Efficacy of a medication adherence enhancing intervention in transplantation: The MAESTRO-Tx trial

Journal of Heart and Lung Transplantation

Volumn 36, Issue 5, 2017, Pages 499-508

  Dobbels, Fabienne ^a,b   De Bleser, Leentje ^a   Berben, Lut ^b   Kristanto, Paulus ^c   Dupont, Lieven ^d   Nevens, Frederik ^d   Vanhaecke, Johan ^d   Verleden, Geert ^d   De Geest, Sabina ^a,b  

^a UNIVERSITY OF LEUVEN   (Belgium)

^b UNIVERSITY OF BASEL   (Switzerland)

^c AARDEX Group   (Belgium)

^d UNIVERSITY HOSPITALS LEUVEN   (Belgium)

Author keywords

heart transplantation; liver transplantation; lung transplantation; medication adherence; randomized controlled trial

Indexed keywords

IMMUNOSUPPRESSIVE AGENT; TACROLIMUS;

ADULT; AGED; ARTICLE; ATTITUDE ASSESSMENT; BASEL ASSESSMENT OF ADHERENCE TO IMMUNOSUPPRESSIVE MEDICATION; BEHAVIOR CHANGE; BEHAVIOR THEORY; CARDIAC GRAFT REJECTION; CLINICAL OUTCOME; CONTROLLED STUDY; DRUG DOSE REDUCTION; EVENT FREE SURVIVAL; FEMALE; FOLLOW UP; GRAFT RECIPIENT; GRAFT SURVIVAL; HEART TRANSPLANTATION; HUMAN; IMMUNOSUPPRESSIVE TREATMENT; INTENTION TO TREAT ANALYSIS; INTERVENTION STUDY; LIVER GRAFT REJECTION; LIVER TRANSPLANTATION; LUNG GRAFT REJECTION; LUNG TRANSPLANTATION; MAJOR CLINICAL STUDY; MALE; MEDICATION COMPLIANCE; MOTIVATIONAL INTERVIEWING; PATIENT COMPLIANCE; PATIENT MONITORING; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SINGLE DRUG DOSE; SOCIAL COGNITIVE THEORY; SURGICAL MORTALITY; SUSTAINABLE DEVELOPMENT; TRANS THEORETICAL MODEL; BELGIUM; COMPARATIVE STUDY; DOSE RESPONSE; DRUG ADMINISTRATION; DRUG EFFECTS; HISTOCOMPATIBILITY; KAPLAN MEIER METHOD; MIDDLE AGED; MORTALITY; POSTOPERATIVE CARE; PROCEDURES; RISK ASSESSMENT; STATISTICS AND NUMERICAL DATA; SURVIVAL RATE; TIME FACTOR; TREATMENT OUTCOME; YOUNG ADULT;

ADULT; AGED; BELGIUM; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG ADMINISTRATION SCHEDULE; FEMALE; FOLLOW-UP STUDIES; GRAFT SURVIVAL; HEART TRANSPLANTATION; HUMANS; IMMUNOSUPPRESSIVE AGENTS; KAPLAN-MEIER ESTIMATE; LIVER TRANSPLANTATION; LUNG TRANSPLANTATION; MALE; MEDICATION ADHERENCE; MIDDLE AGED; POSTOPERATIVE CARE; RISK ASSESSMENT; SURVIVAL RATE; TACROLIMUS; TIME FACTORS; TRANSPLANTATION IMMUNOLOGY; TREATMENT OUTCOME; YOUNG ADULT;

EID: 85011272764     PISSN: 10532498     EISSN: 15573117     Source Type: Journal    
DOI: 10.1016/j.healun.2017.01.007     Document Type: Article

References (40)

1. 1 Fine, R.N., Becker, Y., De Geest, S., et al. Nonadherence consensus conference summary report. Am J Transplant 9 (2009), 35–41.
2. 2 De Bleser, L., Dobbels, F., Berben, L., et al. The spectrum of nonadherence with medication in heart, liver, and lung transplant patients assessed in various ways. Transpl Int 24 (2011), 882–891.
3. 3 Kirk, R., Non-adherence: time for action—not evaluation. J Heart Lung Transplant 32 (2013), 871–872.
4. 4 Dew, M.A., DiMartini, F., De Vito Dabbs, A., et al. Rates and risk factors for nonadherence to the medical regimen after adult solid organ transplantation. Transplantation 83 (2007), 853–873.
5. 5 Nieuwlaat, R., Wilczynski, N., Navarro, T., et al. Interventions for enhancing medication adherence. Cochrane Database Syst Rev(11), 2014, CD000011.
6. 6 De Bleser, L., Matteson, M., Dobbels, F., et al. Interventions to improve medication-adherence after transplantation: a systematic review. Transpl Int 22 (2009), 780–797.
7. 7 Marcelino, C.A., Diaz, L.J., Da Cruz, D.M., The effectiveness of interventions in managing treatment adherence in adult heart transplant patients: a systematic review. JBI Database System Rev Implement Rep 13 (2015), 279–308.
8. 8 Low, J.K., Williams, A., Manias, E., et al. Interventions to improve medication adherence in adult kidney transplant recipients: a systematic review. Nephrol Dial Transplant 30 (2015), 752–761.
9. 9 Klein, A., Otto, G., Kramer, I., Impact of a pharmaceutical care program on liver transplant patients’ compliance with immunosuppressive medication: a prospective, randomized, controlled trial using electronic monitoring. Transplantation 87 (2009), 839–847.
10. 10 Dew, M.A., Goycoolea, J.M., Harris, R.C., et al. An internet-based intervention to improve psychosocial outcomes in heart transplant recipients and family caregivers: development and evaluation. J Heart Lung Transplant 23 (2004), 745–758.
11. 11 DeVito Dabbs, A., Song, M.K., Myers, B.A., et al. A randomized controlled trial of a mobile health intervention to promote self-management after lung transplantation. Am J Transplant 16 (2016), 2172–2180.
12. 12 Chisholm, M.A., Vollenweider, L.J., Mulloy, L.L., et al. Renal transplant patient compliance with free immunosuppressive medications. Transplantation 70 (2000), 1240–1244.
13. 13 Chisholm, M.A., Mulloy, L.L., Jagadeesan, M., et al. Impact of clinical pharmacy services on renal transplant patients’ compliance with immunosuppressive medications. Clin Transplant 15 (2001), 330–336.
14. 14 Hardstaff, R., Green, R., Talbot, D., Noncompliance postrenal transplantation: measuring the extent of the problem using electronic surveillance and nurse practitioner interviews. Transplant Proc, 34, 2002, 1608.
15. 15 Hardstaff, R., Green, R., Talbot, D., Measurement of compliance posttransplantation—the results of a 12-month study using electronic monitoring. Transplant Proc 35 (2003), 796–797.
16. 16 Chisholm, M.A., Mulloy, L.L., DiPiro, J.T., Comparing renal transplant patients’ adherence to free cyclosporine and free tacrolimus immunosuppressant therapy. Clin Transplant 19 (2005), 77–82.
17. 17 De Geest, S., Schafer-Keller, P., Denhaerynck, K., et al. Supporting medication adherence in renal transplantation (SMART): a pilot RCT to improve adherence to immunosuppressive regimens. Clin Transplant 20 (2006), 359–368.
18. 18 Russell, C., Conn, V., Ashbaugh, C., et al. Taking immunosuppressive medications effectively (TIMELink): A pilot randomized controlled trial in adult kidney transplant recipients. Clin Transplant 25 (2011), 864–870.
19. 19 Hlubocky, J.M., Stuckey, L.J., Schuman, A.D., et al. Evaluation of a transplantation specialty pharmacy program. Am J Health Syst Pharm 69 (2012), 340–347.
20. 20 Kuypers, D.R., Peeters, P.C., Sennesael, J.J., et al. Improved adherence to tacrolimus once-daily formulation in renal recipients: a randomized controlled trial using electronic monitoring. Transplantation 95 (2013), 333–340.
21. 21 Chisholm-Burns, M.A., Spivey, C.A., Graff Zivin, J., et al. Improving outcomes of renal transplant recipients with behavioral adherence contracts: a randomized controlled trial. Am J Transplant 13 (2013), 2364–2373.
22. 22 Tschida, S., Aslam, S., Khan, T.T., et al. Managing specialty medication services through a specialty pharmacy program: the case of oral renal transplant immunosuppressant medications. J Manag Care Pharm 19 (2013), 26–41.
23. 23 McGillicuddy, J.W., Gregoski, M.J., Weiland, A.K., et al. Mobile health medication adherence and blood pressure control in renal transplant recipients: a proof-of-concept randomized controlled trial. JMIR Res Protoc, 2, 2013, e32.
24. 24 Joost, R., Dörje, F., Schwitulla, J., et al. Intensified pharmaceutical care is improving immunosuppressive medication adherence in kidney transplant recipients during the first post-transplant year: a quasi-experimental study. Nephrol Dial Transplant 29 (2014), 1597–1607.
25. 25 Henriksson, J., Tydén, G., Höijer, J., et al. A prospective randomized trial on the effect of using an electronic monitoring drug dispensing device to improve adherence and compliance. Transplantation 100 (2016), 203–209.
26. 26 Breu-Dejean, N., Driot, D., Dupoy, J., et al. Efficacy of psychoeducational intervention on allograft function in kidney transplant patients: 10-year results of a prospective randomized study. Exp Clin Transplant 14 (2016), 38–44.
27. 27 Davis, R., Campbell, R., Hildon, Z., Hobbs, L., Michie, S., Theories of behaviour and behaviour change across the social and behavioural sciences: a scoping review. Health Psychol Rev 9 (2015), 323–344.
28. 28 Conn, V.S., Enriquez, M., Ruppar, T.M., Chan, K.C., Meta-analyses of theory use in medication adherence intervention research. Am J Health Behav 40 (2016), 155–171.
29. 29 Michie, S., Wood, C.E., Johnston, M., Abraham, C., Francis, J.J., Hardeman, W., Behaviour change techniques: the development and evaluation of a taxonomic method for reporting and describing behaviour change interventions (a suite of five studies involving consensus methods, randomised controlled trials and analysis of qualitative data). Health Technol Assess 19 (2015), 1–188.
30. 30 WMA Declaration of Helsinki—Ethical Principles for Medical Research Involving Human Subjects. Available at: http://www.wma.net/en/30publications/10policies/b3/. Accessed June 2, 2016.
31. 31 Denhaerynck, K., Schäfer-Keller, P., Young, J., Steiger, J., Bock, A., De Geest, S., Examining assumptions regarding valid electronic monitoring of medication therapy: development of a validation framework and its application on a European sample of kidney transplant patients. BMC Med Res Methodol, 8, 2008, 5.
32. 32 Vrijens, B., De Geest, S., Hughes, D.A., et al. A new taxonomy for describing and defining adherence to medications. Br J Clin Pharmacol 73 (2012), 691–705.
33. 33 Dobbels, F., Berben, L., De Geest, S., et al. The psychometric properties and practicability of self-report instruments to identify medication nonadherence in adult transplant patients: a systematic review. Transplantation 90 (2010), 205–219.
34. 34 Morton, K., Beauchamp, M., Prothero, A., et al. The effectiveness of motivational interviewing for health behaviour change in primary care settings: a systematic review. Health Psychol Rev 9 (2015), 205–223.
35. 35 Salvo, M.C., Cannon-Breland, M.L., Motivational interviewing for medication adherence. J Am Pharm Assoc 55 (2015), e354–e361.
36. 36 El Alili, M., Vrijens, B., Demonceau, J., Evers, S.M., Hiligsmann, M., A scoping review of studies comparing the medication event monitoring system (MEMS) with alternative methods for measuring medication adherence. Br J Clin Pharmacol 82 (2016), 268–279.
37. 37 Nevins, T.E., Robiner, W.N., Thomas, W., Predictive patterns of early medication adherence in renal transplantation. Transplantation 98 (2014), 878–884.
38. 38 Dew, M.A., Dimartini, A.F., De Vito Dabbs, A., et al. Adherence to the medical regimen during the first two years after lung transplantation. Transplantation 85 (2008), 193–202.
39. 39 De Geest, S., Burkhalter, H., Bogert, L., et al. Describing the evolution of medication nonadherence from pretransplant until 3 years post-transplant and determining pretransplant medication nonadherence as risk factor for post-transplant nonadherence to immunosuppressives: the Swiss Transplant Cohort Study. Transpl Int 27 (2014), 657–666.
40. 40 Charlson, M.E., Pompei, P., Ales, K.L., MacKenzie, C.R., A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J Chronic Dis 40 (1987), 373–383.