Antibodies to MOG and AQP4 in children with neuromyelitis optica and limited forms of the disease

Journal of Neurology, Neurosurgery and Psychiatry

Volumn 87, Issue 8, 2016, Pages 897-905

  Lechner, Christian ^a   Baumann, Matthias ^a   Hennes, Eva Maria ^b   Schanda, Kathrin ^a   Marquard, Klaus ^b   Karenfort, Michael ^c   Leiz, Steffen ^d   Pohl, Daniela ^e   Venkateswaran, Sunita ^e   Pritsch, Martin ^f   Koch, Johannes ^g   Schimmel, Mareike ^h   Häusler, Martin ⁱ   Klein, Andrea ^j   Blaschek, Astrid ^k   Thiels, Charlotte ^l   Lücke, Thomas ^l   Gruber Sedlmayr, Ursula ^m   Kornek, Barbara ⁿ   Hahn, Andreas ^o   Leypoldt, Frank ^p,q   Sandrieser, Torsten ^r   Gallwitz, Helge ^s   Stoffels, Johannes ^t   Korenke, Christoph ^u   Reindl, Markus ^a   Rostásy, Kevin ^v   more..

^a INNSBRUCK MEDICAL UNIVERSITY   (Austria)

^b OLGAHOSPITAL   (Germany)

^c UNIVERSITY HOSPITAL DÜSSELDORF   (Germany)

^d Klinikum Dritter Orden   (Germany)

^e CHILDREN S HOSPITAL OF EASTERN ONTARIO   (Canada)

^f Department of Neuropediatrics   (Germany)

^g PARACELSUS MEDICAL UNIVERSITY   (Austria)

^h Children's Hospital Augsburg   (Germany)

ⁱ UNIVERSITY HOSPITAL RWTH AACHEN   (Germany)

^j UNIVERSITY CHILDREN S HOSPITAL   (Switzerland)

^k LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^l RUHR UNIVERSITY BOCHUM   (Germany)

^m MEDICAL UNIVERSITY OF GRAZ   (Austria)

ⁿ MEDICAL UNIVERSITY OF VIENNA   (Austria)

^o UNIVERSITY HOSPITAL GIESSEN   (Germany)

^p UNIVERSITY OF KIEL   (Germany)

^q UNIVERSITY HOSPITAL SCHLESWIG HOLSTEIN   (Germany)

^r Gemeinschaftsklinikum Koblenz Mayen   (Germany)

^s Klinikum Memmingen   (Germany)

^t Children's Hospital Neuburg   (Germany)

^u KLINIKUM OLDENBURG   (Germany)

^v UNIVERSITY OF WITTEN HERDECKE   (Germany)

more..

Author keywords

[No Author keywords available]

Indexed keywords

AQUAPORIN 4 ANTIBODY; MYELIN OLIGODENDROCYTE GLYCOPROTEIN ANTIBODY; PROTEIN ANTIBODY; UNCLASSIFIED DRUG; AQUAPORIN 4; AUTOANTIBODY; MYELIN OLIGODENDROCYTE GLYCOPROTEIN; OLIGOCLONAL BAND;

ADOLESCENT; ARTICLE; BLOOD SAMPLING; CHILD; CLINICAL ARTICLE; CLINICAL FEATURE; CONTROLLED STUDY; DISEASE COURSE; FEMALE; HUMAN; IMMUNOSUPPRESSIVE TREATMENT; INFANT; MALE; MYELOOPTIC NEUROPATHY; NUCLEAR MAGNETIC RESONANCE IMAGING; PATIENT SELECTION; PRIORITY JOURNAL; BLOOD; BRAIN STEM; CEREBROSPINAL FLUID; CLINICAL TRIAL; DIAGNOSTIC IMAGING; IMMUNOLOGY; LEUKOCYTOSIS; MULTICENTER STUDY; MYELITIS; NEUROIMAGING; PATHOLOGY; PRESCHOOL CHILD; RISK FACTOR; SYNDROME;

ADOLESCENT; AQUAPORIN 4; AUTOANTIBODIES; BRAIN STEM; CHILD; CHILD, PRESCHOOL; FEMALE; HUMANS; INFANT; LEUKOCYTOSIS; MAGNETIC RESONANCE IMAGING; MALE; MYELIN-OLIGODENDROCYTE GLYCOPROTEIN; MYELITIS, TRANSVERSE; NEUROIMAGING; NEUROMYELITIS OPTICA; OLIGOCLONAL BANDS; RISK FACTORS; SYNDROME;

EID: 84954288762     PISSN: 00223050     EISSN: 1468330X     Source Type: Journal    
DOI: 10.1136/jnnp-2015-311743     Document Type: Article

References (32)

1. Wingerchuk DM, Lennon VA, Lucchinetti CF, et al. The spectrum of neuromyelitis optica. Lancet Neurol 2007;6:805-15.
2. Wingerchuk DM, Lennon VA, Pittock SJ, et al. Revised diagnostic criteria for neuromyelitis optica. Neurology 2006;66:1485-9.
3. Arrambide G, Rovira A, Tur C, et al. NMO spectrum disorders: how wide is the spectrum? Mult Scler 2014;20:1417.
4. Jarius S, Probst C, Borowski K, et al. Standardized method for the detection of antibodies to aquaporin-4 based on a highly sensitive immunofluorescence assay employing recombinant target antigen. J Neurol Sci 2010;291:52-6.
5. Jarius S, Frederikson J, Waters P, et al. Frequency and prognostic impact of antibodies to aquaporin-4 in patients with optic neuritis. J Neurol Sci 2010;298:158-62.
6. Weinshenker BG, Wingerchuk DM, Vukusic S, et al. Neuromyelitis optica IgG predicts relapse after longitudinally extensive transverse myelitis. Ann Neurol 2006;59:566-9.
7. Chang KH, Lyu RK, Chen CM, et al. Distinct features between longitudinally extensive transverse myelitis presenting with and without anti-Aquaporin 4 antibodies. Mult Scler 2013;19:299-307.
8. Nishiyama S, Ito T, Misu T, et al. A case of NMO seropositive for aquaporin-4 antibody more than 10 years before onset. Neurology 2009;72:1960-1.
9. Kitley J, Woodhall M, Waters P, et al. Myelin-oligodendrocyte glycoprotein antibodies in adults with a neuromyelitis optica phenotype. Neurology 2012;79:1273-7.
10. Höftberger R, Sepulveda M, Armangue T, et al. Antibodies to MOG and AQP4 in adults with neuromyelitis optica and suspected limited forms of the disease. Mult Scler 2015;21:866-74.
11. Sato DK, Callegaro D, Lana-Peixoto MA, et al. Distinction between MOG antibody-positive and AQP4 antibody-positive NMO spectrum disorders. Neurology 2014;82:474-81.
12. Ramanathan S, Reddel SW, Henderson A, et al. Antibodies to myelin oligodendrocyte glycoprotein in bilateral and recurrent optic neuritis. Neurol Neuroimmunol Neuroinflamm 2014;1:e40.
13. Rostásy K, Mader S, Hennes EM, et al. Persisting myelin oligodendrocyte glycoprotein antibodies in aquaporin-4 antibody negative pediatric neuromyelitis optica. Mult Scler 2013;19:1052-9.
14. Rostasy K, Mader S, Schanda K, et al. Anti-myelin oligodendrocyte glycoprotein antibodies in pediatric patients with optic neuritis. Arch Neurol 2012;69:752-6.
15. Mader S, Gredler V, Schanda K, et al. Complement activating antibodies to myelin oligodendrocyte glycoprotein in neuromyelitis optica and related disorders. J Neuroinflammation 2011;8:184.
16. Mayer MC, Breithaupt C, Reindl M, et al. Distinction and temporal stability of conformational epitopes on myelin oligodendrocyte glycoprotein recognized by patients with different inflammatory central nervous system diseases. J Immunol 2013;191:3594-604.
17. Dale RC, Tantsis EM, Merheb V, et al. Antibodies to MOG have a demyelination phenotype and affect oligodendrocyte cytoskeleton. Neurol Neuroimmunol Neuroinflamm 2014;1:e12.
18. Kurtzke JF. Rating neurologic impairment in multiple sclerosis: an expanded disability status scale (EDSS). Neurology 1983;33:1444-52.
19. Di Pauli F, Mader S, Rostasy K, et al. Temporal dynamics of anti-MOG antibodies in CNS demyelinating diseases. Clin Immunol 2011;138:247-54.
20. Wingerchuk MD, Banwell B, Bennett JF, et al. International consensus diagnostic criteria for neuromyelitis optica spectrum disorders. Neurology 2015;85:177-89.
21. Huppke P, Rostasy K, Karenfort M, et al. Acute disseminated encephalomyelitis followed by recurrent or monophasic optic neuritis in pediatric patients. Mult Scler 2013;19:941-6.
22. Pittock SJ, Lennon VA, Krecke K, et al. Brain abnormalities in neuromyelitis optica. Arch Neurol 2006;63:390-6.
23. Kitley J, Waters P, Woodhall M, et al. Neuromyelitis optica spectrum disorders with aquaporin-4 and myelin-oligodendrocyte glycoprotein antibodies: a comparative study. JAMA Neurol 2014;71:276-83.
24. Ketelslegers IA, Van Pelt DE, Bryde S, et al. Anti-MOG antibodies plead against MS diagnosis in an Acquired Demyelinating Syndromes cohort. Mult Scler 2015;21:1513-20.
25. Hacohen Y, Absoud M, Deiva K. Myelin oligodendrocyte glycoprotein antibodies are associated with a non-MS course in children. Neurol Neuroimmunol Neuroinflamm 2015;2:e81.
26. Jiao Y, Fryer JP, Lennon VA, et al. Aquaporin 4 IgG serostatus and outcome in recurrent longitudinally extensive transverse myelitis. JAMA Neurol 2014;71: 48-54.
27. McKeon A, Lennon VA, Lotze T, et al. CNS aquaporin-4 autoimmunity in children. Neurology 2008;71:93-100.
28. Kim HJ, Paul F, Lana-Peixoto MA, et al. MRI characteristics of neuromyelitis optica spectrum disorder: an international update. Neurology 2015;84:1165-73.
29. Tillema JM, McKeon A. The spectrum of neuromyelitis optica (NMO) in childhood. J Child Neurol 2012;27:1437-47.
30. Banwell B, Tenembaum S, Lennon VA, et al. Neuromyelitis optica-IgG in childhood inflammatory demyelinating CNS disorders. Neurology 2008;70:344-52.
31. Baumann M, Sahin K, Lechner C, et al. Clinical and neuroradiological differences of paediatric acute disseminating encephalomyelitis with and without antibodies to the myelin oligodendrocyte glycoprotein. J Neurol Neurosurg Psychiatry 2015;86:265-72.
32. Zamvil SS, Slavin AJ. Does MOG Ig-positive AQP4-seronegative opticospinal inflammatory disease justify a diagnosis of NMO spectrum disorder? Neurol Neuroimmunol Neuroinflamm 2015;2:e62.