. Riedel A, Lang R, Rohm B, Rubach M, Hofmann T, Somoza V. Structure-dependent effects of pyridine derivatives on mechanisms of intestinal fatty acid uptake: regulation of nicotinic acid receptor and fatty acid transporter expression. J Nutr Biochem. 2014;25(7):750-7. Epub 2014/04/29. doi: 10.1016/j. jnutbio.2014.03.002 PMID: 24767308
21. Rohm B, Riedel A, Ley JP, Widder S, Krammer GE, Somoza V. Capsaicin, nonivamide and trans-pellitorine decrease free fatty acid uptake without TRPV1 activation and increase acetyl-coenzyme A synthetase activity in Caco-2 cells. Food Funct. 2015;6(1):173-85. Epub 2014/11/26. doi: 10.1039/c4fo00435c PMID: 25422952
22. Raybould HE. Gut chemosensing: interactions between gut endocrine cells and visceral afferents. Auton Neurosci. 2010;153(1-2):©41-6. Epub 2009/08/14. PubMed Central PMCID: PMC3014315. doi: 10.1016/j.autneu.2009.07.007 PMID: 19674941
23. Rohm B, HolikAK, Somoza MM, Pignitter M, Zaunschirm M, Ley JP, etal. Nonivamide, a capsaicin analog, increases dopamine and serotonin release in SH-SY5Y cells via a TRPV1-independent pathway. Mol Nutr Food Res. 2013;57(11):2008-18. Epub 2013/08/10. doi: 10.1002/mnfr.201200846 PMID: 23929722
24. Holik AK, Rohm B, Somoza MM, Somoza V. N (epsilon) -Carboxymethyllysine (CML), a Maillard reaction product, stimulates serotonin release and activates the receptor for advanced glycation end products (RAGE) in SH-SY5Y cells. Food Funct. 2013;4(7):1111-20. Epub 2013/06/14. doi: 10.1039/c3fo60097a PMID: 23759926