Prepubertal subchronic exposure to soy milk and glyphosate leads to endocrine disruption

Food and Chemical Toxicology

Volumn 100, Issue , 2017, Pages 247-252

  Nardi, Jessica ^a   Moras, Patricia Bonamigo ^a   Koeppe, Carina ^a   Dallegrave, Eliane ^b   Leal, Mirna Bainy ^c   Rossato Grando, Luciana Grazziotin ^a  

^a UNIVERSITY OF PASSO FUNDO   (Brazil)

^b UNIVERSIDADE FEDERAL DE CIÊNCIAS DA SAÚDE DE PORTO ALEGRE   (Brazil)

^c FEDERAL UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

Author keywords

Endocrine disruption; Glyphosate; Soy milk; Testosterone levels

Indexed keywords

GLYPHOSATE; TESTOSTERONE; ENDOCRINE DISRUPTOR; GLYCINE; HERBICIDE;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL COUNT; CONTROLLED STUDY; DIETARY SUPPLEMENT; ENDOCRINE DISEASE; EPIDIDYMAL TAIL MASS; EPIDIDYMIS; EXPOSURE; FOOD INTAKE; HORMONE DETERMINATION; LEYDIG CELL; MALE; NONHUMAN; PREPUBERTY; PROSTATE; PROSTATE WEIGHT; PUBERTY; RAT; REPRODUCTIVE TOXICITY; SEMINAL VESICLE; SEMINIFEROUS TUBULE; SERTOLI CELL; SOYBEAN MILK; SPERM MORPHOLOGY; SPERMATID; SPERMATOZOON COUNT; TESTIS WEIGHT; TESTOSTERONE BLOOD LEVEL; WISTAR RAT; ANALOGS AND DERIVATIVES; ANIMAL; BLOOD; CHEMISTRY; CYTOLOGY; DRUG EFFECTS; ENDOCRINE SYSTEM; ORGAN SIZE; PHARMACOLOGY; SPERMATOZOON;

ANIMALS; ENDOCRINE DISRUPTORS; ENDOCRINE SYSTEM; GLYCINE; HERBICIDES; LEYDIG CELLS; MALE; ORGAN SIZE; PUBERTY; RATS; RATS, WISTAR; SERTOLI CELLS; SOY MILK; SPERMATOZOA; TESTOSTERONE;

EID: 85007569810     PISSN: 02786915     EISSN: 18736351     Source Type: Journal    
DOI: 10.1016/j.fct.2016.12.030     Document Type: Article

References (28)

1. Astiz, M., Alaniz, M., Marra, C., The oxidative damage and inflammation caused by pesticides are reverted by lipoic acid in rat brain. Neurochem. Int. 61 (2012), 1231–1241, 10.1016/j.neuint.2012.09.003.
2. Bohm, G.M., Genovese, M.I., Pigosso, G., Trichez, V., Rombaldi, C.V., Residues of glyphosate and aminomethylphosphonic acid and levels of isoflavones in BRS 244 RR and BRS 154 soybean. Food Sci. Technol. 28 (2008), 192–197, 10.1590/S0101-20612008000500030.
3. Caceres, S., Peña, L., Moyano, G., Martinez-Fernandez, L., Monsalve, B., Illera, M.J., Millan, P., Illera, J.C., Silvan, G., Isoflavones and their effects on the onset of puberty in male Wistar rats. Andrologia 47 (2015), 1139–1146, 10.1111/and.12394.
4. Çağlar, S., Kolankaya, D., The effect of sub-acute and sub-chronic exposure of rats to the glyphosate-based herbicide Roundup. Environ. Toxicol. Pharm. 25 (2008), 57–62, 10.1016/j.etap.2007.08.011.
5. Cattani, D., Cavalli, V.L., Rieg, C., Domingues, J.T., Dal-Cim, T., Tasca, C.I., Silva, F.R., Zamoner, A., Mechanisms underlying the neurotoxicity induced by glyphosate-based herbicide in immature rat hippocampus: involvement of glutamate excitotoxicity. Toxicology 5 (2014), 34–45, 10.1016/j.tox.2014.03.001.
6. Cavalli, V.L., Cattani, D., Rieg, C.E., Pierozan, P., Zanatta, L., Parisotto, E.B., Filho, D.W., Silva, F.R., Pessoa-Pureur, R., Zamoner, A., Roundup disrupts male reproductive functions by triggering calcium-mediated cell death in rat testis and Sertoli cells. Free Radic. Bio Med. 65 (2013), 335–346, 10.1016/j.freeradbiomed.2013.06.043.
7. Clair, E., Mesnage, R., Travert, C., Séralini, G.E., A glyphosate-based herbicide induces necrosis and apoptosis in mature rat testicular cells in vitro, and testosterone decrease at lower levels. Toxicol. in vitro 26 (2012), 269–279, 10.1016/j.tiv.2011.12.009.
8. Creasy, D.M., Evaluation of testicular toxicity in safety evaluation studies: the appropriate use of spermatogenic staging. Toxicol. Pathol. 25 (1997), 119–131.
9. Dallegrave, E., Mantese, F.D., Dalsenter, P.R., Langeloh, A., Oral acute toxicity of glyphosate in Wistar rats. Online J. Veterinary Res. 1 (2002), 29–34.
10. Dallegrave, E., Mantese, F.D., Oliveira, R.T., Andrade, A.J.M., Dalsenter, P.R., Langeloh, A., Pre-and postnatal toxicity of the commercial glyphosate formulation in Wistar rats. Arch. Toxicol. 81 (2007), 665–673, 10.1007/s00204-006-0170-5.
11. Dalsenter, P.R., Dallegrave, E., Mello, J.R.B., Langeloh, A., Oliveira, R.T., Faqi, A.S., Reproductive effects of endosulfan on male offspring of rats exposed during pregnancy and lactation. Hum. Exp. Toxicol. 18 (1999), 583–589, 10.1191/096032799678845124.
12. El-Shenavy, N.S., Oxidative stress responses of rats exposed to Roundup and its active ingredient glyphosate. Environ. Toxicol. Phar 28 (2009), 379–385, 10.1016/j.etap.2009.06.001.
13. Gasnier, C., Dumont, C., Benachour, N., Clair, E., Chagnon, M.C., Séralini, G.E., Glyphosate-based herbicides are toxic and endocrine disruptors in human cell lines. Toxicology 262 (2009), 184–191, 10.1016/j.tox.2009.06.006.
14. Guyton, A.C., Hall, J.E., Textbook of Medical Phisiology. 1988, Guanabara Koogan S.A, Rio de Janeiro.
15. Lephart, E., Setchell, K., Handa, R., Lund, T.D., Behavioral effects of endocrine-disrupting substances: phytoestrogens. ILAR J. 45 (2004), 443–454, 10.1093/ilar.45.4.443.
16. Lund, T., Lephart, E., Dietary soy phytoestrogens produce anxiolytic effects in the elevated plus-maze. Brain Res. 913 (2001), 180–184, 10.1016/S0006-8993(01)02793-7.
17. Mäkinen, O.E., Uniacke-Lowe, T., O'Mahony, J.A., Arendt, E.K., Physicochemical and acid gelation properties of commercial UHT-treated plant-based milk substitutes and lactose free bovine milk. Food Chem. 168 (2014), 630–638, 10.1016/j.foodchem.2014.07.036.
18. Mattar, R., Mazo, D.F.C., Lactose intolerance: changing paradigms due to molecular biology. Rev. Assoc. Med. Bras. 56 (2010), 230–236, 10.1590/S0104-42302010000200025.
19. Mesnage, R., Clair, E., Gress, S., Then, C., Székács, A., Séralini, G.E., Cytotoxicity on human cells of Cry1Sb and Cry1Ac Bt insecticidal toxins alone or with a glyphosate-based herbicide. J. Appl. Toxicol. 33 (2012), 695–699, 10.1002/jat.2712.
20. Napier, I.D., Simon, L., Perry, D., Cooke, P.S., Stocco, D.M., Sepehr, E., Doerge, D.R., Kemppainen, B.W., Morrison, E.E., Akingbemi, B.T., Testicular development in male rats is sensitive to a soy-based diet in the neonatal period. Biol. Reprod. 40 (2013), 1–12, 10.1095/biolreprod.113.113787.
21. O'Hara, L., Smith, L.B., Androgen receptor roles in spermatogenesis and infertility. Best. Pract. Res. Clin. Endocrinol. Metab. 29 (2015), 595–605, 10.1016/j.beem.2015.04.006.
22. OECD-Organisation for Economic Co-operation and Development, Guid. Doc. Assess. Chem. Endocr. Disrupt. 9 (2010), 260–277.
23. Pan, L., Xia, X., Feng, Y., Jiang, C., Cui, Y., Huang, Y., Exposure of juvenile rats to the phytoestrogen daidzein impairs erectile function in a dose-related manner in adulthood. J. Androl. 29 (2008), 55–62, 10.2164/jandrol.107.003392.
24. Romano, M.A., Romano, R.M., Santos, L.D., Wisniewski, P., Campos, D.A., Souza, P.B., Viau, P., Bernardi, M.M., Nunes, M.T., Oliveira, C.A., Glyphosate impairs male offspring reproductive development by disrupting gonadotropin expression. Arch. Toxicol. 86 (2012), 663–673, 10.1007/s00204-011-0788-9.
25. Romano, R.M., Romano, M.A., Moura, M.O., Oliveira, C.A., Glyphosate-roundup exposure delays puberty onset in male rats. Braz J. Vet. Res. Anim. Sci. 45 (2008), 481–487.
26. Setchell, K.D., Clerici, C., Equol: history, chemistry, and formation. J. Nutr. 140 (2010), 1355–1362, 10.3945/jn.109.119776.
27. Thongprakaisang, S., Thiantanawat, A., Rangkadilok, N., Suriyo, T., Satayavivad, J., Glyphosate induces human breast cancer cells growth via estrogen receptors. Food Chem. Toxicol. 59 (2013), 129–136, 10.1016/j.fct.2013.05.057.
28. WHO- World Health Organization, Possible developmental early effects of endocrine disrupters on child health. Endocr. disrupt. child health, 2012, 1–93.