Carboxy-terminal fragment of fibroblast growth factor 23 induces heart hypertrophy in sickle cell disease

Haematologica

Volumn 102, Issue 2, 2017, Pages e33-e35

  Courbebaisse, Marie ^a,b,c,d   Mehel, Hind ^b   Petit Hoang, Camille ^b   Ribeil, Jean Antoine ^e   Sabbah, Laurent ^e   Tuloup Minguez, Véronique ^b   Bergerat, David ^b   Arlet, Jean Benoit ^d,f   Stanislas, Aurélie ^e   Souberbielle, Jean Claude ^b,c   Le Clésiau, Hervé ^g   Fischmeister, Rodolphe ^h   Friedlander, Gérard ^a,b,d   Prié, Dominique ^a,b,c  

^a UNIVERSITÉ PARIS DESCARTES   (France)

^b INSTITUT NECKER ENFANTS MALADES   (France)

^c HÔPITAL NECKER ENFANTS MALADES   (France)

^d HÔPITAL EUROPÉEN GEORGES POMPIDOU   (France)

^e ASSISTANCE PUBLIQUE HÔPITAUX DE PARIS   (France)

^f IMAGINE INSTITUTE   (France)

^g Centre de Santé et d Assurance Maladie Agence de Seine Saint Denis   (France)

^h INSERM   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CALCITRIOL; FIBROBLAST GROWTH FACTOR 23; HEMOGLOBIN; MESSENGER RNA; BETA GLUCURONIDASE; FGFR1 PROTEIN, HUMAN; FIBROBLAST GROWTH FACTOR; FIBROBLAST GROWTH FACTOR RECEPTOR 1; HEMOGLOBIN D PUNJAB; HEMOGLOBIN S; HEMOGLOBIN VARIANT; KLOTHO PROTEIN; PARATHYROID HORMONE;

ANIMAL CELL; CONTROLLED STUDY; DIASTOLIC DYSFUNCTION; DNA SEQUENCE; ECHOCARDIOGRAPHY; GENOTYPE; GLOMERULUS FILTRATION RATE; HEART HYPERTROPHY; HEART LEFT VENTRICLE EJECTION FRACTION; HEMOGLOBIN SC DISEASE; HUMAN; IMMUNOASSAY; KIDNEY FAILURE; LETTER; MAJOR CLINICAL STUDY; MORTALITY; MRNA EXPRESSION ASSAY; NONHUMAN; OXYGEN SATURATION; RAT; SICKLE CELL ANEMIA; SICKLE CELL BETA THALASSEMIA; WESTERN BLOTTING; ADOLESCENT; BLOOD; BLOOD PRESSURE; CARDIOMEGALY; COMPLICATION; FEMALE; GENE EXPRESSION REGULATION; GENETICS; MALE; METABOLISM; PATHOLOGY; PROTEIN DOMAIN; YOUNG ADULT;

ADOLESCENT; ANEMIA, SICKLE CELL; BLOOD PRESSURE; CARDIOMEGALY; ECHOCARDIOGRAPHY; FEMALE; FIBROBLAST GROWTH FACTORS; GENE EXPRESSION REGULATION; GLOMERULAR FILTRATION RATE; GLUCURONIDASE; HEMOGLOBIN, SICKLE; HEMOGLOBINS, ABNORMAL; HUMANS; MALE; PARATHYROID HORMONE; PROTEIN DOMAINS; RECEPTOR, FIBROBLAST GROWTH FACTOR, TYPE 1; YOUNG ADULT;

EID: 85011565172     PISSN: 03906078     EISSN: 15928721     Source Type: Journal    
DOI: 10.3324/haematol.2016.150987     Document Type: Letter

References (15)

1. Sachdev V, Machado RF, Shizukuda Y, et al. Diastolic dysfunction is an independent risk factor for death in patients with sickle cell disease. J Am Coll Cardiol. 2007; 49 (4): 472-479.
2. Voskaridou E, Christoulas D, Terpos E. Sickle-cell disease and the heart: review of the current literature. Br J Haematol. 2012; 157 (6): 664-673.
3. Prié D, Torres PU, Friedlander G. Latest findings in phosphate homeostasis. Kidney International. 2009; 75 (9): 882-889.
4. Faul C. Fibroblast growth factor 23 and the heart. Curr Opin Nephrol Hypertens. 2012; 21 (4): 369-375.
5. Souma N, Isakova T, Lipiszko D, et al. Fibroblast Growth Factor 23 and Cause-Specific Mortality in the General Population: The Northern Manhattan Study. J Clin Endocrinol Metab. 2016; jc2016-2215.
6. Lutsey PL, Alonso A, Selvin E, et al. Fibroblast growth factor-23 and incident coronary heart disease, heart failure, and cardiovascular mortality: the Atherosclerosis Risk in Communities study. J Am Heart Assoc. 2014; 3 (3): e000936.
7. Faul C, Amaral AP, Oskouei B, et al. FGF23 induces left ventricular hypertrophy. J Clin Invest. 2011; 121 (11): 4393-4408.
8. Haymann JP, Stankovic K, Levy P, et al. Glomerular hyperfiltration in adult sickle cell anemia: a frequent hemolysis associated feature. Clin J Am Soc Nephrol. 2010; 5 (5): 756-761.
9. Braithwaite V, Prentice AM, Doherty C, Prentice A. FGF23 is correlated with iron status but not with inflammation and decreases after iron supplementation: a supplementation study. Int J Pediatr Endocrinol. 2012; 2012 (1): 27.
10. Wolf M, Koch TA, Bregman DB. Effects of iron deficiency anemia and its treatment on fibroblast growth factor 23 and phosphate homeostasis in women. J Bone Miner Res. 2013; 28 (8): 1793-1803.
11. Clinkenbeard EL, Farrow EG, Summers LJ, et al. Neonatal iron deficiency causes abnormal phosphate metabolism by elevating FGF23 in normal and ADHR mice. J Bone Miner Res. 2014; 29 (2): 361-369.
12. Zhang Q, Doucet M, Tomlinson RE, et al. The hypoxia-inducible factor- 1alpha activates ectopic production of fibroblast growth factor 23 in tumor-induced osteomalacia. Bone Res. 2016; 4: 16011.
13. Raj VM, Freundlich M, Hamideh D, et al. Abnormalities in renal tubular phosphate handling in children with sickle cell disease. Pediatr Blood Cancer. 2014; 61 (12): 2267-2270.
14. Goetz R, Nakada Y, Hu MC, et al. Isolated C-terminal tail of FGF23 alleviates hypophosphatemia by inhibiting FGF23-FGFR-Klotho complex formation. Proc Natl Acad Sci USA. 2010; 107 (1): 407-412.
15. Goetz R, Ohnishi M, Kir S, et al. Conversion of a paracrine fibroblast growth factor into an endocrine fibroblast growth factor. J Biol Chem. 2012; 287 (34): 29134-29146.