Wearable Microsensor Array for Multiplexed Heavy Metal Monitoring of Body Fluids

ACS Sensors

Volumn 1, Issue 7, 2016, Pages 866-874

  Gao, Wei ^a,b,c   Nyein, Hnin Y Y ^a,b,c   Shahpar, Ziba ^a,b   Fahad, Hossain M ^a,b   Chen, Kevin ^a,b,c   Emaminejad, Sam ^a,b,c   Gao, Yuji ^a,b,c   Tai, Li Chia ^a,b,c   Ota, Hiroki ^a,b,c   Wu, Eric ^a,b   Bullock, James ^a,b,c   Zeng, Yuping ^a   Lien, Der Hsien ^a,b,c   Javey, Ali ^a,b,c  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c LAWRENCE BERKELEY NATIONAL LABORATORY   (United States)

Author keywords

flexible electronics; heavy metals monitoring; multiplexed sensing; sweat; temperature compensation; wearable biosensors

Indexed keywords

BODY FLUIDS; CHEMICAL DETECTION; DRUG PRODUCTS; FLEXIBLE ELECTRONICS; HEAVY METALS; INDUCTIVELY COUPLED PLASMA MASS SPECTROMETRY; METAL ANALYSIS; MICROELECTRODES; VOLTAMMETRY; WEARABLE SENSORS;

CLINICAL INVESTIGATION; HEAVY METAL MONITORING; INDUCTIVELY COUPLED PLASMA MASS SPECTROMETRIES (ICPMS); MICROSENSOR ARRAYS; MULTIPLEXED SENSING; SQUARE WAVE ANODIC STRIPPING VOLTAMMETRY; SWEAT; TEMPERATURE COMPENSATION;

MICROSENSORS;

EID: 85009258072     PISSN: None     EISSN: 23793694     Source Type: Journal    
DOI: 10.1021/acssensors.6b00287     Document Type: Article

References (43)

1. Kim, D. H.; Lu, N. S.; Ma, R.; Kim, Y. S.; Kim, R. H.; Wang, S. D.; Wu, J.; Won, S. M.; Tao, H.; Islam, A.; Yu, K. J.; Kim, T. I.; Chowdhury, R.; Ying, M.; Xu, L. Z.; Li, M.; Chung, H. J.; Keum, H.; McCormick, M.; Liu, P.; Zhang, Y. W.; Omenetto, F. G.; Huang, Y. G.; Coleman, T.; Rogers, J. A. Epidermal Electronics Science 2011, 333, 838-843 10.1126/science.1206157
2. Bandodkar, A. J.; Wang, J. Non-invasive Wearable Electrochemical Sensors: A Review Trends Biotechnol. 2014, 32, 363-371 10.1016/j.tibtech.2014.04.005
3. Schwartz, G.; Tee, B. C. K.; Mei, J.; Appleton, A. L.; Kim, D. H.; Wang, H.; Bao, Z. Flexible Polymer Transistors with High Pressure Sensitivity for Application in Electronic Skin and Health Monitoring Nat. Commun. 2013, 4, 1859 10.1038/ncomms2832
4. Kaltenbrunner, M.; Sekitani, T.; Reeder, J.; Yokota, T.; Kuribara, K.; Tokuhara, T.; Drack, M.; Schwodiauer, R.; Graz, I.; Bauer Gogonea, S.; Bauer, S.; Someya, T. An Ultra-Lightweight Design for Imperceptible Plastic Electronics Nature 2013, 499, 458-463 10.1038/nature12314
5. Takei, K.; Takahashi, T.; Ho, J. C.; Ko, H.; Gillies, A. G.; Leu, P. W.; Fearing, R. S.; Javey, A. Nanowire Active-Matrix Circuitry for Low-Voltage Macroscale Artificial Skin Nat. Mater. 2010, 9, 821-826 10.1038/nmat2835
6. Hammock, M. L.; Chortos, A.; Tee, B. C. K.; Tok, J. B. H.; Bao, Z. The Evolution of Electronic Skin (e-skin): A Brief History, Design Considerations, and Recent Progress Adv. Mater. 2013, 25, 5997-6037 10.1002/adma.201302240
7. Wang, C.; Hwang, D.; Yu, Z.; Takei, K.; Park, J.; Chen, T.; Ma, B.; Javey, A. User-Interactive Electronic Skin for Instantaneous Pressure Visualization Nat. Mater. 2013, 12, 899-904 10.1038/nmat3711
8. Xu, S.; Zhang, Y.; Jia, L.; Mathewson, K. E.; Jang, K.; Kim, J.; Fu, H.; Huang, X.; Chava, P.; Wang, R.; Bhole, S.; Wang, L.; Na, Y. J.; Guan, Y.; Flavin, M.; Han, Z.; Huang, Y.; Rogers, J. A. Soft Microfluidic Assemblies of Sensors, Circuits, and Radios for the Skin Science 2014, 344, 70-74 10.1126/science.1250169
9. Takei, K.; Honda, W.; Harada, S.; Arie, T.; Akita, S. Flexible and Wearable Human-Interactive Health-Monitoring Devices Adv. Healthcare Mater. 2015, 4, 487-500 10.1002/adhm.201400546
10. Fan, F. R.; Lin, L.; Zhu, G.; Wu, W. Z.; Zhang, R.; Wang, Z. L. Transparent Triboelectric Nanogenerators and Self-Powered Pressure Sensors Based on Micropatterned Plastic Films Nano Lett. 2012, 12, 3109-3114 10.1021/nl300988z
11. Chen, K.; Gao, W.; Emaminejad, S.; Kiriya, D.; Ota, H.; Nyein, H. Y. Y.; Takei, K.; Javey, A. Printed Carbon Nanotube Electronics and Sensor Systems Adv. Mater. 2016, 10.1002/adma.201504958
12. Ota, H.; Emaminejad, S.; Gao, Y.; Zhao, A.; Wu, E.; Challa, S.; Chen, K.; Fahad, H. M.; Jha, A. K.; Kiriya, D.; Gao, W.; Shiraki, H.; Morioka, K.; Ferguson, A. R.; Healy, K. E.; Davis, R. W.; Javey, A. Application of 3D Printing for Smart Objects with Embedded Electronic Sensors and Systems Adv. Mater. Technol. 2016, 1, 1600013 10.1002/admt.201600013
13. Schazmann, B.; Morris, D.; Slater, C.; Beirne, S.; Fay, C.; Reuveny, R.; Moyna, N.; Diamond, D. A Wearable Electrochemical Sensor for the Real-Time Measurement of Sweat Sodium Concentration Anal. Methods 2010, 2, 342-348 10.1039/b9ay00184k
14. Jia, W.; Bandodkar, A. J.; Valdés-Ramírez, G.; Windmiller, J. R.; Yang, Z.; Ramírez, J.; Chan, G.; Wang, J. Electrochemical Tattoo Biosensors for Real-Time Noninvasive Lactate Monitoring in Human Perspiration Anal. Chem. 2013, 85, 6553-6560 10.1021/ac401573r
15. Bandodkar, A. J.; Molinnus, D.; Mirza, O.; Guinovart, T.; Windmiller, J. R.; Valdes-Ramirez, G.; Andrade, F. J.; Schoning, M. J.; Wang, J. Epidermal Tattoo Potentiometric Sodium Sensors with Wireless Signal Transduction for Continuous Non-Invasive Sweat Monitoring Biosens. Bioelectron. 2014, 54, 603-609 10.1016/j.bios.2013.11.039
16. Sonner, Z.; Wilder, E.; Heikenfeld, J.; Kasting, G.; Beyette, F.; Swaile, D.; Sherman, F.; Joyce, J.; Hagen, J.; Kelley-Loughnane, N.; Naik, R. The Microfluidics of the Eccrine Sweat Gland, Including Biomarker Partitioning, Transport, and Biosensing Implications Biomicrofluidics 2015, 9, 031301 10.1063/1.4921039
17. Gonzalo-Ruiz, J.; Mas, R.; de Haro, C.; Cabruja, E.; Camero, R.; Alonso-Lomillo, M. A.; Muñoz, F. J. Integration of Biosensors and Drug Delivery Technologies for Early Detection and Chronic Management of Illness Biosens. Bioelectron. 2009, 24, 1788-1791 10.1016/j.bios.2008.07.051
18. Huang, X.; Liu, Y. H.; Chen, K. L.; Shin, W. J.; Lu, C. J.; Kong, G. W.; Patnaik, D.; Lee, S. H.; Cortes, J. F.; Rogers, J. A. Stretchable, Wireless Sensors and Functional Substrates for Epidermal Characterization of Sweat Small 2014, 10, 3083-3090 10.1002/smll.201400483
19. Kim, J.; Imani, S.; de Araujo, W. R.; Warchall, J.; Valdés-Ramírez, G.; Paixão, T. R. L. C.; Mercier, P.; Wang, J. Wearable Salivary Uric Acid Mouthguard Biosensor with Integrated Wireless Electronics Biosens. Bioelectron. 2015, 74, 1061-1068 10.1016/j.bios.2015.07.039
20. Yao, H.; Shum, A. J.; Cowan, M.; Lahdesmaki, I.; Parviz, B. A. A Contact Lens with Embedded Sensor for Monitoring Tear Glucose Level Biosens. Bioelectron. 2011, 26, 3290-3296 10.1016/j.bios.2010.12.042
21. Chu, M. X.; Kudo, H.; Shirai, T.; Miyajima, K.; Saito, H.; Morimoto, N.; Yano, K.; Iwasaki, Y.; Akiyoshi, K.; Mitsubayashi, K. A Soft and Flexible Biosensor Using a Phospholipid Polymer for Continuous Glucose Monitoring Biomed. Microdevices 2009, 11, 837-842 10.1007/s10544-009-9300-1
22. Bandodkar, A. J.; Jia, W.; Yardlmcl, C.; Wang, X.; Ramirez, J.; Wang, J. Tattoo-Based Noninvasive Glucose Monitoring: A Proof-of-Concept Study Anal. Chem. 2015, 87, 394-398 10.1021/ac504300n
23. Gao, W.; Emaminejad, S.; Nyein, H. Y. Y.; Challa, S.; Chen, K.; Peck, A.; Fahad, H. M.; Ota, H.; Shiraki, H.; Kiriya, D.; Lien, D.-H.; Brooks, G. A.; Davis, R. W.; Javey, A. Fully Integrated Wearable Sensor Arrays for Multiplexed In Situ Perspiration Analysis Nature 2016, 529, 509-514 10.1038/nature16521
24. Lee, H.; Choi, T. K.; Lee, Y. B.; Cho, H. R.; Ghaffari, R.; Wang, L.; Choi, H. J.; Chung, T. D.; Lu, N.; Hyeon, T.; Choi, S. H.; Kim, D. H. A Graphene-Based Electrochemical Device with Thermoresponsive Microneedles for Diabetes Monitoring and Therapy Nat. Nanotechnol. 2016, 10.1038/nnano.2016.38
25. Cohn, J. R.; Emmett, E. A. The Excretion of Trace Metals in Human Sweat Ann. Clin. Lab Sci. 1978, 8, 270-275
26. Sears, M. E.; Kerr, K. J.; Bray, R. I. Arsenic, Cadmium, Lead, and Mercury in Sweat: A Systematic Review J. Environ. Public Health 2012, 2012, 184745 10.1155/2012/184745
27. Mudgal, V.; Madaan, N.; Mudgal, A.; Singh, R. B.; Mishra, S. Effect of Toxic Metals on Human Health Open Nutraceuticals J. 2010, 3, 94-99
28. Fraga, C. G. Relevance, Essentiality and Toxicity of Trace Elements in Human Health Mol. Aspects Med. 2005, 26, 235 10.1016/j.mam.2005.07.013
29. Schaefer, M.; Schellenberg, M.; Merle, U.; Weiss, K. H.; Stremmel, W. Wilson Protein Expression, Copper Excretion and Sweat Production in Sweat Glands of Wilson Disease Patients and Controls BMC Gastroenterol. 2008, 8, 29 10.1186/1471-230X-8-29
30. Hohnadel, D. C.; Sunderman, F. W., Jr.; Nechay, M. W.; McNeely, M. D. Atomic Absorption Spectrometry of Nickel, Copper, Zinc, and Lead in Sweat Collected from Healthy Subjects during Sauna Bathing Clin. Chem. 1973, 19, 1288-1292
31. Munro, S.; Ebdon, L.; McWeeny, D. J. J. Application of Inductively Coupled Plasma Mass Spectrometry (ICP-MS) for Trace Metal Determination in Foods J. Anal. At. Spectrom. 1986, 1, 211-219 10.1039/ja9860100211
32. Wang, J. Stripping Analysis: Principles, Instrumentation, and Applications; VCH Publishers: Deerfield Beach, FL, 1985.
33. Stauber, J. L.; Florence, T. M. The Determination of Trace Metals in Sweat by Anodic Stripping Voltammetry Sci. Total Environ. 1987, 60, 263-271 10.1016/0048-9697(87)90420-7
34. de Souza, A. P. R.; Lima, A. S.; Salles, M. O.; Nascimento, A. N.; Bertotti, M. The Use of a Gold Disc Microelectrode for the Determination of Copper in Human Sweat Talanta 2010, 83, 167-170 10.1016/j.talanta.2010.09.001
35. Crew, A.; Cowell, D. C.; Hart, J. P. Development of an Anodic Stripping Voltammetric Assay, Using a Disposable Mercury-Free Screen-Printed Carbon Electrode, for the Determination of Zinc in Human Sweat Talanta 2008, 75, 1221-1226 10.1016/j.talanta.2008.01.043
36. Hutton, E. A.; Ogorevc, B.; Hočevar, S. B.; Smyth, M. R. Bismuth Film Microelectrode for Direct Voltammetric Measurement of Trace Cobalt and Nickel in Some Simulated and Real Body Fluid Samples Anal. Chim. Acta 2006, 557, 57-63 10.1016/j.aca.2005.10.003
37. Kim, J.; de Araujo, W. R.; Samek, I. A.; Bandodkar, A. J.; Jia, W.; Brunetti, B.; Paixão, T. R.L.C.; Wang, J. Wearable Temporary Tattoo Sensor for Real-Time Trace Metal Monitoring in Human Sweat Electrochem. Commun. 2015, 51, 41-45 10.1016/j.elecom.2014.11.024
38. Wang, J. Stripping Analysis at Bismuth Electrodes: A Review Electroanalysis 2005, 17, 1341-1346 10.1002/elan.200403270
39. Bonfil, Y.; Brand, M.; Kirowa-Eisner, E. Characteristics of Subtractive Anodic Stripping Voltammetry of Pb and Cd at Silver and Gold Electrodes Anal. Chim. Acta 2002, 464, 99-114 10.1016/S0003-2670(02)00489-0
40. Wang, J.; Deo, R. P.; Thongngamdee, S.; Ogorevc, B. Effect of Surface-Active Compounds on the Stripping Voltammetric Response of Bismuth Film Electrodes Electroanalysis 2001, 13, 1153-1156 10.1002/1521-4109(200110)13:14<1153::AID-ELAN1153>3.0.CO;2-I
41. Pei, X.; Kang, W.; Yue, W.; Bange, A.; Heineman, W. R.; Papautsky, I. Disposable Copper-Based Electrochemical Sensor for Anodic Stripping Voltammetry Anal. Chem. 2014, 86, 4893-4900 10.1021/ac500277j
42. Soleymani, L.; Fang, Z.; Lam, B.; Xiaomin Bin, X.; Vasilyeva, E.; Ross, A. J.; Sargent, E. H.; Kelley, S. O. Hierarchical Nanotextured Microelectrodes Overcome the Molecular Transport Barrier to Achieve Rapid, Direct Bacterial Detection ACS Nano 2011, 5, 3360-3366 10.1021/nn200586s
43. Omokhodion, F. O.; Howard, J. M. Lead in Sweat and its Relationship to Salivary and Urinary Levels in Normal Healthy Subjects Sci. Total Environ. 1991, 103, 123-128 10.1016/0048-9697(91)90138-5