Can you cause inflammatory bowel disease with fecal transplantation? A 31-patient case-series of fecal transplantation using stool from a donor who later developed Crohn's disease

Gut Microbes

Volumn 8, Issue 3, 2017, Pages 205-207

  Fischer, Monika ^a   Bittar, Mohamad ^a   Papa, Eliseo ^b   Kassam, Zain ^b,c   Smith, Mark ^b,c  

^a INDIANA UNIVERSITY   (United States)

^b MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^c OpenBiome   (United States)

Author keywords

Crohn's disease; fecal microbiota transplant; gut microbiota; stool donor; transmissible

Indexed keywords

ADALIMUMAB; AZATHIOPRINE; INFLIXIMAB; MERCAPTOPURINE; PREDNISONE; RNA 16S; TACROLIMUS;

ADULT; BLOODY DIARRHEA; CLINICAL ARTICLE; CLOSTRIDIUM DIFFICILE INFECTION; COLONOSCOPY; CONTROLLED STUDY; CROHN DISEASE; DNA EXTRACTION; FECAL MICROBIOTA TRANSPLANTATION; FECES ANALYSIS; FEMALE; GENE AMPLIFICATION; HUMAN; INFLAMMATORY BOWEL DISEASE; LETTER; MALE; MICROBIAL DIVERSITY; QUESTIONNAIRE; ULCERATIVE COLITIS; AGED; BACTERIUM; CASE REPORT; CLASSIFICATION; CLOSTRIDIUM INFECTION; DONOR; DONOR SELECTION; FECES; FOLLOW UP; GENETICS; MICROBIOLOGY; MIDDLE AGED; PATHOLOGY; STANDARDS; TREATMENT OUTCOME;

ADULT; AGED; BACTERIA; CLOSTRIDIUM INFECTIONS; CROHN DISEASE; DONOR SELECTION; FECAL MICROBIOTA TRANSPLANTATION; FECES; FEMALE; FOLLOW-UP STUDIES; HUMANS; INFLAMMATORY BOWEL DISEASES; MALE; MIDDLE AGED; RNA, RIBOSOMAL, 16S; TISSUE DONORS; TREATMENT OUTCOME;

EID: 85011697929     PISSN: 19490976     EISSN: 19490984     Source Type: Journal    
DOI: 10.1080/19490976.2017.1283469     Document Type: Letter

References (7)

1. Kostic AD, Xavier RJ, Gevers D. The microbiome in inflammatory bowel disease:current status and the future ahead. Gastroenterology 2014; 146:1489-99; PMID:24560869; http://dx.doi.org/10.1053/j.gastro.2014.02.009
2. Moayyedi P, Surette MG, Kim PT, Libertucci J, Wolfe M, Onischi C, Armstrong D, Marshall JK, Kassam Z, Reinisch W, et al. Fecal microbiota transplantation induces remission in patients with active ulcerative colitis in a randomized controlled trial. Gastroenterology 2015; 149:102-9 e6.
3. Schaubeck M, Clavel T, Calasan J, Lagkouvardos I, Haange SB, Jehmlich N, Basic M, Dupont A, Hornef M, von Bergen M, et al. Dysbiotic gut microbiota causes transmissible Crohn's disease-like ileitis independent of failure in antimicrobial defence. Gut 2016; 65:225-37; PMID:25887379; http://dx.doi.org/10.1136/gutjnl-2015-309333
4. Couturier-Maillard A, Secher T, Rehman A, Normand S, De Arcangelis A, Haesler R, Huot L, Grandjean T, Bressenot A, Delanoye-Crespin A, et al. NOD2-mediated dysbiosis predisposes mice to transmissible colitis and colorectal cancer. J Clin Invest 2013; 123:700-11; PMID:23281400
5. Garrett WS, Lord GM, Punit S, Lugo-Villarino G, Mazmanian SK, Ito S, Glickman JN, Glimcher LH. Communicable ulcerative colitis induced by T-bet deficiency in the innate immune system. Cell 2007; 131:33-45; PMID:17923086; http://dx.doi.org/10.1016/j.cell.2007.08.017
6. Bakken JS, Borody T, Brandt LJ, Brill JV, Demarco DC, Franzos MA, Kelly C, Khoruts A, Louie T, Martinelli LP, et al. Treating Clostridium difficile infection with fecal microbiota transplantation. Clin Gastroenterol Hepatol 2011; 9:1044-9; PMID:21871249; http://dx.doi.org/10.1016/j.cgh.2011.08.014
7. Menees SB, Powell C, Kurlander J, Goel A, Chey WD. A meta-analysis of the utility of C-reactive protein, erythrocyte sedimentation rate, fecal calprotectin, and fecal lactoferrin to exclude inflammatory bowel disease in adults with IBS. Am J Gastroenterol 2015; 110:444-54; PMID:25732419; http://dx.doi.org/10.1038/ajg.2015.6