VP24-karyopherin alpha binding affinities differ between Ebolavirus species, influencing interferon inhibition and VP24 stability

Journal of Virology

Volumn 91, Issue 4, 2017, Pages

  Schwarz, Toni M ^a   Edwards, Megan R ^b   Diederichs, Audrey ^a   Alinger, Joshua B ^b   Leung, Daisy W ^b   Amarasinghe, Gaya K ^b   Basler, Christopher F ^a,c  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^b WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c GEORGIA STATE UNIVERSITY   (United States)

Author keywords

Ebola virus; Filovirus; Interferons; Karyopherin; Protein stability; STAT1

Indexed keywords

INTERFERON; KARYOPHERIN ALPHA; PROTEIN VP24; UNCLASSIFIED DRUG; VIRAL PROTEIN; HYBRID PROTEIN; ISOPROTEIN; PROTEIN BINDING; VP24 PROTEIN, EBOLA VIRUS;

ARTICLE; BINDING AFFINITY; BIOACCUMULATION; BUNDIBUGYO EBOLAVIRUS; CONTROLLED STUDY; EBOLAVIRUS; HALF LIFE TIME; HUMAN; HUMAN CELL; NONHUMAN; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; PROTEIN SYNTHESIS REGULATION; RESTON EBOLAVIRUS; SPECIES DIFFERENCE; VIRUS GENOME; VIRUS REPLICATION; VIRUS STRAIN; VIRUS VIRULENCE; ZAIRE EBOLAVIRUS; AMINO ACID SEQUENCE; CELL LINE; CHEMISTRY; EBOLA HEMORRHAGIC FEVER; GENETICS; METABOLISM; MOLECULAR MODEL; PHYSIOLOGY; PROTEIN CONFORMATION; STRUCTURE ACTIVITY RELATION; VIROLOGY;

ALPHA KARYOPHERINS; AMINO ACID SEQUENCE; CELL LINE; EBOLAVIRUS; HEMORRHAGIC FEVER, EBOLA; HUMANS; INTERFERONS; MODELS, MOLECULAR; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN ISOFORMS; PROTEIN STABILITY; RECOMBINANT FUSION PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP; VIRAL PROTEINS;

EID: 85012024617     PISSN: 0022538X     EISSN: 10985514     Source Type: Journal    
DOI: 10.1128/JVI.01715-16     Document Type: Article

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