메뉴 건너뛰기




Volumn 5, Issue 2, 2003, Pages 108-114

Ethical challenges of informed consent in prehospital research

Author keywords

continuous positive airway pressure; exception to informed consent; informed consent; prehospital; research

Indexed keywords


EID: 85011527306     PISSN: 14818035     EISSN: 14818043     Source Type: Journal    
DOI: 10.1017/S1481803500008253     Document Type: Article
Times cited : (15)

References (40)
  • 1
    • 0009803242 scopus 로고    scopus 로고
    • The problem of consent in emergency medicine research
    • Gray, JD. The problem of consent in emergency medicine research. CJEM. 2001; 3(3):213–8.
    • (2001) CJEM , vol.3 , Issue.3 , pp. 213-218
    • Gray, J.D.1
  • 2
  • 3
    • 0032799177 scopus 로고    scopus 로고
    • Do patients with acute medical conditions have the capacity to give informed consent for emergency medicine research?
    • Smithline, H, Mader, TJ, Crenshaw, BJ. Do patients with acute medical conditions have the capacity to give informed consent for emergency medicine research? Acad Emerg Med. 1999; 6: 776–80.
    • (1999) Acad Emerg Med , vol.6 , pp. 776-780
    • Smithline, H.1    Mader, T.J.2    Crenshaw, B.J.3
  • 4
    • 0032790595 scopus 로고    scopus 로고
    • Informed consent: the most important predictor
    • Prentice, ED. Informed consent: the most important predictor. Acad Emerg Med. 1999; 6: 774–5.
    • (1999) Acad Emerg Med , vol.6 , pp. 774-775
    • Prentice, E.D.1
  • 5
    • 0025295102 scopus 로고
    • Impact of medical hospitalization on treatment: decision-making capacity in the elderly
    • Fitten, LJ, Waite, MS. Impact of medical hospitalization on treatment: decision-making capacity in the elderly. Arch Intern Med. 1990; 150: 1717–21.
    • (1990) Arch Intern Med , vol.150 , pp. 1717-1721
    • Fitten, L.J.1    Waite, M.S.2
  • 6
    • 0025244276 scopus 로고
    • Assessing treatment decision-making capacity in elderly nursing home residents
    • Fitten, LJ, Lusky, R, Hamann, C. Assessing treatment decision-making capacity in elderly nursing home residents. J Am Geriatr Soc. 1990; 38: 1097–104.
    • (1990) J Am Geriatr Soc , vol.38 , pp. 1097-1104
    • Fitten, L.J.1    Lusky, R.2    Hamann, C.3
  • 7
    • 0016086348 scopus 로고
    • Myocardial infarction: case studies of ethics in the consent situation
    • Smith, HL. Myocardial infarction: case studies of ethics in the consent situation. Soc Sci Med. 1974; 8: 399–404.
    • (1974) Soc Sci Med , vol.8 , pp. 399-404
    • Smith, H.L.1
  • 8
    • 0029793324 scopus 로고    scopus 로고
    • Ethical considerations of ensuring an informed and autonomous consent in research involving critically ill patients
    • Silverman, HJ. Ethical considerations of ensuring an informed and autonomous consent in research involving critically ill patients. Am J Respir Crit Care Med. 1996; 154: 582–6.
    • (1996) Am J Respir Crit Care Med , vol.154 , pp. 582-586
    • Silverman, H.J.1
  • 9
    • 0035116532 scopus 로고    scopus 로고
    • Do surrogate decision makers provide accurate consent for intensive care research?
    • Coppolino, M, Ackerson, L. Do surrogate decision makers provide accurate consent for intensive care research? Chest. 2001; 119: 603–12.
    • (2001) Chest , vol.119 , pp. 603-612
    • Coppolino, M.1    Ackerson, L.2
  • 10
    • 0024393178 scopus 로고
    • Informed consent in emergency research: prehospital thrombolytic therapy for acute myocardial infarction
    • Grim, PS, Singer, PA, Gramelspacher, GP, Feldman, T, Childers, RW, Siegler, M. Informed consent in emergency research: prehospital thrombolytic therapy for acute myocardial infarction. JAMA. 1989; 262: 252–5.
    • (1989) JAMA , vol.262 , pp. 252-255
    • Grim, P.S.1    Singer, P.A.2    Gramelspacher, G.P.3    Feldman, T.4    Childers, R.W.5    Siegler, M.6
  • 11
    • 0034910146 scopus 로고    scopus 로고
    • Surrogate consent by family members for out-of-hospital cardiac arrest research
    • Hsieh, M, Dailey, MW, Callaway, CW. Surrogate consent by family members for out-of-hospital cardiac arrest research. Acad Emerg Med. 2001; 8: 851–3.
    • (2001) Acad Emerg Med , vol.8 , pp. 851-853
    • Hsieh, M.1    Dailey, M.W.2    Callaway, C.W.3
  • 12
    • 0022587057 scopus 로고
    • Emergency Cardiac Care Committee, American Heart Association. Standards and guidelines for cardiopulmonary resuscitation (CPR) and emergency cardiac care (ECC). JAMA. 1986; 255: 2841–57.
    • (1986) JAMA , vol.255 , pp. 2841-2857
  • 13
    • 0022640774 scopus 로고
    • Effectiveness of intravenous thrombolytic treatment in acute myocardial infarction. Gruppo Italiano per lo Studio della Streptochinasi nell’Infarcto Miocardico (GISSI). Lancet. 1986; 1: 397–402.
    • (1986) Lancet , vol.1 , pp. 397-402
  • 15
    • 0030735277 scopus 로고    scopus 로고
    • Quantifying the scanty science of prehospital emergency care
    • Callaham, M. Quantifying the scanty science of prehospital emergency care. Ann Emerg Med. 1997; 30: 785–90.
    • (1997) Ann Emerg Med , vol.30 , pp. 785-790
    • Callaham, M.1
  • 16
    • 0034738057 scopus 로고    scopus 로고
    • Mortality and prehospital thrombolysis for acute myocardial infarction: a meta-analysis
    • Morrison, LJ, Verbeek, PR, McDonald, AC, Sawadsky, BV, Cook, DJ. Mortality and prehospital thrombolysis for acute myocardial infarction: a meta-analysis. JAMA. 2000; 283: 2686–92.
    • (2000) JAMA , vol.283 , pp. 2686-2692
    • Morrison, L.J.1    Verbeek, P.R.2    McDonald, A.C.3    Sawadsky, B.V.4    Cook, D.J.5
  • 17
    • 0027176652 scopus 로고
    • Prehospital-initiated vs hospital-initiated thrombolytic therapy. The Myocardial Infarction Triage and Intervention Trial
    • Weaver, WD, Cerqueira, M, Hallstrom, AP, Litwin, PE, Martin, JS, Kudenchuk, PJ, et al. Prehospital-initiated vs hospital-initiated thrombolytic therapy. The Myocardial Infarction Triage and Intervention Trial. JAMA. 1993; 270: 1211–6.
    • (1993) JAMA , vol.270 , pp. 1211-1216
    • Weaver, W.D.1    Cerqueira, M.2    Hallstrom, A.P.3    Litwin, P.E.4    Martin, J.S.5    Kudenchuk, P.J.6
  • 18
    • 0026087881 scopus 로고
    • Prehospital diagnosis and treatment of acute myocardial infarction: a north-south perspective. The Cincinnati Heart Project and the Nashville Prehospital TPA Trial
    • Gibler, WB, Kereiakes, DJ, Dean, EN, Martin, L, Anderson, L, Abbottsmith, CW, et al. Prehospital diagnosis and treatment of acute myocardial infarction: a north-south perspective. The Cincinnati Heart Project and the Nashville Prehospital TPA Trial. Am Heart J. 1991; 121(1 Pt 1):1–11.
    • (1991) Am Heart J , vol.121 , Issue.1 , pp. 1-11
    • Gibler, W.B.1    Kereiakes, D.J.2    Dean, E.N.3    Martin, L.4    Anderson, L.5    Abbottsmith, C.W.6
  • 19
    • 0033950423 scopus 로고    scopus 로고
    • Effect of out-of-hospital pediatric endotracheal intubation on survival and neurological outcome: a controlled clinical trial
    • Gausche, M, Lewis, RJ, Stratton, SJ, Haynes, BE, Gunter, CS, Goodrich, SM, et al. Effect of out-of-hospital pediatric endotracheal intubation on survival and neurological outcome: a controlled clinical trial. JAMA. 2000; 283: 783–90.
    • (2000) JAMA , vol.283 , pp. 783-790
    • Gausche, M.1    Lewis, R.J.2    Stratton, S.J.3    Haynes, B.E.4    Gunter, C.S.5    Goodrich, S.M.6
  • 20
    • 0033531702 scopus 로고    scopus 로고
    • Improved out-of-hospital cardiac arrest survival through the inexpensive optimization of an existing defibrillation program: OPALS study phase II. Ontario Prehospital Advanced Life Support
    • Stiell, IG, Wells, GA, Field, BJ, Spaite, DW, De Maio, VJ, Ward, R, et al. Improved out-of-hospital cardiac arrest survival through the inexpensive optimization of an existing defibrillation program: OPALS study phase II. Ontario Prehospital Advanced Life Support. JAMA. 1999; 281: 1175–81.
    • (1999) JAMA , vol.281 , pp. 1175-1181
    • Stiell, I.G.1    Wells, G.A.2    Field, B.J.3    Spaite, D.W.4    De Maio, V.J.5    Ward, R.6
  • 21
    • 0033436339 scopus 로고    scopus 로고
    • Implementing the final rule
    • Alpert, S. Implementing the final rule. Acad Emerg Med. 1999; 6: 1188–9.
    • (1999) Acad Emerg Med , vol.6 , pp. 1188-1189
    • Alpert, S.1
  • 22
    • 0034654626 scopus 로고    scopus 로고
    • Emergency Cardiac Care. Task force 3: Special aspects of research conduct in the emergency setting: Waiver of informed consent
    • 31st Bethesda Conference.
    • Passamani, ER, Weisfeldt, ML. 31st Bethesda Conference. Emergency Cardiac Care. Task force 3: Special aspects of research conduct in the emergency setting: Waiver of informed consent. J Am Coll Cardiol. 2000; 35: 862–80.
    • (2000) J Am Coll Cardiol , vol.35 , pp. 862-880
    • Passamani, E.R.1    Weisfeldt, M.L.2
  • 23
    • 85011528214 scopus 로고    scopus 로고
    • Available: (database updated 2002 Apr 1; site accessed 2003 Jan 17). Oct 2
    • Title 21 of the Code of Federal Regulations, Section 50.24 (21CFR50.24). Exception from informed consent requirements for emergency research (61 FR 51528). US Food and Drug Administration Department of Health and Human Services; Oct 2, 1996. Available: www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?FR=50.24(database updated 2002 Apr 1; site accessed 2003 Jan 17).
    • (1996) US Food and Drug Administration Department of Health and Human Services
  • 24
    • 85011436078 scopus 로고    scopus 로고
    • Ottawa: Medical Research Council, Natural Sciences and Engineering Research Council of Canada, Social Sciences and Humanities Research Council of Canada Available: (updated 2000 Nov 21; accessed 2003 Jan 17).
    • Tri-Council Policy Statement: ethical conduct for research involving humans. Ottawa: Medical Research Council, Natural Sciences and Engineering Research Council of Canada, Social Sciences and Humanities Research Council of Canada; 1998. Available: www.nserc.ca/programs/ethics/english/ethics/policy.htm (updated 2000 Nov 21; accessed 2003 Jan 17).
    • (1998)
  • 25
    • 0003641378 scopus 로고    scopus 로고
    • Article 2.8. Ottawa: Medical Research Council, Natural Sciences and Engineering Research Council of Canada, Social Sciences and Humanities Research Council of Canada Available: (accessed 2003 Jan 17).
    • Free and informed consent: Research in emergency health situations. Article 2.8. In: Tri-Council Policy Statement: ethical conduct for research involving humans. Ottawa: Medical Research Council, Natural Sciences and Engineering Research Council of Canada, Social Sciences and Humanities Research Council of Canada; 1998. Available: www.nserc.ca/programs/ethics/english/sec02.htm#F (accessed 2003 Jan 17).
    • (1998) Tri-Council Policy Statement: ethical conduct for research involving humans
  • 26
    • 0037225183 scopus 로고    scopus 로고
    • Protecting research subjects under the waiver of informed consent for emergency research: experiences with efforts to inform the community
    • Shah, AN, Surgarman, J. Protecting research subjects under the waiver of informed consent for emergency research: experiences with efforts to inform the community. Ann Emerg Med. 2003; 41: 72–8.
    • (2003) Ann Emerg Med , vol.41 , pp. 72-78
    • Shah, A.N.1    Surgarman, J.2
  • 27
    • 0037228968 scopus 로고    scopus 로고
    • The legacy of the Tuskegee syphilis experiments for emergency exception from informed consent
    • Schmidt, TA. The legacy of the Tuskegee syphilis experiments for emergency exception from informed consent. Ann Emerg Med. 2003; 41: 79–81.
    • (2003) Ann Emerg Med , vol.41 , pp. 79-81
    • Schmidt, T.A.1
  • 28
    • 0035975408 scopus 로고    scopus 로고
    • A comparison of lorazepam, diazepam, and placebo for the treatment of out-of-hospital status epilepticus
    • Alldredge, B, Gelb, A, Isaacs, S, Corry, MD, Allen, F, Ulrich, SK. et al. A comparison of lorazepam, diazepam, and placebo for the treatment of out-of-hospital status epilepticus. N Engl J Med. 2001; 345: 631–7.
    • (2001) N Engl J Med , vol.345 , pp. 631-637
    • Alldredge, B.1    Gelb, A.2    Isaacs, S.3    Corry, M.D.4    Allen, F.5    Ulrich, S.K.6
  • 29
    • 0036311917 scopus 로고    scopus 로고
    • Paramedic-performed rapid sequence intubation of patients with severe head injuries
    • Ochs, M, Davis, D, Hoyt, D, Bailey, D, Marshall, L, Rosen, P. Paramedic-performed rapid sequence intubation of patients with severe head injuries. Ann Emerg Med. 2002; 40: 159–67.
    • (2002) Ann Emerg Med , vol.40 , pp. 159-167
    • Ochs, M.1    Davis, D.2    Hoyt, D.3    Bailey, D.4    Marshall, L.5    Rosen, P.6
  • 30
    • 0037149721 scopus 로고    scopus 로고
    • Amiodarone as compared with lidocaine for shock-resistant ventricular fibrillation [published erratum appears in N Engl J Med 2002;347:955]
    • Dorian, P, Cass, D, Schwartz, B, Cooper, R, Gelaznikas, R, Barr, A. Amiodarone as compared with lidocaine for shock-resistant ventricular fibrillation [published erratum appears in N Engl J Med 2002;347:955]. N Engl J Med. 2002; 346: 884–90.
    • (2002) N Engl J Med , vol.346 , pp. 884-890
    • Dorian, P.1    Cass, D.2    Schwartz, B.3    Cooper, R.4    Gelaznikas, R.5    Barr, A.6
  • 32
    • 0031963555 scopus 로고    scopus 로고
    • Waiver of informed consent: a survey of emergency medicine patients
    • Smithline, HA, Gerstle, ML. Waiver of informed consent: a survey of emergency medicine patients. Am J Emerg Med. 1998; 16: 90–1.
    • (1998) Am J Emerg Med , vol.16 , pp. 90-91
    • Smithline, H.A.1    Gerstle, M.L.2
  • 33
    • 0036250191 scopus 로고    scopus 로고
    • Lessons from everyday lives: a moral justification for acute care research
    • McRae, A, Weijer, C. Lessons from everyday lives: a moral justification for acute care research. Crit Care Med. 2002; 30: 1146–51.
    • (2002) Crit Care Med , vol.30 , pp. 1146-1151
    • McRae, A.1    Weijer, C.2
  • 34
    • 0032812850 scopus 로고    scopus 로고
    • Can acutely ill patients consent to research? Resolving an ethical dilemma with facts
    • Fost, N. Can acutely ill patients consent to research? Resolving an ethical dilemma with facts. Acad Emerg Med. 1999; 6: 772–3.
    • (1999) Acad Emerg Med , vol.6 , pp. 772-773
    • Fost, N.1
  • 35
    • 85011532011 scopus 로고    scopus 로고
    • Bethesda (MD): Office of Extramural Research, National Institutes of Health; May
    • Evaluation of NIH implementation of Section 491 of the Public Health Service Act, mandating a program of protection for research subjects. Review draft final report. NIH contract no. N01-OD-2–2109. Bethesda (MD): Office of Extramural Research, National Institutes of Health; May 1998.
    • (1998)
  • 36
    • 0037007685 scopus 로고    scopus 로고
    • Improving protection for research subjects
    • Steinbrook, R. Improving protection for research subjects. N Engl J Med. 2002; 346: 1425–30.
    • (2002) N Engl J Med , vol.346 , pp. 1425-1430
    • Steinbrook, R.1
  • 38
    • 0034728858 scopus 로고    scopus 로고
    • The new system of review by multicentre research ethics committees: prospective study
    • Tully, J, Ninis, N, Booy, R, Viner, R. The new system of review by multicentre research ethics committees: prospective study. BMJ. 2000; 320: 1179–82.
    • (2000) BMJ , vol.320 , pp. 1179-1182
    • Tully, J.1    Ninis, N.2    Booy, R.3    Viner, R.4
  • 39
    • 0036091748 scopus 로고    scopus 로고
    • Industry-sponsored pharmaceutical trials and research ethics boards: Are they cloaked in too much secrecy?
    • Ferris, L. Industry-sponsored pharmaceutical trials and research ethics boards: Are they cloaked in too much secrecy?. CMAJ. 2002; 166: 1279–80.
    • (2002) CMAJ , vol.166 , pp. 1279-1280
    • Ferris, L.1
  • 40
    • 0037007687 scopus 로고    scopus 로고
    • IRB reform
    • Slater, EE. IRB reform. N Engl J Med. 2002; 346: 1402–4.
    • (2002) N Engl J Med , vol.346 , pp. 1402-1404
    • Slater, E.E.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.