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Angewandte Chemie - International Edition

Volumn 56, Issue 3, 2017, Pages 733-737

Orthogonal Cysteine Protection Enables Homogeneous Multi-Drug Antibody–Drug Conjugates

(7) Levengood, Matthew R a Zhang, Xinqun a Hunter, Joshua H a Emmerton, Kim K a Miyamoto, Jamie B a Lewis, Timothy S a Senter, Peter D a

a SEATTLE GENETICS INC (United States)

Author keywords

antibodies; bioconjugate; cancer; cysteine; drug delivery

Indexed keywords

AMINO ACIDS; ANTIBODIES; CELL CULTURE; DISEASES; DRUG DELIVERY; TARGETED DRUG DELIVERY;

ANTICANCER ACTIVITIES; BIOCONJUGATES; CANCER; CYSTEINE; CYSTEINE RESIDUES; HIGH DRUG LOADINGS; PHYSIO-CHEMICAL PROPERTIES; PROTEIN MODIFICATIONS;

CONTROLLED DRUG DELIVERY;

AMINOBENZOIC ACID DERIVATIVE; ANTIBODY CONJUGATE; ANTINEOPLASTIC AGENT; AURISTATIN; CYSTEINE; MONOCLONAL ANTIBODY; OLIGOPEPTIDE;

CHEMISTRY; CONFORMATION; DRUG DELIVERY SYSTEM;

AMINOBENZOATES; ANTIBODIES, MONOCLONAL; ANTINEOPLASTIC AGENTS; CYSTEINE; DRUG DELIVERY SYSTEMS; IMMUNOCONJUGATES; MOLECULAR CONFORMATION; OLIGOPEPTIDES;

EID: 85007190279 PISSN: 14337851 EISSN: 15213773 Source Type: Journal
DOI: 10.1002/anie.201608292 Document Type: Article

Times cited : (95)

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