Synthesis and biological evaluation of thiazole derivatives as novel USP7 inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 27, Issue 4, 2017, Pages 845-849

  Chen, Chao ^a   Song, Jiemei ^a   Wang, Jinzheng ^a   Xu, Chang ^a   Chen, Caiping ^a   Gu, Wei ^b   Sun, Hongbin ^a   Wen, Xiaoan ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

^b Columbia University ^*  (United States)

Author keywords

Human colon cancer; Thiazole derivatives; USP7 inhibitor

Indexed keywords

ANTINEOPLASTIC AGENT; DEUBIQUITINASE; P 22077; P 5091; PROTEIN P53; PROTEINASE INHIBITOR; THIAZOLE DERIVATIVE; UNCLASSIFIED DRUG; PROTEIN BINDING; UBIQUITIN THIOLESTERASE; USP7 PROTEIN, HUMAN;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER INHIBITION; CELL DEATH; CONTROLLED STUDY; DRUG SYNTHESIS; HCT 116 CELL LINE; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; ANTAGONISTS AND INHIBITORS; APOPTOSIS; BINDING SITE; CHEMISTRY; CONFORMATION; DRUG EFFECTS; ENZYME ACTIVATION; IC50; METABOLISM; MOLECULAR DOCKING; PROTEIN TERTIARY STRUCTURE; SYNTHESIS; X RAY CRYSTALLOGRAPHY;

ANTINEOPLASTIC AGENTS; APOPTOSIS; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; ENZYME ACTIVATION; HCT116 CELLS; HUMANS; INHIBITORY CONCENTRATION 50; MOLECULAR CONFORMATION; MOLECULAR DOCKING SIMULATION; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; THIAZOLES; TUMOR SUPPRESSOR PROTEIN P53; UBIQUITIN THIOLESTERASE;

EID: 85009820712     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2017.01.018     Document Type: Article

References (10)

1. 1 Brooks, C.L., Gu, W., Mol Cell 21 (2006), 307–315.
2. 2 Van Leeuwen, I.M., Higgins, M., Campbell, J., et al. Cell Cycle 10 (2011), 1590–1598.
3. 3 Li, M., Chen, D., Shiloh, A., et al. Nature 416 (2002), 648–653.
4. 4 Li, M., Brooks, C.L., Kon, N., Gu, W., Mol Cell 13 (2004), 879–886.
5. 5 Reverdy, C., Conrath, S., Lopez, R., et al. Chem Biol 19 (2012), 467–477.
6. 6 Chauhan, D., Tian, Z., Nicholson, B., et al. Cancer Cell 22 (2012), 345–358.
7. 7 Altun, M., Kramer, H.B., Willems, L., et al. Chem Biol 18 (2011), 1401–1412.
8. 8 Colland, F., Formstecher, E., Jacq, X., et al. Mol Cancer Ther 8 (2009), 2286–2295.
9. 9 Tavana, D., Li, D.W., Dai, C., et al. Nat Med 22 (2016), 1180–1186.
10. 10 Weinstock, J., Wu, J., Cao, P., et al. ACS Med Chem Lett 3 (2012), 789–792.