Neonatal Iron deficiency causes abnormal phosphate metabolism by elevating FGF23 in normal and ADHR Mice

Journal of Bone and Mineral Research

Volumn 29, Issue 2, 2014, Pages 361-369

  Clinkenbeard, Erica L ^a   Farrow, Emily G ^b   Summers, Lelia J ^a   Cass, Taryn A ^a   Roberts, Jessica L ^a   Bayt, Christine A ^a   Lahm, Tim ^a   Albrecht, Marjorie ^a   Allen, Matthew R ^a   Peacock, Munro ^a   White, Kenneth E ^a  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b CHILDREN S MERCY HOSPITAL   (United States)

Author keywords

BONE; HYPOPHOSPHATEMIA; IRON; KIDNEY; OSTEOCYTE; PHOSPHATE

Indexed keywords

FIBROBLAST GROWTH FACTOR 23; IRON; MESSENGER RNA; PHOSPHATE;

ADULT; ANEMIA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOSOMAL DOMINANT HYPOPHOSPHATEMIC RICKETS; CONTROLLED STUDY; GENOTYPE; GROWTH PLATE; HYPOPHOSPHATEMIA; HYPOXEMIA; HYPOXIA; IN VITRO STUDY; IRON DEFICIENCY; MALE; MOUSE; NEWBORN; NEWBORN DISEASE; NONHUMAN; PHENOTYPE; PHOSPHATE BLOOD LEVEL; PHOSPHATE METABOLISM; PREGNANCY; PREMATURITY; PROTEIN EXPRESSION;

BONE; HYPOPHOSPHATEMIA; IRON; KIDNEY; OSTEOCYTE; PHOSPHATE;

AMINO ACID SUBSTITUTION; ANIMALS; ANIMALS, NEWBORN; ANOXIA; CALCITRIOL; DIET; FAMILIAL HYPOPHOSPHATEMIC RICKETS; FEMALE; FIBROBLAST GROWTH FACTORS; GENE KNOCK-IN TECHNIQUES; HUMANS; IRON; MALE; MICE, MUTANT STRAINS; MUTATION, MISSENSE; PHOSPHATES; PREGNANCY; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER; STEROID HYDROXYLASES;

EID: 84892698159     PISSN: 08840431     EISSN: 15234681     Source Type: Journal    
DOI: 10.1002/jbmr.2049     Document Type: Article

References (35)

1. Econs MJ, McEnery PT,. Autosomal dominant hypophosphatemic rickets/osteomalacia: clinical characterization of a novel renal phosphate-wasting disorder. J Clin Endocrinol Metab. 1997; 82 (2): 674-81.
2. ADHR-Consortium. Autosomal dominant hypophosphataemic rickets is associated with mutations in FGF23. Nat Genet. 2000; 26 (3): 345-8.
3. White KE, Carn G, Lorenz-Depiereux B, Benet-Pages A, Strom TM, Econs MJ,. Autosomal-dominant hypophosphatemic rickets (ADHR) mutations stabilize FGF-23. Kidney Int. 2001; 60 (6): 2079-86.
4. Shimada T, Muto T, Urakawa I, et al. Mutant FGF-23 responsible for autosomal dominant hypophosphatemic rickets is resistant to proteolytic cleavage and causes hypophosphatemia in vivo. Endocrinology. 2002; 143 (8): 3179-82.
5. Gribaa M, Younes M, Bouyacoub Y, et al. An autosomal dominant hypophosphatemic rickets phenotype in a Tunisian family caused by a new FGF23 missense mutation. J Bone Miner Metab. 2010; 28 (1): 111-5.
6. Feng JQ, Ward LM, Liu S, et al. Loss of DMP1 causes rickets and osteomalacia and identifies a role for osteocytes in mineral metabolism. Nat Genet. 2006; 38 (11): 1310-5.
7. Lorenz-Depiereux B, Bastepe M, Benet-Pages A, et al. DMP1 mutations in autosomal recessive hypophosphatemia implicate a bone matrix protein in the regulation of phosphate homeostasis. Nat Genet. 2006; 38 (11): 1248-50.
8. Lorenz-Depiereux B, Schnabel D, Tiosano D, Hausler G, Strom TM,. Loss-of-function ENPP1 mutations cause both generalized arterial calcification of infancy and autosomal-recessive hypophosphatemic rickets. Am J Hum Genet. 2010; 86 (2): 267-72.
9. Saito T, Shimizu Y, Hori M, et al. A patient with hypophosphatemic rickets and ossification of posterior longitudinal ligament caused by a novel homozygous mutation in ENPP1 gene. Bone. 2011; 49 (4): 913-6.
10. Tenenhouse HS, Econs MJ,. Mendelian hypophosphatemias. In:, Valle D, editor. The metabolic and molecular bases of inherited disease. New York: McGraw-Hill; 2001. p. 1-9.
11. Imel EA, Hui SL, Econs MJ,. FGF23 concentrations vary with disease status in autosomal dominant hypophosphatemic rickets. J Bone Miner Res. 2007; 22 (4): 520-6.
12. Farrow EG, Yu X, Summers LJ, et al. Iron deficiency drives an autosomal dominant hypophosphatemic rickets (ADHR) phenotype in fibroblast growth factor-23 (Fgf23) knock-in mice. Proc Natl Acad Sci U S.A. 2011; 108 (46): E1146-55.
13. Shimada T, Mizutani S, Muto T, et al. Cloning,characterization of FGF23 as a causative factor of tumor-induced osteomalacia. Proc Natl Acad Sci U S.A. 2001; 98 (11): 6500-5.
14. Larsson T, Marsell R, Schipani E, et al. Transgenic mice expressing fibroblast growth factor 23 under the control of the alpha1(I) collagen promoter exhibit growth retardation, osteomalacia, and disturbed phosphate homeostasis. Endocrinology. 2004; 145 (7): 3087-94.
15. Haidar R, Musallam KM, Taher AT,. Bone disease and skeletal complications in patients with beta thalassemia major. Bone. 2011; 48 (3): 425-32.
16. Diaz-Castro J, Lopez-Frias MR, Campos MS, et al. Severe nutritional iron-deficiency anaemia has a negative effect on some bone turnover biomarkers in rats. Eur J Nutr. 2012; 51 (2): 241-7.
17. Terpos E, Voskaridou E,. Treatment options for thalassemia patients with osteoporosis. Ann N Y Acad Sci. 2010; 1202: 237-43.
18. Voskaridou E, Stoupa E, Antoniadou L, et al. Osteoporosis and osteosclerosis in sickle cell/beta-thalassemia: the role of the RANKL/osteoprotegerin axis. Haematologica. 2006; 91 (6): 813-6.
19. Braithwaite V, Jarjou LM, Goldberg GR, Jones H, Pettifor JM, Prentice A,. Follow-up study of Gambian children with rickets-like bone deformities and elevated plasma FGF23: possible aetiological factors. Bone. 2012; 50 (1): 218-25.
20. Braithwaite V, Jarjou LM, Goldberg GR, Prentice A,. Iron status and fibroblast growth factor-23 in Gambian children. Bone. 2012; 50 (6): 1351-6.
21. Chepelev NL, Willmore WG,. Regulation of iron pathways in response to hypoxia. Free Radic Biol Med. 2011; 50 (6): 645-66.
22. Breymann C, Honegger C, Holzgreve W, Surbek D,. Diagnosis and treatment of iron-deficiency anaemia during pregnancy and postpartum. Arch Gynecol Obstet. 2010; 282 (5): 577-80.
23. Lahm T, Albrecht M, Fisher AJ, et al. 17beta-Estradiol attenuates hypoxic pulmonary hypertension via estrogen receptor-mediated effects. Am J Respir Crit Care Med. 2012; 185 (9): 965-80.
24. Livak KJ, Schmittgen TD,. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 2001; 25 (4): 402-8.
25. Wang GL, Semenza GL,. Desferrioxamine induces erythropoietin gene expression and hypoxia-inducible factor 1 DNA-binding activity: implications for models of hypoxia signal transduction. Blood. 1993; 82 (12): 3610-5.
26. Bianchi L, Tacchini L, Cairo G,. HIF-1-mediated activation of transferrin receptor gene transcription by iron chelation. Nucleic Acids Res. 1999; 27 (21): 4223-7.
27. Abrams SA,. In utero physiology: role in nutrient delivery and fetal development for calcium, phosphorus, and vitamin D. Am J Clin Nutr. 2007; 85 (2): 604S-7S.
28. Antoniucci DM, Yamashita T, Portale AA,. Dietary phosphorus regulates serum fibroblast growth factor-23 concentrations in healthy men. J Clin Endocrinol Metab. 2006; 91 (8): 3144-9.
29. Burnett SM, Gunawardene SC, Bringhurst FR, Juppner H, Lee H, Finkelstein JS,. Regulation of C-terminal and intact FGF-23 by dietary phosphate in men and women. J Bone Miner Res. 2006; 21 (8): 1187-96.
30. Yu X, Sabbagh Y, Davis SI, Demay MB, White KE,. Genetic dissection of phosphate- and vitamin D-mediated regulation of circulating Fgf23 concentrations. Bone. 2005; 36 (6): 971-7.
31. Wong H, Mylrea K, Feber J, Drukker A, Filler G,. Prevalence of complications in children with chronic kidney disease according to KDOQI. Kidney Int. 2006; 70 (3): 585-90.
32. Miller JL,. Iron deficiency anemia: a common and curable disease. Cold Spring Harb Perspect Med. 2013 Jul 1; 3 (7).
33. Genetos DC, Toupadakis CA, Raheja LF, et al. Hypoxia decreases sclerostin expression and increases Wnt signaling in osteoblasts. J Cell Biochem. 2010; 110 (2): 457-67.
34. Hirao M, Hashimoto J, Yamasaki N, et al. Oxygen tension is an important mediator of the transformation of osteoblasts to osteocytes. J Bone Miner Metab. 2007; 25 (5): 266-76.
35. Riminucci M, Collins MT, Fedarko NS, et al. FGF-23 in fibrous dysplasia of bone and its relationship to renal phosphate wasting. J Clin Invest. 2003; 112 (5): 683-92.