A Randomized Trial Evaluating Whether Topiramate Aids Smoking Cessation and Prevents Alcohol Relapse in Recovering Alcohol-Dependent Men

Alcoholism: Clinical and Experimental Research

Volumn 41, Issue 1, 2017, Pages 197-206

  Anthenelli, Robert M ^a,b   Heffner, Jaimee L ^c   Wong, Esther ^a,b   Tibbs, Jessie ^a   Russell, Katie ^a   Isgro, Melodie ^a,b   Dinh, Elizabeth ^a   Wehrle, Chris ^a   Worley, Matthew J ^a,b   Doran, Neal ^b  

^a VA SAN DIEGO HEALTHCARE SYSTEM   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c Fred Hutchinson Cancer Research Center   (United States)

Author keywords

Alcohol; Nicotine; Relapse Prevention; Smoking Cessation; Topiramate

Indexed keywords

PLACEBO; TOPIRAMATE; FRUCTOSE;

ADULT; ALCOHOL ABSTINENCE; ALCOHOLISM; ARTICLE; ATRIAL FIBRILLATION; BACKACHE; COMPARATIVE STUDY; CONCENTRATION AT STEADY-STATE; CONTROLLED STUDY; CRAVING; DECREASED APPETITE; DEPRESSION; DIZZINESS; DOUBLE BLIND PROCEDURE; DRUG DEPENDENCE; DRUG DOSE TITRATION; DRUG EFFICACY; DRUG SAFETY; DRUG TOLERABILITY; DYSGEUSIA; FOLLOW UP; HEADACHE; HUMAN; MAJOR CLINICAL STUDY; MALE; MEDICATION COMPLIANCE; MENTAL CONCENTRATION; MIDDLE AGED; PARESTHESIA; PATIENT COMPLIANCE; PATIENT COUNSELING; PRIORITY JOURNAL; PROPHYLAXIS; RANDOMIZED CONTROLLED TRIAL; RELAPSE; SIDE EFFECT; SMOKING; SMOKING CESSATION; SMOKING CESSATION PROGRAM; SOMNOLENCE; SUICIDAL IDEATION; TOBACCO DEPENDENCE; TREATMENT DURATION; TREATMENT OUTCOME; UPPER RESPIRATORY TRACT INFECTION; ANALOGS AND DERIVATIVES; CLINICAL TRIAL; MULTICENTER STUDY; PHASE 2 CLINICAL TRIAL; PROCEDURES; RECURRENT DISEASE;

ADULT; ALCOHOL ABSTINENCE; ALCOHOLISM; DOUBLE-BLIND METHOD; FRUCTOSE; HUMANS; MALE; MIDDLE AGED; RECURRENCE; SMOKING; SMOKING CESSATION; TOBACCO USE DISORDER;

EID: 85007594002     PISSN: 01456008     EISSN: 15300277     Source Type: Journal    
DOI: 10.1111/acer.13279     Document Type: Article

References (38)

1. Anthenelli RM, Blom TJ, McElroy SL, Keck PE Jr (2008) Preliminary evidence for gender-specific effects of topiramate as a potential aid to smoking cessation. Addiction 103:687–694.
2. Blodgett JC, Del Re AC, Maisel NC, Finney JW (2014) A meta-analysis of topiramate's effects for individuals with alcohol use disorders. Alcohol Clin Exp Res 38:1481–1488.
3. Bucholz KK, Cadoret R, Cloninger CR, Dinwiddie SH, Hesselbrock VM, Nurnberger JI Jr, Reich T, Schmidt I, Schuckit MA (1994) A new, semi-structured psychiatric interview for use in genetic linkage studies: a report on the reliability of the SSAGA. J Stud Alcohol 55:149–158.
4. Carroll KM, O'Malley SS, Nuro KF (1999) Compliance Enhancement: A Manual for the Psychopharmacotherapy of Drug Abuse and Dependence. Sponsored by NIDA P50 DA 09241. Yale University, West Haven, CT.
5. Cinciripini PM, Robinson JD, Karam-Hage M, Minnix JA, Lam C, Versace F, Brown VL, Engelmann JM, Wetter DW (2013) Effects of varenicline and bupropion sustained-release use plus intensive smoking cessation counseling on prolonged abstinence from smoking and on depression, negative affect, and other symptoms of nicotine withdrawal. JAMA Psychiatry 70:522–533.
6. Cox LS, Tiffany ST, Christen AG (2001) Evaluation of the brief questionnaire of smoking urges (QSU-brief) in laboratory and clinical settings. Nicotine Tob Res 3:7–16.
7. Doyon WM, Thomas AM, Ostroumov A, Dong Y, Dani JA (2013) Potential substrates for nicotine and alcohol interactions: a focus on the mesocorticolimbic dopamine system. Biochem Pharmacol 86:1181–1193.
8. Elkashef A, Kahn R, Yu E, Iturriaga E, Li SH, Anderson A, Chiang N, Ait-Daoud N, Weiss D, McSherry F, Serpi T, Rawson R, Hrymoc M, Weis D, McCann M, Pham T, Stock C, Dickinson R, Campbell J, Gorodetzky C, Haning W, Carlton B, Mawhinney J, Li MD, Johnson BA (2012) Topiramate for the treatment of methamphetamine addiction: a multi-center placebo-controlled trial. Addiction 107:1297–1306.
9. Foulds J, Russ C, Yu CR, Zou KH, Galaznik A, Franzon M, Berg A, Hughes JR (2013) Effect of varenicline on individual nicotine withdrawal symptoms: a combined analysis of eight randomized, placebo-controlled trials. Nicotine Tob Res 15:1849–1857.
10. Foulds J, Williams J, Order-Connors B, Edwards N, Dwyer M, Kline A, Ziedonis DM (2006) Integrating tobacco dependence treatment and tobacco-free standards into addiction treatment: New Jersey's experience. Alcohol Res Health 29:236–240.
11. Guydish J, Passalacqua E, Tajima B, Manser ST (2007) Staff smoking and other barriers to nicotine dependence intervention in addiction treatment settings: a review. J Psychoactive Drugs 39:423–433.
12. Heatherton TF, Kozlowski LT, Frecker RC, Fagerström KO (1991) The Fagerström test for nicotine dependence: a revision of the Fagerström Tolerance Questionnaire. Br J Addict 86:1119–1127.
13. Heffner JL, Barrett SW, Anthenelli RM (2007) Predicting alcohol misusers’ readiness and ability to quit smoking: a critical review. Alcohol Alcohol 42:186–195.
14. Hitchman SC, Fong GT, Zanna MP, Thrasher JF, Chung-Hall J, Siahpush M (2014a) Socioeconomic status and smokers’ number of smoking friends: findings from the International Tobacco Control (ITC) Four Country Survey. Drug Alcohol Depend 143:158–166.
15. Hitchman SC, Fong GT, Zanna MP, Thrasher JF, Laux FL (2014b) The relation between number of smoking friends, and quit intentions, attempts, and success: findings from the International Tobacco Control (ITC) Four Country Survey. Psychol Addict Behav 28:1144–1152.
16. Hughes JR, Hatsukami D (1986) Signs and symptoms of tobacco withdrawal. Arch Gen Psychiatry 43:289–294.
17. Hughes JR, Keely JP, Niaura RS, Ossip-Klein DJ, Richmond RL, Swan GE (2003) Measures of abstinence in clinical trials: issues and recommendations. Nicotine Tob Res 5:13–25.
18. Johnson BA, Ait-Daoud N, Akhtar FZ, Javors MA (2005) Use of oral topiramate to promote smoking abstinence among alcohol-dependent smokers: a randomized controlled trial. Arch Intern Med 165:1600–1605.
19. Joseph AM, Willenbring ML, Nugent SM, Nelson DB (2004) A randomized trial of concurrent versus delayed smoking intervention for patients in alcohol dependence treatment. J Stud Alcohol 65:681–691.
20. Kampman KM, Pettinati HM, Lynch KG, Spratt K, Wierzbicki MR, O'Brien CP (2013) A double-blind, placebo-controlled trial of topiramate for the treatment of comorbid cocaine and alcohol dependence. Drug Alcohol Depend 133:94–99.
21. Knudsen HK, Boyd SE, Studts JL (2010) Substance abuse treatment counselors and tobacco use: a comparison of comprehensive and indoor-only workplace smoking bans. Nicotine Tob Res 12:1151–1155.
22. Knudsen HK, Studts JL (2010) The implementation of tobacco-related brief interventions in substance abuse treatment: a national study of counselors. J Subst Abuse Treat 38:212–219.
23. Kotlyar M, Drone D, Thuras P, Hatsukami DK, Brauer L, Adson DE, al'Absi M (2011) Effect of stress and bupropion on craving, withdrawal symptoms, and mood in smokers. Nicotine Tob Res 13:492–497.
24. Kranzler HR, Covault J, Feinn R, Armeli S, Tennen H, Arias AJ, Gelernter J, Pond T, Oncken C, Kampman KM (2014) Topiramate treatment for heavy drinkers: moderation by a GRIK1 polymorphism. Am J Psychiatry 171:445–452.
25. Little RJ, Rubin DB (2002) Statistical Inference with Missing Data. 2nd ed. Wiley, New York.
26. Montgomery SA, Asberg M (1979) A new depression scale designed to be sensitive to change. Br J Psychiatry 134:382–389.
27. Oncken C, Arias AJ, Feinn R, Litt M, Covault J, Sofuoglu M, Kranzler HR (2014) Topiramate for smoking cessation: a randomized, placebo-controlled pilot study. Nicotine Tob Res 16:288–296.
28. Prochaska J, Delucchi K, Hall S (2004) A meta-analysis of smoking cessation interventions with individuals in substance abuse treatment or recovery. J Consult Clin Psychol 72:1144–1156.
29. Ravva P, Gastonguay MR, Faessel HM, Lee TC, Niaura R (2015) Pharmacokinetic-pharmacodynamic modeling of the effect of varenicline on nicotine craving in adult smokers. Nicotine Tob Res 17:106–113.
30. Reid MS, Palamar J, Raghavan S, Flammino F (2007) Effects of topiramate on cue-induced cigarette craving and the response to a smoked cigarette in briefly abstinent smokers. Psychopharmacology 192:147–158.
31. Schiffer WK, Gerasimov MR, Marsteller DA, Geiger J, Barnett C, Alexoff DL, Dewey SL (2001) Topiramate selectively attenuates nicotine-induced increases in monoamine release. Synapse 42:196–198.
32. Shiffman S (2008) Effect of nicotine lozenges on affective smoking withdrawal symptoms: secondary analysis of a randomized, double-blind, placebo-controlled clinical trial. Clin Ther 30:1461–1475.
33. Skinner HA, Allen BA (1982) Alcohol dependence syndrome: measurement and validation. J Abnorm Psychol 91:199–209.
34. Tsoh JY, Chi FW, Mertens JR, Weisner CM (2011) Stopping smoking during first year of substance use treatment predicted 9-year alcohol and drug treatment outcomes. Drug Alcohol Depend 114:110–118.
35. U.S. Department of Health & Human Services (2003) Clearing the Air: Quit Smoking Today (NIH Publication No. 03-1647). National Cancer Institute, Bethesda, MD.
36. White IR, Royston P, Wood AM (2011) Multiple imputation using chained equations: issues and guidance for practice. Stat Med 30:377–399.
37. Yong HH, Borland R, Cooper J, Cummings KM (2010) Postquitting experience and expectations of adult smokers and their association with subsequent relapse: findings from the International Tobacco Control (ITC) Four Country Survey. Nicotine Tob Res 12:S12–S19.
38. Ziedonis DM, Guydish J, Williams J, Steinberg M, Foulds J (2006) Barriers and solutions to addressing tobacco dependence in addiction treatment programs. Alcohol Res Health 29:228–235.