Chlamydial lipoproteins stimulate toll-like receptors 1/2 mediated inflammatory responses through MyD88-dependent pathway

Frontiers in Microbiology

Volumn 8, Issue JAN, 2017, Pages

  Wang, Yong ^a   Liu, Qiong ^b   Chen, Ding ^c   Guan, Jie ^a   Ma, Linghui ^a   Zhong, Guangming ^c   Shu, Hengping ^a   Wu, Xiang ^a  

^a CENTRAL SOUTH UNIVERSITY   (China)

^b CENTRAL SOUTH UNIVERSITY   (China)

^c University of Texas Health Science Center   (United States)

Author keywords

Chlamydial trachoma; Cytokine; Immune response; Lipoproteins; Toll Like Receptor

Indexed keywords

CD14 ANTIGEN; HOMOFENAZINE; INTERLEUKIN 8 ANTIBODY; LIPOPROTEIN; MYELOID DIFFERENTIATION FACTOR 88; TOLL LIKE RECEPTOR;

ARTICLE; CELL STIMULATION; CHLAMYDIA; CHLAMYDIAL PNEUMONIA; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; GENE EXPRESSION; HEK293 CELL LINE; MOLECULAR CLONING; MOUSE; NONHUMAN; PROTEIN EXPRESSION;

EID: 85011949661     PISSN: None     EISSN: 1664302X     Source Type: Journal    
DOI: 10.3389/fmicb.2017.00078     Document Type: Article

References (35)

1. Akira, S. (2003). Mammalian Toll-like receptors. Curr. Opin. Immunol. 15, 5-11. doi: 10.1016/S0952-7915(02)00013-4
2. Akira, S., and Takeda, K. (2004). Toll-like receptor signalling. Nat. Rev. Immunol. 4, 499-511. doi: 10.1038/nri1391
3. Bas, S., James, R. W., and Gabay, C. (2010). Serum lipoproteins attenuate macrophage activation and Toll-Like Receptor stimulation by bacterial lipoproteins. BMC Immunol. 11:46. doi: 10.1186/1471-2172-11-46
4. Bas, S., Neff, L., Vuillet, M., Spenato, U., Seya, T., Matsumoto, M., et al. (2008). The proinflammatory cytokine response to Chlamydia trachomatis elementary bodies in human macrophages is partly mediated by a lipoprotein, the macrophage infectivity potentiator, through TLR2/TLR1/TLR6 and CD14. J. Immunol. 180, 1158-1168. doi: 10.4049/jimmunol.180.2.1158
5. Basak, C., Pathak, S. K., Bhattacharyya, A., Pathak, S., Basu, J., and Kundu, M. (2005). The secreted peptidyl prolyl cis, trans-isomerase HP0175 of Helicobacter pylori induces apoptosis of gastric epithelial cells in a TLR4-and apoptosis signal-regulating kinase 1-dependent manner. J. Immunol. 174, 5672-5680. doi: 10.4049/jimmunol.174.9.5672
6. Bulut, Y., Faure, E., Thomas, L., Karahashi, H., Michelsen, K. S., Equils, O., et al. (2002). Chlamydial heat shock protein 60 activates macrophages and endothelial cells through Toll-like receptor 4 and MD2 in a MyD88-dependent pathway. J. Immunol. 168, 1435-1440. doi: 10.4049/jimmunol.168.3.1435
7. Casanova, J. L., Abel, L., and Quintana-Murci, L. (2011). Human TLRs and IL-1Rs in host defense: natural insights from evolutionary, epidemiological, and clinical genetics. Annu. Rev. Immunol. 29, 447-491. doi: 10.1146/annurev-immunol-030409-101335
8. Centers for Disease Control Prevention (1997). Chlamydia trachomatis genital infections-United States, 1995. MMWR Morb. Mortal. Wkly. Rep. 46, 193-198.
9. Cohen-Sfady, M., Nussbaum, G., Pevsner-Fischer, M., Mor, F., Carmi, P., Zanin-Zhorov, A., et al. (2005). Heat shock protein 60 activates B cells via the TLR4-MyD88 pathway. J. Immunol. 175, 3594-3602. doi: 10.4049/jimmunol.175.6.3594
10. Corsaro, D., and Greub, G. (2006). Pathogenic potential of novel Chlamydiae and diagnostic approaches to infections due to these obligate intracellular bacteria. Clin. Microbiol. Rev. 19, 283-297. doi: 10.1128/CMR.19.2.283-297.2006
11. Darville, T., O'neill, J. M., Andrews, C. W. Jr., Nagarajan, U. M., Stahl, L., and Ojcius, D. M. (2003). Toll-like receptor-2, but not Toll-like receptor-4, is essential for development of oviduct pathology in chlamydial genital tract infection. J. Immunol. 171, 6187-6197. doi: 10.4049/jimmunol.171.11.6187
12. Fitzgerald, K. A., Rowe, D. C., Barnes, B. J., Caffrey, D. R., Visintin, A., Latz, E., et al. (2003). LPS-TLR4 signaling to IRF-3/7 and NF-kappaB involves the toll adapters TRAM and TRIF. J. Exp. Med. 198, 1043-1055. doi: 10.1084/jem.20031023
13. Flohé, S. B., Brüggemann, J., Lendemans, S., Nikulina, M., Meierhoff, G., Flohé, S., et al. (2003). Human heat shock protein 60 induces maturation of dendritic cells versus a Th1-promoting phenotype. J. Immunol. 170, 2340-2348. doi: 10.4049/jimmunol.170.5.2340
14. Hahn, D. L., Dodge, R. W., and Golubjatnikov, R. (1991). Association of Chlamydia pneumoniae (strain TWAR) infection with wheezing, asthmatic bronchitis, and adult-onset asthma. JAMA 266, 225-230. doi: 10.1001/jama.1991.03470020051031
15. He, X., Nair, A., Mekasha, S., Alroy, J., O'connell, C. M., and Ingalls, R. R. (2011). Enhanced virulence of Chlamydia muridarum respiratory infections in the absence of TLR2 activation. PLoS ONE 6:e20846. doi: 10.1371/journal.pone.0020846
16. Janeway, C. A. Jr., and Medzhitov, R. (2002). Innate immune recognition. Annu. Rev. Immunol. 20, 197-216. doi: 10.1146/annurev.immunol.20.083001.084359
17. Kalayoglu, M. V., Libby, P., and Byrne, G. I. (2002). Chlamydia pneumoniae as an emerging risk factor in cardiovascular disease. JAMA 288, 2724-2731. doi: 10.1001/jama.288.21.2724
18. Kiviat, N. B., Paavonen, J. A., Wølner-Hanssen, P., Critchlow, C. W., Stamm, W. E., Douglas, J., et al. (1990). Histopathology of endocervical infection caused by Chlamydia trachomatis, herpes simplex virus, Trichomonas vaginalis, and Neisseria gonorrhoeae. Hum. Pathol. 21, 831-837. doi: 10.1016/0046-8177(90)90052-7
19. Kufer, T. A., and Sansonetti, P. J. (2007). Sensing of bacteria: NOD a lonely job. Curr. Opin. Microbiol. 10, 62-69. doi: 10.1016/j.mib.2006.11.003
20. Lien, E., Sellati, T. J., Yoshimura, A., Flo, T. H., Rawadi, G., Finberg, R. W., et al. (1999). Toll-like receptor 2 functions as a pattern recognition receptor for diverse bacterial products. J. Biol. Chem. 274, 33419-33425. doi: 10.1074/jbc.274.47.33419
21. Mertz, K. J., McQuillan, G. M., Levine, W. C., Candal, D. H., Bullard, J. C., Johnson, R. E., et al. (1998). A pilot study of the prevalence of chlamydial infection in a national household survey. Sex. Transm. Dis. 25, 225-228. doi: 10.1097/00007435-199805000-00001
22. Mühlradt, P. F., Meyer, H., and Jansen, R. (1996). Identification of S-(2, 3-dihydroxypropyl)cystein in a macrophage-activating lipopeptide from Mycoplasma fermentans. Biochemistry 35, 7781-7786. doi: 10.1021/bi9602831
23. Ohashi, K., Burkart, V., Flohé, S., and Kolb, H. (2000). Cutting edge: heat shock protein 60 is a putative endogenous ligand of the toll-like receptor-4 complex. J. Immunol. 164, 558-561. doi: 10.4049/jimmunol.164.2.558
24. Patton, D. L., and Kuo, C. C. (1989). Histopathology of Chlamydia trachomatis salpingitis after primary and repeated reinfections in the monkey subcutaneous pocket model. J. Reprod. Fertil. 85, 647-656. doi: 10.1530/jrf.0.0850647
25. Peterman, T. A., Tian, L. H., Metcalf, C. A., Satterwhite, C. L., Malotte, C. K., Deaugustine, N., et al. (2006). High incidence of new sexually transmitted infections in the year following a sexually transmitted infection: a case for rescreening. Ann. Intern. Med. 145, 564-572. doi: 10.7326/0003-4819-145-8-200610170-00005
26. Sellati, T. J., Bouis, D. A., Kitchens, R. L., Darveau, R. P., Pugin, J., Ulevitch, R. J., et al. (1998). Treponema pallidum and Borrelia burgdorferi lipoproteins and synthetic lipopeptides activate monocytic cells via a CD14-dependent pathway distinct from that used by lipopolysaccharide. J. Immunol. 160, 5455-5464.
27. Sherman, K. J., Daling, J. R., Stergachis, A., Weiss, N. S., Foy, H. M., Wang, S. P., et al. (1990). Sexually transmitted diseases and tubal pregnancy. Sex. Transm. Dis. 17, 115-121. doi: 10.1097/00007435-199007000-00001
28. Takeda, K., Takeuchi, O., and Akira, S. (2002). Recognition of lipopeptides by Toll-like receptors. J. Endotoxin Res. 8, 459-463. doi: 10.1179/096805102125001073
29. Takeuchi, O., Kawai, T., Mühlradt, P. F., Morr, M., Radolf, J. D., Zychlinsky, A., et al. (2001). Discrimination of bacterial lipoproteins by Toll-like receptor 6. Int. Immunol. 13, 933-940. doi: 10.1093/intimm/13.7.933
30. Tsan, M. F., and Gao, B. (2009). Heat shock proteins and immune system. J. Leukoc. Biol. 85, 905-910. doi: 10.1189/jlb.0109005
31. Vasselon, T., Detmers, P. A., Charron, D., and Haziot, A. (2004). TLR2 recognizes a bacterial lipopeptide through direct binding. J. Immunol. 173, 7401-7405. doi: 10.4049/jimmunol.173.12.7401
32. Wetzler, L. M. (2003). The role of Toll-like receptor 2 in microbial disease and immunity. Vaccine 21(Suppl. 2), S55-S60. doi: 10.1016/s0264-410x(03)00201-9
33. Wright, H. R., Turner, A., and Taylor, H. R. (2008). Trachoma. Lancet 371, 1945-1954. doi: 10.1016/S0140-6736(08)60836-3
34. Wu, X., Lei, L., Gong, S., Chen, D., Flores, R., and Zhong, G. (2011). The chlamydial periplasmic stress response serine protease cHtrA is secreted into host cell cytosol. BMC Microbiol. 11:87. doi: 10.1186/1471-2180-11-87
35. Zhong, G., Fan, P., Ji, H., Dong, F., and Huang, Y. (2001). Identification of a chlamydial protease-like activity factor responsible for the degradation of host transcription factors. J. Exp. Med. 193, 935-942. doi: 10.1084/jem.193.8.935