High incidence of Philadelphia chromosome-like acute lymphoblastic leukemia in older adults with B-ALL

Leukemia

Volumn 31, Issue 4, 2017, Pages 981-984

  Tasian, S K ^a   Hurtz, C ^b   Wertheim, G B ^a   Bailey, N G ^c   Lim, M S ^a,c   Harvey, R C ^d   Chen, I M ^d   Willman, C L ^d   Astles, R ^b   Zebrowski, A ^b   Reshmi, S C ^e   Li, M M ^f   Frey, N V ^b   Luger, S M ^b   Carroll, M ^b   Perl, A E ^b  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

^d UNIVERSITY OF NEW MEXICO SCHOOL OF MEDICINE   (United States)

^e OHIO STATE UNIVERSITY   (United States)

^f CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BCR ABL PROTEIN; CYTOKINE RECEPTOR LIKE FACTOR 2; DASATINIB; IMATINIB; JANUS KINASE 1; JANUS KINASE 2; MAMMALIAN TARGET OF RAPAMYCIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN; RUXOLITINIB; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; PROTEIN KINASE INHIBITOR; PROTEIN TYROSINE KINASE;

ACUTE LYMPHOBLASTIC LEUKEMIA; AGING; B CELL LEUKEMIA; CANCER CHEMOTHERAPY; CANCER INCIDENCE; FLOW CYTOMETRY; FLUORESCENCE IN SITU HYBRIDIZATION; GENE EXPRESSION; GENE MUTATION; GENE OVEREXPRESSION; GENE REARRANGEMENT; HUMAN; LETTER; LEUKOCYTOSIS; MICROARRAY ANALYSIS; NONHUMAN; OVERALL SURVIVAL; PHILADELPHIA 1 CHROMOSOME; POLYMERASE CHAIN REACTION; B LYMPHOCYTE; CHROMOSOME 22; GENE EXPRESSION REGULATION; GENETICS; INCIDENCE; METABOLISM; MIDDLE AGED; SIGNAL TRANSDUCTION;

ANTINEOPLASTIC AGENTS; B-LYMPHOCYTES; CHROMOSOMES, HUMAN, PAIR 22; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; INCIDENCE; MIDDLE AGED; PHILADELPHIA CHROMOSOME; PRECURSOR CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA; PROTEIN KINASE INHIBITORS; PROTEIN-TYROSINE KINASES; SIGNAL TRANSDUCTION;

EID: 85007590873     PISSN: 08876924     EISSN: 14765551     Source Type: Journal    
DOI: 10.1038/leu.2016.375     Document Type: Letter

References (15)

1. Chalandon Y, Thomas X, Hayette S, Cayuela JM, Abbal C, Huguet F et al. Randomized study of reduced-intensity chemotherapy combined with imatinib in adults with Ph-positive acute lymphoblastic leukemia. Blood 2015; 125: 3711-3719
2. Loh ML, Zhang J, Harvey RC, Roberts K, Payne-Turner D, Kang H et al. Tyrosine kinome sequencing of pediatric acute lymphoblastic leukemia: a report from the Children's Oncology Group TARGET Project. Blood 2013; 121: 485-488
3. Roberts KG, Li Y, Payne-Turner D, Harvey RC, Yang YL, Pei D et al. Targetable kinase-activating lesions in Ph-like acute lymphoblastic leukemia. N Engl J Med 2014; 371: 1005-1015
4. Den Boer ML, van Slegtenhorst M, Menezes RX, Cheok MH, Buijs-Gladdines JG, Peters ST et al. A subtype of childhood acute lymphoblastic leukaemia with poor treatment outcome: a genome-wide classification study. Lancet Oncol 2009; 10: 125-134
5. Iacobucci I, Li Y, Roberts KG, Dobson SM, Kim JC, Payne-Turner D et al. Truncating erythropoietin receptor rearrangements in acute lymphoblastic leukemia. Cancer Cell 2016; 29: 186-200
6. Mullighan CG, Su X, Zhang J, Radtke I, Phillips LA, Miller CB et al. Deletion of IKZF1 and prognosis in acute lymphoblastic leukemia. N Engl J Med 2009; 360: 470-480
7. Herold T, Schneider S, Metzeler K, Neumann M, Hartmann L, Roberts KG et al. Philadelphia chromosome-like acute lymphoblastic leukemia in adults have frequent IGH-CRLF2 and JAK2 mutations, persistence of minimal residual disease and poor prognosis. Haematologica 2016; e-pub ahead of print 25 August 2016. Available at: https://www.ncbi.nlm.nih.gov/pubmed/27561722
8. Sive JI, Buck G, Fielding A, Lazarus HM, Litzow MR, Luger S et al. Outcomes in older adults with acute lymphoblastic leukaemia (ALL): results from the international MRC UKALL XII/ECOG2993 trial. Br J Haematol 2012; 157: 463-471
9. Maude SL, Tasian SK, Vincent T, Hall JW, Sheen C, Roberts KG et al. Targeting JAK1/2 and mTOR in murine xenograft models of Ph-like acute lymphoblastic leukemia. Blood 2012; 120: 3510-3518
10. Harvey RC, Mullighan CG, Chen IM, Wharton W, Mikhail FM, Carroll AJ et al. Rearrangement of CRLF2 is associated with mutation of JAK kinases, alteration of IKZF1, Hispanic/Latino ethnicity, and a poor outcome in pediatric B-progenitor acute lymphoblastic leukemia. Blood 2010; 115: 5312-5321
11. Harvey RC, Kang H, Roberts KG, Chen IM, Atlas SR, Bedrick EJ et al. Development and Validation of a Highly Sensitive and Specific Gene Expression Classifier to Prospectively Screen and Identify B-Precursor Acute Lymphoblastic Leukemia (ALL) Patients with a Phialdelphia Chromosome-Like Signature ('Ph-like' or 'BCRABL1-Like') for Therapeutic Targeting and Clinical Intervention. Blood 2013; 123: ASH annual meeting abstract #826
12. Reshmi SC, Harvey RC, Smith A, Chen I-M, Valentine M, Liu Y et al. Frequency of actionable gene fusions in patients with Philadelphia chromosome-like (Ph-like) B-acute lymphoblastic leukemia (ALL): A retrospective study from the Children's Oncology Group (COG). Cancer Res 2015; 75: 4729. Available at: http://www.abstractsonline.com/Plan/ViewAbstract.aspx?sKey=dc74 fcdb-db29-469b-bc53-93d5cc0fa645andcKey=12af84ee-851e-47b1-b80cf57e55ab8a00&mKey=%7b19573A54-AE8F-4E00-9C23-BD6D62268424%7d
13. Tasian SK, Doral MY, Borowitz MJ, Wood BL, Chen IM, Harvey RC et al. Aberrant STAT5 and PI3K/mTOR pathway signaling occurs in human CRLF2-rearranged B-precursor acute lymphoblastic leukemia. Blood 2012; 120: 833-842
14. Tasian SK, Teachey DT, Li Y, Shen F, Harvey RC, Chen IM et al. Potent efficacy of combined PI3K/mTOR and JAK or ABL inhibition in murine xenograft models of Ph-like acute lymphoblastic leukemia. Blood; e-pub ahead of print 24 October 2016; pii: blood-2016-05-707653
15. Perez-Andreu V, Roberts KG, Harvey RC, Yang W, Cheng C, Pei D et al. Inherited GATA3 variants are associated with Ph-like childhood acute lymphoblastic leukemia and risk of relapse. Nat Genet 2013; 45: 1494-1498