Dose-dependent effects of cisplatin on the severity of testicular injury in sprague dawley rats: Reactive oxygen species and endoplasmic reticulum stress

Drug Design, Development and Therapy

Volumn 10, Issue , 2016, Pages 3959-3968

  Soni, Kiran Kumar ^a   Kim, Hye Kyung ^b   Choi, Bo Ram ^a   Karna, Keshab Kumar ^a   You, Jae Hyung ^a   Cha, Jai Seong ^a   Shin, Yu Seob ^a   Lee, Sung Won ^c   Kim, Chul Young ^d   Park, Jong Kwan ^a  

^a Chonbuk National University Medical School   (South Korea)

^b Kyungsung University   (South Korea)

^c Samsung Medical Center   (South Korea)

^d Hanyang University   (South Korea)

Author keywords

CatSper; Cisplatin; Endoplasmic reticulum stress; Oxidative stress; StAR protein; Testicular toxicity

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR; CISPLATIN; GLUCOSE REGULATED PROTEIN 78; HEMOGLOBIN; MALONALDEHYDE; NITROGEN; REACTIVE NITROGEN SPECIES; REACTIVE OXYGEN METABOLITE; STEROIDOGENIC ACUTE REGULATORY PROTEIN; TESTOSTERONE; UREA;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; BLOOD CELL COUNT; BLOOD SAMPLING; BODY WEIGHT; CONTROLLED STUDY; DOSE RESPONSE; ENDOPLASMIC RETICULUM STRESS; EPIDIDYMIS; HEMATOCRIT; HEMATOLOGICAL PARAMETERS; HISTOPATHOLOGY; INJURY SEVERITY; KIDNEY MASS; MALE; NONHUMAN; ORGAN WEIGHT; OXIDATIVE STRESS; PROSTATE WEIGHT; RAT; SEMINAL VESICLE; SINGLE DRUG DOSE; SPERMATOZOON COUNT; SPERMATOZOON MOTILITY; TESTIS INJURY; UREA NITROGEN BLOOD LEVEL; WESTERN BLOTTING; ANIMAL; BLOOD; DRUG EFFECTS; INJURIES; METABOLISM; PATHOLOGY; SPERMATOZOON; SPRAGUE DAWLEY RAT; TESTIS;

ANIMALS; APOPTOSIS; CISPLATIN; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOPLASMIC RETICULUM STRESS; MALE; RATS; RATS, SPRAGUE-DAWLEY; REACTIVE OXYGEN SPECIES; SPERM COUNT; SPERMATOZOA; TESTIS;

EID: 85007496766     PISSN: None     EISSN: 11778881     Source Type: Journal    
DOI: 10.2147/DDDT.S120014     Document Type: Article

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