Lung cancer, genetic predisposition and smoking: The Nordic Twin Study of Cancer

Thorax

Volumn 72, Issue 11, 2017, Pages 1021-1027

  Hjelmborg, Jacob ^a   Korhonen, Tellervo ^b,c,d   Holst, Klaus ^e   Skytthe, Axel ^a   Pukkala, Eero ^f,g   Kutschke, Julia ^b   Harris, Jennifer R ^b   Mucci, Lorelei A ^h,i,j   Christensen, Kaare ^a   Czene, Kamila ^k   Adami, Hans Olov ^j,k   Scheike, Thomas ^b   Kaprio, Jaakko ^b  

^a UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

^b UNIVERSITY OF HELSINKI   (Finland)

^c NATIONAL PUBLIC HEALTH INSTITUTE   (Finland)

^d UNIVERSITY OF EASTERN FINLAND   (Finland)

^e UNIVERSITY OF COPENHAGEN   (Denmark)

^f FINNISH CANCER REGISTRY   (Finland)

^g TAMPERE UNIVERSITY OF TECHNOLOGY   (Finland)

^h HARVARD MEDICAL SCHOOL   (United States)

ⁱ UNIVERSITY OF ICELAND   (Iceland)

^j HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^k KAROLINSKA INSTITUTE   (Sweden)

more..

Author keywords

Lung Cancer; Tobacco and the lung

Indexed keywords

ADULT; ARTICLE; CANCER INCIDENCE; COHORT ANALYSIS; CONTROLLED STUDY; DIZYGOTIC TWINS; FEMALE; FOLLOW UP; GENETIC PREDISPOSITION; HUMAN; LUNG CANCER; MAJOR CLINICAL STUDY; MALE; MONOZYGOTIC TWINS; POPULATION RESEARCH; PRIORITY JOURNAL; RECURRENCE RISK; SMOKING; CHEMICALLY INDUCED; COMPARATIVE STUDY; GENETICS; INCIDENCE; LUNG TUMOR; RETROSPECTIVE STUDY; RISK FACTOR; TIME FACTOR; TWINS;

COHORT STUDIES; FOLLOW-UP STUDIES; HUMANS; INCIDENCE; LUNG NEOPLASMS; RETROSPECTIVE STUDIES; RISK FACTORS; SMOKING; TIME FACTORS; TWINS, DIZYGOTIC; TWINS, MONOZYGOTIC;

EID: 85006993661     PISSN: 00406376     EISSN: 14683296     Source Type: Journal    
DOI: 10.1136/thoraxjnl-2015-207921     Document Type: Article

References (42)

1. Boffetta P, Trichopoulos D. Cancer of the lung, larynx, and pleura. In: Adami H, Hunter DJ, Trichopoulos D, eds. Textbook of Cancer Epidemiology. Oxford; New York: Oxford University Press, 2008:349-77.
2. Czene K, Lichtenstein P, Hemminki K. Environmental and heritable causes of cancer among 9.6 million individuals in the Swedish Family-Cancer Database. Int J Cancer 2002;99:260-6.
3. Lichtenstein P, Holm NV, Verkasalo PK, et al. Environmental and heritable factors in the causation of cancer-analyses of cohorts of twins from Sweden, Denmark, and Finland. N Engl J Med 2000;343:78-85.
4. Mucci LA, Hjelmborg JB, Harris JR, et al. Familial risk and heritability of cancer among twins in Nordic countries. JAMA 2016;315:68-76.
5. Gabrielsen ME, Romundstad P, Langhammer A, et al. Association between a 15q25 gene variant, nicotine-related habits, lung cancer and COPD among 56, 307 individuals from the HUNT study in Norway. Eur J Hum Genet 2013;21:1293-9.
6. Timofeeva MN, Hung RJ, Rafnar T, et al. Influence of common genetic variation on lung cancer risk: Meta-analysis of 14 900 cases and 29 485 controls. Hum Mol Genet 2012;21:4980-95.
7. Hjelmborg JB, Scheike T, Holst K, et al. The heritability of prostate cancer in the Nordic Twin Study of Cancer. Cancer Epidemiol Biomarkers Prev 2014;23: 2303-10.
8. Wienke A, Herskind AM, Christensen K, et al. The heritability of CHD mortality in Danish twins after controlling for smoking and BMI. Twin Res Hum Genet 2005;8:53-9.
9. Osler M, McGue M, Christensen K. Socioeconomic position and twins' health: A life-course analysis of 1266 pairs of middle-aged Danish twins. Int J Epidemiol 2007;36:77-83.
10. Johnson W, Kyvik KO, Mortensen EL, et al. Does education confer a culture of healthy behavior? Smoking and drinking patterns in Danish twins. Am J Epidemiol 2011;173:55-63.
11. Kaprio J, Koskenvuo M. A prospective study of psychological and socioeconomic characteristics, health behavior and morbidity in cigarette smokers prior to quitting compared to persistent smokers and non-smokers. J Clin Epidemiol 1988;41:139-50.
12. Kaprio J, Koskenvuo M. Genetic and environmental factors in complex diseases: The older Finnish Twin Cohort. Twin Res 2002;5:358-65.
13. Nilsen TS, Brandt I, Magnus P, et al. The Norwegian Twin Registry. Twin Res Hum Genet 2012;15:775-80.
14. Harris JR, Magnus P, Tambs K. The Norwegian Institute of Public Health twin program of research: An update. Twin Res Hum Genet 2006;9:858-64.
15. Lichtenstein P, De Faire U, Floderus B, et al. The Swedish Twin Registry: A unique resource for clinical, epidemiological and genetic studies. J Intern Med 2002;252:184-205.
16. Pedersen NL, Lichtenstein P, Svedberg P. The Swedish Twin Registry in the third millennium. Twin Res 2002;5:427-32.
17. Allignol A, Schumacher M, Beyersmann J. Empirical transition matrix of multi-state models: The etm package. J Stat Softw 2011;38. https://www.jstatsoft.org/article/view/v038i04
18. Scheike TH, Holst KK, Hjelmborg JB. Estimating twin concordance for bivariate competing risks twin data. Stat Med 2014;33:1193-204.
19. Scheike TH, Holst KK, Hjelmborg JB. Estimating heritability for cause specific mortality based on twin studies. Lifetime Data Anal 2014;20:210-33.
20. Risch N. Linkage strategies for genetically complex traits. I. Multilocus models. Am J Hum Genet 1990;46:222-8.
21. Risch N. The genetic epidemiology of cancer: Interpreting family and twin studies and their implications for molecular genetic approaches. Cancer Epidemiol Biomarkers Prev 2001;10:733-41.
22. Holst KK, Scheike T, Hjelmborg JB. The liability threshold model for censored twin data. Comput Stat Data Anal 2016;93:324-35.
23. Neale MC, Cardon LR, North Atlantic Treaty Organization. Scientific Affairs Division. Methodology for Genetic Studies of Twins and Families. Dordrecht; Boston: Kluwer Academic Publishers, 1992.
24. Sham P. Statistics in Human Genetics. London; New York: Arnold; John Wiley & Sons, Inc., 1998.
25. Fisher RA. Cancer and smoking. Nature 1958;182:596.
26. Doll R, Hill AB. A study of the aetiology of carcinoma of the lung. Br Med J 1952;2:1271-86.
27. Wynder EL, Graham EA. Tobacco smoking as a possible etiologic factor in bronchiogenic carcinoma: A study of 684 proved cases. J Am Med Assoc 1950;143:329-36.
28. Floderus B, Cederlof R, Friberg L. Smoking and mortality: A 21-year follow-up based on the Swedish Twin Registry. Int J Epidemiol 1988;17:332-40.
29. Kaprio J, Koskenvuo M. Cigarette smoking as a cause of lung cancer and coronary heart disease. A study of smoking-discordant twin pairs. Acta Genet Med Gemellol (Roma) 1990;39:25-34.
30. Rose RJ, Broms U, Korhonen T, et al. Genetics of smoking behavior. In: Kim YK, ed. Handbook of Behavior Genetics. New York: Springer, 2009:411-32.
31. Braun MM, Caporaso NE, Page WF, et al. A cohort study of twins and cancer. Cancer Epidemiol Biomarkers Prev 1995;4:469-73.
32. Yang IA, Holloway JW, Fong KM. Genetic susceptibility to lung cancer and co-morbidities. J Thorac Dis 2013;5(Suppl 5):S454-62.
33. Bierut LJ, Stitzel JA, Wang JC, et al. Variants in nicotinic receptors and risk for nicotine dependence. Am J Psychiatry 2008;165:1163-71.
34. Fowler CD, Lu Q, Johnson PM, et al. Habenular alpha5 nicotinic receptor subunit signalling controls nicotine intake. Nature 2011;471:597-601.
35. Thorgeirsson TE, Geller F, Sulem P, et al. A variant associated with nicotine dependence, lung cancer and peripheral arterial disease. Nature 2008;452:638-42.
36. Thorgeirsson TE, Gudbjartsson DF, Surakka I, et al. Sequence variants at CHRNB3-CHRNA6 and CYP2A6 affect smoking behavior. Nat Genet 2010;42:448-53.
37. Liu JZ, Tozzi F, Waterworth DM, et al. Meta-analysis and imputation refines the association of 15q25 with smoking quantity. Nat Genet 2010;42:436-40.
38. Tobacco and Genetics Consortium. Genome-wide meta-analyses identify multiple loci associated with smoking behavior. Nat Genet 2010;42:441-7.
39. Keskitalo K, Broms U, Heliövaara M, et al. Association of serum cotinine level with a cluster of three nicotinic acetylcholine receptor genes (CHRNA3/CHRNA5/CHRNB4) on chromosome 15. Hum Mol Genet 2009;18:4007-40.
40. Munafò MR, Timofeeva MN, Morris RW, et al. Association between genetic variants on chromosome 15q25 locus and objective measures of tobacco exposure. J Natl Cancer Inst 2012;104:740-8.
41. Carr SR, Akerley W, Hashibe M, et al. Evidence for a genetical contribution to non-smoking-related lung cancer. Thorax 2015;70:1033-9.
42. Sampson JN, Wheeler WA, Yeager M, et al. Analysis of heritability and shared heritability based on genome-wide association studies for thirteen cancer types. J Natl Cancer Inst 2015;107: 279.