Subclinical inflammation influences the association between Vitamin A-And iron status among schoolchildren in Ghana

PLoS ONE

Volumn 12, Issue 2, 2017, Pages

  Abizari, Abdul Razak ^a   Azupogo, Fusta ^a   Brouwer, Inge D ^b  

^a UNIVERSITY FOR DEVELOPMENT STUDIES   (Ghana)

^b WAGENINGEN UNIVERSITY   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

C REACTIVE PROTEIN; FERRITIN; HEMOGLOBIN; IRON; OROSOMUCOID; RETINOL; RETINOL BINDING PROTEIN; TRANSFERRIN RECEPTOR; BIOLOGICAL MARKER; PLASMA RETINOL BINDING PROTEIN;

ARTICLE; CHILD; CHILD HEALTH; CHILD NUTRITION; CONTROLLED STUDY; CROSS-SECTIONAL STUDY; DISEASE ASSOCIATION; FEMALE; FERRITIN BLOOD LEVEL; GHANA; HEMOGLOBIN BLOOD LEVEL; HUMAN; INFLAMMATION; IRON DEFICIENCY; IRON DEFICIENCY ANEMIA; MAJOR CLINICAL STUDY; MALE; NUTRITIONAL HEALTH; NUTRITIONAL STATUS; PREVALENCE; RETINOL DEFICIENCY; RURAL AREA; SUBCLINICAL INFLAMMATION; ANEMIA; ANEMIA, IRON-DEFICIENCY; BLOOD; DEFICIENCY; METABOLISM; PRESCHOOL CHILD; RURAL POPULATION; VITAMIN A DEFICIENCY;

ANEMIA; ANEMIA, IRON-DEFICIENCY; BIOMARKERS; C-REACTIVE PROTEIN; CHILD; CHILD, PRESCHOOL; CROSS-SECTIONAL STUDIES; FEMALE; FERRITINS; GHANA; HEMOGLOBINS; HUMANS; INFLAMMATION; IRON; MALE; NUTRITIONAL STATUS; OROSOMUCOID; PREVALENCE; RECEPTORS, TRANSFERRIN; RETINOL-BINDING PROTEINS, PLASMA; RURAL POPULATION; VITAMIN A; VITAMIN A DEFICIENCY;

EID: 85011407719     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0170747     Document Type: Article

References (67)

1. Hettiarachchi M, Liyanage C. Coexisting micronutrient deficiencies among Sri Lankan pre-school children: A community-based study. Matern Child Nutr. 2012; 8: 259-266. doi:10.1111/j.1740-8709.2010.00290.x PMID: 21166995.
2. Marasinghe E, Chackrewarthy S, Abeysena C, Rajindrajith S. Micronutrient status and its relationship with nutritional status in preschool children in urban Sri Lanka. Asia Pac J Clin Nutr. 2015; 24: 144-151. doi:10.6133/apjcn.2015.24.1.17 PMID: 25740753.
3. Herrador Z, Sordo L, Gadisa E, Buno A, Gomez-Rioja R, Iturzaeta JM, et al. Micronutrient deficiencies and related factors in school-Aged children in Ethiopia: A cross-sectional study in Libo Kemkem and Fogera Districts, Amhara Regional State. Plos One. 2014; 9: 1-20.
4. Singh V, West KP. Vitamin A deficiency and xerophthalmia among school-Aged children in Southeastern Asia. Eur J Clin Nutr. 2004; 58: 1342-1349. doi:10.1038/sj.ejcn.1601973 PMID: 15054414.
5. Swati K, Esam MS. Vitamin A deficiency among school children of Bareilly: Crucial role of nutrition education. Natl J Med Res. 2012; 2: 188-190.
6. Hashizume M, Chiba M, Shinohara A, Iwabuchi S, Sasaki S, Shimoda T, et al. Anaemia, iron deficiency and vitamin A status among school-Aged children in rural Kazakhstan. Public Health Nutr. 2005; 8: 564-571. PMID: 16236185.
7. Palafox N., Gamble M., Dancheck B., Ricks M., Briand K., & Semba R. Vitamin A Deficiency, Iron Deficiency, and Anemia Among Preschool Children in the Republic of the Marshall Islands. Nutrition. 2003. pp. 405-408. PMID: 12714090.
8. Ahmed F, Rahman A, Noor AN, Akhtaruzzaman M, Hughes R. Anaemia and vitamin A status among adolescent schoolboys in Dhaka City, Bangladesh. Public Heal Nutr. 2006; 9: 345-350.
9. Zimmermann MB, Wegmueller R, Zeder C, Chaouki N, Biebinger R, Hurrell RF, et al. Triple fortification of salt with microcapsules of iodine, iron, and vitamin A. Am J Clin Nutr. 2004; 80: 1283-1290. PMID: 15531677.
10. Zimmermann M, Adou P, Torresani T, Zeder C, Hurrell R. Persistence of goiter despite oral iodine supplementation in goitrous children with iron deficiency anemia in Cote d'Ivoire. Am J Clin Nutr. 2000; 71: 88-93. PMID: 10617951.
11. McLean E, Egli I, Benoist B De, Wojdyla D, Cogswell M. Worldwide prevalence of anemia in pre- school aged children, pregnant women and non-pregnant women of reproductive age. In: Kraemer K, Zimmermann MB, editors. Nutritional Anaemia. Basel, Switzerland: Sight and Life Press; 2007. pp. 1-12.
12. WHO. Iron deficiency anaemia. Assessment, prevention and control. A guide for programme managers. Geneva, Switzerland; 2001.
13. Zimmermann MB, Hurrell RF. Nutritional iron deficiency. Lancet. 2007; 370: 511-520. doi:10.1016/S0140-6736(07)61235-5 PMID: 17693180.
14. Batra J, Sood A. Iron Deficiency Anaemia: Effect on Congnitive Development in Children: A Review. Indian J Clin Biochem. 2005; 20: 119-125. doi:10.1007/BF02867410 PMID: 23105543.
15. Chang S, Zeng L, Brouwer ID, Kok FJ, Yan H. Effect of iron deficiency anemia in pregnancy on child mental development in rural China. Pediatrics. 2013; 131: E755-63. doi:10.1542/peds.2011-3513 PMID: 23400604.
16. Jaauregui-Lobera I. Iron deficiency and cognitive functions. Neuropsychiatr Dis Treat. Dove Press; 2014; 10: 2087-95. doi:10.2147/NDT.S72491 PMID: 25419131.
17. WHO. Worldwide prevalence of anaemia. 1993-2005. WHO global database on anaemia. de Benoist B, McLean E, Egli I, Cogswell M, editors. WHO Report. Geneva, Switzerland: WHO; 2008.
18. Haas JD, Brownlie T. Iron deficiency and reduced work capacity: A critical review of the research to determine a causal relationship. J Nutr. 2001; 131: 676S-688S; discussion 688S-690S. PMID: 11160598.
19. UNICEF, Micronutrient Initiative. Vitamin and mineral deficiency: A global progress report. Ottawa Micronutr Initiat. 2004;.
20. Sommer A, West KP. Vitamin A Deficiency: Health, Survival and Vision. Am J Epidemiol. 1998; 147: 1175-1176.
21. Semba RD, Bloem MW. Nutrition and Health in Develping Countries. Second. Totowa, USA: Humana Press; 2008.
22. Villamor E, Fawzi WW. Vitamin A Supplementation: Implications for Morbidity and Mortality in Children. J Infect Dis. 2000; 182: S122-33. doi:10.1086/315921 PMID: 10944494.
23. West KP. Extent of Vitamin A Deficiency among Preschool Children and Women of Reproductive Age. Proceedings of the XX International Vitamin A Consultative Group Meeting. Am Soc Nutr Sci. Proceeding. 2002;75: 2857S-2866S.
24. Sanghvi T, Ross J, Heymann H. Why is reducing vitamin and mineral deficiencies critical for development? The links between VMDs and survival, health, education, and productivity. Food Nutr Bull. 2007; 28: 167-173.
25. Fishman SM, Christian P, West KP. The role of vitamins in the prevention and control of anaemia. Public Health Nutr. 2000; 3: 125-150. PMID: 10948381.
26. Atimati a O, Abiodun PO, Ofovwe GE. Relationship between vitamin A status and anaemia among school age children in Benin. Niger J Paediatr. 2013; 40: 379-383.
27. da Silva LLS, PeixotoM do RG, Hadler MCCM, da Silva SA, Cobayashi F, Cardoso MA, et al. Vitamin A status and associated factors in infants attending at Primary Health Care in Goiaania, Goiaas, Brazil. Rev Bras Epidemiol. 2015; 18: 490-502. doi:10.1590/1980-5497201500020016 PMID: 26083518.
28. Htet MK, Fahmida U, Dillon D, Akib A, Utomo B, Thurnham DI. The influence of vitamin A status on iron-deficiency anaemia in anaemic adolescent schoolgirls in Myanmar. Public Health Nutr. 2013; 17: 1-8.
29. Wieringa FT, Dijkhuizen MA, West CE, Thurnham DI, Muhilal, Van der Meer JWM. Redistribution of vitamin A after iron supplementation in Indonesian infants. Am J Clin Nutr. 2003; 77: 651-657. PMID: 12600856.
30. Al-Mekhlafi HM, Al-Zabedi EM, Al-Maktari MT, Atroosh WM, Al-Delaimy AK, Moktar N, et al. Effects of vitamin A supplementation on iron status indices and iron deficiency anaemia: A randomized controlled trial. Nutrients. 2013; 6: 190-206. doi:10.3390/nu6010190 PMID: 24384995.
31. Mwanri L, Worsley a, Ryan P, Masika J. Supplemental vitamin A improves anemia and growth in anemic school children in Tanzania. J Nutr. 2000; 130: 2691-2696. PMID: 11053508.
32. Bloem MW. Interdependence of vitamin A and iron: An important association for programmes of anaemia control. Proc Nutr Soc. 1995; 54: 501-8. PMID: 8524896.
33. Semba RD, de Pee S, Sun K, Campbell A.A., Bloem MW, Raju VK. Low intake of vitamin A-rich foods among children, aged 12-35 months, in India: Association with malnutrition, anemia, and missed child survival interventions. Nutrition. Elsevier Ltd; 2010; 26: 958-962. doi:10.1016/j.nut.2009.08.010 PMID: 19932005.
34. Gebremedhin S. Effect of a single high dose vitamin A supplementation on the hemoglobin status of children aged 6-59 months: propensity score matched retrospective cohort study based on the data of Ethiopian Demographic and Health Survey 2011. BMC Pediatr. BMC Pediatrics; 2014; 14: 79. doi:10.1186/1471-2431-14-79 PMID: 24649891.
35. Zimmermann MB, Biebinger R, Rohner F, Dib A, Zeder C, Hurrell RF, et al. Vitamin A supplementation in children with poor vitamin A and iron status increases erythropoietin and hemoglobin concentrations without changing total body iron. Am J Clin Nutr. 2006; 84: 580-586. PMID: 16960172.
36. Abizari A, Moretti D, Zimmermann MB, Armar-klemesu M, Brouwer ID. Whole Cowpea Meal Fortified with NaFeEDTA Reduces Iron Deficiency among Ghanaian School Children in a Malaria Endemic Area. J Nutr. 2012; 142: 1836-1842. doi:10.3945/jn.112.165753 PMID: 22915294.
37. ghanadistrict.com. Ghana Districts: A repository of all districts in the republic of Ghana. In: Northern Tolon [Internet]. 2006 [cited 12 Oct 2015]. Available: http://ghanadistricts.com/districts/?news&r=8&-=100.
38. Avornyo VK, Ito O. Spatial Characteristics of Cropping Systems in the Tolon District of Ghana that Mitigate Against Adverse Events. Annual meeting of the American Society of Agronomy, . 2015. pp. 1-2.
39. Erhardt JG, Estes JE, Pfeiffer CM, Biesalski HK, Craft NE. Combined measurement of ferritin, soluble transferrin receptor, retinol binding protein, and C-reactive protein by an inexpensive, sensitive, and simple sandwich enzyme-linked immunosorbent assay technique. J Nutr. 2004; 134: 3127-3132. PMID: 15514286.
40. Pfeiffer CM, Cook JD, Mei Z, Cogswell ME, Looker AC, Lacher DA. Evaluation of an automated soluble transferrin receptor (sTfR) assay on the Roche Hitachi analyzer and its comparison to two ELISA assays. Clin Chim Acta. 2007; 382: 112-6. doi:10.1016/j.cca.2007.04.008 PMID: 17511979.
41. Thurnham DI, McCabe LD, Haldar S, Wieringa FT, Northrop-Clewes CA, McCabe GP. Adjusting plasma ferritin concentrations to remove the effects of subclinical inflammation in the assessment of iron deficiency: A meta-Analysis. Am J Clin Nutr. 2010; 92: 546-555. doi:10.3945/ajcn.2010.29284 PMID: 20610634.
42. Thurnham DI, Northrop-Clewes CA, Knowles J. The Use of Adjustment Factors to Address the Impact of Inflammation on Vitamin A and Iron Status in Humans. J Nutr. 2015; 145: 1137s-1143s. doi:10.3945/jn.114.194712 PMID: 25833890.
43. Cogill B. Anthropometric Indicators Measurement Guide. Washington D.C: FHI 360: Food and Nutrition Technical Assistance (FANTA) Project; 2003.
44. FAO. Guidelines for measuring household and individual dietary diversity. Rome, Italy; 2011.
45. Wessells KR, Hess SY. Asymptomatic Malaria Infection Affects the Interpretation of Biomarkers of Iron and Vitamin A Status, Even after Adjusting for Systemic Inflammation, but Does Not Affect Plasma Zinc Concentrations among Young Children in Burkina Faso. J Nutr. 2014; 144: 2050-8. doi:10.3945/jn.114.200345 PMID: 25411038.
46. O'Brien RM. A caution regarding rules of thumb for variance inflation factors. Qual Quant. 2007; 41: 673-690.
47. WHO. Indicators for Assessing Vitamin A Deficiency and their application in monitoring and evaluating intervention programmes. Geneva, Switzerland; 1996.
48. Abizari A-R, Buxton C, Kwara L, Mensah-Homiah J, Armar-Klemesu M, Brouwer ID. School feeding contributes to micronutrient adequacy of Ghanaian schoolchildren. Br J Nutr. 2014; 112: 1019-1033. doi:10.1017/S0007114514001585 PMID: 24990068.
49. Righetti AA, Wegmuller R, Glinz D, Ouattara M, Adiossan LG, N'Goran EK, et al. Effects of inflammation and Plasmodium falciparum infection on soluble transferrin receptor and plasma ferritin concentration in different age groups: A prospective longitudinal study in Coate d'Ivoire. Am J Clin Nutr. 2013; 97: 1364-1374. doi:10.3945/ajcn.112.050302 PMID: 23615827.
50. Egbi G. Prevalence of vitamin A, zinc, iodine deficiency and anaemia among 2-10 year- old Ghanaian children. African Journal of Food, Agriculture, Nutrition and Development. 2012. pp. 5946-5958.
51. Gibson RS, Bailey KB, Gibbs M, Ferguson EL. A review of phytate, iron, zinc, and calcium concentrations in plant-based complementary foods used in low-income countries and implications for bioavailability. Food Nutr Bull. 2015; 31: 134-146.
52. Gibson RS, Perlas L, Hotz C. Improving the bioavailability of nutrients in plant foods at the household level. Proc Nutr Soc. 2006; 65: 160-168. PMID: 16672077.
53. Willows ND, Gray-Donald K. Serum retinol is associated with hemoglobin concentration in infants who are not vitamin A deficient. Nutr Res. 2003; 23: 891-900.
54. Sales MC, de Azevedo Paiva A, de Queiroz D, Franoa Costa RA, Lins da Cunha MA, Pedraza DF. Nutritional status of iron in children from 6 to 59 months of age and its relation to vitamin A deficiency. Nutr Hosp. 2013; 28: 734-740. doi:10.3305/nh.2013.28.3.6396 PMID: 23848097.
55. Mariath AB, Giachini RM, Lauda LG, Grillo LP. Iron status and serum retinol levels among children and adolescents attended by a Family Health Strategy team in Itajaõa, Santa Catarina State. (Article in Portuguese). Ciência & sauade coletiva. ABRASCOD Associaceão Brasileira de Sauade Coletiva; 2010; 15: 509-16.
56. Persson V, Ahmed F, Gebre-Medhin M, Greiner T. Relationships between vitamin A, iron status and helminthiasis in Bangladeshi school children. Public Health Nutr. 2000; 3: 83-9. PMID: 10786727.
57. WHO. Priorities in the Assessment of Vitamin A and Iron Status in Populations. Panama City; 2010.
58. Otupiri E, Yar D, Hindin J. Prevalence of Parasitaemia, Anaemia and treatment outcomes of Malaria among School Children in a Rural Community in Ghana. J Sci Technol. 2012; 32: 1-10.
59. Sanjoaquin MA, Molyneux ME. Malaria and vitamin A deficiency in African children: A vicious circle? Malar J. 2009; 8: 1-6.
60. Arimond M, Wiesmann D, Becquey E, Carriquiry A, Daniels MC, Deitchler M, et al. Simple Food Group Diversity Indicators Predict Micronutrient Adequacy of Women's Diets in 5 diverse, resource-poor setings. J Nutr. 2010; 140: 2059s-2069s. doi:10.3945/jn.110.123414 PMID: 20881077.
61. Baeten et al. Use of serum retinol-binding protein for prediction of vitamin A deficiency: Effects of HIV-1 infection, protein malnutrition, and the acute phase response. Am J Clin Nutr. 2004; 79: 218-225. PMID: 14749226.
62. Tanumihardjo SA. Vitamin A: biomarkers of nutrition for development. Am J Clin Nutr. 2011; 94: 658S-665S. doi:10.3945/ajcn.110.005777 PMID: 21715511.
63. Talsma EF, Verhoef H, Brouwer ID, Wagt ASM, Hulshof PJM, Melse-Boonstra A, et al. Proxy markers of serum retinol concentration, used alone and in combination, to assess population vitamin A status in Kenyan children: A cross-sectional study. BMC Med. 2015; 13: 30. doi:10.1186/s12916-014-0256-5 PMID: 25856672.
64. Edwin AK, Edwin F, Etwire V. Controlling Sickle Cell Disease in Ghanaethics and options. Pan Afr Med J. 2011; 10.
65. Lulla RR, Thompson AA, Liem RI. Elevated soluble transferrin receptor levels reflect increased erythropoietic drive rather than iron deficiency in pediatric sickle cell disease. Pediatr Blood Cancer. 2010; 55: 141-144. doi:10.1002/pbc.22471 PMID: 20486179.
66. Rothman KJ, Greenland S, Lash TL. Modern-Epidemiology. Third. Lippincott Williams & Wilkins; 2008.
67. Courvoisier DS, Combescure C, Agoritsas T, Gayet-Ageron A, Perneger T V. Performance of logistic regression modeling: Beyond the number of events per variable, the role of data structure. J Clin Epidemiol. 2011; 64: 993-1000. doi:10.1016/j.jclinepi.2010.11.012 PMID: 21411281.