Obesity and hyperglycemia in Korean men with klinefelter syndrome: The Korean endocrine society registry

Endocrinology and Metabolism

Volumn 31, Issue 4, 2016, Pages 598-603

  Han, Seung Jin ^a   Kim, Kyung Soo ^b   Kim, Wonjin ^b   Kim, Jung Hee ^c   Lee, Yong Ho ^d   Nam, Ji Sun ^e   Seo, Ji A ^f   Kim, Bu Kyung ^g   Lee, Jihyun ^h   Chung, Jin Ook ⁱ   Kim, Min Hee ^j   Sohn, Tae Seo ^j   Choi, Han Seok ^k   Hong, Seong Bin ^l   Chung, Yoon Sok ^a  

^a Ajou University School of Medicine   (South Korea)

^b CHA University   (South Korea)

^c Seoul National University College of Medicine   (South Korea)

^d Yonsei University College of Medicine   (South Korea)

^e Yonsei University College of Medicine   (South Korea)

^f Korea University College of Medicine   (South Korea)

^g Kosin University College of Medicine   (South Korea)

^h Catholic University of Daegu   (South Korea)

ⁱ Chonnam National University Medical School   (South Korea)

^j The Catholic University of Korea   (South Korea)

^k Dongguk University Ilsan Hospital   (South Korea)

^l Inha University School of Medicine   (South Korea)

more..

Author keywords

Hyperglycemia; Klinefelter syndrome; Obesity

Indexed keywords

FOLLITROPIN; GLUCOSE; LUTEINIZING HORMONE; TESTOSTERONE;

ADULT; ARTICLE; CHROMOSOME ABERRATION; DISEASE REGISTRY; FOLLITROPIN BLOOD LEVEL; GLUCOSE BLOOD LEVEL; GYNECOMASTIA; HUMAN; HYPERGLYCEMIA; KARYOTYPE 47,XXY; KARYOTYPING; KLINEFELTER SYNDROME; KOREAN (PEOPLE); LUTEINIZING HORMONE BLOOD LEVEL; MAJOR CLINICAL STUDY; MALE; MALE INFERTILITY; MALE SEXUAL DYSFUNCTION; MEDICAL RECORD REVIEW; OBESITY; PREVALENCE; RETROSPECTIVE STUDY; RISK FACTOR; TESTIS SIZE; TESTOSTERONE BLOOD LEVEL;

EID: 85007448380     PISSN: 2093596X     EISSN: 20935978     Source Type: Journal    
DOI: 10.3803/EnM.2016.31.4.598     Document Type: Article

References (27)

1. Lanfranco F, Kamischke A, Zitzmann M, Nieschlag E. Klinefelter's syndrome. Lancet 2004;364:273-83.
2. Visootsak J, Aylstock M, Graham JM Jr. Klinefelter syndrome and its variants: an update and review for the primary pediatrician. Clin Pediatr (Phila) 2001;40:639-51.
3. Smyth CM, Bremner WJ. Klinefelter syndrome. Arch Intern Med 1998;158:1309-14.
4. Gravholt CH, Jensen AS, Host C, Bojesen A. Body composition, metabolic syndrome and type 2 diabetes in Klinefelter syndrome. Acta Paediatr 2011;100:871-7.
5. Bojesen A, Juul S, Birkebaek NH, Gravholt CH. Morbidity in Klinefelter syndrome: a Danish register study based on hospital discharge diagnoses. J Clin Endocrinol Metab 2006; 91:1254-60.
6. Bird RJ, Hurren BJ. Anatomical and clinical aspects of Klinefelter's syndrome. Clin Anat 2016;29:606-19.
7. Groth KA, Skakkebaek A, Host C, Gravholt CH, Bojesen A. Clinical review: Klinefelter syndrome: a clinical update. J Clin Endocrinol Metab 2013;98:20-30.
8. Bojesen A, Kristensen K, Birkebaek NH, Fedder J, Mosekilde L, Bennett P, et al. The metabolic syndrome is frequent in Klinefelter's syndrome and is associated with abdominal obesity and hypogonadism. Diabetes Care 2006;29:1591-8.
9. Ishikawa T, Yamaguchi K, Kondo Y, Takenaka A, Fujisawa M. Metabolic syndrome in men with Klinefelter's syndrome. Urology 2008;71:1109-13.
10. Lee KW, Cha CK, Uhm C, Kwon OY, Lee SK, Chung YS, et al. Impaired glucose tolerance associated with klinefalter syndrome. J Korean Soc Endocrinol 1998;13:495-500.
11. Yoon JY, Hong SM, Park YS, Kim DS, Choi WH, Kim TW, et al. A case of diabetes mellitus associated with Klinefelter's syndrome. Korean J Med 2010;79:701-4.
12. Kim Y, Kim WJ, Huh JH, Lee S, Kim D, Hong JW, et al. A 47, X, +t(X;X)(p22.3;p22.3)del(X)(p11.23q11.2), Y Klinefelter variant with morbid obesity. Yonsei Med J 2013;54:538-40.
13. Lim SH, Bae WH, Kim SJ, Lee YH, Jun IP, Kim SH, et al. Diabetes mellitus in association with Klinefelter syndrome. J Korean Soc Endocrinol 1994;9:46-9.
14. WHO West Pacific Region. The Asia-Pacific perspective: redefining obesity and its treatment. Balmain: Health Communications Australia; 2000
15. American Diabetes Association. Standards of medical care in diabetes: 2010. Diabetes Care 2010;33 Suppl 1:S11-61.
16. Lee SY, Park HS, Kim DJ, Han JH, Kim SM, Cho GJ, et al. Appropriate waist circumference cutoff points for central obesity in Korean adults. Diabetes Res Clin Pract 2007;75: 72-80.
17. Roh E, Ko SH, Kwon HS, Kim NH, Kim JH, Kim CS, et al. Prevalence and management of dyslipidemia in Korea: Korea National Health and Nutrition Examination Survey during 1998 to 2010. Diabetes Metab J 2013;37:433-49.
18. Statistics Korea. Prevalence of obesity [Internet]. Daejeon: Statistics Korea; 2016 [cited 2016 Nov 8]. Available from: http://www.index.go.kr/potal/main/EachDtlPageDetail. do?idx_cd=2705.
19. Pacenza N, Pasqualini T, Gottlieb S, Knoblovits P, Costanzo PR, Stewart Usher J, et al. Clinical presentation of Klinefelter's syndrome: differences according to age. Int J Endocrinol 2012;2012:324835.
20. van den Bergh JP, Hermus AR, Spruyt AI, Sweep CG, Corstens FH, Smals AG. Bone mineral density and quantitative ultrasound parameters in patients with Klinefelter's syndrome after long-term testosterone substitution. Osteoporos Int 2001;12:55-62.
21. Marin P, Holmang S, Jonsson L, Sjostrom L, Kvist H, Holm G, et al. The effects of testosterone treatment on body composition and metabolism in middle-aged obese men. Int J Obes Relat Metab Disord 1992;16:991-7.
22. Aksglaede L, Molgaard C, Skakkebaek NE, Juul A. Normal bone mineral content but unfavourable muscle/fat ratio in Klinefelter syndrome. Arch Dis Child 2008;93:30-4.
23. Pei D, Sheu WH, Jeng CY, Liao WK, Fuh MM. Insulin resistance in patients with Klinefelter's syndrome and idiopathic gonadotropin deficiency. J Formos Med Assoc 1998; 97:534-40.
24. Kim CS, Ko SH, Kwon HS, Kim NH, Kim JH, Lim S, et al. Prevalence, awareness, and management of obesity in Korea: data from the Korea National Health and Nutrition Examination Survey (1998-2011). Diabetes Metab J 2014;38:35-43.
25. Abdel-Razic MM, Abdel-Hamid IA, Elsobky E, El-Dahtory F. Further evidence of the clinical, hormonal, and genetic heterogeneity of Klinefelter syndrome: a study of 216 infertile Egyptian patients. J Androl 2012;33:441-8.
26. Bojesen A, Juul S, Gravholt CH. Prenatal and postnatal prevalence of Klinefelter syndrome: a national registry study. J Clin Endocrinol Metab 2003;88:622-6.
27. Abramsky L, Chapple J. 47, XXY (Klinefelter syndrome) and 47, XYY: estimated rates of and indication for postnatal diagnosis with implications for prenatal counselling. Prenat Diagn 1997;17:363-8.