Increased global arterial and subcutaneous adipose tissue inflammation in patients with moderate-to-severe psoriasis

British Journal of Dermatology

Volumn 176, Issue 3, 2017, Pages 732-740

  Hjuler, K F ^a   Gormsen, L C ^a   Vendelbo, M H ^a   Egeberg, A ^b   Nielsen, J ^a   Iversen, L ^a  

^a AARHUS UNIVERSITY HOSPITAL   (Denmark)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

FLUORODEOXYGLUCOSE F 18; RADIOPHARMACEUTICAL AGENT;

ADULT; AGE DISTRIBUTION; AGED; AORTA; AORTA DISEASE; AORTA WALL; ARTERITIS; ARTICLE; ASCENDING AORTA; BODY MASS; CLINICAL ARTICLE; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DISEASE DURATION; DISEASE SEVERITY; FEMALE; HUMAN; IMAGE ANALYSIS; INFLAMMATION; MALE; OBSERVATIONAL STUDY; OPEN STUDY; POSITRON EMISSION TOMOGRAPHY-COMPUTED TOMOGRAPHY; PRIORITY JOURNAL; PSORIASIS; PSORIASIS AREA AND SEVERITY INDEX; SUBCUTANEOUS FAT; VASCULITIS; AORTITIS; CASE CONTROL STUDY; COMPARATIVE STUDY; DIAGNOSTIC IMAGING; MIDDLE AGED; PANNICULITIS; PATHOLOGY; PROCEDURES;

AGED; AORTITIS; BODY MASS INDEX; CASE-CONTROL STUDIES; FEMALE; FLUORODEOXYGLUCOSE F18; HUMANS; MALE; MIDDLE AGED; PANNICULITIS; POSITRON EMISSION TOMOGRAPHY COMPUTED TOMOGRAPHY; PSORIASIS; RADIOPHARMACEUTICALS; SUBCUTANEOUS FAT;

EID: 85008497396     PISSN: 00070963     EISSN: 13652133     Source Type: Journal    
DOI: 10.1111/bjd.15149     Document Type: Article

References (33)

1. Armstrong AW, Harskamp CT, Ledo L et al. Coronary artery disease in patients with psoriasis referred for coronary angiography. Am J Cardiol 2012; 109:976–80.
2. Armstrong EJ, Harskamp CT, Armstrong AW. Psoriasis and major adverse cardiovascular events: a systematic review and meta-analysis of observational studies. J Am Heart Assoc 2013; 2:e000062.
3. Hjuler KF, Bottcher M, Vestergaard C et al. Increased prevalence of coronary artery disease in severe psoriasis and severe atopic dermatitis. Am J Med 2015; 128:1325–34.
4. Mason JC, Libby P. Cardiovascular disease in patients with chronic inflammation: mechanisms underlying premature cardiovascular events in rheumatologic conditions. Eur Heart J 2015; 36:482–9.
5. Ahlehoff O, Gislason GH, Charlot M et al. Psoriasis is associated with clinically significant cardiovascular risk: a Danish nationwide cohort study. J Intern Med 2011; 270:147–57.
6. Gelfand JM, Neimann AL, Shin DB et al. Risk of myocardial infarction in patients with psoriasis. JAMA 2006; 296:1735–41.
7. Boehncke WH, Boehncke S, Tobin AM et al. The ‘psoriatic march’: a concept of how severe psoriasis may drive cardiovascular comorbidity. Exp Dermatol 2011; 20:303–7.
8. Reich K. The concept of psoriasis as a systemic inflammation: implications for disease management. J Eur Acad Dermatol Venereol 2012; 26:3–11.
9. Dowlatshahi EA, van der Voort EA, Arends LR et al. Markers of systemic inflammation in psoriasis: a systematic review and meta-analysis. Br J Dermatol 2013; 169:266–82.
10. Mehta NN, Yu Y, Saboury B et al. Systemic and vascular inflammation in patients with moderate to severe psoriasis as measured by [18F]-fluorodeoxyglucose positron emission tomography-computed tomography (FDG-PET/CT): a pilot study. Arch Dermatol 2011; 147:1031–9.
11. Naik HB, Natarajan B, Stansky E et al. Severity of psoriasis associates with aortic vascular inflammation detected by FDG PET/CT and neutrophil activation in a prospective observational study. Arterioscler Thromb Vasc Biol 2015; 35:2667–76.
12. Gerdes S, Rostami-Yazdi M, Mrowietz U. Adipokines and psoriasis. Exp Dermatol 2011; 20:81–7.
13. Meijer K, de Vries M, Al-Lahham S et al. Human primary adipocytes exhibit immune cell function: adipocytes prime inflammation independent of macrophages. PLoS ONE 2011; 6:e17154.
14. Versini M, Jeandel PY, Rosenthal E et al. Obesity in autoimmune diseases: not a passive bystander. Autoimmun Rev 2014; 13:981–1000.
15. Setty AR, Curhan G, Choi HK. Obesity, waist circumference, weight change, and the risk of psoriasis in women: Nurses’ Health Study II. Arch Intern Med 2007; 167:1670–5.
16. Jensen P, Zachariae C, Christensen R et al. Effect of weight loss on the severity of psoriasis: a randomized clinical study. JAMA Dermatol 2013; 149:795–801.
17. Dweck MR, Aikawa E, Newby DE et al. Noninvasive molecular imaging of disease activity in atherosclerosis. Circ Res 2016; 119:330–40.
18. Tawakol A, Migrino RQ, Hoffmann U et al. Noninvasive in vivo measurement of vascular inflammation with F-18 fluorodeoxyglucose positron emission tomography. J Nucl Cardiol 2005; 12:294–301.
19. Rudd JH, Warburton EA, Fryer TD et al. Imaging atherosclerotic plaque inflammation with [18F]-fluorodeoxyglucose positron emission tomography. Circulation 2002; 105:2708–11.
20. Tawakol A, Migrino RQ, Bashian GG et al. In vivo 18F-fluorodeoxyglucose positron emission tomography imaging provides a noninvasive measure of carotid plaque inflammation in patients. J Am Coll Cardiol 2006; 48:1818–24.
21. Bucerius J, Hyafil F, Verberne HJ et al. Position paper of the Cardiovascular Committee of the European Association of Nuclear Medicine (EANM) on PET imaging of atherosclerosis. Eur J Nucl Med Mol Imaging 2016; 43:780–92.
22. Mehta NN, Torigian DA, Gelfand JM et al. Quantification of atherosclerotic plaque activity and vascular inflammation using [18-F] fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT). J Vis Exp 2012; 63:e3777.
23. Sacks H, Symonds ME. Anatomical locations of human brown adipose tissue: functional relevance and implications in obesity and type 2 diabetes. Diabetes 2013; 62:1783–90.
24. Bucerius J, Mani V, Wong S et al. Arterial and fat tissue inflammation are highly correlated: a prospective 18F-FDG PET/CT study. Eur J Nucl Med Mol Imaging 2014; 41:934–45.
25. Elkhawad M, Rudd JH, Sarov-Blat L et al. Effects of p38 mitogen-activated protein kinase inhibition on vascular and systemic inflammation in patients with atherosclerosis. JACC Cardiovasc Imaging 2012; 5:911–22.
26. Heusch P, Buchbender C, Beiderwellen K et al. Standardized uptake values for [(1)(8)F] FDG in normal organ tissues: comparison of whole-body PET/CT and PET/MRI. Eur J Radiol 2013; 82:870–6.
27. Tahara N, Kai H, Ishibashi M et al. Simvastatin attenuates plaque inflammation: evaluation by fluorodeoxyglucose positron emission tomography. J Am Coll Cardiol 2006; 48:1825–31.
28. Vanfleteren LE, van Meerendonk AM, Franssen FM et al. A possible link between increased metabolic activity of fat tissue and aortic wall inflammation in subjects with COPD. A retrospective 18F-FDG-PET/CT pilot study. Respir Med 2014; 108:883–90.
29. Balci DD, Balci A, Karazincir S et al. Increased carotid artery intima-media thickness and impaired endothelial function in psoriasis. J Eur Acad Dermatol Venereol 2009; 23:1–6.
30. Enany B, El Zohiery AK, Elhilaly R et al. Carotid intima-media thickness and serum leptin in psoriasis. Herz 2012; 37:527–33.
31. Osto E, Piaserico S, Maddalozzo A et al. Impaired coronary flow reserve in young patients affected by severe psoriasis. Atherosclerosis 2012; 221:113–17.
32. Marnane M, Merwick A, Sheehan OC et al. Carotid plaque inflammation on 18F-fluorodeoxyglucose positron emission tomography predicts early stroke recurrence. Ann Neurol 2012; 71:709–18.
33. Rominger A, Saam T, Wolpers S et al. 18F-FDG PET/CT identifies patients at risk for future vascular events in an otherwise asymptomatic cohort with neoplastic disease. J Nucl Med 2009; 50:1611–20.