메뉴 건너뛰기




Volumn 41, Issue 3, 2017, Pages 284-295

Efficacy and safety of glucagon-like peptide-1 receptor agonists in non-alcoholic fatty liver disease: A systematic review and meta-analysis

Author keywords

[No Author keywords available]

Indexed keywords

AMINOTRANSFERASE; EXENDIN 4; GLUCAGON LIKE PEPTIDE 1 RECEPTOR AGONIST; LIRAGLUTIDE; PLACEBO; ANTILIPEMIC AGENT; GLUCAGON LIKE PEPTIDE 1 RECEPTOR;

EID: 85008517602     PISSN: 22107401     EISSN: 2210741X     Source Type: Journal    
DOI: 10.1016/j.clinre.2016.11.009     Document Type: Article
Times cited : (63)

References (67)
  • 1
    • 84861591910 scopus 로고    scopus 로고
    • The diagnosis and management of non-alcoholic fatty liver disease: practice guideline by the American Gastroenterological Association, American Association for the Study of Liver Diseases, and American College of Gastroenterology
    • Chalasani, N., Younossi, Z., Lavine, J.E., Diehl, A.M., Brunt, E.M., Cusi, K., et al. The diagnosis and management of non-alcoholic fatty liver disease: practice guideline by the American Gastroenterological Association, American Association for the Study of Liver Diseases, and American College of Gastroenterology. Gastroenterology 142 (2012), 1592–1609.
    • (2012) Gastroenterology , vol.142 , pp. 1592-1609
    • Chalasani, N.1    Younossi, Z.2    Lavine, J.E.3    Diehl, A.M.4    Brunt, E.M.5    Cusi, K.6
  • 2
    • 79960029926 scopus 로고    scopus 로고
    • Systematic review: the epidemiology and natural history of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis in adults
    • Vernon, G., Baranova, A., Younossi, Z.M., Systematic review: the epidemiology and natural history of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis in adults. Aliment Pharmacol Ther 34 (2011), 274–285.
    • (2011) Aliment Pharmacol Ther , vol.34 , pp. 274-285
    • Vernon, G.1    Baranova, A.2    Younossi, Z.M.3
  • 3
    • 84930788424 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease: a systematic review
    • Rinella, M.E., Nonalcoholic fatty liver disease: a systematic review. JAMA 313 (2015), 2263–2273.
    • (2015) JAMA , vol.313 , pp. 2263-2273
    • Rinella, M.E.1
  • 5
    • 34249668818 scopus 로고    scopus 로고
    • Epidemiology and natural history of NAFLD and NASH
    • [1–16, vii]
    • Ong, J.P., Younossi, Z.M., Epidemiology and natural history of NAFLD and NASH. Clin Liver Dis, 11, 2007 [1–16, vii].
    • (2007) Clin Liver Dis , vol.11
    • Ong, J.P.1    Younossi, Z.M.2
  • 6
    • 84940959302 scopus 로고    scopus 로고
    • Non-alcoholic fatty liver disease following liver transplantation: a clinical review
    • Merola, J., Liapakis, A., Mulligan, D., Yoo, P., Non-alcoholic fatty liver disease following liver transplantation: a clinical review. Clin Transplant 29 (2015), 728–737.
    • (2015) Clin Transplant , vol.29 , pp. 728-737
    • Merola, J.1    Liapakis, A.2    Mulligan, D.3    Yoo, P.4
  • 7
    • 79960663675 scopus 로고    scopus 로고
    • Non-alcoholic fatty liver disease in children
    • Cheung, C.R., Kelly, D.A., Non-alcoholic fatty liver disease in children. BMJ, 343, 2011, d4460.
    • (2011) BMJ , vol.343 , pp. d4460
    • Cheung, C.R.1    Kelly, D.A.2
  • 8
    • 84859404868 scopus 로고    scopus 로고
    • Role of obesity and lipotoxicity in the development of nonalcoholic steatohepatitis: pathophysiology and clinical implications
    • [711–25.e6]
    • Cusi, K., Role of obesity and lipotoxicity in the development of nonalcoholic steatohepatitis: pathophysiology and clinical implications. Gastroenterology, 142, 2012 [711–25.e6].
    • (2012) Gastroenterology , vol.142
    • Cusi, K.1
  • 9
  • 11
    • 34447267513 scopus 로고    scopus 로고
    • Efficacy and safety of incretin therapy in type 2 diabetes: systematic review and meta-analysis
    • Amori, R.E., Lau, J., Pittas, A.G., Efficacy and safety of incretin therapy in type 2 diabetes: systematic review and meta-analysis. JAMA 298 (2007), 194–206.
    • (2007) JAMA , vol.298 , pp. 194-206
    • Amori, R.E.1    Lau, J.2    Pittas, A.G.3
  • 12
    • 84859003663 scopus 로고    scopus 로고
    • Effects of glucagon-like peptide-1 receptor agonists on weight loss: systematic review and meta-analyses of randomised controlled trials
    • Vilsboll, T., Christensen, M., Junker, A.E., Knop, F.K., Gluud, L.L., Effects of glucagon-like peptide-1 receptor agonists on weight loss: systematic review and meta-analyses of randomised controlled trials. BMJ, 344, 2012, d7771.
    • (2012) BMJ , vol.344 , pp. d7771
    • Vilsboll, T.1    Christensen, M.2    Junker, A.E.3    Knop, F.K.4    Gluud, L.L.5
  • 13
    • 84928211618 scopus 로고    scopus 로고
    • Weight loss effect of glucagon-like peptide-1 mimetics on obese/overweight adults without diabetes: a systematic review and meta-analysis of randomized controlled trials
    • Zhang, F., Tong, Y., Su, N., Li, Y., Tang, L., Huang, L., et al. Weight loss effect of glucagon-like peptide-1 mimetics on obese/overweight adults without diabetes: a systematic review and meta-analysis of randomized controlled trials. J Diabetes 7 (2015), 329–339.
    • (2015) J Diabetes , vol.7 , pp. 329-339
    • Zhang, F.1    Tong, Y.2    Su, N.3    Li, Y.4    Tang, L.5    Huang, L.6
  • 14
    • 84920525855 scopus 로고    scopus 로고
    • Effects of lixisenatide on elevated liver transaminases: systematic review with individual patient data meta-analysis of randomised controlled trials on patients with type 2 diabetes
    • Gluud, L.L., Knop, F.K., Vilsboll, T., Effects of lixisenatide on elevated liver transaminases: systematic review with individual patient data meta-analysis of randomised controlled trials on patients with type 2 diabetes. BMJ Open, 4, 2014, e005325.
    • (2014) BMJ Open , vol.4 , pp. e005325
    • Gluud, L.L.1    Knop, F.K.2    Vilsboll, T.3
  • 15
    • 77951436599 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 receptor is present on human hepatocytes and has a direct role in decreasing hepatic steatosis in vitro by modulating elements of the insulin signaling pathway
    • Gupta, N.A., Mells, J., Dunham, R.M., Grakoui, A., Handy, J., Saxena, N.K., et al. Glucagon-like peptide-1 receptor is present on human hepatocytes and has a direct role in decreasing hepatic steatosis in vitro by modulating elements of the insulin signaling pathway. Hepatology 51 (2010), 1584–1592.
    • (2010) Hepatology , vol.51 , pp. 1584-1592
    • Gupta, N.A.1    Mells, J.2    Dunham, R.M.3    Grakoui, A.4    Handy, J.5    Saxena, N.K.6
  • 16
    • 79956114434 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 reduces hepatic lipogenesis via activation of AMP-activated protein kinase
    • Ben-Shlomo, S., Zvibel, I., Shnell, M., Shlomai, A., Chepurko, E., Halpern, Z., et al. Glucagon-like peptide-1 reduces hepatic lipogenesis via activation of AMP-activated protein kinase. J Hepatol 54 (2011), 1214–1223.
    • (2011) J Hepatol , vol.54 , pp. 1214-1223
    • Ben-Shlomo, S.1    Zvibel, I.2    Shnell, M.3    Shlomai, A.4    Chepurko, E.5    Halpern, Z.6
  • 17
    • 84925548115 scopus 로고    scopus 로고
    • Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement
    • Moher, D., Liberati, A., Tetzlaff, J., Altman, D.G., Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. J Clin Epidemiol 62 (2009), 1006–1012.
    • (2009) J Clin Epidemiol , vol.62 , pp. 1006-1012
    • Moher, D.1    Liberati, A.2    Tetzlaff, J.3    Altman, D.G.4
  • 19
    • 69749109780 scopus 로고    scopus 로고
    • 2009 updated method guidelines for systematic reviews in the Cochrane Back Review Group
    • Furlan, A.D., Pennick, V., Bombardier, C., van Tulder, M., 2009 updated method guidelines for systematic reviews in the Cochrane Back Review Group. Spine (Phila Pa 1976) 34 (2009), 1929–1941.
    • (2009) Spine (Phila Pa 1976) , vol.34 , pp. 1929-1941
    • Furlan, A.D.1    Pennick, V.2    Bombardier, C.3    van Tulder, M.4
  • 20
    • 77957661914 scopus 로고    scopus 로고
    • Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses
    • Stang, A., Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses. Eur J Epidemiol 25 (2010), 603–605.
    • (2010) Eur J Epidemiol , vol.25 , pp. 603-605
    • Stang, A.1
  • 23
    • 40549132473 scopus 로고    scopus 로고
    • Estimation of fail-safe number in meta-analysis
    • Mai, J., Li, H., Fang, J., Liu, X., Rao, X., Estimation of fail-safe number in meta-analysis. J Evid Based Med 6 (2006), 297–303.
    • (2006) J Evid Based Med , vol.6 , pp. 297-303
    • Mai, J.1    Li, H.2    Fang, J.3    Liu, X.4    Rao, X.5
  • 24
  • 25
    • 84957840942 scopus 로고    scopus 로고
    • Liraglutide safety and efficacy in patients with non-alcoholic steatohepatitis (LEAN): a multicentre, double-blind, randomised, placebo-controlled phase 2 study
    • Armstrong, M.J., Gaunt, P., Aithal, G.P., Barton, D., Hull, D., Parker, R., et al. Liraglutide safety and efficacy in patients with non-alcoholic steatohepatitis (LEAN): a multicentre, double-blind, randomised, placebo-controlled phase 2 study. Lancet 387 (2016), 679–690.
    • (2016) Lancet , vol.387 , pp. 679-690
    • Armstrong, M.J.1    Gaunt, P.2    Aithal, G.P.3    Barton, D.4    Hull, D.5    Parker, R.6
  • 26
    • 84892421783 scopus 로고    scopus 로고
    • Exenatide improves type 2 diabetes concomitant with non-alcoholic fatty liver disease
    • Fan, H., Pan, Q., Xu, Y., Yang, X., Exenatide improves type 2 diabetes concomitant with non-alcoholic fatty liver disease. Arq Bras Endocrinol Metabol 57 (2013), 702–708.
    • (2013) Arq Bras Endocrinol Metabol , vol.57 , pp. 702-708
    • Fan, H.1    Pan, Q.2    Xu, Y.3    Yang, X.4
  • 27
    • 84907345097 scopus 로고    scopus 로고
    • Benefits of exenatide on obesity and non-alcoholic fatty liver disease with elevated liver enzymes in patients with type 2 diabetes
    • Shao, N., Kuang, H.Y., Hao, M., Gao, X.Y., Lin, W.J., Zou, W., Benefits of exenatide on obesity and non-alcoholic fatty liver disease with elevated liver enzymes in patients with type 2 diabetes. Diabetes Metab Res Rev 30 (2014), 521–529.
    • (2014) Diabetes Metab Res Rev , vol.30 , pp. 521-529
    • Shao, N.1    Kuang, H.Y.2    Hao, M.3    Gao, X.Y.4    Lin, W.J.5    Zou, W.6
  • 28
    • 84866181193 scopus 로고    scopus 로고
    • The effectiveness of liraglutide in nonalcoholic fatty liver disease patients with type 2 diabetes mellitus compared to sitagliptin and pioglitazone
    • Ohki, T., Isogawa, A., Iwamoto, M., Ohsugi, M., Yoshida, H., Toda, N., et al. The effectiveness of liraglutide in nonalcoholic fatty liver disease patients with type 2 diabetes mellitus compared to sitagliptin and pioglitazone. ScientificWorldJournal, 2012, 2012, 496453.
    • (2012) ScientificWorldJournal , vol.2012 , pp. 496453
    • Ohki, T.1    Isogawa, A.2    Iwamoto, M.3    Ohsugi, M.4    Yoshida, H.5    Toda, N.6
  • 29
    • 78649878256 scopus 로고    scopus 로고
    • Exenatide in the treatment of diabetic patients with non-alcoholic steatohepatitis: a case series
    • Kenny, P.R., Brady, D.E., Torres, D.M., Ragozzino, L., Chalasani, N., Harrison, S.A., Exenatide in the treatment of diabetic patients with non-alcoholic steatohepatitis: a case series. Am J Gastroenterol 105 (2010), 2707–2709.
    • (2010) Am J Gastroenterol , vol.105 , pp. 2707-2709
    • Kenny, P.R.1    Brady, D.E.2    Torres, D.M.3    Ragozzino, L.4    Chalasani, N.5    Harrison, S.A.6
  • 30
    • 84924080351 scopus 로고    scopus 로고
    • Pilot study of liraglutide effects in non-alcoholic steatohepatitis and non-alcoholic fatty liver disease with glucose intolerance in Japanese patients (LEAN-J)
    • Eguchi, Y., Kitajima, Y., Hyogo, H., Takahashi, H., Kojima, M., Ono, M., et al. Pilot study of liraglutide effects in non-alcoholic steatohepatitis and non-alcoholic fatty liver disease with glucose intolerance in Japanese patients (LEAN-J). Hepatol Res 45 (2015), 269–278.
    • (2015) Hepatol Res , vol.45 , pp. 269-278
    • Eguchi, Y.1    Kitajima, Y.2    Hyogo, H.3    Takahashi, H.4    Kojima, M.5    Ono, M.6
  • 32
    • 79955446251 scopus 로고    scopus 로고
    • Effect of vitamin E or metformin for treatment of nonalcoholic fatty liver disease in children and adolescents: the TONIC randomized controlled trial
    • Lavine, J.E., Schwimmer, J.B., Van Natta, M.L., Molleston, J.P., Murray, K.F., Rosenthal, P., et al. Effect of vitamin E or metformin for treatment of nonalcoholic fatty liver disease in children and adolescents: the TONIC randomized controlled trial. JAMA 305 (2011), 1659–1668.
    • (2011) JAMA , vol.305 , pp. 1659-1668
    • Lavine, J.E.1    Schwimmer, J.B.2    Van Natta, M.L.3    Molleston, J.P.4    Murray, K.F.5    Rosenthal, P.6
  • 33
    • 84945185644 scopus 로고    scopus 로고
    • Comparative effectiveness of pharmacological interventions for nonalcoholic steatohepatitis: a systematic review and network meta-analysis
    • Singh, S., Khera, R., Allen, A.M., Murad, M.H., Loomba, R., Comparative effectiveness of pharmacological interventions for nonalcoholic steatohepatitis: a systematic review and network meta-analysis. Hepatology 62 (2015), 1417–1432.
    • (2015) Hepatology , vol.62 , pp. 1417-1432
    • Singh, S.1    Khera, R.2    Allen, A.M.3    Murad, M.H.4    Loomba, R.5
  • 34
    • 80053954605 scopus 로고    scopus 로고
    • Vitamin E and the risk of prostate cancer: the selenium and vitamin E cancer prevention trial (SELECT)
    • Klein, E.A., Thompson, I.M. Jr., Tangen, C.M., Crowley, J.J., Lucia, M.S., Goodman, P.J., et al. Vitamin E and the risk of prostate cancer: the selenium and vitamin E cancer prevention trial (SELECT). JAMA 306 (2011), 1549–1556.
    • (2011) JAMA , vol.306 , pp. 1549-1556
    • Klein, E.A.1    Thompson, I.M.2    Tangen, C.M.3    Crowley, J.J.4    Lucia, M.S.5    Goodman, P.J.6
  • 36
    • 33847378451 scopus 로고    scopus 로고
    • Mortality in randomized trials of antioxidant supplements for primary and secondary prevention: systematic review and meta-analysis
    • Bjelakovic, G., Nikolova, D., Gluud, L.L., Simonetti, R.G., Gluud, C., Mortality in randomized trials of antioxidant supplements for primary and secondary prevention: systematic review and meta-analysis. JAMA 297 (2007), 842–857.
    • (2007) JAMA , vol.297 , pp. 842-857
    • Bjelakovic, G.1    Nikolova, D.2    Gluud, L.L.3    Simonetti, R.G.4    Gluud, C.5
  • 37
    • 84893287256 scopus 로고    scopus 로고
    • Enough is enough: stop wasting money on vitamin and mineral supplements
    • Guallar, E., Stranges, S., Mulrow, C., Appel, L.J., Miller, E.R., Enough is enough: stop wasting money on vitamin and mineral supplements. Ann Intern Med 159 (2013), 850–851.
    • (2013) Ann Intern Med , vol.159 , pp. 850-851
    • Guallar, E.1    Stranges, S.2    Mulrow, C.3    Appel, L.J.4    Miller, E.R.5
  • 38
    • 33751545838 scopus 로고    scopus 로고
    • A placebo-controlled trial of pioglitazone in subjects with nonalcoholic steatohepatitis
    • Belfort, R., Harrison, S.A., Brown, K., Darland, C., Finch, J., Hardies, J., et al. A placebo-controlled trial of pioglitazone in subjects with nonalcoholic steatohepatitis. N Engl J Med 355 (2006), 2297–2307.
    • (2006) N Engl J Med , vol.355 , pp. 2297-2307
    • Belfort, R.1    Harrison, S.A.2    Brown, K.3    Darland, C.4    Finch, J.5    Hardies, J.6
  • 39
    • 67149146438 scopus 로고    scopus 로고
    • Rosiglitazone evaluated for cardiovascular outcomes in oral agent combination therapy for type 2 diabetes (RECORD): a multicentre, randomised, open-label trial
    • Home, P.D., Pocock, S.J., Beck-Nielsen, H., Curtis, P.S., Gomis, R., Hanefeld, M., et al. Rosiglitazone evaluated for cardiovascular outcomes in oral agent combination therapy for type 2 diabetes (RECORD): a multicentre, randomised, open-label trial. Lancet 373 (2009), 2125–2135.
    • (2009) Lancet , vol.373 , pp. 2125-2135
    • Home, P.D.1    Pocock, S.J.2    Beck-Nielsen, H.3    Curtis, P.S.4    Gomis, R.5    Hanefeld, M.6
  • 40
    • 58149389215 scopus 로고    scopus 로고
    • Glucose control and vascular complications in veterans with type 2 diabetes
    • Duckworth, W., Abraira, C., Moritz, T., Reda, D., Emanuele, N., Reaven, P.D., et al. Glucose control and vascular complications in veterans with type 2 diabetes. N Engl J Med 360 (2009), 129–139.
    • (2009) N Engl J Med , vol.360 , pp. 129-139
    • Duckworth, W.1    Abraira, C.2    Moritz, T.3    Reda, D.4    Emanuele, N.5    Reaven, P.D.6
  • 41
    • 84884930937 scopus 로고    scopus 로고
    • The cardiovascular safety of diabetes drugs–insights from the rosiglitazone experience
    • Hiatt, W.R., Kaul, S., Smith, R.J., The cardiovascular safety of diabetes drugs–insights from the rosiglitazone experience. N Engl J Med 369 (2013), 1285–1287.
    • (2013) N Engl J Med , vol.369 , pp. 1285-1287
    • Hiatt, W.R.1    Kaul, S.2    Smith, R.J.3
  • 42
    • 34250212715 scopus 로고    scopus 로고
    • Effect of rosiglitazone on the risk of myocardial infarction and death from cardiovascular causes
    • Nissen, S.E., Wolski, K., Effect of rosiglitazone on the risk of myocardial infarction and death from cardiovascular causes. N Engl J Med 356 (2007), 2457–2471.
    • (2007) N Engl J Med , vol.356 , pp. 2457-2471
    • Nissen, S.E.1    Wolski, K.2
  • 43
    • 77955699301 scopus 로고    scopus 로고
    • High-dose ursodeoxycholic acid therapy for nonalcoholic steatohepatitis: a double-blind, randomized, placebo-controlled trial
    • Leuschner, U.F., Lindenthal, B., Herrmann, G., Arnold, J.C., Rossle, M., Cordes, H.J., et al. High-dose ursodeoxycholic acid therapy for nonalcoholic steatohepatitis: a double-blind, randomized, placebo-controlled trial. Hepatology 52 (2010), 472–479.
    • (2010) Hepatology , vol.52 , pp. 472-479
    • Leuschner, U.F.1    Lindenthal, B.2    Herrmann, G.3    Arnold, J.C.4    Rossle, M.5    Cordes, H.J.6
  • 44
    • 79954764140 scopus 로고    scopus 로고
    • A randomized controlled trial of high-dose ursodesoxycholic acid for nonalcoholic steatohepatitis
    • Ratziu, V., de Ledinghen, V., Oberti, F., Mathurin, P., Wartelle-Bladou, C., Renou, C., et al. A randomized controlled trial of high-dose ursodesoxycholic acid for nonalcoholic steatohepatitis. J Hepatol 54 (2011), 1011–1019.
    • (2011) J Hepatol , vol.54 , pp. 1011-1019
    • Ratziu, V.1    de Ledinghen, V.2    Oberti, F.3    Mathurin, P.4    Wartelle-Bladou, C.5    Renou, C.6
  • 45
    • 77649216380 scopus 로고    scopus 로고
    • Review article: omega-3 fatty acids - a promising novel therapy for non-alcoholic fatty liver disease
    • Masterton, G.S., Plevris, J.N., Hayes, P.C., Review article: omega-3 fatty acids - a promising novel therapy for non-alcoholic fatty liver disease. Aliment Pharmacol Ther 31 (2010), 679–692.
    • (2010) Aliment Pharmacol Ther , vol.31 , pp. 679-692
    • Masterton, G.S.1    Plevris, J.N.2    Hayes, P.C.3
  • 46
    • 33646483917 scopus 로고    scopus 로고
    • A double-blind randomized placebo-controlled trial of orlistat for the treatment of nonalcoholic fatty liver disease
    • Zelber-Sagi, S., Kessler, A., Brazowsky, E., Webb, M., Lurie, Y., Santo, M., et al. A double-blind randomized placebo-controlled trial of orlistat for the treatment of nonalcoholic fatty liver disease. Clin Gastroenterol Hepatol 4 (2006), 639–644.
    • (2006) Clin Gastroenterol Hepatol , vol.4 , pp. 639-644
    • Zelber-Sagi, S.1    Kessler, A.2    Brazowsky, E.3    Webb, M.4    Lurie, Y.5    Santo, M.6
  • 47
    • 84958168252 scopus 로고    scopus 로고
    • Comparative efficacy of anti-diabetic agents on nonalcoholic fatty liver disease in patients with type 2 diabetes mellitus: a systematic review and meta-analysis of randomized and non-randomized studies
    • Tang, W., Xu, Q., Hong, T., Tong, G., Feng, W., Shen, S., et al. Comparative efficacy of anti-diabetic agents on nonalcoholic fatty liver disease in patients with type 2 diabetes mellitus: a systematic review and meta-analysis of randomized and non-randomized studies. Diabetes Metab Res Rev 32 (2016), 200–216.
    • (2016) Diabetes Metab Res Rev , vol.32 , pp. 200-216
    • Tang, W.1    Xu, Q.2    Hong, T.3    Tong, G.4    Feng, W.5    Shen, S.6
  • 48
    • 46349088361 scopus 로고    scopus 로고
    • Rosiglitazone for nonalcoholic steatohepatitis: one-year results of the randomized placebo-controlled Fatty Liver Improvement with Rosiglitazone Therapy (FLIRT) Trial
    • Ratziu, V., Giral, P., Jacqueminet, S., Charlotte, F., Hartemann-Heurtier, A., Serfaty, L., et al. Rosiglitazone for nonalcoholic steatohepatitis: one-year results of the randomized placebo-controlled Fatty Liver Improvement with Rosiglitazone Therapy (FLIRT) Trial. Gastroenterology 135 (2008), 100–110.
    • (2008) Gastroenterology , vol.135 , pp. 100-110
    • Ratziu, V.1    Giral, P.2    Jacqueminet, S.3    Charlotte, F.4    Hartemann-Heurtier, A.5    Serfaty, L.6
  • 49
    • 75449116707 scopus 로고    scopus 로고
    • Long-term efficacy of rosiglitazone in nonalcoholic steatohepatitis: results of the fatty liver improvement by rosiglitazone therapy (FLIRT 2) extension trial
    • Ratziu, V., Charlotte, F., Bernhardt, C., Giral, P., Halbron, M., Lenaour, G., et al. Long-term efficacy of rosiglitazone in nonalcoholic steatohepatitis: results of the fatty liver improvement by rosiglitazone therapy (FLIRT 2) extension trial. Hepatology 51 (2010), 445–453.
    • (2010) Hepatology , vol.51 , pp. 445-453
    • Ratziu, V.1    Charlotte, F.2    Bernhardt, C.3    Giral, P.4    Halbron, M.5    Lenaour, G.6
  • 50
    • 84956914555 scopus 로고    scopus 로고
    • Incretin-based therapies for the treatment of non-alcoholic fatty liver disease: a systematic review and meta-analysis
    • Carbone, L.J., Angus, P.W., Yeomans, N.D., Incretin-based therapies for the treatment of non-alcoholic fatty liver disease: a systematic review and meta-analysis. J Gastroenterol Hepatol 31 (2016), 23–31.
    • (2016) J Gastroenterol Hepatol , vol.31 , pp. 23-31
    • Carbone, L.J.1    Angus, P.W.2    Yeomans, N.D.3
  • 51
    • 73449116035 scopus 로고    scopus 로고
    • Randomized controlled trial testing the effects of weight loss on nonalcoholic steatohepatitis
    • Promrat, K., Kleiner, D.E., Niemeier, H.M., Jackvony, E., Kearns, M., Wands, J.R., et al. Randomized controlled trial testing the effects of weight loss on nonalcoholic steatohepatitis. Hepatology 51 (2010), 121–129.
    • (2010) Hepatology , vol.51 , pp. 121-129
    • Promrat, K.1    Kleiner, D.E.2    Niemeier, H.M.3    Jackvony, E.4    Kearns, M.5    Wands, J.R.6
  • 52
    • 70350619609 scopus 로고    scopus 로고
    • Effects of liraglutide in the treatment of obesity: a randomised, double-blind, placebo-controlled study
    • Astrup, A., Rossner, S., Van Gaal, L., Rissanen, A., Niskanen, L., Al Hakim, M., et al. Effects of liraglutide in the treatment of obesity: a randomised, double-blind, placebo-controlled study. Lancet 374 (2009), 1606–1616.
    • (2009) Lancet , vol.374 , pp. 1606-1616
    • Astrup, A.1    Rossner, S.2    Van Gaal, L.3    Rissanen, A.4    Niskanen, L.5    Al Hakim, M.6
  • 53
    • 84936166069 scopus 로고    scopus 로고
    • A randomized, controlled trial of 3.0 mg of liraglutide in weight management
    • Pi-Sunyer, X., Astrup, A., Fujioka, K., Greenway, F., Halpern, A., Krempf, M., et al. A randomized, controlled trial of 3.0 mg of liraglutide in weight management. N Engl J Med 373 (2015), 11–22.
    • (2015) N Engl J Med , vol.373 , pp. 11-22
    • Pi-Sunyer, X.1    Astrup, A.2    Fujioka, K.3    Greenway, F.4    Halpern, A.5    Krempf, M.6
  • 54
    • 84975893286 scopus 로고    scopus 로고
    • Exenatide in obese or overweight patients without diabetes: a systematic review and meta-analyses of randomized controlled trials
    • Su, N., Li, Y., Xu, T., Li, L., Kwong, J.S., Du, H., et al. Exenatide in obese or overweight patients without diabetes: a systematic review and meta-analyses of randomized controlled trials. Int J Cardiol 219 (2016), 293–300.
    • (2016) Int J Cardiol , vol.219 , pp. 293-300
    • Su, N.1    Li, Y.2    Xu, T.3    Li, L.4    Kwong, J.S.5    Du, H.6
  • 55
    • 77950228684 scopus 로고    scopus 로고
    • Glucagon-like Peptide-1 receptor agonists activate rodent thyroid C-cells causing calcitonin release and C-cell proliferation
    • Bjerre Knudsen, L., Madsen, L.W., Andersen, S., Almholt, K., de Boer, A.S., Drucker, D.J., et al. Glucagon-like Peptide-1 receptor agonists activate rodent thyroid C-cells causing calcitonin release and C-cell proliferation. Endocrinology 151 (2010), 1473–1486.
    • (2010) Endocrinology , vol.151 , pp. 1473-1486
    • Bjerre Knudsen, L.1    Madsen, L.W.2    Andersen, S.3    Almholt, K.4    de Boer, A.S.5    Drucker, D.J.6
  • 56
    • 85019803193 scopus 로고    scopus 로고
    • ® (liraglutide injection): human relevance of rodent thyroid C-cell tumors
    • [accessed 14.12.10]
    • ® (liraglutide injection): human relevance of rodent thyroid C-cell tumors. 2009 http://www.fda.gov/downloads/AdvisoryCommittees/Committees%20MeetingMaterials/Drugs/EndocrinologicandMetabolicDrugsAdvisoryCommittee/UCM151129.pdf [accessed 14.12.10].
    • (2009)
    • Novo Nordisk A/S1
  • 57
    • 85019813518 scopus 로고    scopus 로고
    • ® (liraglutide) US SPC
    • [accessed 04.10.11]
    • ® (liraglutide) US SPC. 2011 http://www.novo-pi.com/victoza.pdf [accessed 04.10.11].
    • (2011)
    • Novo Nordisk A/S1
  • 58
    • 79959559653 scopus 로고    scopus 로고
    • Pancreatitis, pancreatic, and thyroid cancer with glucagon-like peptide-1-based therapies
    • Elashoff, M., Matveyenko, A.V., Gier, B., Elashoff, R., Butler, P.C., Pancreatitis, pancreatic, and thyroid cancer with glucagon-like peptide-1-based therapies. Gastroenterology 141 (2011), 150–156.
    • (2011) Gastroenterology , vol.141 , pp. 150-156
    • Elashoff, M.1    Matveyenko, A.V.2    Gier, B.3    Elashoff, R.4    Butler, P.C.5
  • 59
    • 77649294607 scopus 로고    scopus 로고
    • Weighing risks and benefits of liraglutide–the FDA's review of a new antidiabetic therapy
    • Parks, M., Rosebraugh, C., Weighing risks and benefits of liraglutide–the FDA's review of a new antidiabetic therapy. N Engl J Med 362 (2010), 774–777.
    • (2010) N Engl J Med , vol.362 , pp. 774-777
    • Parks, M.1    Rosebraugh, C.2
  • 60
    • 84899029163 scopus 로고    scopus 로고
    • Incretin treatment and risk of pancreatitis in patients with type 2 diabetes mellitus: systematic review and meta-analysis of randomised and non-randomised studies
    • Li, L., Shen, J., Bala, M.M., Busse, J.W., Ebrahim, S., Vandvik, P.O., et al. Incretin treatment and risk of pancreatitis in patients with type 2 diabetes mellitus: systematic review and meta-analysis of randomised and non-randomised studies. BMJ, 348, 2014, g2366.
    • (2014) BMJ , vol.348 , pp. g2366
    • Li, L.1    Shen, J.2    Bala, M.M.3    Busse, J.W.4    Ebrahim, S.5    Vandvik, P.O.6
  • 61
    • 84890572455 scopus 로고    scopus 로고
    • Effects of glucagon-like peptide-1 receptor agonists on cardiovascular risk: meta-analysis of randomized clinical trials
    • Monami, M., Dicembrini, I., Nardini, C., Fiordelli, I., Mannucci, E., Effects of glucagon-like peptide-1 receptor agonists on cardiovascular risk: meta-analysis of randomized clinical trials. Diabetes Obes Metab 16 (2014), 38–47.
    • (2014) Diabetes Obes Metab , vol.16 , pp. 38-47
    • Monami, M.1    Dicembrini, I.2    Nardini, C.3    Fiordelli, I.4    Mannucci, E.5
  • 62
    • 85007452917 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 receptor agonists and heart failure in type 2 diabetes: systematic review and meta-analysis of randomized and observational studies
    • Li, L., Li, S., Liu, J., Deng, K., Busse, J.W., Vandvik, P.O., et al. Glucagon-like peptide-1 receptor agonists and heart failure in type 2 diabetes: systematic review and meta-analysis of randomized and observational studies. BMC Cardiovasc Disord, 16, 2016, 91.
    • (2016) BMC Cardiovasc Disord , vol.16 , pp. 91
    • Li, L.1    Li, S.2    Liu, J.3    Deng, K.4    Busse, J.W.5    Vandvik, P.O.6
  • 63
    • 84862291156 scopus 로고    scopus 로고
    • A review on the association between glucagon-like peptide-1 receptor agonists and thyroid cancer
    • Chiu, W.-Y., Shih, S.-R., Tseng, C.-H., A review on the association between glucagon-like peptide-1 receptor agonists and thyroid cancer. Exp Diabetes Res, 2012, 2012, 924168.
    • (2012) Exp Diabetes Res , vol.2012 , pp. 924168
    • Chiu, W.-Y.1    Shih, S.-R.2    Tseng, C.-H.3
  • 64
    • 85010310748 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 receptor agonists favorably address all components of metabolic syndrome
    • Chatterjee, S., Ghosal, S., Chatterjee, S., Glucagon-like peptide-1 receptor agonists favorably address all components of metabolic syndrome. World J Diabetes 7 (2016), 441–448.
    • (2016) World J Diabetes , vol.7 , pp. 441-448
    • Chatterjee, S.1    Ghosal, S.2    Chatterjee, S.3
  • 65
    • 84954384684 scopus 로고    scopus 로고
    • Glucagon-like peptide 1 decreases lipotoxicity in non-alcoholic steatohepatitis
    • Armstrong, M.J., Hull, D., Guo, K., Barton, D., Hazlehurst, J.M., Gathercole, L.L., et al. Glucagon-like peptide 1 decreases lipotoxicity in non-alcoholic steatohepatitis. J Hepatol 64 (2016), 399–408.
    • (2016) J Hepatol , vol.64 , pp. 399-408
    • Armstrong, M.J.1    Hull, D.2    Guo, K.3    Barton, D.4    Hazlehurst, J.M.5    Gathercole, L.L.6
  • 66
    • 84894327806 scopus 로고    scopus 로고
    • Increased de novo lipogenesis is a distinct characteristic of individuals with nonalcoholic fatty liver disease
    • Lambert, J.E., Ramos-Roman, M.A., Browning, J.D., Parks, E.J., Increased de novo lipogenesis is a distinct characteristic of individuals with nonalcoholic fatty liver disease. Gastroenterology 146 (2014), 726–735.
    • (2014) Gastroenterology , vol.146 , pp. 726-735
    • Lambert, J.E.1    Ramos-Roman, M.A.2    Browning, J.D.3    Parks, E.J.4
  • 67
    • 84859942552 scopus 로고    scopus 로고
    • Effect of adipose tissue insulin resistance on metabolic parameters and liver histology in obese patients with nonalcoholic fatty liver disease
    • Lomonaco, R., Ortiz-Lopez, C., Orsak, B., Webb, A., Hardies, J., Darland, C., et al. Effect of adipose tissue insulin resistance on metabolic parameters and liver histology in obese patients with nonalcoholic fatty liver disease. Hepatology 55 (2012), 1389–1397.
    • (2012) Hepatology , vol.55 , pp. 1389-1397
    • Lomonaco, R.1    Ortiz-Lopez, C.2    Orsak, B.3    Webb, A.4    Hardies, J.5    Darland, C.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.