Th1–Th2 regulation and allergy: Bifurcation analysis of the non-autonomous system

Modeling and Simulation in Science, Engineering and Technology

Volumn , Issue 9780817645557, 2008, Pages 145-155

  Vogel, Reinhard ^a   Behn, Ulrich ^a  

^a UNIVERSITY OF LEIPZIG   (Germany)

Author keywords

allergy; bifurcation analysis; hyposensitization; nonautonomous dynamical systems; Th1 Th2 regulation; venom immunotherapy

Indexed keywords

EID: 85008633825     PISSN: 21643679     EISSN: 21643725     Source Type: Book Series    
DOI: 10.1007/978-0-8176-4556-4_13     Document Type: Chapter

References (17)

1. Romagnani, S.: Human Th1 and Th2: doubt no more. Immunology Today, 12, 256–257 (1991).
2. Romagnani, S. (ed): Th1 and Th2 cells in health and disease. Chemical Immunology, 63, Karger, Basel (1996).
3. Heppt, W., Reuz, H., Roecken, M. (eds): Allergologie. Springer, Berlin (1998).
4. Blaser, K., Carballido, J., Faith, A., Crameri, R., Akdis, C.: Determinants and mechanisms of human immune responses to bee venom phospholipase A2. Int. Arch. Allergy Immunol., 117, 1–10 (1998).
5. McHugh, S.M., Deighton, J., Stewart, A.G., Lachmann, P.J., Ewan, P.W.: Bee venom immunotherapy induces a shift in cytokine response from a Th2 to a Th1 dominant pattern: comparison of rush and conventional immunotherapy. Clin. Exp. Allergy, 25, 828–838 (1995).
6. Schuerwegh, A.J., Cluck, L.S.D., Bridts, C.H., Stevens, W.J.: Wasp venom immunotherapy induces a shift from IL-4-producing towards interferon-gamma-producing CD4+ and CD8+ T lymphocytes. Clin. Exp. Allergy, 31, 740–746 (2001).
7. Tari, M.G., Mancino, M., Madonna, F., Buzzoni, L., Parmiani, S.: Immunologic evaluation of 24 month course of sublingual immunotherapy. Allergol. Immonopathol. (Madr), 22, 209–216, (1994).
8. Noon, L., Cantab, B.C.: Prophylactic inoculation against hay fever. Lancet 1, 1572–1574 (1911).
9. Behn, U., Dambeck, H., Metzner, G.: Modeling Th1–Th2 regulation, allergy, and hyposensitization. In: Bagnoli, F., Ruffo, S. (eds) Dynamical Modeling in Biotechnologies (Lectures presented at the EU Advanced Workshop, Torino, May 27–June 9, 1996). World Scientific, Singapore, 227–244 (2001).
10. Richter, J., Metzner, G., Behn, U.: Venom immunotherapy: A mathematical model. J. Theor. Med., 4, 119–132 (2002).
11. Richter, J., Behn, U., Metzner, G.: Modelling of Th1–Th2 regulation, allergy and venom immunotherapy. In: Marone, G. (ed) Clinical Immunology and Allergy in Medicine, Proc. 21st EAACI Congress 2002, Naples. JGC Editions, Naples, 257–262 (2003).
12. Ruedl, C., Bachmann, M.F., Kopf, M.: The antigen dose determines T helper subset development by regulation of CD40 ligand. Eur. J. Immunol., 30, 2056–2064 (2000).
13. Goldberg, A., Confino-Cohen, R.: Maintenance venom immunotherapy administered at 3-month intervals is both safe and efficacious. J. Allergy Clin. Immunol., 107, 902–906 (2001).
14. Langa, J.A., Robinson, J.C., Suárez, A.: Stability, instability, and bifurcation phenomena in non-autonomous differential equations. Nonlinearity, 15, 887–903 (2002).
15. Akdis, M., Blaser, K., Akdis, C.A.: TReg cells and allergy: a question of balance and antigen specifity. Nature Rev. Immunol., 3 Viewpoint (online only), doi: 10.1038/nri1047 (2003).
16. Ngoc, L.P., Gold, D.R., Tzianabos, A.O., Weiss, S.T., Celedón, J.C.: Cytokines, allergy, and asthma. Curr. Opin. Allergy Clin. Immunol., 5, 161–166 (2005).
17. Hantusch, B., et al.: Internal images: Human anti-idiotypic Fab antibodies mimic the IgE epitopes of grass pollen allergen Phl p 5a. Mol. Immunol., 43, 2180–2187 (2006).