메뉴 건너뛰기




Volumn 86, Issue , 2017, Pages 562-569

Modulation of the lipid profile and insulin levels of streptozotocin induced diabetic rats by ethanol extract of Cnidoscolus aconitifolius leaves and some fractions: Effect on the oral glucose tolerance of normoglycemic rats

Author keywords

Cnidoscolus aconitifolius; Diabetes; Glucose tolerance; Herbal medicine

Indexed keywords

ANTIDIABETIC AGENT; CNIDOSCOLUS ACONITIFOLIUS EXTRACT; GLIBENCLAMIDE; GLUCOSE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN CHOLESTEROL; PLANT EXTRACT; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; VERY LOW DENSITY LIPOPROTEIN CHOLESTEROL; ALCOHOL; GLUCOSE BLOOD LEVEL; INSULIN; LIPID; STREPTOZOCIN;

EID: 85007247333     PISSN: 07533322     EISSN: 19506007     Source Type: Journal    
DOI: 10.1016/j.biopha.2016.11.133     Document Type: Article
Times cited : (36)

References (30)
  • 1
    • 84863393610 scopus 로고    scopus 로고
    • Diabetes mellitus: an overview on its pharmacological aspects and reported medicinal plants having antidiabetic activity
    • [1] Patel, D.K., Kumar, R., Laloo, D., Hemalatha, S., Diabetes mellitus: an overview on its pharmacological aspects and reported medicinal plants having antidiabetic activity. Asia. Pac. J. Trop. Biomed. 2 (2012), 411–420.
    • (2012) Asia. Pac. J. Trop. Biomed. , vol.2 , pp. 411-420
    • Patel, D.K.1    Kumar, R.2    Laloo, D.3    Hemalatha, S.4
  • 2
    • 84901808296 scopus 로고    scopus 로고
    • The global implications of diabetes and cancer
    • [2] Yuankai, S., Frank, B., The global implications of diabetes and cancer. Lancet 383 (2014), 1947–1948.
    • (2014) Lancet , vol.383 , pp. 1947-1948
    • Yuankai, S.1    Frank, B.2
  • 3
    • 84922802493 scopus 로고    scopus 로고
    • Effect of livingstonepotato (Plectranthus esculentus N.E.Br) on hyperglycemia, antioxidant activity and lipid metabolism of streptozotocin induced diabetic rats
    • [3] Eleazu, C.O., Eleazu, K.C., Chukwuma, S.C., Okoronkwo, J., Emelike, C.U., Effect of livingstonepotato (Plectranthus esculentus N.E.Br) on hyperglycemia, antioxidant activity and lipid metabolism of streptozotocin induced diabetic rats. Toxicol. Rep. 1 (2014), 674–681.
    • (2014) Toxicol. Rep. , vol.1 , pp. 674-681
    • Eleazu, C.O.1    Eleazu, K.C.2    Chukwuma, S.C.3    Okoronkwo, J.4    Emelike, C.U.5
  • 4
    • 85007266961 scopus 로고    scopus 로고
    • Textbook of Biochemistry for Medical Students. 7th Ed. (2013) 335–338.
    • [4] S.S. Vasudevan, S.K.V. Seekumari, Textbook of Biochemistry for Medical Students. 7th Ed. (2013) 335–338.
    • Vasudevan, S.S.1    Seekumari, S.K.V.2
  • 5
    • 84882268810 scopus 로고    scopus 로고
    • Synergistic postprandial blood glucose modulatory properties of Vernonia amygdalina (Del.), Gongronema latifolium (Benth.) and Occimum gratissimum (Linn.) aqueous decoctions
    • [5] Ejike, E.C.C.C., Awazie, S.O., Nwangozi, P.A., Godwin, C.D., Synergistic postprandial blood glucose modulatory properties of Vernonia amygdalina (Del.), Gongronema latifolium (Benth.) and Occimum gratissimum (Linn.) aqueous decoctions. J. Ethnopharmacol. 149 (2013), 111–116.
    • (2013) J. Ethnopharmacol. , vol.149 , pp. 111-116
    • Ejike, E.C.C.C.1    Awazie, S.O.2    Nwangozi, P.A.3    Godwin, C.D.4
  • 6
    • 85007266965 scopus 로고    scopus 로고
    • World Health Organization (WHO). WHO experts committee on diabetic mellitus: Second report. WHO, Geneva (1980), Pg. 646, Technical Report Series.
    • [6] World Health Organization (WHO). WHO experts committee on diabetic mellitus: Second report. WHO, Geneva (1980), Pg. 646, Technical Report Series.
  • 7
    • 85007266957 scopus 로고    scopus 로고
    • Antidiabetic potential of the aqueous leaf extract of Cnidoscolus aconitifolius on streptozotocin Induced Diabetes in Wistar rat hepatocytes
    • [7] Mordi, J.C., Antidiabetic potential of the aqueous leaf extract of Cnidoscolus aconitifolius on streptozotocin Induced Diabetes in Wistar rat hepatocytes. Curr. Res. J. Biol. Sci. 4 (2012), 164–167.
    • (2012) Curr. Res. J. Biol. Sci. , vol.4 , pp. 164-167
    • Mordi, J.C.1
  • 8
    • 78650768936 scopus 로고    scopus 로고
    • Ameliorative effects of Cnidoscolus aconitifolius on alloxan toxicity in Wistar rats
    • [8] Azeez, O.I., Oyagbemi, A.A., Oyeyemi, M.O., Odetola, A.A., Ameliorative effects of Cnidoscolus aconitifolius on alloxan toxicity in Wistar rats. Afr. Health Sci. 10 (2010), 283–291.
    • (2010) Afr. Health Sci. , vol.10 , pp. 283-291
    • Azeez, O.I.1    Oyagbemi, A.A.2    Oyeyemi, M.O.3    Odetola, A.A.4
  • 9
    • 85007164877 scopus 로고    scopus 로고
    • Effect of Cnidoscolus aconitifolius (Family Euphorbiaceae) aqueous leaf extract on some antioxidant enzymes and haematological parameters of high fat diet and streptozotocin induced diabetic Wistar albino rats
    • [9] Obichi, E.A., Monago, C.C., Belonwu, D.C., Effect of Cnidoscolus aconitifolius (Family Euphorbiaceae) aqueous leaf extract on some antioxidant enzymes and haematological parameters of high fat diet and streptozotocin induced diabetic Wistar albino rats. J. Appl. Sci. Environ. Managt. 19 (2015), 201–209.
    • (2015) J. Appl. Sci. Environ. Managt. , vol.19 , pp. 201-209
    • Obichi, E.A.1    Monago, C.C.2    Belonwu, D.C.3
  • 10
    • 0013159661 scopus 로고    scopus 로고
    • Potential nutritional and health benefits of the spinach
    • J. Jarick ASHS Press Arlington, VA
    • [10] Kuti, J.O., Torres, E.S., Potential nutritional and health benefits of the spinach. Jarick, J., (eds.) Progress in New Crops, 1996, ASHS Press, Arlington, VA, 516–520.
    • (1996) Progress in New Crops , pp. 516-520
    • Kuti, J.O.1    Torres, E.S.2
  • 11
    • 0033557955 scopus 로고    scopus 로고
    • The nutritive values of chaya leaf meal (Cnidoscolus aconitifolius) studies with broilers chickens
    • [11] Atuahene, C.C., Poku-Prempeh, B., Twun, G., The nutritive values of chaya leaf meal (Cnidoscolus aconitifolius) studies with broilers chickens. Anim. Feed Sci. Technol. 77 (1999), 163–172.
    • (1999) Anim. Feed Sci. Technol. , vol.77 , pp. 163-172
    • Atuahene, C.C.1    Poku-Prempeh, B.2    Twun, G.3
  • 12
    • 84945946128 scopus 로고    scopus 로고
    • GC–MS determination of bioactive constituents of the methanol fractions of Cnidoscolus aconitifolius
    • [12] Achi, N.K., Ohaeri, O.C., GC–MS determination of bioactive constituents of the methanol fractions of Cnidoscolus aconitifolius. Brit. J. Pharm. Res. 5 (2015), 163–172.
    • (2015) Brit. J. Pharm. Res. , vol.5 , pp. 163-172
    • Achi, N.K.1    Ohaeri, O.C.2
  • 13
    • 0003633755 scopus 로고
    • Guide for the Care and Use of Laboratory Animals
    • National Institute of Health Bethesda, MD
    • [13] National Research Council (NRC), Guide for the Care and Use of Laboratory Animals. 1985, National Institute of Health, Bethesda, MD, 8523.
    • (1985) , pp. 8523
    • National Research Council1
  • 14
    • 0021048099 scopus 로고
    • A new approach to practical acute toxicity testing
    • [14] Lorke, D.A., A new approach to practical acute toxicity testing. Arch. Toxicol. 54 (1983), 275–287.
    • (1983) Arch. Toxicol. , vol.54 , pp. 275-287
    • Lorke, D.A.1
  • 15
    • 0034907655 scopus 로고    scopus 로고
    • Effect of garlic oil on the levels of various enzymes in the serum and tissue of streptozotocin induced diabetic rats
    • [15] Ohaeri, O.C., Effect of garlic oil on the levels of various enzymes in the serum and tissue of streptozotocin induced diabetic rats. Bio. Sci. Rep. 2 (2001), 19–24.
    • (2001) Bio. Sci. Rep. , vol.2 , pp. 19-24
    • Ohaeri, O.C.1
  • 16
    • 77953208585 scopus 로고    scopus 로고
    • Acute and sub-acute toxicity of Amalakyyadi churna
    • [16] Uma, R.B., Acute and sub-acute toxicity of Amalakyyadi churna. Pharmacology 1 (2010), 625–633.
    • (2010) Pharmacology , vol.1 , pp. 625-633
    • Uma, R.B.1
  • 17
    • 84922787342 scopus 로고    scopus 로고
    • Chemical composition of mistletoe extract (Loranthus micranthus) and its effect on protein: lipid metabolism and the antioxidant status of alloxan induced diabetic rats
    • [17] Ononogbu, C., Ohaeri, O.C., Eleazu, C.O., Eleazu, K.C., Chemical composition of mistletoe extract (Loranthus micranthus) and its effect on protein: lipid metabolism and the antioxidant status of alloxan induced diabetic rats. J. Med. Res. 1 (2012), 057–062.
    • (2012) J. Med. Res. , vol.1 , pp. 057-062
    • Ononogbu, C.1    Ohaeri, O.C.2    Eleazu, C.O.3    Eleazu, K.C.4
  • 18
    • 0036381740 scopus 로고    scopus 로고
    • Transdermal delivery of insulin from a novel biphasic lipid system in diabetic rats
    • [18] King, M.J., Badea, I., Solomon, J., Kumar, P., Gaspar, K.J., Foldvari, M., Transdermal delivery of insulin from a novel biphasic lipid system in diabetic rats. Diab. Technol. Ther. 4 (2002), 479–488.
    • (2002) Diab. Technol. Ther. , vol.4 , pp. 479-488
    • King, M.J.1    Badea, I.2    Solomon, J.3    Kumar, P.4    Gaspar, K.J.5    Foldvari, M.6
  • 19
    • 0003974503 scopus 로고
    • Clinical Guide to Laboratory Tests
    • third ed. WB Saunders Company Philadelphia, PA
    • [19] Tietz, N.W., Clinical Guide to Laboratory Tests. third ed., 1995, WB Saunders Company, Philadelphia, PA, 518–519.
    • (1995) , pp. 518-519
    • Tietz, N.W.1
  • 21
    • 0015348189 scopus 로고
    • Estimation of the concentration of low density lipoprotein cholesterol in plasma: with-out use of the preparative ultracentrifuge
    • [21] Friedewald, W.T., Levy, R.I., Fredrickson, D.S., Estimation of the concentration of low density lipoprotein cholesterol in plasma: with-out use of the preparative ultracentrifuge. Clin. Chem. 18 (1972), 499–505.
    • (1972) Clin. Chem. , vol.18 , pp. 499-505
    • Friedewald, W.T.1    Levy, R.I.2    Fredrickson, D.S.3
  • 22
    • 0003869136 scopus 로고
    • Handbook of Histopathological and Histochemical Techniques
    • 3rd edition Redwood: Bun Ltd. Trowbridge, Esher
    • [22] Dunn, W.L., Handbook of Histopathological and Histochemical Techniques. 3rd edition, 1974, Redwood: Bun Ltd., Trowbridge, Esher.
    • (1974)
    • Dunn, W.L.1
  • 23
    • 84984972962 scopus 로고    scopus 로고
    • Effect of kolaviron: a biflavanoid complex from Garcinia kola on some biochemical parameters in experimentally induced benign prostatic hyperplasic rats
    • [23] Kalu, W.O., Okafor, P.N., Ijeh, I.I., Eleazu, C., Effect of kolaviron: a biflavanoid complex from Garcinia kola on some biochemical parameters in experimentally induced benign prostatic hyperplasic rats. Biomed. Pharmacother. 83 (2016), 1436–1443.
    • (2016) Biomed. Pharmacother. , vol.83 , pp. 1436-1443
    • Kalu, W.O.1    Okafor, P.N.2    Ijeh, I.I.3    Eleazu, C.4
  • 24
    • 84860463899 scopus 로고    scopus 로고
    • Metabolomic analysis of rat serum in streptozotocin-induced diabetes and after treatment with oral triethylenetetramine (TETA)
    • [24] Ugarte, M., Brown, M., Hollywood, K.A., Cooper, G.J., Bishop, P.N., Dunn, W.B., Metabolomic analysis of rat serum in streptozotocin-induced diabetes and after treatment with oral triethylenetetramine (TETA). Genome Med., 4, 2012, 35.
    • (2012) Genome Med. , vol.4 , pp. 35
    • Ugarte, M.1    Brown, M.2    Hollywood, K.A.3    Cooper, G.J.4    Bishop, P.N.5    Dunn, W.B.6
  • 26
    • 84908525157 scopus 로고    scopus 로고
    • Maniple Manuel of Clinical Biochemistry
    • Jaypee Brothers, Medical Publishers Pvt. Limited (300 pages)
    • [26] Shivananda, B.N., Shivananda, N.B., Maniple Manuel of Clinical Biochemistry. 2007, Jaypee Brothers, Medical Publishers Pvt. Limited (300 pages).
    • (2007)
    • Shivananda, B.N.1    Shivananda, N.B.2
  • 27
    • 84942983661 scopus 로고    scopus 로고
    • Effect of aqueous and alcoholic extract of Sesbania sesban (Linn) Merr root on glycemic control in streptozotocin-induced diabetic mice
    • [27] Choudhary, M., Aggarwal, N., Choudhary, N., Gupta, P., Budhwar, V., Effect of aqueous and alcoholic extract of Sesbania sesban (Linn) Merr root on glycemic control in streptozotocin-induced diabetic mice. Drug Dev Ther. 5 (2014), 115–122.
    • (2014) Drug Dev Ther. , vol.5 , pp. 115-122
    • Choudhary, M.1    Aggarwal, N.2    Choudhary, N.3    Gupta, P.4    Budhwar, V.5
  • 28
    • 79960995779 scopus 로고    scopus 로고
    • Anti-hyperglycemic and antioxidant activities of alcoholic extract of Commiphora mukul gum resin in streptozotocin induced diabetic rats
    • [28] Ramesh, B., Karuna, R., Sreenivasa, R., Anti-hyperglycemic and antioxidant activities of alcoholic extract of Commiphora mukul gum resin in streptozotocin induced diabetic rats. Pathophysiology 18 (2011), 255–261.
    • (2011) Pathophysiology , vol.18 , pp. 255-261
    • Ramesh, B.1    Karuna, R.2    Sreenivasa, R.3
  • 29
    • 84908501999 scopus 로고    scopus 로고
    • Biochemical basis of the use of cocoyam (Colocassia esculenta L.) in the dietary management of diabetes and its complications in streptozotocin induced diabetes in rats
    • [29] Eleazu, C.O., Okafor, P.N., Ijeh, I., Biochemical basis of the use of cocoyam (Colocassia esculenta L.) in the dietary management of diabetes and its complications in streptozotocin induced diabetes in rats. Asia. Pac. J. Trop. Dis. 4 (2014), S705–S711.
    • (2014) Asia. Pac. J. Trop. Dis. , vol.4 , pp. S705-S711
    • Eleazu, C.O.1    Okafor, P.N.2    Ijeh, I.3
  • 30
    • 84882620252 scopus 로고    scopus 로고
    • Efficacy of Evolvulus alsinoides (L.) on insulin and antioxidants activity in pancreas of streptozotocin induced diabetic rats
    • [30] Gomathi, D., Ravikumar, G., Kalaiselvi, M., Devaki, K., Uma, C., Efficacy of Evolvulus alsinoides (L.) on insulin and antioxidants activity in pancreas of streptozotocin induced diabetic rats. J. Diab. Metab. Dis., 12, 2013, 39.
    • (2013) J. Diab. Metab. Dis. , vol.12 , pp. 39
    • Gomathi, D.1    Ravikumar, G.2    Kalaiselvi, M.3    Devaki, K.4    Uma, C.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.