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Volumn 17, Issue 6, 2016, Pages 1145-1154

Evaluating sativex® in neuropathic pain management: A clinical and neurophysiological assessment in multiple sclerosis

Author keywords

Central neuropathic pain; Laser evoked potentials; Multiple sclerosis; Sativex; TMS

Indexed keywords

NABIXIMOLS; PLANT EXTRACT; TETRAHYDROCANNABINOL-CANNABIDIOL COMBINATION;

EID: 85010905685     PISSN: 15262375     EISSN: 15264637     Source Type: Journal    
DOI: 10.1093/pm/pnv080     Document Type: Article
Times cited : (55)

References (50)
  • 1
    • 40549117895 scopus 로고    scopus 로고
    • Current management of pain associated with multiple sclerosis
    • Pollmann W, Feneberg W. Current management of pain associated with multiple sclerosis. CNS Drugs 2008; 22: 291–324.
    • (2008) CNS Drugs , vol.22 , pp. 291-324
    • Pollmann, W.1    Feneberg, W.2
  • 2
    • 42949154269 scopus 로고    scopus 로고
    • Neuropathic pain: Redefinition and a grading system for clinical and research purposes
    • Treede RD, Jensen TS, Campbell JN, et al. Neuropathic pain: Redefinition and a grading system for clinical and research purposes. Neurology 2008; 70: 1630–5.
    • (2008) Neurology , vol.70 , pp. 1630-1635
    • Treede, R.D.1    Jensen, T.S.2    Campbell, J.N.3
  • 3
    • 77957350020 scopus 로고    scopus 로고
    • Patient orientated longitudinal study of multiple sclerosis in south west England (The South West Impact of Multiple Sclerosis Project, SWIMS) 1: Protocol and baseline characteristics of cohort
    • Zajicek JP, Ingram WM, Vickery J, et al. Patient orientated longitudinal study of multiple sclerosis in south west England (The South West Impact of Multiple Sclerosis Project, SWIMS) 1: Protocol and baseline characteristics of cohort. BMC Neurol 2010; 10: 88.
    • (2010) BMC Neurol , vol.10
    • Zajicek, J.P.1    Ingram, W.M.2    Vickery, J.3
  • 4
    • 33750870000 scopus 로고    scopus 로고
    • Epidemiology and treatment of pain in multiple sclerosis subjects
    • Solaro C. Epidemiology and treatment of pain in multiple sclerosis subjects. Neurol Sci 2006 Sep; 27 (suppl 4): s291–3.
    • (2006) Neurol Sci , vol.27 , Issue.4 , pp. s291-s2s3
    • Solaro, C.1
  • 5
    • 33846662156 scopus 로고    scopus 로고
    • Meta-analysis of cannabis based treatments for neuropathic and multiple sclerosis-related pain
    • Iskedjian M, Brezza B, Gordon A, Piwko C, Einarson TR. Meta-analysis of cannabis based treatments for neuropathic and multiple sclerosis-related pain. Curr Med Res Opin 2007; 23: 17–24.
    • (2007) Curr Med Res Opin , vol.23 , pp. 17-24
    • Iskedjian, M.1    Brezza, B.2    Gordon, A.3    Piwko, C.4    Einarson, T.R.5
  • 6
    • 43049162559 scopus 로고    scopus 로고
    • Managing neuropathic pain with Sativex: A review of its pros and cons
    • Perez J, Ribera MV. Managing neuropathic pain with Sativex: A review of its pros and cons. Expert Opin Pharmacother 2008; 9: 1189–95.
    • (2008) Expert Opin Pharmacother , vol.9 , pp. 1189-1195
    • Perez, J.1    Ribera, M.V.2
  • 7
    • 84937953069 scopus 로고    scopus 로고
    • Effect of Sativex on spasticity-associated symptoms in patients with multiple sclerosis
    • Meuth SG, Vila C, Dechant KL. Effect of Sativex on spasticity-associated symptoms in patients with multiple sclerosis. Expert Rev Neurother 2015; 15: 909–18.
    • (2015) Expert Rev Neurother , vol.15 , pp. 909-918
    • Meuth, S.G.1    Vila, C.2    Dechant, K.L.3
  • 8
    • 28844489930 scopus 로고    scopus 로고
    • A tale of two cannabinoids: The therapeutic rationale for combining tetrahydrocannabinol and cannabidiol
    • Russo E, Guy GW. A tale of two cannabinoids: The therapeutic rationale for combining tetrahydrocannabinol and cannabidiol. Med Hypotheses 2006; 66: 234–46.
    • (2006) Med Hypotheses , vol.66 , pp. 234-246
    • Russo, E.1
  • 9
    • 0033965479 scopus 로고    scopus 로고
    • Neuropharmacology and therapeutic potential of cannabinoids
    • Pertwee RG. Neuropharmacology and therapeutic potential of cannabinoids. Addict Biol 2000; 5: 37–44.
    • (2000) Addict Biol , vol.5 , pp. 37-44
    • Pertwee, R.G.1
  • 10
    • 38449094747 scopus 로고    scopus 로고
    • Cannabinoid-based medicines for neurological disorders–clinical evidence
    • Wright S. Cannabinoid-based medicines for neurological disorders–clinical evidence. Mol Neurobiol 2007 Aug; 36 (1): 129–36.
    • (2007) Mol Neurobiol , vol.36 , Issue.1 , pp. 129-136
    • Wright, S.1
  • 11
    • 79953822342 scopus 로고    scopus 로고
    • A randomized, double-blind, placebo-controlled, parallel-group, enriched-design study of nabiximols* (Sativex VR), as add-on therapy, in subjects with refractory spasticity caused by multiple sclerosis
    • Novotna A, Mares J, Ratcliffe S, et al. A randomized, double-blind, placebo-controlled, parallel-group, enriched-design study of nabiximols* (Sativex VR), as add-on therapy, in subjects with refractory spasticity caused by multiple sclerosis. Eur J Neurol 2011; 18: 1122–31.
    • (2011) Eur J Neurol , vol.18 , pp. 1122-1131
    • Novotna, A.1    Mares, J.2    Ratcliffe, S.3
  • 12
    • 84876488583 scopus 로고    scopus 로고
    • A double-blind, randomized, placebo-controlled, parallel-group study of THC/CBD oromucosal spray in combination with the existing treatment regimen, in the relief of central neuropathic pain in patients with multiple sclerosis
    • Langford RM, Mares J, Novotna A, et al. A double-blind, randomized, placebo-controlled, parallel-group study of THC/CBD oromucosal spray in combination with the existing treatment regimen, in the relief of central neuropathic pain in patients with multiple sclerosis. J Neurol 2013; 260: 984–97.
    • (2013) J Neurol , vol.260 , pp. 984-997
    • Langford, R.M.1    Mares, J.2    Novotna, A.3
  • 13
    • 36348982602 scopus 로고    scopus 로고
    • Sativex successfully treats neuropathic pain characterised by allodynia: A randomised, double-blind, placebocontrolled clinical trial
    • Nurmikko TJ, Serpell MG, Hoggart B, et al. Sativex successfully treats neuropathic pain characterised by allodynia: A randomised, double-blind, placebocontrolled clinical trial. Pain 2007; 133: 210–20.
    • (2007) Pain , vol.133 , pp. 210-220
    • Nurmikko, T.J.1    Serpell, M.G.2    Hoggart, B.3
  • 14
    • 36849070991 scopus 로고    scopus 로고
    • Oromucosal delta9-tetrahydrocannabinol/cannabidiol for neuropathic pain associated with multiple sclerosis: An uncontrolled, open-label, 2-year extension trial
    • Rog DJ, Nurmikko TJ, Young CA. Oromucosal delta9-tetrahydrocannabinol/cannabidiol for neuropathic pain associated with multiple sclerosis: An uncontrolled, open-label, 2-year extension trial. Clin Ther 2007; 29: 2068–79.
    • (2007) Clin Ther , vol.29 , pp. 2068-2079
    • Rog, D.J.1    Nurmikko, T.J.2    Young, C.A.3
  • 15
    • 33646539482 scopus 로고    scopus 로고
    • Can pain be more or less neuropathic? Comparison of symptom assessment tools with ratings of certainty by clinicians
    • Bennett MI, Smith BH, Torrance N, Lee AJ. Can pain be more or less neuropathic? Comparison of symptom assessment tools with ratings of certainty by clinicians. Pain 2006; 122: 289–99.
    • (2006) Pain , vol.122 , pp. 289-299
    • Bennett, M.I.1    Smith, B.H.2    Torrance, N.3    Lee, A.J.4
  • 17
    • 0036895397 scopus 로고    scopus 로고
    • Laserevoked potential abnormalities in central pain patients: The influence of spontaneous and provoked pain
    • Garcia-Larrea L, Convers P, Magnin M, et al. Laserevoked potential abnormalities in central pain patients: The influence of spontaneous and provoked pain. Brain 2002; 125: 2766–81.
    • (2002) Brain , vol.125 , pp. 2766-2781
    • Garcia-Larrea, L.1    Convers, P.2    Magnin, M.3
  • 19
    • 66349136308 scopus 로고    scopus 로고
    • Nociceptive laser-evoked brain potentials do not reflect nociceptive-specific neural activity
    • Mouraux A, Iannetti GD. Nociceptive laser-evoked brain potentials do not reflect nociceptive-specific neural activity. J Neurophysiol 2009; 101: 3258–69.
    • (2009) J Neurophysiol , vol.101 , pp. 3258-3269
    • Mouraux, A.1    Iannetti, G.D.2
  • 20
    • 84861599446 scopus 로고    scopus 로고
    • Gamma-band oscillations in the primary somatosensory cortex–a direct and obligatory correlate of subjective pain intensity
    • Zhang ZG, Hu L, Hung YS, Mouraux A, Iannetti GD. Gamma-band oscillations in the primary somatosensory cortex–a direct and obligatory correlate of subjective pain intensity. J Neurosci 2012; 32 (22): 7429–38.
    • (2012) J Neurosci , vol.32 , Issue.22 , pp. 7429-7438
    • Zhang, Z.G.1    Hu, L.2    Hung, Y.S.3    Mouraux, A.4    Iannetti, G.D.5
  • 21
    • 34249038339 scopus 로고    scopus 로고
    • Gamma oscillations in human primary somatosensory cortex reflect pain perception
    • Gross J, Schnitzler A, Timmermann L, Ploner M. Gamma oscillations in human primary somatosensory cortex reflect pain perception. PLoS Biol 2007; 5: e133.
    • (2007) Plos Biol , vol.5
    • Gross, J.1    Schnitzler, A.2    Timmermann, L.3    Ploner, M.4
  • 22
    • 0032816598 scopus 로고    scopus 로고
    • Inhibition of the human primary motor area by painful heat stimulation of the skin
    • Valeriani M, Restuccia D, Di Lazzaro V, et al. Inhibition of the human primary motor area by painful heat stimulation of the skin. Clin Neurophysiol 1999; 110: 1475–80.
    • (1999) Clin Neurophysiol , vol.110 , pp. 1475-1480
    • Valeriani, M.1    Restuccia, D.2    Di Lazzaro, V.3
  • 23
    • 20044376310 scopus 로고    scopus 로고
    • Comparison of pain syndromes associated with nervous or somatic lesions and development of a new neuropathic pain diagnostic questionnaire (DN4)
    • Bouhassira D, Attal N, Alchaar H, et al. Comparison of pain syndromes associated with nervous or somatic lesions and development of a new neuropathic pain diagnostic questionnaire (DN4). Pain 2005; 114 (1-2): 29–36.
    • (2005) Pain , vol.114 , Issue.1-2 , pp. 29-36
    • Bouhassira, D.1    Attal, N.2    Alchaar, H.3
  • 24
    • 28544436950 scopus 로고    scopus 로고
    • Diagnostic criteria for multiple sclerosis: 2005 revisions to the ‘‘McDonald Criteria’’
    • Polman CH, Reingold SC, Edan G, et al. Diagnostic criteria for multiple sclerosis: 2005 revisions to the ‘‘McDonald Criteria’’. Ann Neurol 2005; 58: 840–6.
    • (2005) Ann Neurol , vol.58 , pp. 840-846
    • Polman, C.H.1    Reingold, S.C.2    Edan, G.3
  • 25
    • 79952501096 scopus 로고    scopus 로고
    • Diagnostic criteria for multiple sclerosis: 2010 revisions to the McDonald criteria
    • Polman CH1, Reingold SC, Banwell B, et al. Diagnostic criteria for multiple sclerosis: 2010 revisions to the McDonald criteria. Ann Neurol 2011; 69: 292–302.
    • (2011) Ann Neurol , vol.69 , pp. 292-302
    • Ch, P.1    Reingold, S.C.2    Banwell, B.3
  • 27
    • 44849131341 scopus 로고    scopus 로고
    • Validity, reliability, and clinical importance of change in a 0–10 Numeric Rating Scale Measure of Spasticity: A post hoc analysis of a randomized, double-blind, placebo-controlled trial
    • Farrar JT, Troxel AB, Stott C, Duncombe P, Jensen MP. Validity, reliability, and clinical importance of change in a 0–10 Numeric Rating Scale Measure of Spasticity: A post hoc analysis of a randomized, double-blind, placebo-controlled trial. Clin Ther 2008; 30: 974–85.
    • (2008) Clin Ther , vol.30 , pp. 974-985
    • Farrar, J.T.1    Troxel, A.B.2    Stott, C.3    Duncombe, P.4    Jensen, M.P.5
  • 28
    • 0023130157 scopus 로고
    • Interrater reliability of a modified Ashworth scale of muscle spasticity
    • Bohannon R, Smith M. Interrater reliability of a modified Ashworth scale of muscle spasticity. Phys Ther 1987; 67: 206.
    • (1987) Phys Ther , vol.67
    • Bohannon, R.1    Smith, M.2
  • 30
    • 0027932909 scopus 로고
    • Noninvasive electrical and magnetic stimulation of the brain, spinal cord and roots: Basic principles and procedures for routine clinical application. Report of an IFCN committee. Electroencephalogr
    • Rossini PM, Barker AT, Berardelli A, et al. Noninvasive electrical and magnetic stimulation of the brain, spinal cord and roots: Basic principles and procedures for routine clinical application. Report of an IFCN committee. Electroencephalogr. Clin Neurophysiol 1994; 91: 79–92.
    • (1994) Clin Neurophysiol , vol.91 , pp. 79-92
    • Rossini, P.M.1    Barker, A.T.2    Berardelli, A.3
  • 31
    • 55249123118 scopus 로고    scopus 로고
    • Determinants of laser-evoked EEG responses: Pain perception or stimulus saliency?
    • Iannetti GD, Hughes NP, Lee MC, Mouraux A. Determinants of laser-evoked EEG responses: Pain perception or stimulus saliency? J Neurophysiol 2008; 100: 815–28.
    • (2008) J Neurophysiol , vol.100 , pp. 815-828
    • Iannetti, G.D.1    Hughes, N.P.2    Lee, M.C.3    Mouraux, A.4
  • 32
    • 84919667443 scopus 로고    scopus 로고
    • Shaping thalamocortical plasticity: A marker of cortical pain integration in patients with post-anoxic unresponsive wakefulness syndrome?
    • Naro A, Leo A, Russo M, et al. Shaping thalamocortical plasticity: A marker of cortical pain integration in patients with post-anoxic unresponsive wakefulness syndrome? Brain Stimul 2014; 8: 97-104.
    • (2014) Brain Stimul , vol.8 , pp. 97-104
    • Naro, A.1    Leo, A.2    Russo, M.3
  • 33
    • 0028329965 scopus 로고
    • Electrophysiological and psychophysical quantification of temporal summation in the human nociceptive system
    • Arendt-Nielsen L, Brennum J, Sindrup S, Bak P. Electrophysiological and psychophysical quantification of temporal summation in the human nociceptive system. Eur J Appl Physiol Occup Physiol 1994; 68: 266–73.
    • (1994) Eur J Appl Physiol Occup Physiol , vol.68 , pp. 266-273
    • Arendt-Nielsen, L.1    Brennum, J.2    Sindrup, S.3    Bak, P.4
  • 34
    • 0027475549 scopus 로고
    • The nociceptive flexion reflex as a tool for exploring pain control systems in headache and other pain syndromes
    • Sandrini G, Arrigo A, Bono G, Nappi G. The nociceptive flexion reflex as a tool for exploring pain control systems in headache and other pain syndromes. Cephalalgia 1993; 13: 21–7.
    • (1993) Cephalalgia , vol.13 , pp. 21-27
    • Sandrini, G.1    Arrigo, A.2    Bono, G.3    Nappi, G.4
  • 35
    • 84906240281 scopus 로고    scopus 로고
    • Human brain responses to concomitant stimulation of Ad and C nociceptors
    • Hu L, Cai MM, Xiao P, Luo F, Iannetti GD. Human brain responses to concomitant stimulation of Ad and C nociceptors. J Neurosci 2014 20; 34: 11439–51.
    • J Neurosci 2014 20 , vol.34 , pp. 11439-11451
    • Hu, L.1    Cai, M.M.2    Xiao, P.3    Luo, F.4    Iannetti, G.D.5
  • 36
    • 1242283941 scopus 로고    scopus 로고
    • EEGLAB: An open source toolbox for analysis of single-trial EEG dynamics including independent component analysis
    • Delorme A, Makeig S. EEGLAB: An open source toolbox for analysis of single-trial EEG dynamics including independent component analysis. J Neurosci Methods 2004; 134: 9–21.
    • (2004) J Neurosci Methods , vol.134 , pp. 9-21
    • Delorme, A.1    Makeig, S.2
  • 37
    • 0032829330 scopus 로고    scopus 로고
    • Event-related EEG/MEG synchronization and desynchronization: Basic principles
    • Pfurtscheller G, Lopes da Silva FH. Event-related EEG/MEG synchronization and desynchronization: Basic principles. Clin Neurophysiol 1999; 110: 1842–57.
    • (1999) Clin Neurophysiol , vol.11 , pp. 1842-1845
    • Pfurtscheller, G.1    Lopes Da Silva, F.H.2
  • 39
    • 24044506007 scopus 로고    scopus 로고
    • Central pain in multiple sclerosis–prevalence and clinical characteristics
    • Osterberg A, Boivie J, Thuomas KA. Central pain in multiple sclerosis–prevalence and clinical characteristics. Eur J Pain 2005; 9: 531–42.
    • (2005) Eur J Pain , vol.9 , pp. 531-542
    • Osterberg, A.1    Boivie, J.2    Thuomas, K.A.3
  • 40
    • 79954418857 scopus 로고    scopus 로고
    • MRI of the central nervous system in MS patients with and without pain
    • Svendsen KB1, Sørensen L, Jensen TS, Hansen HJ, Bach FW. MRI of the central nervous system in MS patients with and without pain. Eur J Pain 2011; 15: 395–401.
    • (2011) Eur J Pain , vol.15 , pp. 395-401
    • Kb, S.1    Sørensen, L.2    Jensen, T.S.3    Hansen, H.J.4    Bach, F.W.5
  • 41
    • 0034747415 scopus 로고    scopus 로고
    • Selective cannabinoid CB1 receptor activation inhibits spinal nociceptive transmission in vivo
    • Kelly S, Chapman V. Selective cannabinoid CB1 receptor activation inhibits spinal nociceptive transmission in vivo. J Neurophysiol 2001; 86: 3061–4.
    • (2001) J Neurophysiol , vol.86 , pp. 3061-3064
    • Kelly, S.1    Chapman, V.2
  • 42
    • 34548482940 scopus 로고    scopus 로고
    • On the pharmacological properties of delta-9-tetrahydrocannabinol (THC)
    • Costa B. On the pharmacological properties of delta-9-tetrahydrocannabinol (THC). Chem Biodivers 2007; 4: 1664.
    • (2007) Chem Biodivers , vol.4
    • Costa, B.1
  • 43
    • 84864312284 scopus 로고    scopus 로고
    • Cannabinoids suppress inflammatory and neuropathic pain by targeting a3 glycine receptors
    • Xiong W, Cui T, Cheng K, et al. Cannabinoids suppress inflammatory and neuropathic pain by targeting a3 glycine receptors. J Exp Med 2012; 209: 1121–34.
    • (2012) J Exp Med , vol.209 , pp. 1121-1134
    • Xiong, W.1    Cui, T.2    Cheng, K.3
  • 46
    • 84878728428 scopus 로고    scopus 로고
    • Antinociception induced by motor cortex stimulation: Somatotopy of behavioral response and profile of neuronal activation
    • Franca NR, Toniolo EF, Franciosi AC, et al. Antinociception induced by motor cortex stimulation: Somatotopy of behavioral response and profile of neuronal activation. Behav Brain Res 2013; 250: 211–21.
    • (2013) Behav Brain Res , vol.250 , pp. 211-221
    • Franca, N.R.1    Toniolo, E.F.2    Franciosi, A.C.3
  • 47
    • 70449533773 scopus 로고    scopus 로고
    • Lack of effect of cannabis-based treatment on clinical and laboratory measures in multiple sclerosis
    • Centonze D, Mori F, Koch G, et al. Lack of effect of cannabis-based treatment on clinical and laboratory measures in multiple sclerosis. Neurol Sci 2009; 30: 531–4.
    • (2009) Neurol Sci , vol.30 , pp. 531-534
    • Centonze, D.1    Mori, F.2    Koch, G.3
  • 48
    • 84866353731 scopus 로고    scopus 로고
    • Mechanisms of pain in multiple sclerosis: A combined clinical and neurophysiological study
    • Truini A, Galeotti F, La Cesa S, et al. Mechanisms of pain in multiple sclerosis: A combined clinical and neurophysiological study. Pain 2012; 153: 2048–54.
    • (2012) Pain , vol.153 , pp. 2048-2054
    • Truini, A.1    Galeotti, F.2    La Cesa, S.3
  • 49
    • 20444459375 scopus 로고    scopus 로고
    • Effect of the cannabinoid CB1 receptor antagonist, SR141716, on nociceptive response and nerve demyelination in rodents with chronic constriction injury of the sciatic nerve
    • Costa B, Trovato AE, Colleoni M, et al. Effect of the cannabinoid CB1 receptor antagonist, SR141716, on nociceptive response and nerve demyelination in rodents with chronic constriction injury of the sciatic nerve. Pain 2005; 116: 52–61.
    • (2005) Pain , vol.116 , pp. 52-61
    • Costa, B.1    Trovato, A.E.2    Colleoni, M.3
  • 50
    • 67651048942 scopus 로고    scopus 로고
    • Neuropathic pain: A maladaptive response of the nervous system to damage
    • Costigan M, Scholz J, Woolf CJ. Neuropathic pain: A maladaptive response of the nervous system to damage. Ann Rev Neurosci 2009; 32: 1–32.
    • (2009) Ann Rev Neurosci , vol.32 , pp. 1-32
    • Costigan, M.1    Scholz, J.2    Woolf, C.J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.