On the front line of HIV virological monitoring: Barriers and facilitators from a provider perspective in resource-limited settings

AIDS Care - Psychological and Socio-Medical Aspects of AIDS/HIV

Volumn 28, Issue 1, 2016, Pages 1-10

  Rutstein, S E ^a,b   Golin, C E ^a   Wheeler, S B ^a   Kamwendo, D ^c   Hosseinipour, M C ^b,c   Weinberger, M ^a   Miller, W C ^a,b   Biddle, A K ^a   Soko, A ^c   Mkandawire, M ^d   Mwenda, R ^e   Sarr, A ^f   Gupta, S ^f   Mataya, R ^d  

^a IL   (United States)

^b UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF NORTH CAROLINA PROJECT   (Malawi)

^d LOMA LINDA UNIVERSITY   (United States)

^e MINISTRY OF HEALTH   (Malawi)

^f CENTERS FOR DISEASE CONTROL AND PREVENTION   (United States)

Author keywords

HIV; provider perceptions; resource limited settings; viral load monitoring

Indexed keywords

ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT;

ANTIVIRAL THERAPY; ARTICLE; CD4 LYMPHOCYTE COUNT; CLINICAL DECISION MAKING; CLINICAL PRACTICE; COUNSELING; DRIED BLOOD SPOT TESTING; FEMALE; HIV TEST; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTED PATIENT; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; MAJOR CLINICAL STUDY; MEDICATION COMPLIANCE; PATIENT EDUCATION; PATIENT MONITORING; PRIORITY JOURNAL; PUBLIC HOSPITAL; TREATMENT FAILURE; VIRUS LOAD; VIRUS REPLICATION; ADULT; DRUG EFFECTS; DRUG MONITORING; ECONOMICS; HEALTH CARE COST; HEALTH CARE PERSONNEL; HEALTH CARE PLANNING; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; HIV INFECTIONS; INTERVIEW; MALAWI; MALE; PERCEPTION; PROCEDURES; PSYCHOLOGY; VIROLOGY; WORKLOAD;

ADULT; ANTI-HIV AGENTS; ANTIRETROVIRAL THERAPY, HIGHLY ACTIVE; DRUG MONITORING; FEMALE; HEALTH CARE COSTS; HEALTH PERSONNEL; HEALTH RESOURCES; HIV INFECTIONS; HUMANS; INTERVIEWS AS TOPIC; MALAWI; MALE; PERCEPTION; VIRAL LOAD; WORKLOAD;

EID: 84955185474     PISSN: 09540121     EISSN: 13600451     Source Type: Journal    
DOI: 10.1080/09540121.2015.1058896     Document Type: Article

References (48)

1. Anderson, A. M., & Bartlett, J. A. (2006). Changing antiretroviral therapy in the setting of virologic relapse: Review of the current literature. Current HIV/AIDS Reports, 3(2), 79-85.
2. Arnold, E. A., Hazelton, P., Lane, T., Christopoulos, K. A., Galindo, G. R., Steward, W. T., & Morin, S. F. (2012). A qualitative study of provider thoughts on implementing pre-exposure prophylaxis (PrEP) in clinical settings to prevent HIV infection. PLoS ONE, 7(7), e40603.
3. Boeije, H. (2002). A purposeful approach to the constant comparative method in the analysis of qualitative interviews. Quality & Quantity, 36, 391-409.
4. Braun, V., & Clark, V. (2006). Using thematic analysis in psychology. Qualitative Research in Psychology, 3(2), 77-101.
5. Callaghan, M., Ford, N., & Schneider, H. (2010). A systematic review of task-shifting for HIV treatment and care in Africa. Human Resources for Health, 8, 8-17.
6. Calmy, A., Ford, N., Hirschel, B., Reynolds, S. J., Lynen, L., Goemaere, E.,Rodriguez, W. (2007). HIV viral load monitoring in resource-limited regions: Optional or necessary? Clinical Infectious Diseases, 44(1), 128-134.
7. Chaiwarith, R., Wachirakaphan, C., Kotarathititum, W., Praparatanaphan, J., Sirisanthana, T., & Supparatpinyo, K. (2007). Sensitivity and specificity of using CD4+ measurement and clinical evaluation to determine antiretroviral treatment failure in Thailand. International Journal of Infectious Diseases, 11(5), 413-416.
8. Chan, A. K., Ford, D., Namata, H., Muzambi, M., Nkhata, M. J., Abongomera, G.,Gibb, D. M. (2014). The lablite project: A cross-sectional mapping survey of decentralized HIV service provision in Malawi, Uganda and Zimbabwe. BMC Health Services Research, 14, 352-368.
9. Corbin, J., & Strauss, A. (2008). Basics of qualitative research (3rd ed.). Thousand Oaks, CA: Sage.
10. Crowe, Suzanne. (2012). Point-of-care implementation guidelines: Directing scale-up of point-of-care testing for HIVrelated diagnostics in Malawi. Malawi: Ministry of Health.
11. Friese, S. (2014). Qualitative data analysis with ATLAS.ti (2nd ed.). Thousand Oaks, CA: Sage.
12. Gsponer, T., Petersen, M., Egger, M., Phiri, S., Maathuis, M. H., Boulle, A.,Keiser, O. (2012). The causal effect of switching to second-line ART in programmes without access to routine viral load monitoring. AIDS, 26(1), 57-65.
13. Hosseinipour, M. C., van Oosterhout, J. J., Weigel, R., Phiri, S., Kamwendo, D., Parkin, N.,Kumwenda, J. (2009). The public health approach to identify antiretroviral therapy failure: High-level nucleoside reverse transcriptase inhibitor resistance among Malawians failing firstline antiretroviral therapy. AIDS, 23(9), 1127-1134.
14. Johannessen, A. (2010). Dried blood spots in HIV monitoring: Applications in resource-limited settings. Bioanalysis, 2(11), 1893-1908.
15. Johannessen, A., Troseid, M., & Calmy, A. (2009). Dried blood spots can expand access to virological monitoring of HIV treatment in resource-limited settings. Journal of Antimicrobial Chemotherapy, 64(6), 1126-1129.
16. Keiser, O., Tweya, H., Braitstein, P., Dabis, F., MacPhail, P., Boulle, A.,Egger, M. (2010). Mortality after failure of antiretroviral therapy in sub-Saharan Africa. Tropical Medicine & International Health, 15(2), 251-258.
17. Krakower, D.,Ware, N., Mitty, J. A., Maloney, K., & Mayer, K. H. (2014). HIV providers' perceived barriers and facilitators to implementing pre-exposure prophylaxis in care settings: A qualitative study. AIDS and Behavior, 18(9), 1712-1721.
18. Kumarasamy, N., Madhavan, V., Venkatesh, K. K., Saravanan, S., Kantor, R., Balakrishnan, P., Schooley, R. (2009). High frequency of clinically significant mutations after first-line generic highly active antiretroviral therapy failure: Implications for second-line options in resource-limited settings. Clinical Infectious Diseases, 49(2), 306-309.
19. Lester, R., Hamilton, R., Charalambous, S., Dwadwa, T., Chandler, C., Churchyard, G. J., & Grant, A. D. (2010). Barriers to implementation of isoniazid preventive therapy in HIV clinics: A qualitative study. AIDS, 24(Suppl. 5), S45-S48.
20. Lynen, L., Van Griensven, J., & Elliott, J. (2010). Monitoring for treatment failure in patients on first-line antiretroviral treatment in resource-constrained settings. Current Opinion in HIV and AIDS, 5(1), 1-5.
21. Madec, Y., Leroy, S., Rey-Cuille, M. A., Huber, F., & Calmy, A. (2013). Persistent difficulties in switching to second line ART in sub-saharan Africa-a systematic review and meta-analysis. PLoS ONE, 8(12), e82724.
22. Malawi Ministry of Health. (Ed.). (2014). Clinical management of HIV in children and adults. Lilongwe: Ministry of Health.
23. Marconi, V. C., Sunpath, H., Lu, Z., Gordon, M., Koranteng-Apeagyei, K., Hampton, J.,Kuritzkes, D. R. (2008). Prevalence of HIV-1 drug resistance after failure of a first highly active antiretroviral therapy regimen in KwaZulu Natal, South Africa. Clinical Infectious Diseases, 46(10), 1589-1597.
24. Marshall, M. N. (1996). Sampling for qualitative research. Family Practice, 13(6), 522-526.
25. Mee, P., Fielding, K. L., Charalambous, S., Churchyard, G. J., & Grant, A. D. (2008). Evaluation of the WHO criteria for antiretroviral treatment failure among adults in South Africa. AIDS (London, England), 22(15), 1971-1977.
26. Moore,D. M.,Awor, A., Downing, R.,Kaplan, J., Montaner, J. S., Hancock, J.,Mermin, J. (2008). CD4+ T-cell count monitoring does not accurately identify HIVinfected adults with virologic failure receiving antiretroviral therapy. JAIDS Journal of Acquired Immune Deficiency Syndromes, 49(5), 477-484.
27. van Oosterhout, J. J., Brown, L., Weigel, R., Kumwenda, J. J., Mzinganjira, D., Saukila, N.,Hosseinipour, M. C. (2009). Diagnosis of antiretroviral therapy failure in Malawi: Poor performance of clinical and immunological WHO criteria. Tropical medicine & international health, 14(8), 856-861.
28. Pannus, P., Fajardo, E., Metcalf, C., Garone, D., Jalon, O., Nundwe, S.,Mwenda, R. (2014). Task-shifting of dried blood spot (DBS) sample collection for viral load testing in Thyolo, Malawi: The role of Health Surveillance Assistants. Paper presented at the International AIDS Conference, Melbourne, Australia.
29. Pujades-Rodriguez, M., O'Brien, D., Humblet, P., & Calmy, A. (2008). Second-line antiretroviral therapy in resource-limited settings: The experience of Medecins Sans Frontieres. AIDS, 22(11), 1305-1312.
30. Rawizza, H. E., Chaplin, B., Meloni, S. T., Eisen, G., Rao, T., Sankale, J. L.,Kanki, P. J. (2011). Immunologic criteria are poor predictors of virologic outcome: Implications for HIV treatment monitoring in resource-limited settings. Clinical Infectious Diseases, 53(12), 1283-1290.
31. Reid, S. D., Fidler, S. J., & Cooke, G. S. (2013). Tracking the progress of HIV: The impact of point-of-care tests on antiretroviral therapy. Clinical Epidemiology, 5, 387-396.
32. Rewari, B. B., Bachani, D., Rajasekaran, S., Deshpande, A., Chan, P. L., & Srikantiah, P. (2010). Evaluating patients for second-line antiretroviral therapy in India: The role of targeted viral load testing. JAIDS Journal of Acquired Immune Deficiency Syndromes, 55(5), 610-614.
33. Reynolds, S. J., Kityo, C., Mbamanya, F., Dewar, R., Ssali, F., Quinn, T. C.,Dybul, M. (2009). Evolution of drug resistance after virological failure of a first-line highly active antiretroviral therapy regimen in Uganda. Antiviriral Therapy, 14(2), 293-297.
34. Reynolds, S. J., Nakigozi, G., Newell, K., Ndyanabo, A., Galiwongo, R., Boaz, I.,Serwadda, D. (2009). Failure of immunologic criteria to appropriately identify antiretroviral treatment failure in Uganda. AIDS (London, England), 23(6), 697-700.
35. Roberts, T., Bygrave, H., Fajardo, E., & Ford, N. (2012). Challenges and opportunities for the implementation of virological testing in resource-limited settings. Journal of the International AIDS Society, 15(2), 17324.
36. Rutstein, S., Hosseinipour, M. C., Soko, A., Mkandawire, M., Stein, E., Mclendon, C.,Mataya, R. (2014, October 8-12). Low rates of virologic failure among previously unmonitored patients in Malawi. Paper presented at the IDWeek, Philadelphia, PA.
37. Rutstein, S., Kamwendo, D., Hosseinipour, M. C., Soko, A., Sarr, A., Gupta, S., & Mataya, R. (2014, July 20-25). Implementing virologic monitoring using dried bloods spots at district hospitals in Malawi: Challenges and opportunities. Paper presented at the AIDS 2014, Melbourne, Australia.
38. Rutstein, S. E., Hosseinipour, M. C., Kamwendo, D., Soko, A., Mkandawire, M., Biddle, A. K.,Mataya, R. (2015). Dried blood spots for viral load monitoring in Malawi: Feasible and effective. PLoS ONE, 10(4), e0124748.
39. Rutstein, S. E., Kamwendo, D., Lugali, L., Thengolose, I., Tegha, G., Fiscus, S. A.,Mataya, R. (2014). Measures of viral load using Abbott Realtime HIV-1 assay on venous and fingerstick dried blood spots from provider-collected specimens in Malawian District Hospitals. Journal of Clinical Virology, 60(4), 392-398.
40. Saldana, J. (2013). The coding manual for qualitative researchers (3rd ed.). Thousand Oaks, CA: Sage.
41. Sigaloff, K. C., Hamers, R. L.,Wallis, C. L., Kityo, C., Siwale, M., Ive, P.,deWit, T. F. (2011). Unnecessary antiretroviral treatment switches and accumulation of HIV resistance mutations; two arguments for viral load monitoring in Africa. JAIDS Journal of Acquired Immune Deficiency Syndromes, 58(1), 23-31.
42. Sinunu, M. A., Schouten, E. J.,Kellerman, S. E. (2013). Integrated HIV program report July-September 2013.
43. Lilongwe: Government of Malawi Ministry of Health. UNAIDS. (2013). Access to antireretroviral therapy in Africa: Status report on progress towards the 2015 targets. Geneva: UNAIDS.
44. Usdin, M., Guillerm, M., & Calmy, A. (2010). Patient needs and point-of-care requirements for HIV load testing in resource-limited settings. The Journal of Infectious Diseases, 201(Suppl. 1), S73-S77.
45. WHO. (2006). Sexually transmitted diseases diagnostics initiative WHO special program for research and training in tropical diseases.
46. WHO. (2013). Consolidated guidelines on the use of antiretroviral drugs for treating and preventing HIV infection. Geneva: Author.
47. WHO. (2014). Technical and operational considerations for implementing HIV viral load testing. Geneva: Author.
48. Yin, R. K. (2011). Qualitative research from start to finish. New York, NY: The Guilford Press.