MOG-antibody associated demyelinating disease of the CNS: A clinical and pathological study in Chinese Han patients

Journal of Neuroimmunology

Volumn 305, Issue , 2017, Pages 19-28

  Zhou, Lei ^a   Huang, Yongheng ^b   Li, Haiqing ^a   Fan, Jie ^a   Zhangbao, Jingzi ^a   Yu, Hai ^a   Li, Yuxin ^a   Lu, Jiahong ^a   Zhao, Chongbo ^a,c   Lu, Chuanzhen ^a   Wang, Min ^b   Quan, Chao ^a  

^a FUDAN UNIVERSITY   (China)

^b FUDAN UNIVERSITY   (China)

^c Shanghai Jing'an District Centre Hospital   (China)

Author keywords

[No Author keywords available]

Indexed keywords

AQUAPORIN 4 ANTIBODY; MYELIN OLIGODENDROCYTE GLYCOPROTEIN ANTIBODY; PROTEIN ANTIBODY; STEROID; UNCLASSIFIED DRUG; AQP4 PROTEIN, HUMAN; AQUAPORIN 4; AUTOANTIBODY; MYELIN OLIGODENDROCYTE GLYCOPROTEIN;

ADULT; AGED; ANTIBODY DETECTION; ARTICLE; BRAIN DAMAGE; BRAIN EDEMA; CENTRAL NERVOUS SYSTEM DISEASE; CHILD; CLINICAL ARTICLE; CLINICAL FEATURE; COHORT ANALYSIS; CONTROLLED STUDY; DEMYELINATING DISEASE; DISEASE COURSE; DISEASE DURATION; FEMALE; HAN CHINESE; HUMAN; IMMUNOFLUORESCENCE TEST; MALE; MIDDLE AGED; OPTIC NERVE LESION; OPTIC NEURITIS; RETINA GANGLION CELL; RETINAL NERVE FIBER LAYER THICKNESS; SCHOOL CHILD; SPINAL CORD DISEASE; TREATMENT RESPONSE; VISUAL IMPAIRMENT; WHITE MATTER LESION; YOUNG ADULT; ANIMAL; ASIAN CONTINENTAL ANCESTRY GROUP; BLOOD; BRAIN; DIAGNOSTIC IMAGING; ENZYME LINKED IMMUNOSORBENT ASSAY; ETHNOLOGY; EYE; IMAGE PROCESSING; IMMUNOLOGY; NONPARAMETRIC TEST; NUCLEAR MAGNETIC RESONANCE IMAGING; PATHOLOGY; PATHOPHYSIOLOGY; RETINA; SPINAL CORD; VISUAL ACUITY;

ADULT; AGED; ANIMALS; AQUAPORIN 4; ASIAN CONTINENTAL ANCESTRY GROUP; AUTOANTIBODIES; BRAIN; CHILD; DEMYELINATING AUTOIMMUNE DISEASES, CNS; ENZYME-LINKED IMMUNOSORBENT ASSAY; EYE; FEMALE; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; MYELIN-OLIGODENDROCYTE GLYCOPROTEIN; RETINA; SPINAL CORD; STATISTICS, NONPARAMETRIC; VISUAL ACUITY; YOUNG ADULT;

EID: 85010695777     PISSN: 01655728     EISSN: 18728421     Source Type: Journal    
DOI: 10.1016/j.jneuroim.2017.01.007     Document Type: Article

References (40)

1. Aktas, O., Collateral benefit: the comeback of MOG antibodies as a biomarker in neurological practice. J. Neurol. Neurosurg. Psychiatry, 86(3), 2015, 243.
2. Baumann, M., Sahin, K., Lechner, C., Hennes, E.M., Schanda, K., Mader, S., Karenfort, M., Selch, C., Häusler, M., Eisenkölbl, A., Salandin, M., Gruber-Sedlmayr, U., Blaschek, A., Kraus, V., Leiz, S., Finsterwalder, J., Gotwald, T., Kuchukhidze, G., Berger, T., Reindl, M., Rostásy, K., Clinical and neuroradiological differences of paediatric acute disseminating encephalomyelitis with and without antibodies to the myelin oligodendrocyte glycoprotein. J. Neurol. Neurosurg. Psychiatry 86:3 (2015), 265–272.
3. Berger, T., Rubner, P., Schautzer, F., Egg, R., Ulmer, H., Mayringer, I., Dilitz, E., Deisenhammer, F., Reindl, M., Antimyelin antibodies as a predictor of clinically definite multiple sclerosis after a first demyelinating event. N. Engl. J. Med. 349:2 (2003), 139–145.
4. Bernard-Valnet, R., Liblau, R.S., Vukusic, S., Marignier, R., Neuromyelitis optica: a positive appraisal of seronegative cases. Eur. J. Neurol. 22:12 (2015), 1511–1518.
5. Bettelli, E., Baeten, D., Jager, A., Sobel, R.A., Kuchroo, V.K., Myelin oligodendrocyte glycoprotein-specific T and B cells cooperate to induce a Devic-like disease in mice. J. Clin. Invest. 116:9 (2006), 2393–2402.
6. Brilot, F., Dale, R.C., Selter, R.C., Grummel, V., Kalluri, S.R., Aslam, M., Busch, V., Zhou, D., Cepok, S., Hemmer, B., Antibodies to native myelin oligodendrocyte glycoprotein in children with inflammatory demyelinating central nervous system disease. Ann. Neurol. 66:6 (2009), 833–842.
7. Brunner, C., Lassmann, H., Waehneldt, T.V., Matthieu, J.M., Linington, C., Differential ultrastructural localization of myelin basic protein, myelin/oligodendroglial glycoprotein, and 2′, 3′-cyclic nucleotide 3′-phosphodiesterase in the CNS of adult rats. J. Neurochem. 52:1 (1989), 296–304.
8. Cobo-Calvo, A., Sepulveda, M., Bernard-Valnet, R., Ruiz, A., Brassat, D., Martinez-Yelamos, S., Saiz, A., Marignier, R., Antibodies to myelin oligodendrocyte glycoprotein in aquaporin 4 antibody seronegative longitudinally extensive transverse myelitis: clinical and prognostic implications. Mult. Scler. 22:3 (2016), 312–319.
9. Hoftberger, R., Sepulveda, M., Armangue, T., Blanco, Y., Rostasy, K., CoboCalvo, A., Olascoaga, J., Ramio-Torrenta, L., Reindl, M., Benito-Leon, J., Casanova, B., Arrambide, G., Sabater, L., Graus, F., Dalmau, J., Saiz, A., Antibodies to MOG and AQP4 in adults with neuromyelitis optica and suspected limited forms of the disease. Mult. Scler. 21:7 (2015), 866–874.
10. Iglesias, A., Bauer, J., Litzenburger, T., Schubart, A., Linington, C., T- and B-cell responses to myelin oligodendrocyte glycoprotein in experimental autoimmune encephalomyelitis and multiple sclerosis. Glia 36:2 (2001), 220–234.
11. Ikeda, K., Kiyota, N., Kuroda, H., Sato, D.K., Nishiyama, S., Takahashi, T., Misu, T., Nakashima, I., Fujihara, K., Aoki, M., Severe demyelination but no astrocytopathy in clinically definite neuromyelitiso ptica with anti-myelin-oligodendrocyte glycoprotein antibody. Mult. Scler. 21:5 (2015), 656–659.
12. Jarius, S., Ruprecht, K., Kleiter, I., Borisow, N., Asgari, N., Pitarokoili, K., Pache, F., Stich, O., Beume, L.A., Hümmert, M.W., Ringelstein, M., Trebst, C., Winkelmann, A., Schwarz, A., Buttmann, M., Zimmermann, H., Kuchling, J., Franciotta, D., Capobianco, M., Siebert, E., Lukas, C., Korporal-Kuhnke, M., Haas, J., Fechner, K., Brandt, A.U., Schanda, K., Aktas, O., Paul, F., Reindl, M., Wildemann, B., in cooperation with the Neuromyelitis Optica Study Group (NEMOS), MOG-IgG in NMO and related disorders: a multicenter study of 50 patients. Part 2: epidemiology, clinical presentation, radiological and laboratory features, treatment responses, and long-term outcome. J. Neuroinflammation, 13(1), 2016, 280 (b).
13. Jarius, S., Ruprecht, K., Kleiter, I., Borisow, N., Asgari, N., Pitarokoili, K., Pache, F., Stich, O., Beume, L.A., Hümmert, M.W., Trebst, C., Ringelstein, M., Aktas, O., Winkelmann, A., Buttmann, M., Schwarz, A., Zimmermann, H., Brandt, A.U., Franciotta, D., Capobianco, M., Kuchling, J., Haas, J., Korporal-Kuhnke, M., Lillevang, S.T., Fechner, K., Schanda, K., Paul, F., Wildemann, B., Reindl, M., in cooperation with the Neuromyelitis Optica Study Group (NEMOS), MOG-IgG in NMO and related disorders: a multicenter study of 50 patients. Part 1: frequency, syndrome specificity, influence of disease activity, long-term course, association with AQP4-IgG, and origin. J. Neuroinflammation, 13(1), 2016, 279 (a).
14. Kim, S.M., Woodhall, M.R., Kim, J.S., Kim, S.J., Park, K.S., Vincent, A., Lee, K.W., Waters, P., Antibodies to MOG in adults with inflammatory demyelinating disease of the CNS. Neurol. Neuroimmunol. Neuroinflamm., 2(6), 2015, e163.
15. Kitley, J., Woodhall, M., Waters, P., Leite, M.I., Devenney, E., Craig, J., Palace, J., Vincent, A., Myelin-oligodendrocyte glycoprotein antibodies in adults with a neuromyelitis optica phenotype. Neurology 79:12 (2012), 1273–1277.
16. Kitley, J., Waters, P., Woodhall, M., Leite, M.I., Murchison, A., George, J., Kuker, W., Chandratre, S., Vincent, A., Palace, J., Neuromyelitis optica spectrum disorders with aquaporin-4 and myelin-oligodendrocyte glycoprotein antibodies: a comparative study. JAMA Neurol. 71:3 (2014), 276–283.
17. Krishnamoorthy, G., Lassmann, H., Wekerle, H., Holz, A., Spontaneous opticospinal encephalomyelitis in a double-transgenic mouse model of autoimmune T cell/B cell cooperation. J. Clin. Invest. 116:9 (2006), 2385–2392.
18. Lalive, P.H., Hausler, M.G., Maurey, H., Mikaeloff, Y., Tardieu, M., Wiendl, H., Schroeter, M., Hartung, H.P., Kieseier, B.C., Menge, T., Highly reactive anti-myelin oligodendrocyte glycoprotein antibodies differentiate demyelinating diseases from viral encephalitis in children. Mult. Scler. 17:3 (2011), 297–302.
19. Lechner, C., Baumann, M., Hennes, E.M., Schanda, K., Marquard, K., Karenfort, M., Leiz, S., Pohl, D., Venkateswaran, S., Pritsch, M., Koch, J., Schimmel, M., Hausler, M., Klein, A., Blaschek, A., Thiels, C., Lucke, T., Gruber-Sedlmayr, U., Kornek, B., Hahn, A., Leypoldt, F., Sandrieser, T., Gallwitz, H., Stoffels, J., Korenke, C., Reindl, M., Rostasy, K., Antibodies to MOG and AQP4 in children with neuromyelitis optica and limited forms of the disease. J. Neurol. Neurosurg. Psychiatry 87:8 (2016), 897–905.
20. Lennon, V.A., Wingerchuk, D.M., Kryzer, T.J., Pittock, S.J., Lucchinetti, C.F., Fujihara, K., Nakashima, I., Weinshenker, B.G., A serum autoantibody marker of neuromyelitis optica: distinction from multiple sclerosis. Lancet 364:9451 (2004), 2106–2112.
21. Lennon, V.A., Kryzer, T.J., Pittock, S.J., Verkman, A.S., Hinson, S.R., IgG marker of optic-spinal multiple sclerosis binds to the aquaporin-4 water channel. J. Exp. Med. 202:4 (2005), 473–477.
22. Mader, S., Gredler, V., Schanda, K., Rostasy, K., Dujmovic, I., Pfaller, K., Lutterotti, A., Jarius, S., Di Pauli, F., Kuenz, B., Ehling, R., Hegen, H., Deisenhammer, F., Aboul-Enein, F., Storch, M.K., Koson, P., Drulovic, J., Kristoferitsch, W., Berger, T., Reindl, M., Complement activating antibodies to myelin oligodendrocyte glycoprotein in neuromyelitis optica and related disorders. J. Neuroinflammation, 8, 2011, 184.
23. Mayer, M.C., Meinl, E., Glycoproteins as targets of autoantibodies in CNS inflammation: MOG and more. Ther. Adv. Neurol. Disord. 5:3 (2012), 147–159.
24. Mealy, M.A., Whetstone, A., Orman, G., Izbudak, I., Calabresi, P.A., Levy, M., Longitudinally extensive optic neuritis as an MRI biomarker distinguishes neuromyelitis optica from multiple sclerosis. J. Neurol. Sci. 355:1–2 (2015), 59–63.
25. Misu, T., Hoftberger, R., Fujihara, K., Wimmer, I., Takai, Y., Nishiyama, S., Nakashima, I., Konno, H., Bradl, M., Garzuly, F., Itoyama, Y., Aoki, M., Lassmann, H., Presence of six different lesion types suggests diverse mechanisms of tissue injury in neuromyelitis optica. Acta Neuropathol. 125:6 (2013), 815–827.
26. Nakajima, H., Motomura, M., Tanaka, K., Fujikawa, A., Nakata, R., Maeda, Y., Shima, T., Mukaino, A., Yoshimura, S., Miyazaki, T., Shiraishi, H., Kawakami, A., Tsujino, A., Antibodies to myelin oligodendrocyte glycoprotein in idiopathic optic neuritis. BMJ Open, 5(4), 2015, e007766.
27. Pache, F., Zimmermann, H., Mikolajczak, J., Schumacher, S., Lacheta, A., Oertel, F.C., Bellmann-Strobl, J., Jarius, S., Wildemann, B., Reindl, M., Waldman, A., Soelberg, K., Asgari, N., Ringelstein, M., Aktas, O., Gross, N., Buttmann, M., Ach, T., Ruprecht, K., Paul, F., Brandt, A.U., in cooperation with the Neuromyelitis Optica Study Group (NEMOS), MOG-IgG in NMO and related disorders: a multicenter study of 50 patients. Part 4: afferent visual system damage after optic neuritis in MOG-IgG-seropositive versus AQP4-IgG-seropositive patients. J. Neuroinflammation, 13(1), 2016, 282.
28. Polman, C.H., Reingold, S.C., Banwell, B., Clanet, M., Cohen, J.A., Filippi, M., Fujihara, K., Havrdova, E., Hutchinson, M., Kappos, L., Lublin, F.D., Montalban, X., O'Connor, P., Sandberg-Wollheim, M., Thompson, A.J., Waubant, E., Weinshenker, B., Wolinsky, J.S., Diagnostic criteria for multiple sclerosis: 2010 revisions to the McDonald criteria. Ann. Neurol. 69:2 (2011), 292–302.
29. Popescu, B.F., Lennon, V.A., Parisi, J.E., Howe, C.L., Weigand, S.D., Cabrera-Gomez, J.A., Newell, K., Mandler, R.N., Pittock, S.J., Weinshenker, B.G., Lucchinetti, C.F., Neuromyelitisoptica unique area postrema lesions: nausea, vomiting, and pathogenic implications. Neurology 76:14 (2011), 1229–1237.
30. Ramanathan, S., Reddel, S.W., Henderson, A., Parratt, J.D., Barnett, M., Gatt, P.N., Merheb, V., Kumaran, R.Y., Pathmanandavel, K., Sinmaz, N., Ghadiri, M., Yiannikas, C., Vucic, S., Stewart, G., Bleasel, A.F., Booth, D., Fung, V.S., Dale, R.C., Brilot, F., Antibodies to myelin oligodendrocyte glycoprotein in bilateral and recurrent optic neuritis. Neurol. Neuroimmunol. Neuroinflamm., 1(4), 2014, e40.
31. Sato, D.K., Callegaro, D., Lana-Peixoto, M.A., Waters, P.J., de Haidar Jorge, F.M., Takahashi, T., Nakashima, I., Apostolos-Pereira, S.L., Talim, N., Simm, R.F., Lino, A.M., Misu, T., Leite, M.I., Aoki, M., Fujihara, K., Distinction between MOG antibody-positive and AQP4 antibody-positive NMO spectrum disorders. Neurology 82:6 (2014), 474–481.
32. Simon, J.H., Li, D., Traboulsee, A., Coyle, P.K., Arnold, D.L., Barkhof, F., Frank, J.A., Grossman, R., Paty, D.W., Radue, E.W., Wolinsky, J.S., Standardized MR imaging protocol for multiple sclerosis: Consortium of MS Centers consensus guidelines. AJNR Am. J. Neuroradiol. 27:2 (2006), 455–461.
33. Siritho, S., Sato, D.K., Kaneko, K., Fujihara, K., Prayoonwiwat, N., The clinical spectrum associated with myelin oligodendrocyte glycoprotein antibodies (anti-MOG-Ab) in Thai patients. Mult. Scler. 22:7 (2016), 964–968.
34. Spadaro, M., Gerdes, L.A., Mayer, M.C., Ertl-Wagner, B., Laurent, S., Krumbholz, M., Breithaupt, C., Hogen, T., Straube, A., Giese, A., Hohlfeld, R., Lassmann, H., Meinl, E., Kumpfel, T., Histopathology and clinical course of MOG-antibody-associated encephalomyelitis. Ann. Clin. Transl. Neurol. 2:3 (2015), 295–301.
35. Storch, M.K., Stefferl, A., Brehm, U., Weissert, R., Wallstrom, E., Kerschensteiner, M., Olsson, T., Linington, C., Lassmann, H., Autoimmunity to myelin oligodendrocyte glycoprotein in rats mimics the spectrum of multiple sclerosis pathology. Brain Pathol. 8:4 (1998), 681–694.
36. Trebst, C., Jarius, S., Berthele, A., Paul, F., Schippling, S., Wildemann, B., Borisow, N., Kleiter, I., Aktas, O., Kumpfel, T., Neuromyelitis Optica Study Group (NEMOS), Update on the diagnosis and treatment of neuromyelitis optica: recommendations of the Neuromyelitis Optica Study Group (NEMOS). J. Neurol. 261:1 (2014), 1–16.
37. van Pelt, E.D., Wong, Y.Y., Ketelslegers, I.A., Hamann, D., Hintzen, R.Q., Neuromyelitis optica spectrum disorders: comparison of clinical and magnetic resonance imaging characteristics of AQP4-IgG versus MOG-IgG seropositive cases in the Netherlands. Eur. J. Neurol. 23:3 (2016), 580–587.
38. Wingerchuk, D.M., Lennon, V.A., Pittock, S.J., Lucchinetti, C.F., Weinshenker, B.G., Revised diagnostic criteria for neuromyelitis optica. Neurology 66:10 (2006), 1485–1489.
39. Wingerchuk, D.M., Lennon, V.A., Lucchinetti, C.F., Pittock, S.J., Weinshenker, B.G., The spectrum of neuromyelitis optica. Lancet Neurol. 6:9 (2007), 805–815.
40. Zamvil, S.S., Slavin, A.J., Does MOG Ig-positive AQP4-seronegative opticospinal inflammatory disease justify a diagnosis of NMO spectrum disorder?. Neurol. Neuroimmunol. Neuroinflamm., 2(1), 2015, e62.