Shortened antimicrobial treatment for acute Otitis media in young children

New England Journal of Medicine

Volumn 375, Issue 25, 2016, Pages 2446-2456

  Hoberman, Alejandro ^a   Paradise, Jack L ^a   Rockette, Howard E ^b   Kearney, Diana H ^a   Bhatnagar, Sonika ^a   Shope, Timothy R ^a   Martin, Judith M ^a   Kurs Lasky, Marcia ^a   Copelli, Susan J ^a   Colborn, D Kathleen ^a   Block, Stan L ^d   Labella, John J ^c   Lynch, Thomas G ^c   Cohen, Norman L ^c   Haralam, MaryAnn ^a   Pope, Marcia A ^a   Nagg, Jennifer P ^a   Green, Michael D ^a   Shaikh, Nader ^a  

^a CHILDREN S HOSPITAL OF PITTSBURGH   (United States)

^b UNIVERSITY OF PITTSBURGH GRADUATE SCHOOL OF PUBLIC HEALTH   (United States)

^c Children's Community Pediatrics   (United States)

^d Kentucky Pediatric Research Institute   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMOXICILLIN PLUS CLAVULANIC ACID; ANTIFUNGAL AGENT; PENICILLIN DERIVATIVE; PLACEBO; PNEUMOCOCCUS VACCINE; ANTIINFECTIVE AGENT;

ACUTE OTITIS MEDIA; ANTIBIOTIC SENSITIVITY; ANTIMICROBIAL THERAPY; ARTICLE; BACTERIAL COLONIZATION; CHILD; CLINICAL FEATURE; CONTROLLED STUDY; DERMATITIS; DIAPER DERMATITIS; DIARRHEA; DISEASE SEVERITY; DRUG TREATMENT FAILURE; FEMALE; HAEMOPHILUS INFLUENZAE; HUMAN; MAJOR CLINICAL STUDY; MALE; NASOPHARYNX; NONHUMAN; OUTCOME ASSESSMENT; PNEUMOCOCCAL INFECTION; PRESCHOOL CHILD; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RECURRENT INFECTION; SCORING SYSTEM; STREPTOCOCCUS PNEUMONIAE; SYMPTOM; TREATMENT DURATION; TREATMENT RESPONSE; ACUTE DISEASE; ANTIBIOTIC RESISTANCE; CLINICAL TRIAL; DRUG ADMINISTRATION; INFANT; ISOLATION AND PURIFICATION; MICROBIOLOGY; MULTICENTER STUDY; OTITIS MEDIA; PROGNOSIS; TREATMENT FAILURE;

ACUTE DISEASE; AMOXICILLIN-POTASSIUM CLAVULANATE COMBINATION; ANTI-INFECTIVE AGENTS; DRUG ADMINISTRATION SCHEDULE; DRUG RESISTANCE, BACTERIAL; FEMALE; HAEMOPHILUS INFLUENZAE; HUMANS; INFANT; MALE; NASOPHARYNX; OTITIS MEDIA; PROGNOSIS; STREPTOCOCCUS PNEUMONIAE; TREATMENT FAILURE;

EID: 85007079700     PISSN: 00284793     EISSN: 15334406     Source Type: Journal    
DOI: 10.1056/NEJMoa1606043     Document Type: Article

References (15)

1. Schappert SM, Rechtsteiner EA. Ambulatory medical care utilization estimates for 2007. Vital Health Stat 13 2011;1-38.
2. Finkelstein JA, Metlay JP, Davis RL, Rifas-Shiman SL, Dowell SF, Platt R. Antimicrobial use in defined populations of infants and young children. Arch Pediatr Adolesc Med 2000;154:395-400.
3. Lieberthal AS, Carroll AE, Chonmaitree T, et al. The diagnosis and management of acute otitis media. Pediatrics 2013; 131(3):e964-99.
4. Hoberman A, Paradise JL, Rockette HE, et al. Treatment of acute otitis media in children under 2 years of age. N Engl J Med 2011;364:105-15.
5. Tähtinen PA, Laine MK, Huovinen P, Jalava J, Ruuskanen O, Ruohola A. A placebo-controlled trial of antimicrobial treatment for acute otitis media. N Engl J Med 2011;364:116-26.
6. Kozyrskyj A, Klassen TP, Moffatt M, Harvey K. Short-course antibiotics for acute otitis media. Cochrane Database Syst Rev 2010;9:CD001095.
7. Dagan R, McCracken GH Jr. Flaws in design and conduct of clinical trials in acute otitis media. Pediatr Infect Dis J 2002;21:894-902.
8. Shaikh N, Hoberman A, Paradise JL, et al. Responsiveness and construct validity of a symptom scale for acute otitis media. Pediatr Infect Dis J 2009;28:9-12.
9. Shaikh N, Hoberman A, Paradise JL, et al. Development and preliminary evaluation of a parent-reported outcome instrument for clinical trials in acute otitis media. Pediatr Infect Dis J 2009;28:5-8.
10. Kaleida PH, Stool SE. Assessment of otoscopists' accuracy regarding middleear effusion: otoscopic validation. Am J Dis Child 1992;146:433-5.
11. Kaleida PH, Ploof DL, Kurs-Lasky M, et al. Mastering diagnostic skills: Enhancing Proficiency in Otitis Media, a model for diagnostic skills training. Pediatrics 2009;124(4):e714-20.
12. Shaikh N, Rockette HE, Hoberman A, Kurs-Lasky M, Paradise JL. Determination of the minimal important difference for the Acute Otitis Media Severity of Symptom scale. Pediatr Infect Dis J 2015;34(3): e41-3.
13. Lipsitch M. Measuring and interpreting associations between antibiotic use and penicillin resistance in Streptococcus pneumoniae. Clin Infect Dis 2001;32:1044-54.
14. Paradise JL, Rockette HE, Colborn DK, et al. Otitis media in 2253 Pittsburgharea infants: prevalence and risk factors during the first two years of life. Pediatrics 1997;?99:?318-33.
15. Schumi J, Wittes JT. Through the looking glass: understanding non-inferiority. Trials 2011;12:106.