A Sensor for Low Environmental Oxygen in the Mouse Main Olfactory Epithelium

Neuron

Volumn 92, Issue 6, 2016, Pages 1196-1203

  Bleymehl, Katherin ^a   Pérez Gómez, Anabel ^a   Omura, Masayo ^b   Moreno Pérez, Ana ^a   Macías, David ^c   Bai, Zhaodai ^b   Johnson, Randall S ^c,d   Leinders Zufall, Trese ^a   Zufall, Frank ^a   Mombaerts, Peter ^b  

^a SAARLAND UNIVERSITY   (Germany)

^b MAX PLANCK RESEARCH UNIT FOR NEUROGENETICS   (Germany)

^c UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^d KAROLINSKA INSTITUTE   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

GUANYLATE CYCLASE; GUCY1B2 PROTEIN; TRANSIENT RECEPTOR POTENTIAL CHANNEL 2; UNCLASSIFIED DRUG; GUCY1B2 PROTEIN, MOUSE; OXYGEN; TRANSIENT RECEPTOR POTENTIAL CHANNEL C; TRPC2 PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; AVERSION; AXON; B LYMPHOCYTE; CALCIUM TRANSPORT; CONDITIONED PLACE AVERSION; CONTROLLED STUDY; FEMALE; IN VIVO STUDY; MALE; MOUSE; NONHUMAN; OLFACTORY BULB; OLFACTORY EPITHELIUM; OXYGEN SENSING; OXYGENATION; PRIORITY JOURNAL; SENSORY NERVE CELL; SENSORY STIMULATION; ANIMAL; CHEMORECEPTOR CELL; CYTOLOGY; GENETICS; KNOCKOUT MOUSE; METABOLISM; MUTATION; OLFACTORY MUCOSA;

ANIMALS; CHEMORECEPTOR CELLS; MICE; MICE, KNOCKOUT; MUTATION; OLFACTORY MUCOSA; OXYGEN; SOLUBLE GUANYLYL CYCLASE; TRPC CATION CHANNELS;

EID: 85008262614     PISSN: 08966273     EISSN: 10974199     Source Type: Journal    
DOI: 10.1016/j.neuron.2016.11.001     Document Type: Article

References (30)

1. Buck, L., Axel, R., A novel multigene family may encode odorant receptors: a molecular basis for odor recognition. Cell 65 (1991), 175–187.
2. Chamero, P., Katsoulidou, V., Hendrix, P., Bufe, B., Roberts, R., Matsunami, H., Abramowitz, J., Birnbaumer, L., Zufall, F., Leinders-Zufall, T., G protein G(α)o is essential for vomeronasal function and aggressive behavior in mice. Proc. Natl. Acad. Sci. USA 108 (2011), 12898–12903.
3. Cheung, B.H., Cohen, M., Rogers, C., Albayram, O., de Bono, M., Experience-dependent modulation of C. elegans behavior by ambient oxygen. Curr. Biol. 15 (2005), 905–917.
4. Cunningham, C.L., Gremel, C.M., Groblewski, P.A., Drug-induced conditioned place preference and aversion in mice. Nat. Protoc. 1 (2006), 1662–1670.
5. Deacon, R.M., Burrowing in rodents: a sensitive method for detecting behavioral dysfunction. Nat. Protoc. 1 (2006), 118–121.
6. Derbyshire, E.R., Marletta, M.A., Structure and regulation of soluble guanylate cyclase. Annu. Rev. Biochem. 81 (2012), 533–559.
7. Dey, S., Stowers, L., Think you know how smell works? Sniff again. Cell 165 (2016), 1566–1567.
8. Francis, S.H., Busch, J.L., Corbin, J.D., Sibley, D., cGMP-dependent protein kinases and cGMP phosphodiesterases in nitric oxide and cGMP action. Pharmacol. Rev. 62 (2010), 525–563.
9. Gray, J.M., Karow, D.S., Lu, H., Chang, A.J., Chang, J.S., Ellis, R.E., Marletta, M.A., Bargmann, C.I., Oxygen sensation and social feeding mediated by a C. elegans guanylate cyclase homologue. Nature 430 (2004), 317–322.
10. Koglin, M., Vehse, K., Budaeus, L., Scholz, H., Behrends, S., Nitric oxide activates the β 2 subunit of soluble guanylyl cyclase in the absence of a second subunit. J. Biol. Chem. 276 (2001), 30737–30743.
11. Leypold, B.G., Yu, C.R., Leinders-Zufall, T., Kim, M.M., Zufall, F., Axel, R., Altered sexual and social behaviors in trp2 mutant mice. Proc. Natl. Acad. Sci. USA 99 (2002), 6376–6381.
12. Li, Q., Liberles, S.D., Aversion and attraction through olfaction. Curr. Biol. 25 (2015), R120–R129.
13. López-Barneo, J., González-Rodríguez, P., Gao, L., Fernández-Agüera, M.C., Pardal, R., Ortega-Sáenz, P., Oxygen sensing by the carotid body: mechanisms and role in adaptation to hypoxia. Am. J. Physiol. Cell Physiol. 310 (2016), C629–C642.
14. Lucas, P., Ukhanov, K., Leinders-Zufall, T., Zufall, F., A diacylglycerol-gated cation channel in vomeronasal neuron dendrites is impaired in TRPC2 mutant mice: mechanism of pheromone transduction. Neuron 40 (2003), 551–561.
15. Macías, D., Fernández-Agüera, M.C., Bonilla-Henao, V., López-Barneo, J., Deletion of the von Hippel-Lindau gene causes sympathoadrenal cell death and impairs chemoreceptor-mediated adaptation to hypoxia. EMBO Mol. Med. 6 (2014), 1577–1592.
16. Morton, D.B., Atypical soluble guanylyl cyclases in Drosophila can function as molecular oxygen sensors. J. Biol. Chem. 279 (2004), 50651–50653.
17. Munger, S.D., Leinders-Zufall, T., Zufall, F., Subsystem organization of the mammalian sense of smell. Annu. Rev. Physiol. 71 (2009), 115–140.
18. Munger, S.D., Leinders-Zufall, T., McDougall, L.M., Cockerham, R.E., Schmid, A., Wandernoth, P., Wennemuth, G., Biel, M., Zufall, F., Kelliher, K.R., An olfactory subsystem that detects carbon disulfide and mediates food-related social learning. Curr. Biol. 20 (2010), 1438–1444.
19. Omura, M., Mombaerts, P., Trpc2-expressing sensory neurons in the main olfactory epithelium of the mouse. Cell Rep. 8 (2014), 583–595.
20. Omura, M., Mombaerts, P., Trpc2-expressing sensory neurons in the mouse main olfactory epithelium of type B express the soluble guanylate cyclase Gucy1b2. Mol. Cell. Neurosci. 65 (2015), 114–124.
21. Pérez-Gómez, A., Bleymehl, K., Stein, B., Pyrski, M., Birnbaumer, L., Munger, S.D., Leinders-Zufall, T., Zufall, F., Chamero, P., Innate predator odor aversion driven by parallel olfactory subsystems that converge in the ventromedial hypothalamus. Curr. Biol. 25 (2015), 1340–1346.
22. 2 detection by the carotid and aortic bodies. Zufall, F., Munger, S.D., (eds.) Chemosensory Transduction: The Detection of Odors, Tastes, and Other Chemostimuli, 2016, Academic Press, 321–338.
23. Saraiva, L.R., Ibarra-Soria, X., Khan, M., Omura, M., Scialdone, A., Mombaerts, P., Marioni, J.C., Logan, D.W., Hierarchical deconstruction of mouse olfactory sensory neurons: from whole mucosa to single-cell RNA-seq. Sci. Rep., 5, 2015, 18178.
24. Scott, K., Out of thin air: sensory detection of oxygen and carbon dioxide. Neuron 69 (2011), 194–202.
25. Semenza, G.L., Oxygen sensing, homeostasis, and disease. N. Engl. J. Med. 365 (2011), 537–547.
26. Stowers, L., Holy, T.E., Meister, M., Dulac, C., Koentges, G., Loss of sex discrimination and male-male aggression in mice deficient for TRP2. Science 295 (2002), 1493–1500.
27. Vermehren-Schmaedick, A., Ainsley, J.A., Johnson, W.A., Davies, S.A., Morton, D.B., Behavioral responses to hypoxia in Drosophila larvae are mediated by atypical soluble guanylyl cyclases. Genetics 186 (2010), 183–196.
28. Vorhees, C.V., Williams, M.T., Morris water maze: procedures for assessing spatial and related forms of learning and memory. Nat. Protoc. 1 (2006), 848–858.
29. Zheng, C., Feinstein, P., Bozza, T., Rodriguez, I., Mombaerts, P., Peripheral olfactory projections are differentially affected in mice deficient in a cyclic nucleotide-gated channel subunit. Neuron 26 (2000), 81–91.
30. Zimmer, M., Gray, J.M., Pokala, N., Chang, A.J., Karow, D.S., Marletta, M.A., Hudson, M.L., Morton, D.B., Chronis, N., Bargmann, C.I., Neurons detect increases and decreases in oxygen levels using distinct guanylate cyclases. Neuron 61 (2009), 865–879.