Restarting Dabigatran Etexilate 24 h After Reversal With Idarucizumab and Redosing Idarucizumab in Healthy Volunteers

Journal of the American College of Cardiology

Volumn 67, Issue 13, 2016, Pages 1654-1656

  Glund, Stephan ^a   Stangier, Joachim ^a   van Ryn, Joanne ^a   Schmohl, Michael ^a   Moschetti, Viktoria ^a   Haazen, Wouter ^a   De Smet, Marina ^a   Gansser, Dietmar ^a   Norris, Stephen ^a   Lang, Benjamin ^a   Reilly, Paul ^a   Kreuzer, Jörg ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

DABIGATRAN ETEXILATE; DRUG ANTIBODY; IDARUCIZUMAB; PLACEBO; ANTITHROMBIN; DABIGATRAN; MONOCLONAL ANTIBODY;

ADULT; ANTICOAGULATION; BLOOD CLOTTING TIME; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG HYPERSENSITIVITY; DRUG SAFETY; ECARIN CLOTTING TIME; FEMALE; HUMAN; HUMAN EXPERIMENT; LETTER; MALE; NORMAL HUMAN; PARTIAL THROMBOPLASTIN TIME; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; THROMBIN TIME; VOLUNTEER; ADVERSE DRUG REACTION; CROSSOVER PROCEDURE; DOSE RESPONSE; DRUG INTERACTION; DRUG MONITORING; MIDDLE AGED; PROCEDURES; RETREATMENT;

ANTIBODIES, MONOCLONAL, HUMANIZED; ANTITHROMBINS; CROSS-OVER STUDIES; DABIGATRAN; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; DRUG MONITORING; DRUG-RELATED SIDE EFFECTS AND ADVERSE REACTIONS; FEMALE; HEALTHY VOLUNTEERS; HUMANS; MALE; MIDDLE AGED; RETREATMENT;

EID: 85008882753     PISSN: 07351097     EISSN: 15583597     Source Type: Journal    
DOI: 10.1016/j.jacc.2016.01.043     Document Type: Letter

References (3)

1. 1 Schiele, F., van Ryn, J., Canada, K., et al. A specific antidote for dabigatran: functional and structural characterization. Blood 121 (2013), 3554–3562.
2. 2 Glund, S., Stangier, J., Schmohl, M., et al. Safety, tolerability, and efficacy of idarucizumab for the reversal of the anticoagulant effect of dabigatran in healthy male volunteers: a randomised, placebo-controlled, double-blind phase 1 trial. Lancet 386 (2015), 680–690.
3. 3 Pollack, C.V., Reilly, P.A., Eikelboom, J., et al. Idarucizumab for dabigatran reversal. N Engl J Med 373 (2015), 511–520.