Brain-derived neurotrophic factor (BDNF) as a potential mechanism of the effects of acute exercise on cognitive performance

Journal of Sport and Health Science

Volumn 4, Issue 1, 2015, Pages 14-23

  Piepmeier, Aaron T ^a   Etnier, Jennifer L ^a  

^a UNIVERSITY OF NORTH CAROLINA AT GREENSBORO   (United States)

Author keywords

Isoforms; Mediators; Memory; Mental health; Physical activity

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; ISOPROTEIN;

ADULT; COGNITION; CONTROLLED STUDY; EXERCISE; FEMALE; HIPPOCAMPUS; HUMAN; MAJOR CLINICAL STUDY; MALE; MEMORY; NEUROANATOMY; NEUROSCIENCE; PRIORITY JOURNAL; REVIEW; SPATIAL LEARNING; SPATIAL MEMORY; SYNAPTIC POTENTIAL; TASK PERFORMANCE;

EID: 85009760126     PISSN: 20952546     EISSN: 22132961     Source Type: Journal    
DOI: 10.1016/j.jshs.2014.11.001     Document Type: Review

References (45)

1. Chang Y.K., Labban J.D., Gapin J.I., Etnier J.L. The effects of acute exercise on cognitive performance: a meta-analysis. Brain Res 2012, 1453:87-101.
2. Lambourne K., Tomporowski P. The effect of exercise-induced arousal on cognitive task performance: a meta-regression analysis. Brain Res 2010, 1341:12-24.
3. Dietrich A., Audiffren M. The reticular-activating hypofrontality (RAH) model of acute exercise. Neurosci Biobehav Rev 2011, 35:1305-1325.
4. McMorris T., Collard K., Corbett J., Dicks M., Swain J.P. A test of the catecholamines hypothesis for an acute exercise-cognition interaction. Pharmacol Biochem Behav 2008, 89:106-115.
5. Cirulli F., Berry A., Chiarotti F., Alleva E. Intrahippocampal administration of BDNF in adult rats affects short-term behavioral plasticity in the Morris water maze and performance in the elevated plus-maze. Hippocampus 2004, 14:802-807.
6. Mu J.S., Li W.P., Yao Z.B., Zhou X.F. Deprivation of endogenous brain-derived neurotrophic factor results in impairment of spatial learning and memory in adult rats. Brain Res 1999, 835:259-265.
7. Pan W., Banks W.A., Fasold M.B., Bluth J., Kastin A.J. Transport of brain-derived neurotrophic factor across the blood-brain barrier. Neuropharmacology 1998, 37:1553-1561.
8. Poduslo J.F., Curran G.L. Permeability at the blood-brain and blood-nerve barriers of the neurotrophic factors: NGF, CNTF, NT-3, BDNF. Brain Res Mol Brain Res 1996, 36:280-286.
9. Knaepen K., Goekint M., Heyman E.M., Meeusen R. Neuroplasticity - exercise-induced response of peripheral brain-derived neurotrophic factor: a systematic review of experimental studies in human subjects. Sports Med 2010, 40:765-801.
10. Horch H.W., Kru A., Portbury S.D., Katz L.C., Hughes H., Carolina N. Destabilization of cortical dendrites and spines by BDNF. Neuron 1999, 23:353-364.
11. Neeper S.A., Gómez-Pinilla F., Choi J., Cotman C.W. Physical activity increases mRNA for brain-derived neurotrophic factor and nerve growth factor in rat brain. Brain Res 1996, 726:49-56.
12. Erickson K.I., Prakash R.S., Voss M.W., Chaddock L., Heo S., McLaren M., et al. Brain-derived neurotrophic factor is associated with age-related decline in hippocampal volume. J Neurosci 2010, 30:5368-5375.
13. Laske C., Stransky E., Leyhe T., Eschweiler G.W., Schott K., Langer H., et al. Decreased brain-derived neurotrophic factor (BDNF)- and β-thromboglobulin (β-TG)-blood levels in Alzheimer's disease. J Thromb Haemost 2006, 96:102-103.
14. Laske C., Stransky E., Leyhe T., Eschweiler G.W., Schott K., Langer H., et al. BDNF serum and CSF concentrations in Alzheimer's disease, normal pressure hydrocephalus and healthy controls. J Psychiatr Res 2007, 41:387-394.
15. Ferris L.T., Williams J.S., Shen C.L. The effect of acute exercise on serum brain-derived neurotrophic factor levels and cognitive function. Med Sci Sports Exerc 2007, 39:728-734.
16. Griffin É.W., Mullally S., Foley C., Warmington S.A., O'Mara S.M., Kelly A.M. Aerobic exercise improves hippocampal function and increases BDNF in the serum of young adult males. Physiol Behav 2011, 104:934-941.
17. Rasmussen P., Brassard P., Adser H., Pedersen M.V., Leick L., Hart E., et al. Evidence for a release of brain-derived neurotrophic factor from the brain during exercise. Exp Physiol 2009, 94:1062-1069.
18. Tang S.W., Chu E., Hui T., Helmeste D., Law C. Influence of exercise on serum brain-derived neurotrophic factor concentrations in healthy human subjects. Neurosci Lett 2008, 431:62-65.
19. Rojas Vega S., Strüder H.K., Vera Wahrmann B., Schmidt A., Bloch W., Hollmann W. Acute BDNF and cortisol response to low intensity exercise and following ramp incremental exercise to exhaustion in humans. Brain Res 2006, 1121:59-65.
20. Winter B., Breitenstein C., Mooren F.C., Voelker K., Fobker M., Lechtermann A., et al. High impact running improves learning. Neurobiol Learn Mem 2007, 87:597-609.
21. Seifert T., Brassard P., Wissenberg M., Rasmussen P., Nordby P., Stallknecht B., et al. Endurance training enhances BDNF release from the human brain. Am J Physiol Regul Integr Comp Physiol 2010, 298:R372-R377.
22. Pardridge W.M., Wu D., Sakane T. Combined use of carboxyl-directed protein pegylation and vector-mediated blood-brain barrier drug delivery system optimizes brain uptake of brain-derived neurotrophic factor following intravenous administration. Pharm Res 1998, 15:576-582.
23. Pardridge W.M. Blood-brain barrier delivery. Drug Discov Today 2007, 12:54-61.
24. Kyeremanteng C., James J., Mackay J., Merali Z. A study of brain and serum brain-derived neurotrophic factor protein in Wistar and Wistar-Kyoto rat strains after electroconvulsive stimulus. Pharmacopsychiatry 2012, 45:244-249.
25. Rosenfeld R.D., Zeni L., Haniu M., Talvenheimo J., Radka S.F., Bennett L., et al. Purification and identification of brain-derived neurotrophic factor from human serum. Protein Expr Purif 1995, 6:465-471.
26. Pliego-Rivero F.B., Bayatti N., Giannakoulopoulos X., Glover V., Bradford H.F., Stern G., et al. Brain-derived neurotrophic factor in human platelets. Biochem Pharmacol 1997, 54:207-209.
27. Radka S.F., Hoist P.A., Fritsche M., Altar C.A. Presence of brain-derived neurotrophic factor in brain and human and rat but not mouse serum detected by a sensitive and specific immunoassay. Brain Res 1996, 709:122-130.
28. Brunelli A., Dimauro I., Sgrò P., Emerenziani G.P., Magi F., Baldari C., et al. Acute exercise modulates BDNF and pro-BDNF protein content in immune cells. Med Sci Sports Exerc 2012, 44:1871-1880.
29. Lu B., Pang P.T., Woo N.H. The yin and yang of neurotrophin action. Nat Rev Neurosci 2005, 6:603-614.
30. Barker P.A. Whither proBDNF?. Nat Neurosci 2009, 12:105-106.
31. Cunha C., Brambilla R., Thomas K.L. A simple role for BDNF in learning and memory?. Front Mol Neurosci 2010, 3:1. 10.3389/neuro.02.001.2010.
32. Carlino D., Leone E., Di Cola F., Baj G., Marin R., Dinelli G., et al. Low serum truncated-BDNF isoform correlates with higher cognitive impairment in schizophrenia. J Psychiatr Res 2011, 45:273-279.
33. Tongiorgi E., Sartori A., Baj G., Bratina A., Di Cola F., Zorzon M., et al. Altered serum content of brain-derived neurotrophic factor isoforms in multiple sclerosis. J Neurol Sci 2012, 320:161-165.
34. Yoshida T., Ishikawa M., Iyo M., Hashimoto K. Serum levels of mature brain-derived neurotrophic factor (BDNF) and its precursor proBDNF in healthy subjects. Open Clin Chem J 2012, 5:7-12.
35. Yoshida T., Ishikawa M., Niitsu T., Nakazato M., Watanabe H., Shiraishi T., et al. Decreased serum levels of mature brain-derived neurotrophic factor (BDNF), but not its precursor proBDNF, in patients with major depressive disorder. PLoS One 2012, 7:e42676. 10.1371/journal.pone.0042676.
36. Lee J.K.W., Koh A.C.H., Koh S.X.T., Liu G.J.X., Nio A.Q.X., Fan P.W.P. Neck cooling and cognitive performance following exercise-induced hyperthermia. Eur J Appl Physiol 2014, 114:375-384.
37. Skriver K., Roig M., Lundbye-Jensen J., Pingel J., Helge J.W., Kiens B., et al. Acute exercise improves motor memory: exploring potential biomarkers. Neurobiol Learn Mem 2014, 116C:46-58.
38. Tonoli C., Heyman E., Buyse L., Roelands B., Piacentini M.F., Bailey S., et al. Neurotrophins and cognitive functions in T1D compared to healthy controls: effects of a high-intensity exercise. Appl Physiol Nutr Metab 2014, 1-21.
39. Tsai C.L., Chen F.C., Pan C.Y., Wang C.H., Huang T.H., Chen T.C. Impact of acute aerobic exercise and cardiorespiratory fitness on visuospatial attention performance and serum BDNF levels. Psychoneuroendocrinology 2014, 41:121-131.
40. Vaynman S., Ying Z., Gomez-Pinilla F. Hippocampal BDNF mediates the efficacy of exercise on synaptic plasticity and cognition. Eur J Neurosci 2004, 20:2580-2590.
41. Erickson K.I., Voss M.W., Prakash R.S., Basak C., Szabo A., Chaddock L., et al. Exercise training increases size of hippocampus and improves memory. Proc Natl Acad Sci U S A 2011, 1-6.
42. Van Praag H., Shubert T., Zhao C., Gage F.H. Exercise enhances learning and hippocampal neurogenesis in aged mice. J Neurosci 2005, 25:8680-8685.
43. Cotman C.W., Engesser-Cesar C. Exercise enhances and protects brain function. Exerc Sport Sci Rev 2002, 30:75-79.
44. Maric M., Wiers R.W., Prins P.J.M. Ten ways to improve the use of statistical mediation analysis in the practice of child and adolescent treatment research. Clin Child Fam Psychol Rev 2012, 15:177-191.
45. Hayes A.F. Introduction to mediation, moderation, and conditional process analysis: a regression-based approach 2013, The Guilford Press, New York.