Anti-Rhodotorula activity of mycophenolic acid enhanced in the presence of polyene antibiotic nystatin

Letters in Applied Microbiology

Volumn 64, Issue 2, 2017, Pages 144-149

  Kinoshita, H ^a   Wongsuntornpoj, S ^a   Ihara, F ^b   Nihira, T ^a,c  

^a OSAKA UNIVERSITY   (Japan)

^b NATIONAL INSTITUTE OF FRUIT TREE SCIENCE   (Japan)

^c MAHIDOL UNIVERSITY   (Thailand)

Author keywords

antifungal; mycophenolic acid; nystatin; polyene; Rhodotorula; synergistic effect

Indexed keywords

ANTIFUNGAL AGENTS; BIOASSAY; CYTOLOGY; FUNGICIDES; ORGANIC COMPOUNDS; STRAIN;

ACTIVE COMPOUNDS; ANTIFUNGALS; ENTOMOPATHOGENIC FUNGUS; FUNGAL CELLS; MYCOPHENOLIC ACIDS; NYSTATIN; POLYENE; POLYENE ANTIBIOTICS; RHODOTORULA; SYNERGISTIC EFFECT;

FUNGI;

MYCOPHENOLIC ACID; NYSTATIN; AMPHOTERICIN B; ANTIFUNGAL AGENT; POLYENE;

ANTIBIOTICS; ANTIMICROBIAL ACTIVITY; BACTERIUM; BIOASSAY; CELLS AND CELL COMPONENTS; DRUG; ENTOMOPATHOGENIC ORGANISM; INFECTIOUS DISEASE; PATHOGEN; RESOURCE; YEAST;

AKANTHOMYCES; AKANTHOMYCES ARACHNOPHILIUS; AKANTHOMYCES CINEREUS; AKANTHOMYCES GRACILIS; AKANTHOMYCES NOVOGUINEENSIS; AKANTHOMYCES PISTILLARIAEFORMIS; ANTIFUNGAL ACTIVITY; ARTICLE; ASCHERSONIA ALEYRODIS; BEAUVERIA BASSIANA; CONTROLLED STUDY; CORDYCEPS; CORDYCEPS CRINALIS; CORDYCEPS INDIGOTICA; CORDYCEPS PARADOXA; CORDYCEPS PROLIFICA; CORDYCEPS RAMOSOPULVINATA; CORDYCEPS TAKAOMONTANA; CORDYCEPS TUBECULATA; DRUG POTENTIATION; DRUG SCREENING; ENTOMOPATHOGENIC FUNGUS; FUNGAL STRAIN; FUNGUS CULTURE; HIRSUTELLA NEOVOLKIANA; HIRSUTELLA NUTANS; LECANICILLIUM LECANII; METARHIZIUM; METARHIZIUM ANISOPLIAE; METARHIZIUM FLAVORIDIE; MINIMUM INHIBITORY CONCENTRATION; NOMURAEA RILEYI; NONHUMAN; PAECILOMYCES; PAECILOMYCES CATENIANNULATUS; PAECILOMYCES FARINOSUS; PAECILOMYCES FUMOSOROSEUS; PAECILOMYCES TENUIPES; POLYCEPHALOMYCES; RHODOTORULA; RHODOTORULA GLUTINIS; RHODOTORULA MINUTA; RHODOTORULA MUCILOGINOSA; TORRUBIELLA MINUTISSIMA; TORRUBIELLA SUPERFICIALIS; ANTIFUNGAL RESISTANCE; CELL MEMBRANE PERMEABILITY; DRUG EFFECTS; MICROBIAL SENSITIVITY TEST;

FUNGI; RHODOTORULA (ERYTHROBASIDIUM CLADE);

AMPHOTERICIN B; ANTIFUNGAL AGENTS; CELL MEMBRANE PERMEABILITY; DRUG RESISTANCE, FUNGAL; DRUG SYNERGISM; MICROBIAL SENSITIVITY TESTS; MYCOPHENOLIC ACID; NYSTATIN; POLYENES; RHODOTORULA;

EID: 85006839751     PISSN: 02668254     EISSN: 1472765X     Source Type: Journal    
DOI: 10.1111/lam.12692     Document Type: Article

References (23)

1. Bentley, R. (2000) Mycophenolic acid: a one hundred year odyssey from antibiotic to immunosuppressant. Chem Rev 100, 3801–3826.
2. Carollo, C.A., Calil, A.L., Schiave, L.A., Guaratini, T., Roberts, D.W., Lopes, N.P. and Braga, G.U. (2010) Fungal tyrosine betaine, a novel secondary metabolite from conidia of entomopathogenic Metarhizium spp. fungi. Fungal Biol 114, 473–480.
3. Clinical and Laboratory Standards (2008) M27–A3 Reference Method for Broth Dilution Antifungal Susceptibility Testing of Yeasts: Approved Standard, 3rd ed. Wayne, PA: Clinical and Laboratory Standards Institute.
4. Fox, E.M. and Howlett, B.J. (2008) Secondary metabolism: regulation and role in fungal biology. Curr Opin Microbiol 11, 481–487.
5. Isaka, M., Kittakoop, P., Kirtikara, K., Hywel-Jones, N.L. and Thebtaranonth, Y. (2005) Bioactive substances from insect pathogenic fungi. Acc Chem Res 38, 813–823.
6. Isaka, M., Yangchum, A., Rachtawee, P., Komwijit, S. and Lutthisungneon, A. (2010) Hopane-type triterpenes and binaphthopyrones from the scale insect pathogenic fungus Aschersonia paraphysata BCC 11964. J Nat Prod 73, 688–692.
7. Isaka, M., Palasarn, S., Tobwor, P., Boonruangprapa, T. and Tasanathai, K. (2012) Bioactive anthraquinone dimers from the leafhopper pathogenic fungus Torrubiella sp. BCC 28517. J Antibiot (Tokyo) 65, 571–574.
8. Jenks, M.H. and Reines, D. (2005) Dissection of the molecular basis of mycophenolate resistance in Saccharomyces cerevisiae. Yeast 22, 1181–1190.
9. Kathiravan, M.K., Salake, A.B., Chothe, A.S., Dudhe, P.B., Watode, R.P., Mukta, M.S. and Gadhwe, S. (2012) The biology and chemistry of antifungal agents: a review. Bioorg Med Chem 20, 5678–5698.
10. Kinoshita, H., Yoshioka, M., Ihara, F. and Nihira, T. (2016) Cryptic antifungal compounds active by synergism with polyene antibiotics. J Biosci Bioeng 121, 394–398.
11. Köhler, G.A., Gong, X., Bentink, S., Theiss, S., Pagani, G.M., Agabian, N. and Hedstrom, L. (2005) The functional basis of mycophenolic acid resistance in Candida albicans IMP dehydrogenase. J Biol Chem 280, 11295–11302.
12. Kuephadungphan, W., Phongpaichit, S., Luangsa-ard, J.J. and Rukachaisirikul, V. (2014) Antimicrobial activity of invertebrate-pathogenic fungi in the genera Akanthomyces and Gibellula. Mycoscience 55, 127–133.
13. Lee, S.Y., Nakajima, I., Ihara, F., Kinoshita, H. and Nihira, T. (2005) Cultivation of entomopathogenic fungi for the search of antibacterial compounds. Mycopathologia 160, 321–325.
14. Mele, T.S. and Halloran, P.F. (2000) The use of mycophenolate mofetil in transplant recipients. Immunopharmacology 47, 215–245.
15. Recamier, K.S., Hernandez-Gomez, A., Gonzalez-Damian, J. and Ortega-Blake, I. (2010) Effect of membrane structure on the action of polyenes: I. Nystatin action in cholesterol- and ergosterol-containing membranes. J Membrane Biol 237, 31–40.
16. Regueira, T.B., Kildegaard, K.R., Hansen, B.G., Mortensen, U.H., Hertweck, C. and Nielsen, J. (2011) Molecular basis for mycophenolic acid biosynthesis in Penicillium brevicompactum. Appl Environ Microbiol 77, 3035–3043.
17. Spiliopoulou, A., Anastassiou, E.D. and Christofidou, M. (2012) Rhodotorula fungemia of an intensive care unit patient and review of published cases. Mycopathologia 174, 301–309.
18. Stadler, M., Quang, D.N., Tomita, A., Hashimoto, T. and Asakawa, Y. (2006) Changes in secondary metabolism during stromatal ontogeny of Hypoxylon fragiforme. Mycol Res 110, 811–820.
19. Tuon, F.F. and Costa, S.F. (2008) Rhodotorula infection. A systematic review of 128 cases from literature. Rev Iberoam Micol 25, 135–140.
20. Vandeputte, P., Ferrari, S. and Coste, A.T. (2012) Antifungal resistance and new strategies to control fungal infections. Int J Microbiol 2012, 713687.
21. Wagenaar, M.M., Gibson, D.M. and Clardy, J. (2002) Akanthomycin, a new antibiotic pyridone from the entomopathogenic fungus Akanthomyces gracilis. Org Lett 4, 671–673.
22. Wirth, F. and Goldani, L.Z. (2012) Epidemiology of Rhodotorula: an emerging pathogen. Interdiscip Perspect Infect Dis 2012, 465717.
23. Zaas, A.K., Boyce, M., Schell, W., Lodge, B.A., Miller, J.L. and Perfect, J.R. (2003) Risk of fungemia due to Rhodotorula and antifungal susceptibility testing of Rhodotorula isolates. J Clin Microbiol 41, 5233–5235.