Photoacoustic spectroscopy for the determination of lung cancer biomarkers—A preliminary investigation

Sensors (Switzerland)

Volumn 17, Issue 1, 2017, Pages

  Saalberg, Yannick ^a,b   Bruhns, Henry ^a   Wolff, Marcus ^a  

^a HAMBURG UNIVERSITY OF APPLIED SCIENCES   (Germany)

^b UNIVERSITY OF THE WEST OF SCOTLAND   (United Kingdom)

Author keywords

Biomarker; Breath analysis; IR spectra; Lung cancer; OPO; Optical parametric oscillator; PAS; Photoacoustic spectroscopy; VOC; Volatile organic compound

Indexed keywords

ABSORPTION SPECTROSCOPY; BIOLOGICAL ORGANS; BIOMARKERS; DIAGNOSIS; DISEASES; OPTICAL PARAMETRIC OSCILLATORS; PHOTOACOUSTIC EFFECT; POLYAMIDES; VOLATILE ORGANIC COMPOUNDS;

BREATH ANALYSIS; EXAMINATION METHODS; IR SPECTRUM; LIMITS OF DETECTION; LUNG CANCER; LUNG CANCER SCREENING; NATIONAL INSTITUTE OF STANDARDS AND TECHNOLOGY; SPECTROSCOPIC DETECTION;

PHOTOACOUSTIC SPECTROSCOPY;

VOLATILE ORGANIC COMPOUND;

BREATH ANALYSIS; EARLY CANCER DIAGNOSIS; HUMAN; LUNG TUMOR; SPECTROSCOPY;

BREATH TESTS; EARLY DETECTION OF CANCER; HUMANS; LUNG NEOPLASMS; SPECTRUM ANALYSIS; VOLATILE ORGANIC COMPOUNDS;

EID: 85010665924     PISSN: 14248220     EISSN: None     Source Type: Journal    
DOI: 10.3390/s17010210     Document Type: Article

References (46)

1. Ferlay, J.; Soerjomataram, I.; Dikshit, R.; Eser, S.; Mathers, C.; Rebelo, M.; Parkin, D.M.; Forman, D.; Bray, F. Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. Int. J. Cancer 2015, 136, E359-E386.
2. Stewart, B.W.; Wild, C.P. World Cancer Report 2014; International Agency for Research on Cancer/World Health Organization: Lyon, France, 2014.
3. Smith, R.A.; Manassaram-Baptiste, D.; Brooks, D.; Cokkinides, V.; Doroshenk, M.; Saslow, D.; Wender, R.C.; Brawley, O.W. Cancer screening in the United States, 2014: A review of current American Cancer Society guidelines and current issues in cancer screening. CA Cancer J. Clin. 2014, 64, 30-51.
4. Moyer, V.A. Screening for lung cancer: U.S. Preventive Services Task Force recommendation statement. Ann. Intern. Med. 2014, 160, 330-338.
5. Rami-Porta, R.; Crowley, J.J.; Goldstraw, P. The revised TNM staging system for lung cancer. Ann. Thorac. Cardiovasc. Surg. 2009, 15, 4-9.
6. Taivans, I.; Bukovskis, M.; Strazda, G.; Jurka, N. Breath testing as a method for detecting lung cancer. Expert Rev. Anticancer Ther. 2014, 14, 121-123.
7. Van’t Westeinde, S.C.; van Klaveren, R.J. Screening and early detection of lung cancer. Cancer J. 2011, 17, 3-10.
8. Ligor, T.; Pater, Ł.; Buszewski, B. Application of an artificial neural network model for selection of potential lung cancer biomarkers. J. Breath Res. 2015, 9, 027106.
9. Poli, D.; Goldoni, M.; Corradi, M.; Acampa, O.; Carbognani, P.; Internullo, E.; Casalini, A.; Mutti, A. Determination of aldehydes in exhaled breath of patients with lung cancer by means of on-fiber-derivatisation SPME-GC/MS. J. Chrom. B. 2010, 878, 2643-2651.
10. Phillips, M.; Cataneo, R.N.; Cummin, A.R.C.; Gagliardi, A.J.; Gleeson, K.; Greenberg, J.; Maxfield, R.A.; Rom, W.N. Detection of lung cancer with volatile markers in the breath. Chest 2003, 123, 2115-2123.
11. WHO International Programme on Chemical Safety Biomarkers in Risk Assessment: Validity and Validation. Available online: http://www.inchem.org/documents/ehc/ehc/ehc222.htm (accessed on 18 October 2016).
12. Saalberg, Y.; Wolff, M. VOC breath biomarkers in lung cancer. Clin. Chim. Acta 2016, 459, 5-9.
13. Tittel, F.K.; Richter, D.; Fried, A. Mid-Infrared Laser Applications in Spectroscopy. In Solid-State Mid-Infrared Laser Sources; Sorokina, I.T., Vodopyanov, K.L., Eds.; Springer: Berlin/Heidelberg, Germany, 2003; PP 458-529.
14. Klingbeil, A.E. Mid-IR Laser Absorption Diagnostics for Hydrocarbon Vapor Sensing in Harsh Environments. Ph.D Thesis, Stanford University, Stanford, CA, USA, 2007.
15. Bell, A.G. Upon the Production of Sound by Radiant Energy. Philos. Mag. 1881, 11, 150.
16. Michaelian, K.H. Photoacoustic IR Spectroscopy: Instrumentation, Applications and Data Analysis, 2nd ed.; Wiley: Somerset, NJ, USA, 2010.
17. Sigrist, M.W. Laser photoacoustic spectrometry for trace gas monitoring. Analyst 1994, 119, 525-531.
18. Bajtarevic, A.; Ager, C.; Pienz, M.; Klieber, M.; Schwarz, K.; Ligor, M.; Ligor, T.; Filipiak, W.; Denz, H.; Fiegl, M et al. Noninvasive detection of lung cancer by analysis of exhaled breath. BMC Cancer 2009, 9, 348.
19. Bruhns, H.; Saalberg, Y.; Wolff, M. Photoacoustic Hydrocarbon Spectroscopy Using a Mach-Zehnder Modulated cw OPO. Sens. Transducers 2015, 188, 40-47.
20. Elia, A.; Lugarà, P.M.; Di Franco, C.; Spagnolo, V. Photoacoustic techniques for trace gas sensing based on semiconductor laser sources. Sensors 2009, 9, 9616-9628.
21. Pacific Northwest National Laboratory. Available online: https://secure2.pnl.gov/nsd/nsd.nsf/Welcome (accessed on 20 November 2016).
22. Goertzel, G. An Algorithm for the Evaluation of Finite Trigonometric Series. Am. Math. Monthly 1958, 65, 34-35.
23. Oppenheim, A.V.; Schafer, R.W. Discrete-Time Signal Processing, 3rd ed.; Pearson: Upper Saddle River, NJ, USA, 2010.
24. Sysel, P.; Rajmic, P. Goertzel algorithm generalized to non-integer multiples of fundamental frequency. J. Adv. Signal Process. 2012, 2012, 56.
25. Bruhns, H.; Marianovich, A.; Wolff, M. Photoacoustic Spectroscopy Using a MEMS Microphone with Inter-IC Sound Digital Output. Int. J. Thermophys. 2014, 35, 2292-2301.
26. Bruhns, H.; Marianovich, A.; Rhein, S.; Wolff, M. Digital MEMS Microphone with Inter-IC Sound Interface for Photoacoustic Spectroscopy. In Proceedings of the 14th International Meeting on Chemical Sensors, IMCS 2012, Nuremberg, Germany, 20-23 May 2012; pp 1217-1219.
27. Buszewski, B.; Ligor, T.; Jezierski, T.; Wenda-Piesik, A.; Walczak, M.; Rudnicka, J. Identification of volatile lung cancer markers by gas chromatography-mass spectrometry: Comparison with discrimination by canines. Anal. Bioanal. Chem. 2012, 404, 141-146.
28. Fu, X.-A.; Li, M.; Knipp, R.J.; Nantz, M.H.; Bousamra, M. Noninvasive detection of lung cancer using exhaled breath. Cancer Med. 2014, 3, 174-181.
29. Gordon, S.M.; Szidon, J.P.; Krotoszynski, B.K.; Gibbons, R.D.; O’Neill, H.J. Volatile organic compounds in exhaled air from patients with lung cancer. Clin. Chem. 1985, 31, 1278-1282.
30. Ligor, M.; Ligor, T.; Bajtarevic, A.; Ager, C.; Pienz, M.; Klieber, M.; Denz, H.; Fiegl, M.; Hilbe, W.; Weiss, W et al. Determination of volatile organic compounds in exhaled breath of patients with lung cancer using solid phase microextraction and gas chromatography mass spectrometry. Clin. Chem. Lab. Med. 2009, 47, 550-560.
31. Ulanowska, A.; Kowalkowski, T.; Trawi nska, E.; Buszewski, B. The application of statistical methods using VOCs to identify patients with lung cancer. J. Breath Res. 2011, 5, 046008.
32. Chen, X.; Xu, F.; Wang, Y.; Pan, Y.; Lu, D.; Wang, P.; Ying, K.; Chen, E.; Zhang, W. A study of the volatile organic compounds exhaled by lung cancer cells in vitro for breath diagnosis. Cancer 2007, 110, 835-844.
33. Poli, D.; Carbognani, P.; Corradi, M.; Goldoni, M.; Acampa, O.; Balbi, B.; Bianchi, L.; Rusca, M.; Mutti, A. Exhaled volatile organic compounds in patients with non-small cell lung cancer: cross sectional and nested short-term follow-up study. Respir. Res. 2005, 6, 71.
34. Handa, H.; Usuba, A.; Maddula, S.; Baumbach, J.I.; Mineshita, M.; Miyazawa, T. Exhaled breath analysis for lung cancer detection using ion mobility spectrometry. PLoS One 2014, 9, e114555.
35. Rudnicka, J.; Kowalkowski, T.; Ligor, T.; Buszewski, B. Determination of volatile organic compounds as biomarkers of lung cancer by SPME-GC-TOF/MS and chemometrics. J. Chromatogr. B 2011, 879, 3360-3366.
36. Phillips, M.; Gleeson, K.; Hughes, J.M.B.; Greenberg, J.; Cataneo, R.N.; Baker, L.; McVay, W.P. Volatile organic compounds in breath as markers of lung cancer: A cross-sectional study. Lancet 1999, 353, 1930-1933.
37. Fuchs, P.; Loeseken, C.; Schubert, J.K.; Miekisch, W. Breath gas aldehydes as biomarkers of lung cancer. Int. J. Cancer 2010, 126, 2663-2670.
38. Szulejko, J.E.; McCulloch, M.; Jackson, J.; McKee, D.L.; Walker, J.C.; Solouki, T. Evidence for Cancer Biomarkers in Exhaled Breath. IEEE Sensors J. 2010, 10, 185-210.
39. Krilaviciute, A.; Heiss, J.A.; Leja, M.; Kupcinskas, J.; Haick, H.; Brenner, H. Detection of cancer through exhaled breath: a systematic review. Oncotarget 2015, 6, 38643-38657.
40. Mochalski, P.; King, J.; Unterkofler, K.; Amann, A. Stability of selected volatile breath constituents in Tedlar, Kynar and Flexfilm sampling bags. Analyst 2013, 138, 1405-1418.
41. Beauchamp, J.; Herbig, J.; Gutmann, R.; Hansel, A. On the use of Tedlar®bags for breath-gas sampling and analysis. J. Breath Res. 2008, 2, 046001.
42. Steeghs, M.M.L.; Cristescu, S.M.; Harren, F.J.M. The suitability of Tedlar bags for breath sampling in medical diagnostic research. Physiol. Meas. 2007, 28, 73-84.
43. Heymes, F.; Aprin, L.; Bony, A.; Forestier, S.; Cirocchi, S.; Dusserre, G. An experimental investigation of evaporation rates for different volatile organic compounds. Proc. Safety Prog. 2013, 32, 193-198.
44. Hirschmann, C.B.; Koivikko, N.S.; Raittila, J.; Tenhunen, J.; Ojala, S.; Rahkamaa-Tolonen, K.; Marbach, R.; Hirschmann, S.; Keiski, R.L. FT-IR-cPAS-new photoacoustic measurement technique for analysis of hot gases: a case study on VOCs. Sensors 2011, 11, 5270-5289.
45. Kessler, W. Multivariate Datenanalyse: Für die Pharma-Biound Prozessanalytik; Wiley-VCH: Weinheim, Germany, 2007.
46. Kohl, I.; Beauchamp, J.; Cakar-Beck, F.; Herbig, J.; Dunkl, J.; Tietje, O.; Tiefenthaler, M.; Boesmueller, C.; Wisthaler, A.; Breitenlechner, M et al. First observation of a potential non-invasive breath gas biomarker for kidney function. J. Breath Res. 2013, 7, 017110.