Medial prefrontal cortex stimulation accelerates therapy response of exposure therapy in acrophobia

Brain Stimulation

Volumn 10, Issue 2, 2017, Pages 291-297

  Herrmann, Martin J ^a   Katzorke, Andrea ^a   Busch, Yasmin ^a   Gromer, Daniel ^a   Polak, Thomas ^a   Pauli, Paul ^a   Deckert, Jürgen ^a  

^a UNIVERSITY OF WÜRZBURG   (Germany)

Author keywords

Acrophobia; Medial prefrontal cortex; Psychotherapy; Repetitive transcranial magnetic stimulation; Virtual reality

Indexed keywords

ACROPHOBIA; ADULT; ARTICLE; BRAIN DEPTH STIMULATION; CLINICAL ARTICLE; CONTROLLED STUDY; FEAR; FEMALE; FOLLOW UP; HUMAN; MALE; MEDIAL PREFRONTAL CORTEX; NERVE STIMULATOR; PHOBIA; PRIORITY JOURNAL; PSYCHOMETRY; RANDOMIZED CONTROLLED TRIAL; SELF REPORT; SKIN CONDUCTANCE; TREATMENT RESPONSE; VIRTUAL REALITY EXPOSURE THERAPY; ANIMAL; ANXIETY DISORDERS; CONDITIONING; DOUBLE BLIND PROCEDURE; IMPLOSIVE THERAPY; MIDDLE AGED; MULTIMODALITY CANCER THERAPY; PHOBIC DISORDERS; PHYSIOLOGY; PREFRONTAL CORTEX; PROCEDURES; PSYCHOLOGY; TRANSCRANIAL MAGNETIC STIMULATION; TREATMENT OUTCOME;

ADULT; ANIMALS; ANXIETY DISORDERS; COMBINED MODALITY THERAPY; CONDITIONING (PSYCHOLOGY); DOUBLE-BLIND METHOD; FEAR; FEMALE; HUMANS; IMPLOSIVE THERAPY; MALE; MIDDLE AGED; PHOBIC DISORDERS; PREFRONTAL CORTEX; TRANSCRANIAL MAGNETIC STIMULATION; TREATMENT OUTCOME;

EID: 85007477143     PISSN: 1935861X     EISSN: 18764754     Source Type: Journal    
DOI: 10.1016/j.brs.2016.11.007     Document Type: Article

References (48)

1. [1] Wittchen, H.U., Jacobi, F., Rehm, J., Gustavsson, A., Svensson, M., Jonsson, B., et al. The size and burden of mental disorders and other disorders of the brain in Europe 2010. European neuropsychopharmacology. J Eur Coll Neuropsychopharmacol 21:9 (2011), 655–679.
2. [2] Kessler, R.C., Angermeyer, M., Anthony, J.C., Deg, R., Demyttenaere, K., Gasquet, I., et al. Lifetime prevalence and age-of-onset distributions of mental disorders in the world health Organization's world mental health survey initiative. World psychiatry. official J World Psychiatric Assoc 6:3 (2007), 168–176.
3. [3] Gustavsson, A., Svensson, M., Jacobi, F., Allgulander, C., Alonso, J., Beghi, E., et al. Cost of disorders of the brain in Europe 2010. European neuropsychopharmacology. J Eur Coll Neuropsychopharmacol 21:10 (2011), 718–779.
4. [4] Bandelow, B., Lichte, T., Rudolf, S., Wiltink, J., Beutel, M., S3-Leitlinie angststörungen. 2015, Springer: Heidelberg.
5. [5] Gloster, A.T., Wittchen, H.U., Einsle, F., Lang, T., Helbig-Lang, S., Fydrich, T., et al. Psychological treatment for panic disorder with agoraphobia: a randomized controlled trial to examine the role of therapist-guided exposure in situ in CBT. J Consult Clin Psychol 79:3 (2011), 406–420.
6. [6] Bajbouj, M., Padberg, F., A perfect match: noninvasive brain stimulation and psychotherapy. Eur Archives Psychiatry Clin Neurosci 264:Suppl 1 (2014), 27–33.
7. [7] Vennewald, N., Diemer, J., Zwanzger, P., Repetitive transkranielle magnetstimulation (rTMS) bei angsterkrankungen—eine mögliche therapieoption? Eine systematische übersicht. = Repetitive transcranial magnetic stimulation (rTMS) for anxiety disorders—a possible therapeutic option? A systematic review. Fortschritte Neurol Psychiatr 81:10 (2013), 550–560.
8. [8] Deppermann, S., Vennewald, N., Diemer, J., Sickinger, S., Haeussinger, F.B., Notzon, S., et al. Does rTMS alter neurocognitive functioning in patients with panic disorder/agoraphobia? An fNIRS-based investigation of prefrontal activation during a cognitive task and its modulation via sham-controlled rTMS. BioMed Res Int, 2014, 2014, 542526.
9. [9] Balconi, M., Ferrari, C., Left DLPFC rTMS stimulation reduced the anxiety bias effect or how to restore the positive memory processing in high-anxiety subjects. Psychiatry Res 209:3 (2013), 554–559.
10. [10] Berlim, M.T., Van Den Eynde, F., Repetitive transcranial magnetic stimulation over the dorsolateral prefrontal cortex for treating posttraumatic stress disorder: an exploratory meta-analysis of randomized, double-blind and sham-controlled trials. Can J psychiatry Revue Can de psychiatrie 59:9 (2014), 487–496.
11. [11] Li, H., Wang, J., Li, C., Xiao, Z., Repetitive transcranial magnetic stimulation (rTMS) for panic disorder in adults. Cochrane database Syst Rev, 9, 2014 CD009083.
12. [12] Marin, M.F., Camprodon, J.A., Dougherty, D.D., Milad, M.R., Device-based brain stimulation to augment fear extinction: implications for PTSD treatment and beyond. Depress anxiety 31:4 (2014), 269–278.
13. [13] Vervliet, B., Craske, M.G., Hermans, D., Fear extinction and relapse: state of the art. Annu Rev Clin Psychol 9 (2013), 215–248.
14. [14] Baek, K., Chae, J.H., Jeong, J., The effect of repetitive transcranial magnetic stimulation on fear extinction in rats. Neuroscience 200 (2012), 159–165.
15. [15] Quirk, G.J., Mueller, D., Neural mechanisms of extinction learning and retrieval. Neuropsychopharmacol official Publ Am Coll Neuropsychopharmacol 33:1 (2008), 56–72.
16. [16] Phelps, E.A., Delgado, M.R., Nearing, K.I., LeDoux, J.E., Extinction learning in humans: role of the amygdala and vmPFC. Neuron 43:6 (2004), 897–905.
17. [17] Kalisch, R., Korenfeld, E., Stephan, K.E., Weiskopf, N., Seymour, B., Dolan, R.J., Context-dependent human extinction memory is mediated by a ventromedial prefrontal and hippocampal network. J Neurosci official J Soc Neurosci 26:37 (2006), 9503–9511.
18. [18] Guhn, A., Dresler, T., Hahn, T., Muhlberger, A., Strohle, A., Deckert, J., et al. Medial prefrontal cortex activity during the extinction of conditioned fear: an investigation using functional near-infrared spectroscopy. Neuropsychobiology 65:4 (2012), 173–182.
19. [19] Guhn, A., Dresler, T., Andreatta, M., Müller, L.D., Hahn, T., Tupak, S.V., et al. Medial prefrontal cortex stimulation modulates the processing of conditioned fear. Front Behav Neurosci, 2014, 8.
20. [20] Deppermann, S., Notzon, S., Kroczek, A., Rosenbaum, D., Haeussinger, F.B., Diemer, J., et al. Functional co-activation within the prefrontal cortex supports the maintenance of behavioural performance in fear-relevant situations before an iTBS modulated virtual reality challenge in participants with spider phobia. Behav brain Res 307 (2016), 208–217.
21. [21] Muhlberger, A., Herrmann, M.J., Wiedemann, G.C., Ellgring, H., Pauli, P., Repeated exposure of flight phobics to flights in virtual reality. Behav Res Ther 39:9 (2001), 1033–1050.
22. [22] Shiban, Y., Schelhorn, I., Pauli, P., Muhlberger, A., Effect of combined multiple contexts and multiple stimuli exposure in spider phobia: a randomized clinical trial in virtual reality. Behav Res Ther 71 (2015), 45–53.
23. [23] Ressler, K.J., Rothbaum, B.O., Tannenbaum, L., Anderson, P., Graap, K., Zimand, E., et al. Cognitive enhancers as adjuncts to psychotherapy: use of d-cycloserine in phobic individuals to facilitate extinctionof fear. Archives general psychiatry 61:11 (2004), 1136–1144.
24. [24] Rothbaum, B.O., Hodges, L.F., Kooper, R., Opdyke, D., Williford, J.S., North, M., Effectiveness of computer-generated (virtual reality) graded exposure in the treatment of acrophobia. Am J psychiatry 152:4 (1995), 626–628.
25. [25] World Medical A, World Medical Association Declaration of Helsinki: ethical principles for medical research involving human subjects. Jama 310:20 (2013), 2191–2194.
26. [26] Cohen, D.C., Comparison of self-report and overt-behavioral procedures for assessing acrophobia. Behav Ther 8:1 (1977), 17–23.
27. [27] Abelson, J.L., Curtis, G.C., Cardiac and neuroendocrine responses to exposure therapy in height phobics: desynchrony within the 'physiological response system. Behav Res Ther 27:5 (1989), 561–567.
28. [28] Spielberger, C.D., Sydeman, S.J., State-Trait Anxiety Inventory and State-Trait Anger Expression Inventory. The use of psychological testing for treatment planning and outcome assessment. 1994, Lawrence Erlbaum Associates, Inc, Hillsdale, NJ, England, 292–321 pp.
29. [29] Taylor, S., Zvolensky, M.J., Cox, B.J., Deacon, B., Heimberg, R.G., Ledley, D.R., et al. Robust dimensions of anxiety sensitivity: development and initial validation of the Anxiety Sensitivity Index-3. Psychol Assess 19:2 (2007), 176–188.
30. [30] Krohne, H.W., Egloff, B., Kohlmann, C.-W., Tausch, A., Untersuchungen mit einer deutschen Version der” Positive and Negative Affect Schedule”(PANAS). Diagnostica 42 (1996), 139–156.
31. [31] Hautzinger M, Bailer M, Hofmeister D, Keller F. Allgemeine depressionsskala (ADS). Psychiatr Prax 39(06): 302–304.
32. [32] Mühlberger, A., Kinateder, M., Brütting, J., Eder, S., Müller, M., Gromer, D., et al. Influence of information and instructions on human behavior in tunnel accidents: a virtual reality study. J Virtual Real Broadcast 12:3 (2015), 1–13.
33. [33] Morina, N., Ijntema, H., Meyerbroker, K., Emmelkamp, P.M., Can virtual reality exposure therapy gains be generalized to real-life? A meta-analysis of studies applying behavioral assessments. Behav Res Ther 74 (2015), 18–24.
34. [34] Madeira, O., Höhenangst in virtueller Realität., 2015, University of Würzburg, Würzburg Master thesis.
35. [35] Gromer, D., Madeira, O., Gast, P., Nehfischer, M., Jost, M., Müller, M., et al. Height simulation in a virtual reality CAVE system: effects of presence on fear responses. 57th conference of experimental psychologists (TeaP): hildesheim, Germany, 2015.
36. [36] Jasper, H.H., The ten twenty electrode system of the international federation. Electroencephalogr Clin neurophysiology 10 (1958), 371–375.
37. [37] Kim, S.C., Jo, Y.S., Kim, I.H., Kim, H., Choi, J.S., Lack of medial prefrontal cortex activation underlies the immediate extinction deficit. J Neurosci official J Soc Neurosci 30:3 (2010), 832–837.
38. [38] Milad, M.R., Quirk, G.J., Neurons in medial prefrontal cortex signal memory for fear extinction. Nature 420:6911 (2002), 70–74.
39. [39] Milad, M.R., Vidal-Gonzalez, I., Quirk, G.J., Electrical stimulation of medial prefrontal cortex reduces conditioned fear in a temporally specific manner. Behav Neurosci 118:2 (2004), 389–394.
40. [40] Notzon, S., Deppermann, S., Fallgatter, A., Diemer, J., Kroczek, A., Domschke, K., et al. Psychophysiological effects of an iTBS modulated virtual reality challenge including participants with spider phobia. Biol Psychol 112 (2015), 66–76.
41. [41] Quirk, G.J., Likhtik, E., Pelletier, J.G., Paré, D., Stimulation of medial prefrontal cortex decreases the responsiveness of central amygdala output neurons. J Neurosci 23:25 (2003), 8800–8807.
42. [42] Glotzbach-Schoon, E., Andreatta, M., Reif, A., Ewald, H., Troger, C., Baumann, C., et al. Contextual fear conditioning in virtual reality is affected by 5HTTLPR and NPSR1 polymorphisms: effects on fear-potentiated startle. Front Behav Neurosci, 7, 2013, 31.
43. [43] Diemer, J., Alpers, G.W., Peperkorn, H.M., Shiban, Y., Muhlberger, A., The impact of perception and presence on emotional reactions: a review of research in virtual reality. Front Psychol, 6, 2015, 26.
44. [44] Baumgartner, T., Speck, D., Wettstein, D., Masnari, O., Beeli, G., Jancke, L., Feeling present in arousing virtual reality worlds: prefrontal brain regions differentially orchestrate presence experience in adults and children. Front Hum Neurosci, 2, 2008, 8.
45. [45] Asthana, M., Nueckel, K., Muhlberger, A., Neueder, D., Polak, T., Domschke, K., et al. Effects of transcranial direct current stimulation on consolidation of fear memory. Front psychiatry, 4, 2013, 107.
46. [46] Wietschorke, K., Lippold, J., Jacob, C., Polak, T., Herrmann, M.J., Transcranial direct current stimulation of the prefrontal cortex reduces cue-reactivity in alcohol dependent patients. J Neural Transm 123:10 (2016), 1173–1178.
47. [47] Vierheilig, N., Mühlberger, A., Polak, T., Herrmann, M.J., Transcranial direct current stimulation of the prefrontal cortex increases attention to visual target stimuli. J Neural Transm 123:10 (2016), 1195–1203.
48. [48] van 't Wout, M., Mariano, T.Y., Garnaat, S.L., Reddy, M.K., Rasmussen, S.A., Greenberg, B.D., Can transcranial direct current stimulation augment extinction of conditioned fear?. Brain Stimul 9:7 (2016), 529–536.