Effect of probiotics on diarrhea in children with severe acute malnutrition: A randomized controlled study in Uganda

Journal of Pediatric Gastroenterology and Nutrition

Volumn 64, Issue 3, 2017, Pages 396-403

  Grenov, Benedikte ^a   Namusoke, Hanifa ^b   Lanyero, Betty ^b   Nabukeera Barungi, Nicolette ^b   Ritz, Christian ^a   Mølgaard, Christian ^a   Friis, Henrik ^a   Michaelsen, Kim F ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b MULAGO NATIONAL REFERRAL HOSPITAL   (Uganda)

Author keywords

Diarrhea; Low Income Country; Probiotic; Severe Acute Malnutrition; Young Children

Indexed keywords

AMPICILLIN; CEFTRIAXONE; CHLORAMPHENICOL; CIPROFLOXACIN; CLOXACILLIN; GENTAMICIN; MALTODEXTRIN; PLACEBO; PROBIOTIC AGENT;

ANTIBIOTIC THERAPY; ARTICLE; BIFIDOBACTERIUM ANIMALIS; CHILD; CLINICAL ASSESSMENT; CONTROLLED STUDY; COUGHING; DIARRHEA; DISEASE SEVERITY; DOUBLE BLIND PROCEDURE; FEMALE; FEVER; FOLLOW UP; HOSPITAL PATIENT; HOSPITALIZATION; HUMAN; INCIDENCE; INFANT; LACTOBACILLUS RHAMNOSUS; MAJOR CLINICAL STUDY; MALE; MALNUTRITION; MORBIDITY; MORTALITY; OUTCOME ASSESSMENT; OUTPATIENT; PNEUMONIA; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; UGANDA; VOMITING; WEIGHT GAIN; AMBULATORY CARE; COMPLICATION; INTENTION TO TREAT ANALYSIS; PRESCHOOL CHILD; STATISTICAL MODEL; TREATMENT OUTCOME;

AMBULATORY CARE; BIFIDOBACTERIUM ANIMALIS; CHILD, PRESCHOOL; DIARRHEA; DOUBLE-BLIND METHOD; FEMALE; FOLLOW-UP STUDIES; HOSPITALIZATION; HUMANS; INFANT; INTENTION TO TREAT ANALYSIS; LACTOBACILLUS RHAMNOSUS; MALE; MODELS, STATISTICAL; PROBIOTICS; SEVERE ACUTE MALNUTRITION; TREATMENT OUTCOME; UGANDA;

EID: 85009403502     PISSN: 02772116     EISSN: 15364801     Source Type: Journal    
DOI: 10.1097/MPG.0000000000001515     Document Type: Article

References (39)

1. Black RE, Victora CG, Walker SP, et al. Maternal and child undernutrition and overweight in low-income and middle-income countries. Lancet 2013;382:427-51.
2. World Health Organization, World Food Programme, United Nations System Standing Committee on Nutrition, The United Nations Childrens fund. Community-based management of severe acute malnutrition. A Joint Statement by the World Health Organization, the World Food Programme, the United Nations System Standing Committee on Nutrition and the United Nations Childrens Fund, 2007. Report No.: ISBN: 978-92-806-4147-9. http://www.who.int/nutrition/topics/Statement-community-based-man-sev-Acute-mal-eng.pdf. Accessed August 10, 2016.
3. Brewster DR. Inpatient management of severe malnutrition: Time for a change in protocol and practice. Ann Trop Paediatr 2011;31:97-107.
4. Irena AH, Mwambazi M, Mulenga V. Diarrhea is a major killer of children with severe acute malnutrition admitted to inpatient set-up in Lusaka, Zambia. Nutr J 2011;10:110.
5. Talbert A, Thuo N, Karisa J, et al. Diarrhoea complicating severe acute malnutrition in Kenyan children: A prospective descriptive study of risk factors and outcome. PloS One 2012;7:e38321.
6. Allen SJ, Martinez EG, Gregorio GV, et al. Probiotics for treating acute infectious diarrhoea. Cochrane Database Syst Rev (11)2010CD003048.
7. Szajewska H, Guarino A, Hojsak I, et al., European Society for Pediatric Gastroenterology, Hepatology, and Nutrition. Use of probiotics for management of acute gastroenteritis: A position paper by the ESPGHAN Working Group for Probiotics and Prebiotics. J Pediatr Gastroenterol Nutr 2014;58:531-9.
8. Goldenberg JZ, Lytvyn L, Steurich J, et al. Probiotics for the prevention of pediatric antibiotic-Associated diarrhea. Cochrane Database Syst Rev (12)2015CD004827.
9. Szajewska H, Canani RB, Guarino A, et al. Probiotics for the prevention of antibiotic-Associated diarrhea in children. J Pediatr Gastroenterol Nutr 2016;62:495-506.
10. Bernaola Aponte G, Bada Mancilla CA, Carreazo NY, et al. Probiotics for treating persistent diarrhea in children. Cochrane Database Syst Rev (8)2013CD007401.
11. Chisti MJ, Tebruegge M, La Vincente S, et al. Pneumonia in severely malnourished children in developing countries-mortality risk, aetiology and validity of WHO clinical signs: A systematic review. Trop Med Int Health 2009;14:1173-89.
12. Hao Q, Dong BR, Wu T. Probiotics for preventing acute upper respiratory tract infections. Cochrane Database Syst Rev (2)2015CD006895.
13. Onubi OJ, Poobalan AS, Dineen B, et al. Effects of probiotics on child growth: A systematic review. J Health Popul Nutr 2015;34:8.
14. Kerac M, Bunn J, Seal A, et al. Probiotics and prebiotics for severe acute malnutrition (PRONUT study): A double-blind efficacy randomised controlled trial in Malawi. Lancet 2009;374:136-44.
15. Hojsak I, Abdović S, Szajewska H, et al. Lactobacillus GG in the prevention of nosocomial gastrointestinal and respiratory tract infections. Pediatrics 2010;125:e1171.
16. Hojsak I, Snovak N, Abdović S, et al. Lactobacillus GG in the prevention of gastrointestinal and respiratory tract infections in children who attend day care centers: A randomized, double-blind, placebo-controlled trial. Clin Nutr 2010;29:312-6.
17. Taipale T, Pienihäkkinen K, Isolauri E, et al. Bifidobacterium animalis subsp. lactis BB-12 in reducing the risk of infections in infancy. Br J Nutr 2011;105:409-16.
18. Weizman Z, Asli G, Alsheikh A. Effect of a probiotic infant formula on infections in child care centers: comparison of two probiotic agents. Pediatrics 2005;115:5-9.
19. Basu S, Paul DK, Ganguly S, et al. Efficacy of high-dose Lactobacillus rhamnosus GG in controlling acute watery diarrhea in Indian children: A randomized controlled trial. J Clin Gastroenterol 2009;43:208-13.
20. Basu S, Chatterjee M, Ganguly S, et al. Effect of Lactobacillus rhamnosus GG in persistent J Clin Gastroenterol 2007;41:756-60.
21. Oberhelman RA, Gilman RH, Sheen P, et al. A placebo-controlled trial of Lactobacillus GG to prevent diarrhea in undernourished Peruvian children. J Pediatr 1999;134:15-20.
22. World Health Organization. WHO. Guideline: Updates on the management of severe acute malnutrition in infants and children. Geneva: World Health Organization; 2013. Report No.: ISBN 978 92 4 150632 8. http://www.who.int/nutrition/publications/guidelines/updates-management-SAM-infantandchildren/en/. Accessed August 10, 2016.
23. Ministry of Health, Uganda. Integrated Management of Acute Malnutrition Guidelines; 2010. www.unicef.org/uganda/IMAM-Guidelines-final-version.pdf. Accessed August 10, 2016.
24. Grenov B, Namusoke H, Nabukeera-Barungi N, et al. Validation of a simple stool diary used by caregivers to document diarrhea among young children in a low-income country. J Pediatr Gastroenterol Nutr 2016 [Epub ahead of print].
25. World Health Organization. Diarrhoea definition. http://who.int/topics/diarrhoea/en/. Accessed August 10, 2016
26. Lewis K, PATH. Vesikari Clinical Severity Scoring System Manual; 2011 May. http://www.path.org/publications/detail.php?i=2228. Accessed August 10, 2016.
27. R Core Team. R: A language and environment for statistical computing. R Foundation for Statistical Computing, Vienna, Austria: R Core Team; 2013. http://www.R-project.org/. Accessed August 10, 2016.
28. Little RJ, Yosef M, Cain KC, et al. A hot-deck multiple imputation procedure for gaps in longitudinal data on recurrent events. Stat Med 2008;27:103-20.
29. Szajewska H, Kołodziej M. Systematic review with meta-Analysis: Lactobacillus rhamnosus GG in the prevention of antibiotic-Associated diarrhoea in children and adults. Aliment Pharmacol Ther 2015;42:1149-57.
30. SzajewskaH, SkórkaA, RuszczyńskiM, et al. Meta-Analysis: Lactobacillus GG for treating acute gastroenteritis in children-updated analysis of randomised controlled trials. Aliment Pharmacol Ther 2013;38:467-76.
31. Vanderhoof JA, Whitney DB, Antonson DL, et al. Lactobacillus GG in the prevention of antibiotic-Associated diarrhea in children. J Pediatr 1999;135:564-8.
32. Hilton E, Kolakowski P, Singer C, et al. Efficacy of Lactobacillus GG as a diarrheal preventive in travelers. J Travel Med 1997;4:41-3.
33. Saavedra JM, Bauman NA, Oung I, et al. Feeding of Bifidobacterium bifidum and Streptococcus thermophilus to infants in hospital for prevention of diarrhoea and shedding of rotavirus. Lancet 1994;344:1046-9.
34. Chouraqui J-P, Van Egroo L-D, Fichot M-C. Acidified milk formula supplemented with Bifidobacterium lactis: impact on infant diarrhea in residential care settings. J Pediatr Gastroenterol Nutr 2004;38: 288-92.
35. Hojsak I, Tokić Pivac V, Močić Pavić A, et al. Bifidobacterium animalis subsp. lactis fails to prevent common infections in hospitalized children: A randomized, double-blind, placebo-controlled study. Am J Clin Nutr 2015;101:680-4.
36. Hojsak I, Močić Pavić A, Kos T, et al. Bifidobacterium animalis subsp. lactis in prevention of common infections in healthy children attending day care centers: randomized, double blind, placebo-controlled study. Clin Nutr Edinb Scotl 2016;35:587-91.
37. Crane RJ, Jones KD, Berkley JA. Environmental enteric dysfunction: An overview. Food Nutr Bull 2015;36(suppl 1):76S-87S.
38. Braegger C, Chmielewska A, Decsi T, et al. Supplementation of infant formula with probiotics and/or prebiotics: A systematic review and comment by the ESPGHAN committee on nutrition. J Pediatr Gastroenterol Nutr 2011;52:238-50.
39. Urben LM, Wiedmar J, Boettcher E, et al. Bugs or drugs: Are probiotics safe for use in the critically ill? Curr Gastroenterol Rep 2014;16:388.