Glycogen Synthase Kinase 3b Inhibition Improves Myocardial Angiogenesis and Perfusion in a Swine Model of Metabolic Syndrome

Journal of the American Heart Association

Volumn 5, Issue 7, 2016, Pages

  Potz, Brittany A ^a   Sabe, Ashraf A ^a   Elmadhun, Nassrene Y ^a   Clements, Richard T ^a   Robich, Michael P ^a   Sodha, Neel R ^a   Sellke, Frank W ^a  

^a BROWN UNIVERSITY   (United States)

Author keywords

Angiogenesis; Cardiovascular diseases; Diabetes mellitus; Hypercholesterolemia; Obesity

Indexed keywords

ADENYLATE KINASE; BETA CATENIN; GLYCOGEN SYNTHASE KINASE 3BETA; MANGANESE SUPEROXIDE DISMUTASE; PLAKOGLOBIN; PROTEIN KINASE B; TRANSCRIPTION FACTOR FKHR; VASCULAR ENDOTHELIAL CADHERIN; VASCULOTROPIN RECEPTOR 1; 3-(4-FLUOROPHENYLETHYLAMINO)-1-METHYL-4-(2-METHYL-1H-INDOL-3-YL)-1H-PYRROLE-2,5-DIONE; CADHERIN; INDOLE DERIVATIVE; MALEIMIDE DERIVATIVE; SUPEROXIDE DISMUTASE;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD VESSEL DENSITY; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL SURVIVAL; CONTROLLED STUDY; CORONARY ARTERY BLOOD FLOW; DENSITOMETRY; GLUCOSE TOLERANCE TEST; HEART MUSCLE PERFUSION; IMMUNOHISTOCHEMISTRY; METABOLIC SYNDROME X; MITOCHONDRIAL RESPIRATION; NONHUMAN; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN STABILITY; SIGNAL TRANSDUCTION; YORKSHIRE PIG; ANIMAL; ANTAGONISTS AND INHIBITORS; CARDIAC MUSCLE; CHRONIC DISEASE; CORONARY BLOOD VESSEL; DISEASE MODEL; DRUG EFFECTS; HEART; HEART MUSCLE ISCHEMIA; LIPID DIET; METABOLISM; PATHOLOGY; PIG;

ANIMALS; BETA CATENIN; CADHERINS; CHRONIC DISEASE; CORONARY CIRCULATION; CORONARY VESSELS; DIET, HIGH-FAT; DISEASE MODELS, ANIMAL; FORKHEAD BOX PROTEIN O1; GAMMA CATENIN; GLYCOGEN SYNTHASE KINASE 3 BETA; HEART; INDOLES; MALEIMIDES; METABOLIC SYNDROME; MYOCARDIAL ISCHEMIA; MYOCARDIUM; NEOVASCULARIZATION, PHYSIOLOGIC; PROTO-ONCOGENE PROTEINS C-AKT; SUPEROXIDE DISMUTASE; SUS SCROFA; SWINE; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-1;

EID: 85009954334     PISSN: None     EISSN: 20479980     Source Type: Journal    
DOI: 10.1161/JAHA.116.003694     Document Type: Article

References (22)

1. Galassi A, Reynolds K, He J. Metabolic syndrome and risk of cardiovascular disease: a meta-analysis. Am J Med. 2006;119:812–819.
2. Abaci A, Oguzhan A, Kahraman S, Eryol NK, Unal S, Arinc H, Ergin A. Effect of diabetes mellitus on formation of coronary collateral vessels. Circulation. 1999;99:2239–2242.
3. Boodhwani M, Sellke FW. Therapeutic angiogenesis in diabetes and hypercholesterolemia: influence of oxidative stress. Antioxid Redox Signal. 2009;11:1945–1959.
4. Sutherland C. What are the bona fide GSK3 substrates? Int J Alzheimers Dis. 2011;2011:505607.
5. Wu D, Pan W. GSK3: a multifaceted kinase in Wnt signaling. Trends Biochem Sci. 2011;35:161–168.
6. Hoang MV, Nagy JA, Senger DR. Cbc42-mediated inhibition of GSK-3B improves angio-architecture and lumen formation during VEGF-driven pathological angiogenesis. Microvasc Res. 2011;81:34–43.
7. Miura T, Miki T. GSK-3 b, a therapeutic target for cardiomyocyte protection. Circ J. 2009;73:1184–1192.
8. Birdsey GM, Shah AV, Dufton N, Reynolds LE, Almagro LO, Yang Y, Hodivaladilke K, Aspalter IM, Khan ST, Mason JC, Dejana E, Go B, Gerhardt H, Adams RH, Randi AM. The endothelial transcription factor ERG promotes vascular stability and growth through Wnt/b-catenin signaling. Dev Cell. 2015;32:82– 96.
9. Badorff C, Ruetten H, Mueller S, Stahmer M, Gehring D, Jung F, Ihling C, Zeiher AM, Dimmeler S. Fas receptor signaling inhibits glycogen synthase kinase 3 b and induces cardiac hypertrophy following pressure overload. J Clin Invest. 2002;109:373–381.
10. Sambasivarao SV. Overfed Ossabaw swine with early stage metabolic syndrome have normal coronary collateral development in response to chronic ischemia. Basic Res Cardiol. 2012;107:243–264.
11. Sabe AA, Potz BA, Elmadhun NY, Liu Y, Feng J, Abid MR, Abbott JD, Senger DR, Sellke FW. Calpain inhibition improves collateral dependent perfusion in a hypercholesterolemic swine model of chronic myocardial ischemia. J Thorac Cardiovasc Surg. 2016;151:245–252.
12. Potz B, Sabe A, Elmadhun NY, Feng J, Liu Y, Mitchell H, Quesenberry P, Abid MR, Sellke FW. Calpain inhibition decreases myocardial apoptosis in a swine model of chronic myocardial ischemia. Surgery. 2015;158:445–452.
13. Go~ni-Oliver P, Lucas JJ, Avila J, Hernaandez F. N-terminal cleavage of GSK-3 by calpain. J Biol Chem. 2007;282:22406–22413.
14. Robich MP, Osipov RM, Nezafat R, Feng J, Clements RT, Bianchi C, Boodhwani M, Coady MA, Laham RJ, Sellke FW. Resveratrol improves myocardial perfusion in a swine model of hypercholesterolemia and chronic myocardial ischemia. Circulation. 2010;122:S142–S149.
15. Wagman AS, Maurer U, Dejardin E, Green DR. Glycogen synthase kinase-3 regulates mitochondrial outer membrane permeabilization and apoptosis by destabilization of MCL-1. Mol Cell. 2006;21:749–760.
16. Juhaszova M, Zorov DB, Yaniv Y, Nuss HB, Wang S, Sollott SJ. Role of glycogen synthase kinase-3b in cardioprotection. Circ Res. 2010;104:1240–1252.
17. Liberman Z, Plotkin B, Tennenbaum T, Eldar-Finkelman H. Coordinated phosphorylation of insulin receptor substrate-1 by glycogen synthase kinase-3 and protein kinase C betaII in the diabetic fat tissue. Am J Physiol Endocrinol Metab. 2008;294:1169–1177.
18. Liberman Z, Eldar-Finkelman H. Serine 332 phosphorylation of insulin receptor substrate-1 by glycogen synthase kinase-3 attenuates insulin signaling. J Biol Chem. 2005;280:4422–4428.
19. Elmadhun NY, Lassaletta AD, Chu LMSF. Metformin alters the insulin signaling pathway in ischemic cardiac tissue in a swine model of metabolic syndrome. J Thorac Cardiovasc Surg. 2013;145:258–266.
20. Badorff C, Holzmann Y, Zeiher AM, Dimmeler S. Glycogen synthase kinase-3 couples AKT-dependent signaling to the regulation of p21Cip1 degradation. J Biol Chem. 2002;277:9684–9689.
21. Fl€ugel D, G€orlach A, Kietzmann T. GSK-3B regulates cell growth, migration, and angiogenesis via Fbw7 and USP28-dependent degradation of HIF-1. Blood. 2012;119:1292–1302.
22. An JH, Vranas K, Lucke M, Inoue H, Hisamoto N, Matsumoto K, Blackwell TK. Regulation of the Caenorhabditis elegans oxidative stress defense protein SKN-1 by glycogen synthase kinase-3. Proc Natl Acad Sci USA. 2005;102:16275–16280.