Enhanced viral clearance and reduced leukocyte infiltration in experimental herpes encephalitis after intranasal infection of CXCR3-deficient mice

Journal of NeuroVirology

Volumn 23, Issue 3, 2017, Pages 394-403

  Zimmermann, J ^a   Hafezi, W ^b   Dockhorn, A ^a   Lorentzen, Eva U ^b   Krauthausen, M ^a   Getts, Daniel R ^c,d,e   Muller M ^a   Kühn, Joachim E ^b   King, Nicholas J C ^e  

^a UNIVERSITY HOSPITAL BONN   (Germany)

^b UNIVERSITY HOSPITAL MÜNSTER   (Germany)

^c NORTHWESTERN UNIVERSITY   (United States)

^d Cour Pharmaceutical Development Company ^*  (United States)

^e UNIVERSITY OF SYDNEY   (Australia)

Author keywords

CXCR3; Herpes simplex encephalitis; HSV 1; Intranasal infection route

Indexed keywords

CHEMOKINE RECEPTOR CXCR3; CXCL10 PROTEIN, MOUSE; CXCR3 PROTEIN, MOUSE; GAMMA INTERFERON; GAMMA INTERFERON INDUCIBLE PROTEIN 10; TUMOR NECROSIS FACTOR; VIRUS DNA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL INFILTRATION; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; HERPES SIMPLEX ENCEPHALITIS; HERPES SIMPLEX VIRUS 1; IMMUNE RESPONSE; IMMUNOCOMPETENT CELL; LEUKOCYTE; MICROGLIA; MOUSE; NERVE CELL; NERVOUS SYSTEM INFLAMMATION; NONHUMAN; NOSE INFECTION; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; T LYMPHOCYTE; VIRAL CLEARANCE; VIRUS LOAD; VIRUS STRAIN; WEIGHT REDUCTION; ANIMAL; BODY WEIGHT LOSS; BRAIN; C57BL MOUSE; CELL MOTION; DEFICIENCY; DISEASE MODEL; DISEASE RESISTANCE; GENE EXPRESSION REGULATION; GENETICS; GROWTH, DEVELOPMENT AND AGING; HUMAN; HUMAN ALPHAHERPESVIRUS 1; IMMUNOLOGY; INTRANASAL DRUG ADMINISTRATION; KNOCKOUT MOUSE; PATHOLOGY; VIROLOGY;

ADMINISTRATION, INTRANASAL; ANIMALS; BRAIN; CELL MOVEMENT; CHEMOKINE CXCL10; DISEASE MODELS, ANIMAL; DISEASE RESISTANCE; DNA, VIRAL; ENCEPHALITIS, HERPES SIMPLEX; GENE EXPRESSION REGULATION; HERPESVIRUS 1, HUMAN; HUMANS; INTERFERON-GAMMA; LEUKOCYTES; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICROGLIA; RECEPTORS, CXCR3; TUMOR NECROSIS FACTOR-ALPHA; VIRAL LOAD; WEIGHT LOSS;

EID: 85010739138     PISSN: 13550284     EISSN: 15382443     Source Type: Journal    
DOI: 10.1007/s13365-016-0508-6     Document Type: Article

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