Elevated soluble transferrin receptor levels reflect increased erythropoietic drive rather than iron deficiency in pediatric sickle cell disease

Pediatric Blood and Cancer

Volumn 55, Issue 1, 2010, Pages 141-144

  Lulla, Rishi R ^a   Thompson, Alexis A ^a   Liem, Robert I ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

Author keywords

Iron deficiency; Pediatric; Sickle cell disease; Soluble transferrin receptor

Indexed keywords

BIOLOGICAL MARKER; FERRITIN; FERROUS SULFATE; HEMOGLOBIN; TRANSFERRIN; TRANSFERRIN RECEPTOR;

ARTICLE; CHILD; CORRELATION ANALYSIS; HEMOLYSIS; HUMAN; IRON DEFICIENCY; IRON METABOLISM; MAJOR CLINICAL STUDY; PRESCHOOL CHILD; PRIORITY JOURNAL; RETICULOCYTE COUNT; SCHOOL CHILD; SCREENING; SICKLE CELL ANEMIA; TREATMENT RESPONSE;

ANEMIA, IRON-DEFICIENCY; ANEMIA, SICKLE CELL; BIOLOGICAL MARKERS; CHILD; CHILD, PRESCHOOL; COHORT STUDIES; HUMANS; INFANT; PROSPECTIVE STUDIES; PROTOPORPHYRIA, ERYTHROPOIETIC; RECEPTORS, TRANSFERRIN; SOLUBILITY;

EID: 77953273775     PISSN: 15455009     EISSN: 15455017     Source Type: Journal    
DOI: 10.1002/pbc.22471     Document Type: Article

References (14)

1. Vichinsky E, Kleman K, Embury S, et al. The diagnosis of iron deficiency anemia in sickle cell disease. Blood 1981;58:963-968. (Pubitemid 12227935)
2. Stettler N, Zemel BS, Kawchak DA, et al. Iron status of children with sickle cell disease. JPEN J Parenter Enteral Nutr 2001;25:36-38.
3. Koduri PR. Iron in sickle cell disease: A review why less is better. Am J Hematol 2003;73:59-63.
4. Grotto HZ, Kimura EM, Carneiro MV. Soluble transferrin receptor in sickle cell diseases: Correlation with spleen function. Sao Paulo Med J 1999;117:145-150.
5. Das Gupta A, Abbi A. High serum transferrin receptor level in anemia of chronic disorders indicates coexistent iron deficiency. Am J Hematol 2003;72:158-161. (Pubitemid 36258605)
6. Beguin Y. Soluble transferrin receptor for the evaluation of erythropoiesis and iron status. Clin Chim Acta 2003;329:9-22. (Pubitemid 36183479)
7. Lopez-Sall P, Diop PA, Diagne I, et al. Transferrine soluble receptors' contribution to the assessment of iron status in homozygous drepanocytic anemia. Ann Biol Clin (Paris) 2004;62:415-421.
8. Singhal A, Cook JD, Skikne BS, et al. The clinical significance of serum transferrin receptor levels in sickle cell disease. Br J Haematol 1993;84:301-304. (Pubitemid 23201700)
9. Serjeant G, Serjeant B, Stephens A, et al. Determinants of haemoglobin level in steady-state homozygous sickle cell disease. Br J Haematol 1996;92:143-149. (Pubitemid 26020699)
10. Tancabelic J, Sheth S, Paik M, et al. Serum transferrin receptor as a marker of erythropoiesis suppression in patients on chronic transfusion. Am J Hematol 1999;60:121-125. (Pubitemid 29047431)
11. King L, Reid M, Forrester TE. Iron deficiency anaemia in Jamaican children, aged 1-5 years, with sickle cell disease.West Indian Med J 2005;54:292-296.
12. Mohanty D, Mukherjee MB, Colah RB, et al. Iron deficiency anaemia in sickle cell disorders in India. Indian J Med Res 2008;127:366-369.
13. Castro O, MedinaI A, Gaskin P, et al. Iron deficiency decreases hemolysis in sickle cell anemia. Rev Bras Hematol Hemoter 2009;31:51-53.
14. Thompson RJ, Jr., Gustafson KE, Bonner MJ, et al. Neurocognitive development of young children with sickle cell disease through three years of age. J Pediatr Psychol 2002;27:235-244.