The effect of mindfulness meditation training on biological acute stress responses in generalized anxiety disorder

Psychiatry Research

Volumn 262, Issue , 2018, Pages 328-332

  Hoge, Elizabeth A ^a,b   Bui, Eric ^a,c   Palitz, Sophie A ^a   Schwarz, Noah R ^a   Owens, Maryann E ^a   Johnston, Jennifer M ^d   Pollack, Mark H ^e   Simon, Naomi M ^a,c  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b GEORGETOWN UNIVERSITY MEDICAL CENTER   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

^d BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e RUSH UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Acute stress; Anxiety; Meditation; Mindfulness based intervention; Psychological stress; Resilience; Stress reactivity

Indexed keywords

CORTICOTROPIN; INTERLEUKIN 6; TUMOR NECROSIS FACTOR;

ACUTE STRESS; ADULT; ARTICLE; ATTENTION; CONTROLLED STUDY; DISEASE SEVERITY; FEMALE; GENERAL MENTAL DISEASE ASSESSMENT; GENERALIZED ANXIETY DISORDER; HUMAN; MAJOR CLINICAL STUDY; MALE; MEDITATION; MENTAL STRESS; MINDFULNESS; MINDFULNESS BASED STRESS REDUCTION; OUTCOME ASSESSMENT; PRIORITY JOURNAL; PSYCHOLOGICAL RESILIENCE; RELAPSE; THERAPY EFFECT; TRIER SOCIAL STRESS TEST; ANXIETY DISORDER; AROUSAL; BLOOD; COMPARATIVE STUDY; COPING BEHAVIOR; MIDDLE AGED; PHYSIOLOGY; PSYCHOLOGY; RANDOMIZED CONTROLLED TRIAL;

ADAPTATION, PSYCHOLOGICAL; ADRENOCORTICOTROPIC HORMONE; ADULT; ANXIETY DISORDERS; AROUSAL; FEMALE; HUMANS; INTERLEUKIN-6; MALE; MEDITATION; MIDDLE AGED; MINDFULNESS; STRESS, PSYCHOLOGICAL; TUMOR NECROSIS FACTOR-ALPHA;

EID: 85010496851     PISSN: 01651781     EISSN: 18727123     Source Type: Journal    
DOI: 10.1016/j.psychres.2017.01.006     Document Type: Article

References (39)

1. Arranz, L., Guayerbas, N., De la Fuente, M., Impairment of several immune functions in anxious women. J. Psychosom. Res. 62:1 (2007), 1–8.
2. Aschbacher, K., Epel, E., Wolkowitz, O.M., Prather, A.A., Puterman, E., Dhabhar, F.S., Maintenance of a positive outlook during acute stress protects against pro-inflammatory reactivity and future depressive symptoms. Brain Behav. Immun. 26:2 (2012), 346–352.
3. Bremner, J.D., Vythilingam, M., Vermetten, E., Adil, J., Khan, S., Nazeer, A., Afzal, N., McGlashan, T., Elzinga, B., Anderson, G.M., Heninger, G., Southwick, S.M., Charney, D.S., Cortisol response to a cognitive stress challenge in posttraumatic stress disorder (PTSD) related to childhood abuse. Psychoneuroendocrinology 28:6 (2003), 733–750.
4. Britton, W.B., Shahar, B., Szepsenwol, O., Jacobs, W.J., Mindfulness-based cognitive therapy improves emotional reactivity to social stress: results from a randomized controlled trial. Behav. Ther. 43:2 (2012), 365–380.
5. Campbell, J., Ehlert, U., Acute psychosocial stress: does the emotional stress response correspond with physiological responses?. Psychoneuroendocrinology 37:8 (2012), 1111–1134.
6. Carpenter, L.L., Carvalho, J.P., Tyrka, A.R., Wier, L.M., Mello, A.F., Mello, M.F., Anderson, G.M., Wilkinson, C.W., Price, L.H., Decreased adrenocorticotropic hormone and cortisol responses to stress in healthy adults reporting significant childhood maltreatment. Biol. Psychiatry 62:10 (2007), 1080–1087.
7. Carroll, D., Phillips, A.C., Thomas, G.N., Gale, C.R., Deary, I., Batty, G.D., Generalized anxiety disorder is associated with metabolic syndrome in the Vietnam experience study. Biol. Psychiatry 66:1 (2009), 91–93.
8. Charney, D.S., Psychobiological mechanisms of resilience and vulnerability: implications for successful adaptation to extreme stress. Am. J. Psychiatry 161:2 (2004), 195–216.
9. Chiesa, A., Serretti, A., A systematic review of neurobiological and clinical features of mindfulness meditations. Psychol. Med 40:8 (2010), 1239–1252.
10. Chrousos, G.P., The role of stress and the hypothalamic-pituitary-adrenal axis in the pathogenesis of the metabolic syndrome: neuro-endocrine and target tissue-related causes. Int J. Obes. Relat. Metab. Disord. 24:Suppl 2 (2000), S50–S55.
11. Doering, L.V., Cross, R., Vredevoe, D., Martinez-Maza, O., Cowan, M.J., Infection, depression, and immunity in women after coronary artery bypass: a pilot study of cognitive behavioral therapy. Alter. Ther. Health Med 13:3 (2007), 18–21.
12. First, M.B., Spitzer, R.L., Miriam, G., Williams, J., Structured Clinical Interview for DSM-IV-TR Axis I Disorders, Research Version. Patient Edition. (SCID-I/P), 2002, Biometrics Research, New York State Psychiatric Institute, New York (November 2002).
13. Gerra, G., Zaimovic, A., Zambelli, U., Timpano, M., Reali, N., Bernasconi, S., Brambilla, F., Neuroendocrine responses to psychological stress in adolescents with anxiety disorder. Neuropsychobiology 42:2 (2000), 82–92.
14. Goyal, M., Singh, S., Sibinga, E.M., Gould, N.F., Rowland-Seymour, A., Sharma, R., Berger, Z., Sleicher, D., Maron, D.D., Shihab, H.M., Ranasinghe, P.D., Linn, S., Saha, S., Bass, E.B., Haythornthwaite, J.A., Meditation programs for psychological stress and well-being: a systematic review and meta-analysis. JAMA Intern. Med. 174:3 (2014), 357–368.
15. Hoge, E.A., Bui, E., Marques, L., Metcalf, C.A., Morris, L.K., Robinaugh, D.J., Worthington, J.J., Pollack, M.H., Simon, N.M., Randomized controlled trial of mindfulness meditation for generalized anxiety disorder: effects on anxiety and stress reactivity. J. Clin. Psychiatry 74:8 (2013), 786–792.
16. Jezova, D., Hlavacova, N., Makatsori, A., Duncko, R., Loder, I., Hinghofer-Szalkay, H., Increased anxiety induced by listening to unpleasant music during stress exposure is associated with reduced blood pressure and ACTH responses in healthy men. Neuroendocrinology 98:2 (2013), 144–150.
17. Kaur, J., A comprehensive review on metabolic syndrome. Cardiol. Res. Pr., 2014, 2014, 943162.
18. King, A.P., Abelson, J.L., Britton, J.C., Phan, K.L., Taylor, S.F., Liberzon, I., Medial prefrontal cortex and right insula activity predict plasma ACTH response to trauma recall. Neuroimage 47:3 (2009), 872–880.
19. Kirschbaum, C., Pirke, K.M., Hellhammer, D.H., The ‘Trier social stress test’ – a tool for investigating psychobiological stress responses in a laboratory setting. Neuropsychobiology 28:1–2 (1993), 76–81.
20. Kudielka, B.M., von Kanel, R., Preckel, D., Zgraggen, L., Mischler, K., Fischer, J.E., Exhaustion is associated with reduced habituation of free cortisol responses to repeated acute psychosocial stress. Biol. Psychol. 72:2 (2006), 147–153.
21. Lteif, G.N., Mavissakalian, M.R., Life events and panic disorder/agoraphobia. Compr. Psychiatry 36:2 (1995), 118–122.
22. Mantella, R.C., Butters, M.A., Amico, J.A., Mazumdar, S., Rollman, B.L., Begley, A.E., Reynolds, C.F., Lenze, E.J., Salivary cortisol is associated with diagnosis and severity of late-life generalized anxiety disorder. Psychoneuroendocrinology 33:6 (2008), 773–781.
23. Pace, T.W., Mletzko, T.C., Alagbe, O., Musselman, D.L., Nemeroff, C.B., Miller, A.H., Heim, C.M., Increased stress-induced inflammatory responses in male patients with major depression and increased early life stress. Am. J. Psychiatry 163:9 (2006), 1630–1633.
24. Pace, T.W., Negi, L.T., Sivilli, T.I., Issa, M.J., Cole, S.P., Adame, D.D., Raison, C.L., Innate immune, neuroendocrine and behavioral responses to psychosocial stress do not predict subsequent compassion meditation practice time. Psychoneuroendocrinology 35:2 (2010), 310–315.
25. Peckins, M.K., Dockray, S., Eckenrode, J.L., Heaton, J., Susman, E.J., The longitudinal impact of exposure to violence on cortisol reactivity in adolescents. J. Adolesc. Health 51:4 (2012), 366–372.
26. Pradhan, A.D., Manson, J.E., Rossouw, J.E., Siscovick, D.S., Mouton, C.P., Rifai, N., Wallace, R.B., Jackson, R.D., Pettinger, M.B., Ridker, P.M., Inflammatory biomarkers, hormone replacement therapy, and incident coronary heart disease: prospective analysis from the Women's Health Initiative observational study. JAMA 288:8 (2002), 980–987.
27. Pruessner, J.C., Gaab, J., Hellhammer, D.H., Lintz, D., Schommer, N., Kirschbaum, C., Increasing correlations between personality traits and cortisol stress responses obtained by data aggregation. Psychoneuroendocrinology 22:8 (1997), 615–625.
28. Pruessner, J.C., Kirschbaum, C., Meinlschmid, G., Hellhammer, D.H., Two formulas for computation of the area under the curve represent measures of total hormone concentration versus time-dependent change. Psychoneuroendocrinology 28:7 (2003), 916–931.
29. Ridker, P.M., Rifai, N., Stampfer, M.J., Hennekens, C.H., Plasma concentration of interleukin-6 and the risk of future myocardial infarction among apparently healthy men. Circulation 101:15 (2000), 1767–1772.
30. Roest, A.M., Martens, E.J., de Jonge, P., Denollet, J., Anxiety and risk of incident coronary heart disease: a meta-analysis. J. Am. Coll. Cardiol. 56:1 (2010), 38–46.
31. Rose, R.D., Buckey, J.C. Jr., Zbozinek, T.D., Motivala, S.J., Glenn, D.E., Cartreine, J.A., Craske, M.G., A randomized controlled trial of a self-guided, multimedia, stress management and resilience training program. Behav. Res. Ther. 51:2 (2013), 106–112.
32. Salters-Pedneault, K., Roemer, L., Tull, M.T., Rucker, L., Mennin, D.S., Evidence of broad deficits in emotion regulation associated with chronic worry and generalized anxiety disorder. Cogn. Ther. Res. 30:4 (2006), 469–480.
33. Schommer, N.C., Hellhammer, D.H., Kirschbaum, C., Dissociation between reactivity of the hypothalamus-pituitary-adrenal axis and the sympathetic-adrenal-medullary system to repeated psychosocial stress. Psychosom. Med. 65:3 (2003), 450–460.
34. Segal, Z.V., Bieling, P., Young, T., MacQueen, G., Cooke, R., Martin, L., Bloch, R., Levitan, R.D., Antidepressant monotherapy vs sequential pharmacotherapy and mindfulness-based cognitive therapy, or placebo, for relapse prophylaxis in recurrent depression. Arch. Gen. Psychiatry 67:12 (2010), 1256–1264.
35. Teasdale, J.D., Segal, Z.V., Williams, J.M., Ridgeway, V.A., Soulsby, J.M., Lau, M.A., Prevention of relapse/recurrence in major depression by mindfulness-based cognitive therapy. J. Consult. Clin. Psychol. 68:4 (2000), 615–623.
36. Tully, P.J., Cosh, S.M., Baune, B.T., A review of the affects of worry and generalized anxiety disorder upon cardiovascular health and coronary heart disease. Psychol. Health Med. 18:6 (2013), 627–644.
37. von Kanel, R., Kudielka, B.M., Hanebuth, D., Preckel, D., Fischer, J.E., Different contribution of interleukin-6 and cortisol activity to total plasma fibrin concentration and to acute mental stress-induced fibrin formation. Clin. Sci. 109:1 (2005), 61–67.
38. Watanabe, A., Nakao, K., Tokuyama, M., Takeda, M., Prediction of first episode of panic attack among white-collar workers. Psychiatry Clin. Neurosci. 59:2 (2005), 119–126.
39. Wirtz, P.H., von Kanel, R., Emini, L., Suter, T., Fontana, A., Ehlert, U., Variations in anticipatory cognitive stress appraisal and differential proinflammatory cytokine expression in response to acute stress. Brain Behav. Immun. 21:6 (2007), 851–859.