Therapeutic effect of retinoic acid in lupus nephritis

Japanese Journal of Clinical Immunology

Volumn 35, Issue 1, 2012, Pages 1-7

  Kinoshita, Koji ^a   Funauchi, Masanori ^a  

^a KINKI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

lupus; nephritis; retinoid

Indexed keywords

EID: 85009507809     PISSN: 09114300     EISSN: 13497413     Source Type: Journal    
DOI: 10.2177/jsci.35.1     Document Type: Article

References (24)

1. Cantorna, M. T., et al. : In vitamin A deficiency multiple mechanisms establish a regulatory T helper cell imbalance with excess Th1 and in-sufficient Th2 function. J. Immunol. 152 : 1515–1522, 1994.
2. Huang, M. E., et al. : Use of all-trans retinoic acid in the treatment of acute promyelocytic leukemia. Blood. 72 : 567–572, 1988.
3. Ward, A. et al. : Etretinate : A review of its pharmacological properties and therapeutic efficacy in psoriasis and other skin disorders. Drugs. 26 : 9–43, 1983.
4. Peck, G. L., et al. : Isotretinoin versus placebo in the treatment of cystic acne : A randomized double-blind study. J. Am. Acad. Dermatol. 6 : 735–745, 1982.
5. Iwata, M., et al. : Retinoic acids exert direct effects on T cells to suppress Th1 development and enhance Th2 development via retinoic acid receptors. Int. Immunol. 15 : 1017–1025, 2003.
6. Racke, M. K., et al. : Retinoid treatment of experimental allergic encephalomyelitis. ILP4 production correlates with improved disease course. J. Immunol. 154 : 450–458, 1995.
7. Nozaki, Y., et al. : Anti-inflammatory effect of all-trans-retinoic acid in inflammatory arthritis. Clinical Immunology. 119 : 272–279, 2006.
8. Wagner. J., et al. : Retinoic acid reduces glomerular injury in a rat model of glomerular damage. J. Am. Soc. Nephrol. 11 : 1479–1487, 2000.
9. Lehrke, I., et al. : Retinoid receptor-specific agonists alleviate experimental glomerulonephritis. Am. J. Physiol. Renal Physiol. 282 : 741–751, 2002.
10. Moreno-Manzano, V., et al. : Retinoids as a potential treatment for experimental puromycin-induced nephrosis. Br. J. Pharmacol. 139 : 823–831, 2003.
11. Kishimoto, K., et al. : Therapeutic Effect of Retinoic Acid on Unilateral Ureteral Obstruction Model. Nephron Exp. Nephrol. 118 : E69-e78, 2011.
12. Finck, B. K., et al. : Interleukin 6 promotes murine lupus in NZB/NZW F1 mice. J. Clin. Invest. 94 : 585–591, 1994.
13. Santiago, M. L., et al. : Interleukin-4 protects against a genetically linked lupus-like autoimmune syndrome. J. Exp. Med. 185 : 65–70, 1997.
14. Takahashi, S., et al. : Imbalance towards Th1 predominance is associated with acceleration of lupus-like autoimmune syndrome in MRL mice. J. Clin. Invest. 97 : 1597–1604, 1996.
15. Nakajima, A., et al. : Roles of IL-4 and IL-12 in the development of lupus in NZB/W F1 mice. J. Immunol. 158 : 1466–1472, 1997.
16. Kinoshita, K., et al. : Retinoic acid reduces autoimmune renal injury and increases survival in NZB/W F1 mice. J. Immunol. 170 : 5793–5798, 2003.
17. Felli, M. P., et al. : Retinoic acid-induced down-regulation of the interleukin-2 promoter via cis-regulatory sequences containing an octamer motif. Mol. Cell. Biol. 11 : 4771–4778, 1991.
18. Cippitelli, M., et al. : Retinoic acid-induced transcriptional modulation of the human interferon-γ promoter. J. Biol. Chem. 271: 26783–26793, 1996.
19. Cantorna, M. T., et al. : Vitamin A down-regulation of IFN-γ synthesis in cloned mouse Th1 lymphocytes depends on the CD28 costimulatory pathway. J. Immunol. 156:2674–2679, 1996.
20. Schwarting, A., et al. : IFN-γ receptor signaling is essential for the initiation, acceleration, and destruction of autoimmune kidney disease in MRL-Faslpr mice. J. Immunol. 161: 494–503, 1998.
21. Ozmen, L., et al. Experimental therapy of systemic lupus erythematosus: The treatment of NZB/W mice with mouse soluble interferon-gamma receptor inhibits the onset of glomerulonephritis. Eur. J. Immunol. 25 : 6–12, 1995.
22. Park, C. L. B. et al. : Isotypic profiles and other fine characteristics of immune responses to exogenous thymus-dependent and -independent antigens by mice with lupus syndromes. J. Immunol. 130 : 2161–2167, 1983.
23. Nozaki, Y., et al. : The beneficial effects of treatment with all-trans-retinoic acid plus corticosteroid on autoimmune nephritis in NZB/ WF mice. Clinical and Experimental Immunology. 139 : 74–83, 2005.
24. Kinoshita, K., et al. : Successful Treatment With Retinoids in Patients With Lupus Nephritis. Am. J. Kid. Dis. 55 : 344–347, 2010.