Structural insights into reovirus σ1 interactions with two neutralizing antibodies

Journal of Virology

Volumn 91, Issue 4, 2017, Pages

  Dietrich, Melanie H ^a   Ogden, Kristen M ^b   Katen, Sarah P ^b,d   Reiss, Kerstin ^a,e   Sutherland, Danica M ^b,f   Carnahan, Robert H ^c   Goff, Matthew ^c   Cooper, Tracy ^c   Dermody, Terence S ^b,f   Stehle, Thilo ^a,b  

^a UNIVERSITY OF TÜBINGEN   (Germany)

^b VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

^c VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d Assembly Biosciences Inc R D Main Facility   (United States)

^e PHAST GmbH   (Germany)

^f UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

Crystal structure; Fab fragments; Flow cytometry; Immune escape; Mammalian reoviruses; Monoclonal antibodies; Quaternary binding epitope; Receptor binding; Surface plasmon resonance; Virus neutralization

Indexed keywords

IMMUNOGLOBULIN F(AB) FRAGMENT; JUNCTIONAL ADHESION MOLECULE A; NEUTRALIZING ANTIBODY; INFLUENZA VIRUS HEMAGGLUTININ; PROTEIN BINDING; VIRAL PROTEIN; VIRUS ANTIBODY;

ANTIGEN ANTIBODY REACTION; ANTIGEN BINDING; ANTIGEN RECOGNITION; ARTICLE; BINDING SITE; CARBOXY TERMINAL SEQUENCE; COMPLEX FORMATION; CONTROLLED STUDY; CROSS REACTION; HEMAGGLUTINATION INHIBITION; HYDROGEN BOND; MAMMALIAN ORTHOREOVIRUS 1; MAMMALIAN ORTHOREOVIRUS 3; NONHUMAN; PROTEIN BINDING; PROTEIN EXPRESSION; VIRION; VIRUS ATTACHMENT; VIRUS INFECTIVITY; VIRUS NEUTRALIZATION; AMINO ACID SEQUENCE; ANIMAL; CELL LINE; CHEMISTRY; CHO CELL LINE; CRICETULUS; DRUG EFFECTS; IMMUNOLOGY; METABOLISM; MOLECULAR DOCKING; MOLECULAR DYNAMICS; MOUSE; PHYSIOLOGY; PROTEIN CONFORMATION; PROTEIN DOMAIN; REOVIRIDAE; SERODIAGNOSIS; STRUCTURE ACTIVITY RELATION; VIRUS REPLICATION;

AMINO ACID SEQUENCE; ANIMALS; ANTIBODIES, NEUTRALIZING; ANTIBODIES, VIRAL; BINDING SITES; CELL LINE; CHO CELLS; CRICETULUS; HEMAGGLUTININ GLYCOPROTEINS, INFLUENZA VIRUS; IMMUNOGLOBULIN FAB FRAGMENTS; MICE; MOLECULAR DOCKING SIMULATION; MOLECULAR DYNAMICS SIMULATION; NEUTRALIZATION TESTS; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN INTERACTION DOMAINS AND MOTIFS; REOVIRIDAE; STRUCTURE-ACTIVITY RELATIONSHIP; VIRAL PROTEINS; VIRUS REPLICATION;

EID: 85011961621     PISSN: 0022538X     EISSN: 10985514     Source Type: Journal    
DOI: 10.1128/JVI.01621-16     Document Type: Article

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