Oral food desensitization in children with IgE-mediated cow's milk allergy: Immunological changes underlying desensitization

Allergy, Asthma and Immunology Research

Volumn 9, Issue 1, 2017, Pages 35-42

  Perezábad, Laura ^a   Reche, Marta ^b   Valbuena, Teresa ^b   López Fandiño, Rosina ^a   Molina, Elena ^a   López Expósito, Iván ^a  

^a INSTITUTE OF FOOD SCIENCE RESEARCH CIAL   (Spain)

^b HOSPITAL UNIVERSITARIO INFANTA SOFÍA   (Spain)

Author keywords

Children; Cow's milk allergy; Desensitization; Milk oral immunotherapy

Indexed keywords

BETA CASEIN; FOOD ALLERGEN; GAMMA INTERFERON; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G4; INTERLEUKIN 10; INTERLEUKIN 13; INTERLEUKIN 5; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR FOXP3; TRANSCRIPTION FACTOR GATA 3; TRANSCRIPTION FACTOR T BET; TUMOR NECROSIS FACTOR;

ARTICLE; CHILD; CLINICAL ARTICLE; CLINICAL PROTOCOL; COMPARATIVE STUDY; CONTROLLED STUDY; CYTOKINE PRODUCTION; DESENSITIZATION; FEMALE; HIGH TEMPERATURE; HUMAN; IMMUNE RESPONSE; IMMUNOGLOBULIN BLOOD LEVEL; MALE; MILK ALLERGY; ORAL IMMUNOTHERAPY; PATIENT SAFETY; PERIPHERAL BLOOD MONONUCLEAR CELL; PRESCHOOL CHILD; REGULATORY T LYMPHOCYTE; SCHOOL CHILD; TH1 CELL; TH2 CELL; THERAPY EFFECT;

EID: 85007524730     PISSN: 20927355     EISSN: 20927363     Source Type: Journal    
DOI: 10.4168/aair.2017.9.1.35     Document Type: Article

References (50)

1. Skripak JM, Matsui EC, Mudd K, Wood RA. The natural history of IgE-mediated cow's milk allergy. J Allergy Clin Immunol 2007;120: 1172-7.
2. Vanto T, Helppilä S, Juntunen-Backman K, Kalimo K, Klemola T, Korpela R, et al. Prediction of the development of tolerance to milk in children with cow's milk hypersensitivity. J Pediatr 2004;144:218-22.
3. Høst A, Halken S, Jacobsen HP, Christensen AE, Herskind AM, Plesner K. Clinical course of cow's milk protein allergy/intolerance and atopic diseases in childhood. Pediatr Allergy Immunol 2002;13 Suppl 15:23-8.
4. Santos A, Dias A, Pinheiro JA. Predictive factors for the persistence of cow's milk allergy. Pediatr Allergy Immunol 2010;21:1127-34.
5. Bock SA, Muñoz-Furlong A, Sampson HA. Fatalities due to anaphylactic reactions to foods. J Allergy Clin Immunol 2001;107:191-3.
6. Bock SA, Muñoz-Furlong A, Sampson HA. Further fatalities caused by anaphylactic reactions to food, 2001-2006. J Allergy Clin Immunol 2007;119:1016-8.
7. Lieberman JA, Sicherer SH. Quality of life in food allergy. Curr Opin Allergy Clin Immunol 2011;11:236-42.
8. Wood RA. Food-specific immunotherapy: past, present, and future. J Allergy Clin Immunol 2008;121:336-7.
9. Martorell Calatayud C, Muriel García A, Martorell Aragonés A, De La Hoz Caballer B. Safety and efficacy profile and immunological changes associated with oral immunotherapy for IgE-mediated cow's milk allergy in children: systematic review and meta-analysis. J Investig Allergol Clin Immunol 2014;24:298-307.
10. Brozek JL, Terracciano L, Hsu J, Kreis J, Compalati E, Santesso N, et al. Oral immunotherapy for IgE-mediated cow's milk allergy: a systematic review and meta-analysis. Clin Exp Allergy 2012;42:363-74.
11. Pajno GB. Oral desensitization for milk allergy in children: state of the art. Curr Opin Allergy Clin Immunol 2011;11:560-4.
12. Sopo SM, Onesimo R, Giorgio V, Fundarò C. Specific oral tolerance induction (SOTI) in pediatric age: clinical research or just routine practice? Pediatr Allergy Immunol 2010;21:e446-9.
13. Keet CA, Seopaul S, Knorr S, Narisety S, Skripak J, Wood RA. Longterm follow-up of oral immunotherapy for cow's milk allergy. J Allergy Clin Immunol 2013;132:737-739.e6.
14. Savilahti EM, Kuitunen M, Savilahti E, Mäkelä MJ. Specific antibodies in oral immunotherapy for cow's milk allergy: kinetics and prediction of clinical outcome. Int Arch Allergy Immunol 2014;164:32-9.
15. Pajno GB, Caminiti L, Salzano G, Crisafulli G, Aversa T, Messina MF, et al. Comparison between two maintenance feeding regimens after successful cow's milk oral desensitization. Pediatr Allergy Immunol 2013;24:376-81.
16. Lee JH, Kim WS, Kim H, Hahn YS. Increased cow's milk proteinspecific IgG4 levels after oral desensitization in 7-to 12-month-old infants. Ann Allergy Asthma Immunol 2013;111:523-8.
17. Skripak JM, Nash SD, Rowley H, Brereton NH, Oh S, Hamilton RG, et al. A randomized, double-blind, placebo-controlled study of milk oral immunotherapy for cow's milk allergy. J Allergy Clin Immunol 2008;122:1154-60.
18. Longo G, Barbi E, Berti I, Meneghetti R, Pittalis A, Ronfani L, et al. Specific oral tolerance induction in children with very severe cow's milk-induced reactions. J Allergy Clin Immunol 2008;121:343-7.
19. García-Ara C, Pedrosa M, Belver MT, Martín-Muñoz MF, Quirce S, Boyano-Martínez T. Efficacy and safety of oral desensitization in children with cow's milk allergy according to their serum specific IgE level. Ann Allergy Asthma Immunol 2013;110:290-4.
20. Pajno GB, Caminiti L, Ruggeri P, De Luca R, Vita D, La Rosa M, et al. Oral immunotherapy for cow's milk allergy with a weekly updosing regimen: a randomized single-blind controlled study. Ann Allergy Asthma Immunol 2010;105:376-81.
21. Bedoret D, Singh AK, Shaw V, Hoyte EG, Hamilton R, DeKruyff RH, et al. Changes in antigen-specific T-cell number and function during oral desensitization in cow's milk allergy enabled with omalizumab. Mucosal Immunol 2012;5:267-76.
22. Clark AT, Ewan PW. Food allergy in childhood. Arch Dis Child 2003;88:79-81.
23. González Jiménez D, Larrea Tamayo E, Díaz Martin JJ, Molinos Norniella C, Pérez Solis D, Menéndez Arias C, et al. Eficacia y seguridad de una pauta rush de inducción de tolerancia oral en pacientes con alergia a proteínas de leche de vaca: evolución clínica e inmunológica. An Pediatr (Barc) 2013;79:346-51.
24. Vázquez-Ortiz M, Alvaro-Lozano M, Alsina L, Garcia-Paba MB, Piquer-Gibert M, Giner-Muñoz MT, et al. Safety and predictors of adverse events during oral immunotherapy for milk allergy: severity of reaction at oral challenge, specific IgE and prick test. Clin Exp Allergy 2013;43:92-102.
25. Meglio P, Bartone E, Plantamura M, Arabito E, Giampietro PG. A protocol for oral desensitization in children with IgE-mediated cow's milk allergy. Allergy 2004;59:980-7.
26. Alonso-Lebrero E, Fuentes V, Zapatero L, Pérez-Bustamante S, Pineda F, Martinez-Molero MI. Goat's milk allergies in children following specific oral tolerance induction to cow's milk. Allergol Immunopathol (Madr) 2008;36:180-1.
27. Tripodi S, Comberiati P, Di Rienzo Businco A, Bianchi A, Bondanini F, Sargentini V, et al. Severe anaphylaxis to sheep's milk cheese in a child desensitized to cow's milk through specific oral tolerance induction. Eur Ann Allergy Clin Immunol 2013;45:56-60.
28. Rodríguez del Río P, Sánchez-García S, Escudero C, Pastor-Vargas C, Sánchez Hernández JJ, Pérez-Rangel I, et al. Allergy to goat's and sheep's milk in a population of cow's milk-allergic children treated with oral immunotherapy. Pediatr Allergy Immunol 2012;23:128-32.
29. Sánchez-García S, Rodríguez del Río P, Escudero C, García-Fernández C, Ramirez A, Ibáñez MD. Efficacy of oral immunotherapy protocol for specific oral tolerance induction in children with cow's milk allergy. Isr Med Assoc J 2012;14:43-7.
30. Zapatero L, Alonso E, Fuentes V, Martínez MI. Oral desensitization in children with cow's milk allergy. J Investig Allergol Clin Immunol 2008;18:389-96.
31. Staden U, Rolinck-Werninghaus C, Brewe F, Wahn U, Niggemann B, Beyer K. Specific oral tolerance induction in food allergy in children: efficacy and clinical patterns of reaction. Allergy 2007;62:1261-9.
32. Perezábad L, Reche M, Valbuena T, López-Fandiño R, Molina E, López-Expósito I. Clinical efficacy and immunological changes subjacent to egg oral immunotherapy. Ann Allergy Asthma Immunol 2015;114:504-9.
33. Meglio P, Giampietro PG, Carello R, Gabriele I, Avitabile S, Galli E. Oral food desensitization in children with IgE-mediated hen's egg allergy: a new protocol with raw hen's egg. Pediatr Allergy Immunol 2013;24:75-83.
34. Narisety SD, Skripak JM, Steele P, Hamilton RG, Matsui EC, Burks AW, et al. Open-label maintenance after milk oral immunotherapy for IgE-mediated cow's milk allergy. J Allergy Clin Immunol 2009; 124:610-2.
35. Wood RA, Sicherer SH, Vickery BP, Jones SM, Liu AH, Fleischer DM, et al. The natural history of milk allergy in an observational cohort. J Allergy Clin Immunol 2013;131:805-12.
36. Elizur A, Rajuan N, Goldberg MR, Leshno M, Cohen A, Katz Y. Natural course and risk factors for persistence of IgE-mediated cow's milk allergy. J Pediatr 2012;161:482-487.e1.
37. Fiocchi A, Terracciano L, Bouygue GR, Veglia F, Sarratud T, Martelli A, et al. Incremental prognostic factors associated with cow's milk allergy outcomes in infant and child referrals: the Milan Cow's Milk Allergy Cohort study. Ann Allergy Asthma Immunol 2008;101:166-73.
38. Meglio P, Giampietro PG, Gianni S, Galli E. Oral desensitization in children with immunoglobulin E-mediated cow's milk allergy-follow-up at 4 yr and 8 months. Pediatr Allergy Immunol 2008;19:412-9.
39. Savilahti EM, Rantanen V, Lin JS, Karinen S, Saarinen KM, Goldis M, et al. Early recovery from cow's milk allergy is associated with decreasing IgE and increasing IgG4 binding to cow's milk epitopes. J Allergy Clin Immunol 2010;125:1315-1321.e9.
40. Alvaro M, Giner MT, Vázquez M, Lozano J, Domínguez O, Piquer M, et al. Specific oral desensitization in children with IgE-mediated cow's milk allergy. Evolution in one year. Eur J Pediatr 2012;171: 1389-95.
41. Tsuge I, Kondo Y, Tokuda R, Kakami M, Kawamura M, Nakajima Y, et al. Allergen-specific helper T cell response in patients with cow's milk allergy: simultaneous analysis of proliferation and cytokine production by carboxyfluorescein succinimidyl ester dilution assay. Clin Exp Allergy 2006;36:1538-45.
42. Tiemessen MM, Van Ieperen-Van Dijk AG, Bruijnzeel-Koomen CA, Garssen J, Knol EF, Van Hoffen E. Cow's milk-specific T-cell reactivity of children with and without persistent cow's milk allergy: key role for IL-10. J Allergy Clin Immunol 2004;113:932-9.
43. Michaud B, Aroulandom J, Baiz N, Amat F, Gouvis-Echraghi R, Candon S, et al. Casein-specific IL-4-and IL-13-secreting T cells: a tool to implement diagnosis of cow's milk allergy. Allergy 2014;69: 1473-80.
44. Shek LP, Bardina L, Castro R, Sampson HA, Beyer K. Humoral and cellular responses to cow milk proteins in patients with milk-induced IgE-mediated and non-IgE-mediated disorders. Allergy 2005;60:912-9.
45. Sletten GB, Halvorsen R, Egaas E, Halstensen TS. Memory T cell proliferation in cow's milk allergy after CD25+ regulatory T cell removal suggests a role for casein-specific cellular immunity in IgEmediated but not in non-IgE-mediated cow's milk allergy. Int Arch Allergy Immunol 2007;142:190-8.
46. Vickery BP, Pons L, Kulis M, Steele P, Jones SM, Burks AW. Individualized IgE-based dosing of egg oral immunotherapy and the development of tolerance. Ann Allergy Asthma Immunol 2010;105: 444-50.
47. Jones SM, Pons L, Roberts JL, Scurlock AM, Perry TT, Kulis M, et al. Clinical efficacy and immune regulation with peanut oral immunotherapy. J Allergy Clin Immunol 2009;124: 292-300, 300.e1-97.
48. Akdis CA, Blesken T, Akdis M, Wüthrich B, Blaser K. Role of interleukin 10 in specific immunotherapy. J Clin Invest 1998;102:98-106.
49. Shreffler WG, Wanich N, Moloney M, Nowak-Wegrzyn A, Sampson HA. Association of allergen-specific regulatory T cells with the onset of clinical tolerance to milk protein. J Allergy Clin Immunol 2009;123:43-52.e7.
50. Varshney P, Jones SM, Scurlock AM, Perry TT, Kemper A, Steele P, et al. A randomized controlled study of peanut oral immunotherapy: clinical desensitization and modulation of the allergic response. J Allergy Clin Immunol 2011;127:654-60.