HIV viral load scale-up: Multiple interventions to meet the HIV treatment cascade

Current Opinion in HIV and AIDS

Volumn 12, Issue 2, 2017, Pages 157-164

  Carmona, Sergio ^a   Peter, Trevor ^b   Berrie, Leigh ^a  

^a UNIVERSITY OF THE WITWATERSRAND   (South Africa)

^b CLINTON HEALTH ACCESS INITIATIVE   (United States)

Author keywords

90 90 90; HIV; scale up; viral load

Indexed keywords

ANTIRETROVIRAL THERAPY; HEALTH CARE PERSONNEL; HEALTH LITERACY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS; LABORATORY TEST; MEDICAL EDUCATION; NONHUMAN; POINT OF CARE TESTING; PRIORITY JOURNAL; REVIEW; SCALE UP; VIRAL LOAD TESTING; VIRUS LOAD; DISEASE MANAGEMENT; DRUG MONITORING; GLOBAL HEALTH; HIV INFECTIONS; PROCEDURES; UTILIZATION; VIROLOGY;

ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT;

ANTI-HIV AGENTS; DISEASE MANAGEMENT; DRUG MONITORING; GLOBAL HEALTH; HIV INFECTIONS; HUMANS; VIRAL LOAD;

EID: 85010976824     PISSN: 1746630X     EISSN: 17466318     Source Type: Journal    
DOI: 10.1097/COH.0000000000000352     Document Type: Review

References (39)

1. UNAIDS. Fact sheet November 2016. http://wwwunaidsorg/sites/default/files/media-Asset/UNAIDS-FactSheet-enpdf. [Accessed August 2016]. 2016
2. UNAIDS. Ambitious treatment targets: writing the final chapter of the AIDS epidemic, discussion paper. 2014 UNAIDS presented the targets in 2014 as a call for action to elimate HIV, these are supported by the new WHO HIV treatment guidelines.
3. WHO. WHO. Consolidated guidelines on the use of antiretroviral drugs for treating and preventing HIV infection: recommendations for a public health approach: WHO, 2013: 272. http://appswhoint/iris/bitstream/10665/85321/1/9789241505727-engpdf?ua=1 [Accessed June 2013]
4. Ford N, Meintjes G, Pozniak A, et al. The future role of CD4 cell count for monitoring antiretroviral therapy. Lancet Infect Dis 2015; 15:241-247.
5. Lecher S, Ellenberger D, Kim AA, et al. Scale-up of HIV viral load monitoring-seven sub-Saharan African countries. MMWR Morb Mortal Wkly Rep 2015; 64:1287-1290.
6. MSF. Putting HIV and HCV to the test. 2015; http://www.msfaccess.org/sites/default/files/HIV-HCV-Report-Diagnostic-Guide-2015.pdf.
7. UNAIDS. 90-90-90 On the right track towards the global target. 2016; http://reliefweb.int/sites/reliefweb.int/files/resources/90-90-90-Progress-Report-FINAL.pdf.
8. Alvarez P, Prieto L, Martin L, et al. Evaluation of four commercial virological assays for early infant HIV-1 diagnosis using dried blood specimens. Pediatr Res 2016. [Epub ahead of print]
9. Boillot F, Serrano L, Muwonga J, et al. Implementation and operational research: programmatic feasibility of dried blood spots for the virological follow-up of patients on antiretroviral treatment in nord kivu, democratic Republic of the Congo. J Acquir Immune Defic Syndr 2016; 71:e9-e15.
10. Smit PW, Sollis KA, Fiscus S, et al. Systematic review of the use of dried blood spots for monitoring HIV viral load and for early infant diagnosis. PLoS One 2014; 9:e86461.
11. WHO. Combined global demand forecasts for antiretroviral medicines and HIV diagnostics in low-And middle-income countries from 2015 to 2020. 2016; http://apps.who.int/iris/bitstream/10665/250088/1/97892 41511322-eng.pdf?ua=1.
12. WHO. July 2014 interim technical update. Technical and operational considerations for implementing HIV viral load testing. Geneva, Switzerland: WHO; 2014.
13. WHO. The availability and use of diagnostics for HIV: A 2012/2013 WHO survey of low-And middle-income countries. Geneva, Switzerland: World Health Organization; 2014.
14. WHO. Guidance for development of national laboratory strategic plans. Geneva, Switzerland: WHO; 2010.
15. Department of State. Office of Global AIDS Coordinator. PEPFAR blueprint: creating an AIDS-free generation. Department of State; 2012.
16. Roberts T, Cohn J, Bonner K, Hargreaves S. Scale-up of routine viral load testing in resource-poor settings: current and future implementation challenges. Clin Infect Dis 2016; 62:1043-1048.
17. MSF. Achieving undetectable: what questions remain in scaling-up HIV virological treatment monitoring? MSF undetectable volume 6. Geneva, Switzerland: MSF Access Campaign; 2014.
18. Hamel DJ, Sankale JL, Samuels JO, et al. Building laboratory capacity to support HIV care in Nigeria: Harvard/APIN PEPFAR, 2004-2012. Afr J Lab Med 2015; 4:190.
19. MSF. Getting to undetectable: usage of HIV viral load monitoring in five countries: MSF undetectable volume 5. Geneva, Switzerland: MSF Access Campaign; 2014.
20. WHO. Improving the quality of HIV-related point-of-care testing: ensuring the reliability and accuracy of test results. 2015; http://apps.who.int/iris/bitstream/10665/199799/1/9789241508179-eng.pdf.
21. Gershy-Damet GM, Rotz P, Cross D, et al. The World Health Organization African region laboratory accreditation process: improving the quality of laboratory systems in the African region. Am J Clin Pathol 2010; 134:393-400.
22. Scott LE, Carmona S, Gous N, et al. Use of a prequalification panel for rapid scale-up of high-Throughput HIV viral load testing. J Clin Microbiol 2012; 50:4083-4086.
23. Nguyen S, Ramos A, Chang J, et al. Monitoring the quality of HIV-1 viral load testing through a proficiency testing program using dried tube specimens in resource-limited settings. J Clin Microbiol 2015; 53:1129-1136.
24. UNITAID. HIV/AIDS diagnostics technology landscape, 5th ed. 2015; http://unitaid.org/images/marketdynamics/publications/UNITAID-HIV-Nov-2015-Dx-Landscape.PDF.
25. Pannus P, Fajardo E, Metcalf C, et al. Pooled HIV-1 viral load testing using dried blood spots to reduce the cost of monitoring antiretroviral treatment in a resource-limited setting. J Acquir Immune Defic Syndr 2013; 64:134-137.
26. Rutstein SE, Hosseinipour MC, Kamwendo D, et al. Dried blood spots for viral load monitoring in Malawi: feasible and effective. PLoS One 2015; 10:e0124748.
27. Phillips A, Shroufi A, Vojnov L, et al. Sustainable HIV treatment in Africa through viral-load-informed differentiated care. Nature 2015; 528:S68-S76.
28. Louis FJ, Osborne AJ, Elias VJ, et al. Specimen referral network to rapidly scale-up CD4 testing: The hub and spoke model for Haiti. J AIDS Clin Res 2015; 6:.
29. Jamieson D, Kellerman SE. The 90 90 90 strategy to end the HIV Pandemic by 2030: can the supply chain handle it? J Int AIDS Soc 2016; 19:20917.
30. Rutstein SE, Golin CE, Wheeler SB, et al. On the front line of HIV virological monitoring: barriers and facilitators from a provider perspective in resourcelimited settings. AIDS Care 2016; 28:1-10.
31. USAID. USAID mHealth compendium special edition May 2016: reaching scale. Arlington, VA: African Strategies for Health, Management Sciences for Health; 2016.
32. Sado H. Health enabled, momconnect: one year of operation: A case study August 2014-2015. SA DoH; 2015.
33. Peter JE, Barron P, Pillay Y. Using mobile technology to improve maternal, child and youth health and treatment of HIV patients. S Afr Med J 2015; 106:3-4.
34. Ngabo F, Nguimfack J, Nwaigwe F, et al. Designing and implementing an innovative SMS-based alert system (RapidSMS-MCH) to monitor pregnancy and reduce maternal and child deaths in Rwanda. Pan Afr Med J 2012; 13:31.
35. Awiti PO, Grotta A, van der Kop M, et al. The effect of an interactive weekly mobile phone messaging on retention in prevention of mother to child transmission (PMTCT) of HIV program: study protocol for a randomized controlled trial (WELTEL PMTCT). BMC Med Inform Decis Mak 2016; 16:86.
36. Horvath T, Azman H, Kennedy GE, Rutherford GW. Mobile phone text messaging for promoting adherence to antiretroviral therapy in patients with HIV infection. Cochrane Database Syst Rev 2012; 3:CD009756.
37. Glencross DK, Coetzee LM, Cassim N. An integrated tiered service delivery model (ITSDM) based on local CD4 testing demands can improve turnaround times and save costs whilst ensuring accessible and scalable CD4 services across a national programme. PLoS One 2014; 9:e114727.
38. Group ISS, Lundgren JD, Babiker AG, et al. Initiation of antiretroviral therapy in early asymptomatic HIV infection. N Engl J Med 2015; 373:795-807.
39. WHO. Consolidated guidelines on the use of antiretroviral drugs for treating and preventing HIV infection. Recommendations for a public health approach, 2nd ed. 2015. http://apps.who.int/iris/bitstream/10665/208825/1/9789241549684-eng.pdf?ua=1