Superantigens and adhesins of infant gut commensal Staphylococcus aureus strains and association with subsequent development of atopic eczema

British Journal of Dermatology

Volumn 176, Issue 2, 2017, Pages 439-445

  Nowrouzian, F L ^a   Lina, G ^b   Hodille, E ^b   Lindberg, E ^a   Hesselmar, B ^a   Saalman, R ^a   Adlerberth, I ^a   Wold, A E ^a  

^a UNIVERSITY OF GOTHENBURG   (Sweden)

^b CENTRE INTERNATIONAL DE RECHERCHE EN INFECTIOLOGIE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ADHESIN; BETA HEMOLYSIN; BINDING PROTEIN; BONE SIALOPROTEIN BINDING PROTEIN; COLLAGEN BINDING PROTEIN; ELASTIN BINDING PROTEIN; ENTEROTOXIN G; ENTEROTOXIN I; ENTEROTOXIN L; ENTEROTOXIN M; ENTEROTOXIN N; ENTEROTOXIN O; EXFOLIATIN; EXFOLIATIVE TOXIN A; FIBRINOGEN BINDING PROTEIN; HEMOLYSIN; STAPHYLOCOCCUS ENTEROTOXIN A; STAPHYLOCOCCUS ENTEROTOXIN C; SUPERANTIGEN; SUPERANTIGEN SELM; TOXIC SHOCK SYNDROME TOXIN 1; UNCLASSIFIED DRUG; ADHESIN, STAPHYLOCOCCUS AUREUS; ENTEROTOXIN;

ARTICLE; ATOPIC DERMATITIS; BACTERIAL COLONIZATION; BACTERIAL COUNT; BACTERIAL GENE; BACTERIAL STRAIN; BACTERIUM CULTURE; BACTERIUM ISOLATE; CLINICAL ARTICLE; COMMENSAL; CONTROLLED STUDY; DISEASE ASSOCIATION; FECES ANALYSIS; GENE IDENTIFICATION; HUMAN; IMMUNOPATHOGENESIS; IMMUNOSTIMULATION; INFANT; INTESTINE FLORA; NEWBORN; NONHUMAN; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; STAPHYLOCOCCUS AUREUS; COLON; DERMATITIS, ATOPIC; FECES; GENETICS; IMMUNOLOGY; ISOLATION AND PURIFICATION; METABOLISM; MICROBIOLOGY; PRESCHOOL CHILD;

ADHESINS, BACTERIAL; CHILD, PRESCHOOL; COLON; DERMATITIS, ATOPIC; ENTEROTOXINS; FECES; GASTROINTESTINAL MICROBIOME; HUMANS; INFANT; STAPHYLOCOCCUS AUREUS; SUPERANTIGENS;

EID: 85006814796     PISSN: 00070963     EISSN: 13652133     Source Type: Journal    
DOI: 10.1111/bjd.15138     Document Type: Article

References (35)

1. Dharmage SC, Lowe AJ, Matheson MC et al. Atopic dermatitis and the atopic march revisited. Allergy 2014; 69:17–27.
2. Strachan DP. Hay fever, hygiene, and household size. BMJ 1989; 299:1259–60.
3. Matricardi PM, Rosmini F, Riondino S et al. Exposure to foodborne and orofecal microbes versus airborne viruses in relation to atopy and allergic asthma: epidemiological study. BMJ 2000; 320:412–17.
4. Bisgaard H, Li N, Bonnelykke K et al. Reduced diversity of the intestinal microbiota during infancy is associated with increased risk of allergic disease at school age. J Allergy Clin Immunol 2011; 128:646–52.
5. Wang M, Karlsson C, Olsson C et al. Reduced diversity in the early fecal microbiota of infants with atopic eczema. J Allergy Clin Immunol 2008; 121:129–34.
6. Ismail IH, Oppedisano F, Joseph SJ et al. Reduced gut microbial diversity in early life is associated with later development of eczema but not atopy in high-risk infants. Pediatr Allergy Immunol 2012; 23:674–81.
7. Lindberg E, Adlerberth I, Hesselmar B et al. High rate of transfer of Staphylococcus aureus from parental skin to infant gut flora. J Clin Microbiol 2004; 42:530–4.
8. Lindberg E, Adlerberth I, Matricardi P et al. Effect of lifestyle factors on Staphylococcus aureus gut colonization in Swedish and Italian infants. Clin Microbiol Infect 2011; 17:1209–15.
9. Alibayov B, Zdenkova K, Sykorova H, Demnerova K. Molecular analysis of Staphylococcus aureus pathogenicity islands (SaPI) and their superantigens combination of food samples. J Microbiol Methods 2014; 107:197–204.
10. Lina G, Bohach GA, Nair SP et al. Standard nomenclature for the superantigens expressed by Staphylococcus. J Infect Dis 2004; 189:2334–6.
11. Thomas D, Chou S, Dauwalder O et al. Diversity in Staphylococcus aureus enterotoxins. Chem Immunol Allergy 2007; 93:24–41.
12. Lindberg E, Nowrouzian F, Adlerberth I et al. Long-time persistence of superantigen-producing Staphylococcus aureus strains in the intestinal microflora of healthy infants. Pediatr Res 2000; 48:741–7.
13. Lundell AC, Adlerberth I, Lindberg E et al. Increased levels of circulating soluble CD14 but not CD83 in infants are associated with early intestinal colonization with Staphylococcus aureus. Clin Exp Allergy 2007; 37:62–71.
14. Lundell AC, Hesselmar B, Nordstrom I et al. High circulating immunoglobulin A levels in infants are associated with intestinal toxigenic Staphylococcus aureus and a lower frequency of eczema. Clin Exp Allergy 2009; 39:662–70.
15. Totté JE, van der Feltz WT, Hennekam M et al. Prevalence and odds of Staphylococcus aureus carriage in atopic dermatitis: a systematic review and meta-analysis. Br J Dermatol 2016; 175:687–95.
16. Leung D. Superantigens, steroid insensitivity and innate immunity in atopic eczema. Acta Derm Venereol Suppl (Stockh) 2005; 215:11–15.
17. Jarraud S, Peyrat M, Lim A et al. egc, a highly prevalent operon of enterotoxin gene, forms a putative nursery of superantigens in Staphylococcus aureus. J Immunol 2001; 1:669–77.
18. Becker K, Friedrich AW, Peters G et al. Systematic survey on the prevalence of genes coding for staphylococcal enterotoxins SElM, SElO, and SElN. Mol Nutr Food Res 2004; 48:488–95.
19. Nowrouzian FL, Dauwalder O, Meugnier H et al. Adhesin and superantigen genes and the capacity of Staphylococcus aureus to colonize the infantile gut. J Infect Dis 2011; 204:714–21.
20. Ferry T, Thomas D, Genestier A et al. Comparative prevalence of superantigen genes in Staphylococcus aureus isolates causing sepsis with and without septic shock. Clin Infect Dis 2005; 41:771–7.
21. Nowrouzian FL, Ali A, Badiou C et al. Impacts of enterotoxin gene cluster-encoded superantigens on local and systemic experimental Staphylococcus aureus infections. Eur J Clin Microbiol Infect Dis 2015; 34:1443–9.
22. Adlerberth I, Strachan DP, Matricardi PM et al. Gut microbiota and development of atopic eczema in 3 European birth cohorts. J Allergy Clin Immunol 2007; 120:343–50.
23. Adlerberth I, Lindberg E, Aberg N et al. Reduced enterobacterial and increased staphylococcal colonization of the infantile bowel: an effect of hygienic lifestyle? Pediatr Res 2006; 59:96–101.
24. Williams HC. Diagnostic criteria for atopic dermatitis. Lancet 1996; 348:1391–2.
25. Hanifin JM, Rajka G. Diagnostic features of atopic dermatitis. Acta Derm Venereol Suppl (Stockh) 1980; 92:44–7.
26. Hesselmar B, Sjoberg F, Saalman R et al. Pacifier cleaning practices and risk of allergy development. Pediatrics 2013; 131:e1829–37.
27. Nowrouzian F, Hesselmar B, Saalman R et al. Escherichia coli in infants’ intestinal microflora: colonization rate, strain turnover, and virulence gene carriage. Pediatr Res 2003; 54:8–14.
28. Ong PY, Leung DY. The infectious aspects of atopic dermatitis. Immunol Allergy Clin North Am 2010; 30:309–21.
29. Lundell AC, Andersson K, Josefsson E et al. Soluble CD14 and CD83 from human neonatal antigen-presenting cells are inducible by commensal bacteria and suppress allergen-induced human neonatal Th2 differentiation. Infect Immun 2007; 75:4097–104.
30. Madhok V, Futamura M, Thomas KS et al. What's new in atopic eczema? An analysis of systematic reviews published in 2012 and 2013. Part 2. Treatment and prevention. Clin Exp Dermatol 2015; 40:349–54.
31. Madhok V, Futamura M, Thomas KS et al. What's new in atopic eczema? An analysis of systematic reviews published in 2012 and 2013. Part 1. Epidemiology, mechanisms of disease and methodological issues. Clin Exp Dermatol 2015; 40:238–42.
32. + dendritic cells. PLOS ONE 2013; 8:e75594.
33. Bath-Hextall FJ, Birnie AJ, Ravenscroft JC et al. Interventions to reduce Staphylococcus aureus in the management of atopic eczema: an updated Cochrane review. Br J Dermatol 2010; 163:12–26.
34. Skov L, Halkjaer LB, Agner T et al. Neonatal colonization with Staphylococcus aureus is not associated with development of atopic dermatitis. Br J Dermatol 2009; 160:1286–91.
35. Islander U, Andersson A, Lindberg E et al. Superantigenic Staphylococcus aureus stimulates production of interleukin-17 from memory but not naive T cells. Infect Immun 2010; 78:381–6.