Retinoids as a potential treatment for experimental puromycin-induced nephrosis

British Journal of Pharmacology

Volumn 139, Issue 4, 2003, Pages 823-831

  Moreno Manzano, V ^a   Mampaso, F ^a   Sepulveda Munoz J C ^a   Alique, M ^a   Chen, S ^b   Ziyadeh, F N ^b   Iglesias de La Cruz, M C ^b   Rodriguez J ^a   Nieto, E ^a   Orellana, J M ^a   Reyes, P ^a   Arribas, I ^a   Xu, Q ^c   Kitamura, M ^d   Cazana, F J Lucio ^a  

^a UNIVERSITY OF ALCALÁ   (Spain)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c UNIVERSITY COLLEGE LONDON   (United Kingdom)

^d JIKEI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Adhesion molecules; Inflammation; Kidney; Nephrosis; Podocyte; Proteinuria; Puromycin aminonucleoside; Tretinoin (all trans retinoic acid)

Indexed keywords

FIBRONECTIN; MONOCYTE CHEMOTACTIC PROTEIN 1; RETINOIC ACID; RETINOID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; APOPTOSIS; ARTICLE; CELL DAMAGE; CELL INFILTRATION; CONTROLLED STUDY; CREATININE CLEARANCE; DISEASE MODEL; FEMALE; LEUKOCYTE; MINIMAL CHANGE GLOMERULONEPHRITIS; NEPHROSIS; NICK END LABELING; NONHUMAN; PODOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEINURIA; PUROMYCIN INDUCED NEPHROSIS; RAT;

ADMINISTRATION, ORAL; ANIMALS; APOPTOSIS; CELL CULTURE TECHNIQUES; CELL MOVEMENT; CHEMOKINE CCL2; DISEASE MODELS, ANIMAL; DRUG COMBINATIONS; EPITHELIAL CELLS; FEMALE; FIBRONECTINS; FOOD; INJECTIONS, INTRAPERITONEAL; KIDNEY GLOMERULUS; LEUKOCYTES, MONONUCLEAR; MICE; NEPHROSIS; PROTEINURIA; PUROMYCIN AMINONUCLEOSIDE; RATS; RATS, WISTAR; RETINOIDS; TIME FACTORS;

EID: 10744220228     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0705311     Document Type: Article

References (67)

1. ALTUCCI, L., ROSSIN, A., RAFFELSBERGER, W., REITMAIR, A., CHOMIENNE, C. & GRONEMEYER, H. (2001). Retinoic acid-induced apoptosis in leukemia cells is mediated by paracrine action of tumor-selective death ligand TRAIL. Nat. Med., 7, 680-686.
2. BARISONI, L., KRIZ, W., MUNDEL, P. & D'AGATI, V. (1999). The dysregulated podocyte phenotype: a novel concept in the pathogenesis of collapsing idiopathic focal segmental glomerulosclerosis and HIV-associated nephropathy. J. Am. Soc. Nephrol., 10, 51-61.
3. BERENS, K.L., VERANI, R.R. & LUKE, D.R. (1998). Role of neutrophils and macrophages in experimental nephrosis of the rat. Renal Failure, 20, 53-63.
4. BJORN, S.F., BANGSTAD, H.J., HANSSEN, K.F., NYBERG, G., WALKER, J.D., VIBERTI, G.C. & OSTERBY, R. (1995). Glomerular epithelial foot processes and filtration slits in IDDM patients. Diabetologia, 38, 1197-1204.
5. CHANA, R.S. & WHEELER, D.C. (1999). Fibronectin augments monocyte adhesion to low-density lipoprotein-stimulated mesangial cells. Kidney Int., 55, 179-188.
6. CHOMCZYNSKI, P. & SACCHI, N. (1987). Single-step method of RNA isolation by acid guanidinium thiocyanate- phenol-chloroform extraction. Anal. Biochem, 162, 156-159.
7. CORDELL, J.L., FALINI, B., ERBER, W.N., GHOSH, A.K., ABDULAZIZ, Z., MACDONALD, S., PULFORD, K.A., STEIN, H. & MASON, D.Y. (1984). Immunoenzymatic labeling of monoclonal antibodies using immune complexes of alkaline phosphatase and monoclonal anti-alkaline phosphatase (APAAP complexes). J. Histochem. Cytochem., 32, 219-229.
8. DATTA, P.K. & LIANOS, E.A. (1999). Retinoic acids inhibit inducible nitric oxide synthase expression in mesangial cells. Kidney Int., 56, 486-493.
9. DE LUCA, L.M. (1991). Retinoids and their receptors in differentiation, embryogenesis, and neoplasia. FASEB J., 5, 2924-2933.
10. DESREUMAUX, P., DUBUQUOY, L., NUTTEN, S., PEUCHMAUR, M., ENGLARO, W., SCHOONJANS, K., DERIJARD, B., DESVERGNE, B., WAHLI, W., CHAMBON, P., LEIBOWITZ, M.D., COLOMBEL, J.F. & AUWERX, J. (2001). Attenuation of colon inflammation through activators of the retinoid X receptor (RXR)/peroxisome proliferator-activated receptor gamma (PPARgamma) heterodimer. A basis for new therapeutic strategies. J. Exp. Med., 193, 827-838.
11. DIAMOND, J.R., PESEK, I., RUGGIERI, S. & KARNOVSKY, M.J. (1989). Essential fatty acid deficiency during acute puromycin nephrosis ameliorates late renal injury. Am. J. Physiol., 257, F798-F807.
12. EDDY, A.A., CRARY, G.S. & MICHAEL, A.F. (1986). Identification of lymphohemopoietic cells in the kidneys of normal rats. Am. J. Pathol., 124, 335-342.
13. EDDY, A.A., MCCULLOCH, L., LIU, E. & ADAMS, J. (1991). A relationship between proteinuria and acute tubulointerstitial disease in rats with experimental nephrotic syndrome. Am. J. Pathol., 138, 1111-1123.
14. EDDY, A.A. & MICHAEL, A.F. (1988). Acute tubulointerstitial nephritis associated with aminonucleoside nephrosis. Kidney Int., 33, 14-23.
15. FERNANDEZ, L., ROMERO, M., SOTO, H. & MOSQUERA, J. (2001). Increased apoptosis in acute puromycin aminonucleoside nephrosis. Exp. Nephrol., 9, 99-108.
16. FRIES, J.W., SANDSTROM, D.J., MEYER, T.W. & RENNKE, H.G. (1989). Glomerular hypertrophy and epithelial cell injury modulate progressive glomerulosclerosis in the rat. Lab. Invest., 60, 205-218.
17. GIGUERE, V. (1994). Retinoic acid receptors and cellular retinoid binding proteins: complex interplay in retinoid signaling. Endocrine. Rev., 15, 61-79.
18. HARRIS, K.P., LEFKOWITH, J.B., KLAHR, S. & SCHREINER, G.F. (1990). Essential fatty acid deficiency ameliorates acute renal dysfunction in the rat after the administration of the aminonucleoside of puromycin. J. Clin. Invest., 86, 1115-1123.
19. HARRISON, D.J. (1988). Cell death in the diseased glomerulus. Histopathology, 12, 679-683.
20. INOKUCHI, S., SHIRATO, I., KOBAYASHI, N., KOIDE, H., TOMINO, Y. & SAKAI, T. (1996). Re-evaluation of foot process effacement in acute puromycin aminonucleoside nephrosis. Kidney Int., 50, 1278-1287.
21. IWATA, M., MUKAI, M., NAKAI, Y. & ISEKI, R. (1992). Retinoic acids inhibit activation-induced apoptosis in T cell hybridomas and thymocytes. J. Immunol., 149, 3302-3308.
22. KETLEY, N.J., ALLEN, P.D., KELSEY, S.M. & NEWLAND, A.C. (1997). Modulation of idarubicin-induced apoptosis in human acute myeloid leukemia blasts by all-trans retinoic acid, 1,25(OH)2 vitamin D3, and granulocyte-macrophage colony-stimulating factor. Blood, 90, 4578-4587.
23. KIKUCHI, H., KAWACHI, H., ITO, Y, MATSUI, K., NOSAKA, H., SAITO, A., ORIKASA, M., ARAKAWA, M. & SHIMIZU, F. (2000). Severe proteinuria, sustained for 6 months, induces tubular epithelial cell injury and cell infiltration in rats but not progressive interstitial fibrosis. Nephrol Dial Transplant, 15, 799-810.
24. KITAMURA, M. & FINE, L.G. (1999). The concept of glomerular self-defense. Kidney Int., 55, 1639-1671.
25. KRIZ, W., ELGER, M., NAGATA, M., KRETZLER, M., UIKER, S., KOEPPEN-HAGEMAN, I., TENSCHERT, S. & LEMLEY, K.V. (1994). The role of podocytes in the development of glomerular sclerosis. Kidney Int. Suppl., 45, S64-S72.
26. KRIZ, W., GRETZ, N. & LEMLEY, K.V. (1998). Progression of glomerular diseases: is the podocyte the culprit? Kidney Int., 54, 687-697.
27. LAN, H.Y., PATERSON, D.J. & ATKINS, R.C. (1991). Initiation and evolution of interstitial leukocytic infiltration in experimental glomerulonephritis. Kidney Int., 40, 425-433.
28. LARSEN, F.G., NIELSEN-KUDSK, F., JAKOBSEN, P., WEISMANN, K. & KRAGBALLE, K. (1992). Pharmacokinetics and therapeutic efficacy of retinoids in skin diseases. Clin. Pharmacokinet., 23, 42-61.
29. LEHRKE, I., SHCAIER, M., SCHADE, K., MORATH, C., WALDHERR, R., RITZ, E. & WAGNER, J (2002). Retinoid receptor-specific agonists alleviate experimental glomerulonephritis. Am. J. Physiol., 282, F741-F751.
30. LIU, Z.H., STRIKER, G.E., STETLER-STEVENSON, M., FUKUSHIMA, P., PATEL, A. & STRIKER, L.J. (1996). TNF-alpha and IL-1 alpha induce mannose receptors and apoptosis in glomerular mesangial but not endothelial cells. Am. J. Physiol., 270, C1595-C1601.
31. LOTAN, R. (1996). Retinoids in cancer chemoprevention. FASEB J., 10, 1031-1039.
32. LUCIO-CAZAÑA, F.J., NAKAYAMA, K., XU, Q., KONTA, T., MORENO-MANZANO, V., FURUSU, A. & KITAMURA, M. (2001). Suppression of constitutive but not Il-1 beta-inducible expression of monocyte chemoattractant protein-1 in mesangial cells by retinoic acids: intervention in the activator protein-1 pathway. J. Am. Soc. Nephrol., 12, 688-694.
33. MAGIL, A.B., PICHLER, R.H. & JOHNSON, R.J. (1997). Osteopontin in chronic puromycin aminonucleoside nephrosis. J. Am. Soc. Nephrol., 8, 1383-1390.
34. MAMPASO, F.M. & WILSON, C.B. (1983). Characterization of inflammatory cells in autoimmune tubulointerstitial nephritis in rats. Kidney Int., 23, 448-457.
35. MARTIN, A., ESCUDERO, E. & MAMPASO, F. (1997). Role of leucocyte adhesion molecules in aminonucleoside of puromycin (PAN)-associated interstitial nephritis. Clin. Exp. Immunol., 108, 78-87.
36. MESSINA, A., DAVIES, D.J., DILLANE, P.C. & RYAN, G.B. (1987). Glomerular epithelial abnormalities associated with the onset of proteinuria in aminonucleoside nephrosis. Am. J. Pathol., 126, 220-229.
37. MORENO-MANZANO, V., ISHIKAWA, Y., LUCIO-CAZANA, J. & KITAMURA, M. (1999a). Suppression of apoptosis by all-trans-retinoic acid. Dual intervention in the c-Jun N-terminal kinase-AP-1 pathway. J. Biol. Chem., 274, 20251-20258.
38. MORENO-MANZANO, V., RODRÍGUEZ-PUYOL, M., RODRÍGUEZ-PUYOL, D. & LUCIO-CAZAÑA, F.J. (1999b). Tretinoin prevents age-related renal changes and stimulates antioxidant defenses in cultured renal mesangial cells. J. Pharmacol. Exp. Ther., 289, 123-132.
39. MORENO-MANZANO, V., SEPÚLVEDA-MUÑOZ, J.C., JIMENEZ, J.R., RODRÍGUEZ-PUYOL, M., RODRÍGUEZ-PUYOL, D., KITAMURA, M. & LUCIO-CAZAÑA, F.J. (2000). Human renal mesangial cells are a target for the anti-inflammatory action of 9-cis retinoic acid. Br. J. Pharmacol., 131, 1673-1683.
40. MUNDEL, P., REISER, J., ZUNIGA MEJIA BORJA, A., PAVENSTADT, H., DAVIDSON, G.R., KRIZ, W. & ZELLER, R. (1997). Rearrangements of the cytoskeleton and cell contacts induce process formation during differentiation of conditionally immortalized mouse podocyte cell lines. Exp. Cell. Res., 236, 248-258.
41. NEILSON, E.G. (1989). Pathogenesis and therapy of interstitial nephritis. Kidney Int., 35, 1257-1270.
42. OKAZAWA, H., SHIMIZU, J., KAMEI, M., IMAFUKU, I., HAMADA, H. & KANAZAWA, I. (1996). Bcl-2 inhibits retinoic acid-induced apoptosis during the neural differentiation of embryonal stem cells. J. Cell Biol., 132, 955-968.
43. OU, Z.L. & NATORI, Y. (1999). Gene expression of CC chemokines in experimental acute tubulointerstitial nephritis. J. Lab. Clin. Med., 133, 41-47.
44. REISER, J., PIXLEY, F.J., HUG, A., KRIZ, W., SMOYER, W.E., STANLEY, E.R. & MUNDEL, P. (2000). Regulation of mouse podocyte process dynamics by protein tyrosine phosphatases. Kidney Int., 57, 2035-2042.
45. ROLLINS, B.J., MORRISON, E.D. & STILES, C.D. (1988). Cloning and expression of JE, a gene inducible by platelet-derived growth factor and whose product has cytokine-like properties. Proc. Natl. Acad. Sci. USA, 85, 3738-3742.
46. ROVIN, B.H. & PHAN, L.T. (1998). Chemotactic factors and renal inflammation. Am. J. Kidney Dis., 31, 1065-1084.
47. RYAN, G.B. & KARNOVSKY, M.J. (1975). An ultrastructural study of the mechanisms of proteinuria in aminonucleoside nephrosis. Kidney Int., 8, 219-232.
48. SANDAU, K., PFEILSCHIFTER, J. & BRUNE, B. (1997). The balance between nitric oxide and superoxide determines apoptotic and necrotic death of rat mesangial cells. J. Immunol., 158, 4938-4946.
49. SCHRANTZ, N., BLANCHARD, D.A., AUFFREDOU, M.T., SHARMA, S., LECA, G. & VAZQUEZ, A. (1999). Role of caspases and possible involvement of retinoblastoma protein during TGFβ-mediated apoptosis of human B lymphocytes. Oncogene, 18, 3511-3519.
50. SHARMA, K. & ZIYADEH, F. (1994). Renal hypertrophy is associated with upregulation of TGF-β1 gene expression in diabetic BB rat and NOD mouse. Am. J. Physiol., 267, F1094-F1101.
51. SHIH, P.T., ELICES, M.J., FANG, Z.T., UGAROVA, T.P., STRAHL, D., TERRITO, M.C., FRANK, J.S., KOVACH, N.L., CABANAS, C., BERLINER, J.A. & VORA, D.K. (1999). Minimally modified low-density lipoprotein induces monocyte adhesion to endothelial connecting segment-1 by activating beta1 integrin. J. Clin. Invest., 103, 613-625.
52. SHIMIZU, A., MASUDA, Y., KITAMURA, H., ISHIZAKI, M., SUGISAKI, Y. & YAMANAKA, N. (1996). Apoptosis in progressive crescentic glomerulonephritis. Lab. Invest., 74, 941-951.
53. SUGIYAMA, H., KASHIHARA, N., MAKINO, H., YAMASAKI, Y. & OTA, A. (1996a). Apoptosis in glomerular sclerosis. Kidney Int., 49, 103-111.
54. SUGIYAMA, H., KASHIHARA, N., MAKINO, H., YAMASAKI, Y. & OTA, Z. (1996b). Reactive oxygen species induce apoptosis in cultured human mesangial cells. J. Am. Soc. Nephrol., 7, 2357-2363.
55. SUN, S.Y., WAN, H., YUE, P., HONG, W.K. & LOTAN, R. (2000). Evidence that retinoic acid receptor beta induction by retinoids is important for tumor cell growth inhibition. J. Biol. Chem., 275, 17149-17153.
56. TAKEMURA, T., MURAKAMI, K., MIYAZATO, H., YAGI, K. & YOSHIOKA, K. (1995). Expression of Fas antigen and Bcl-2 in human glomerulonephritis. Kidney Int., 48, 1886-1892.
57. TANG, W.W., QI, M., WARREN, J.S. & VAN, G.Y. (1997). Chemokine expression in experimental tubulointerstitial nephritis. J. Immunol., 159, 870-876.
58. TEELMANN, K., TSUKAGUCHI, T., KLAUS, M. & ELIASON, J.F. (1993). Comparison of the therapeutic effects of a new arotinoid, Ro 40-8757, and all-trans- and 13-cis-retinoic acids on rat breast cancer. Cancer Res., 53, 2319-2325.
59. THACHER, S.M., VASUDEVAN, J. & CHANDRARATNA, R.A. (2000). Therapeutic applications for ligands of retinoid receptors. Curr. Pharm. Des., 6, 25-58.
60. WAGNER, J., DECHOW, C., MORATH, C., LEHRKE, I., AMANN, K., WALDHERR, R., FLOEGE, J. & RIIZ, E. (2000). Retinoic acid reduces glomerular injury in a rat model of glomerular damage. J. Am. Soc. Nephrol., 11, 1479-1487.
61. WANG, S.Y., LAROSA, G.J. & GUDAS, L.J. (1985). Molecular cloning of gene sequences transcriptionally regulated by retinoic acid and dibutyryl cyclic AMP in cultured mouse teratocarcinoma cells. Dev. Biol., 107, 75-86.
62. WU, J.C., FAN, G.M., KITAZAWA, K. & SUGISAKI, T. (1996). The relationship of adhesion molecules and leukocyte infiltration in chronic tubulointerstitial nephritis induced by puromycin amino-nucleoside in Wistar rats. Clin. Immunol Immunopathol., 79, 229-235.
63. WU, S., DONIGAN, A., PLATSOUCAS, C.D., JUNG, W., SOPRANO, D.R. & SOPRANO, K.J. (1997). All-trans-retinoic acid blocks cell cycle progression of human ovarian adenocarcinoma cells at late G1. Exp. Cell Res., 232, 277-286.
64. YANG, T., MICHELE, D., PARK, J., SMART, A.M., LIN, Z., BROSIUS, F.C., SCHNERMANN, J.B. & BRIGGS, J.P. (1999). Expression of peroxisomal proliferator-activated receptors and retinoid X receptors in the kidney. Am. J. Physiol., 277, F966-F973.
65. YANG, Y., VACCHIO, M.S. & ASHWELL, J.D. (1993). 9-cis-retinoic acid inhibits activation-driven T-cell apoptosis: implications for retinoid X receptor involvement in thymocyte development. Proc. Natl. Acad. Sci. U.S.A., 90, 6170-6174.
66. YOKOO, T. & KITAMURA, M. (1997). IL-1beta depresses expression of the 70-kilodalton heat shock protein and sensitizes glomerular cells to oxidant-initiated apoptosis. J. Immunol., 159, 2886-2892.
67. ZAULI, G., VISANI, G., VITALE, M., GIBELLINI, D., BERTOLASO, L. & CAPITANI, S. (1995). All-trans retinoic acid shows multiple effects on the survival, proliferation and differentiation of human fetal CD34+ haemopoietic progenitor cells. Br. J. Haematol., 90, 274-282.