High prevalence of ESBL-producing klebsiella pneumoniae causing community-onset infections in China

Frontiers in Microbiology

Volumn 7, Issue NOV, 2016, Pages

  Zhang, Jing ^a,b   Zhou, Kai ^a   Zheng, Beiwen ^a   Zhao, Lina ^c   Shen, Ping ^a   Ji, Jinru ^a   Wei, Zeqing ^a   Li, Lanjuan ^a   Zhou, Jianying ^b   Xiao, Yonghong ^a  

^a ZHEJIANG UNIVERSITY   (China)

^b ZHEJIANG UNIVERSITY   (China)

^c THE FIRST AFFILIATED HOSPITAL OF SOOCHOW UNIVERSITY   (China)

Author keywords

Community onset infections; CTX M; Hypervirulent K. pneumoniae; Resistance mechanisms; Sequence type

Indexed keywords

CARBAPENEMASE; EXTENDED SPECTRUM BETA LACTAMASE;

ANTIBIOTIC SENSITIVITY; ARTICLE; BACTERIAL VIRULENCE; CHINA; GENE SEQUENCE; GENOTYPE; KLEBSIELLA PNEUMONIAE; NONHUMAN; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION; PREVALENCE;

EID: 85006789698     PISSN: None     EISSN: 1664302X     Source Type: Journal    
DOI: 10.3389/fmicb.2016.01830     Document Type: Article

References (39)

1. Alikhan, N. F., Petty, N. K., Ben Zakour, N. L., and Beatson, S. A. (2011). BLAST Ring Image Generator (BRIG): simple prokaryote genome comparisons. BMC Genomics 12:402. doi: 10.1186/1471-2164-12-402
2. An, S., Chen, J., Wang, Z., Wang, X., Yan, X., Li, J., et al. (2012). Predominant characteristics of CTX-M-producing Klebsiella pneumoniae isolates from patients with lower respiratory tract infection in multiple medical centers in China. FEMS Microbiol. Lett. 332, 137-145. doi: 10.1111/j.1574-6968.2012.02586.x
3. Arpin, C., Quentin, C., Grobost, F., Cambau, E., Robert, J., Dubois, V., et al. (2009). Nationwide survey of extended-spectrum (beta)-lactamase-producing Enterobacteriaceae in the French community setting. J. Antimicrob. Chemother. 63, 1205-1214. doi: 10.1093/jac/dkp108
4. Bialek-Davenet, S., Criscuolo, A., Ailloud, F., Passet, V., Jones, L., Delannoy-Vieillard, A. S., et al. (2014). Genomic definition of hypervirulent and multidrug-resistant Klebsiella pneumoniae clonal groups. Emerg. Infect. Dis. 20, 1812-1820. doi: 10.3201/eid2011.140206
5. Brisse, S., Passet, V., and Grimont, P. A. (2014). Description of Klebsiella quasipneumoniae sp. nov., isolated from human infections, with two subspecies, Klebsiella quasipneumoniae subsp. quasipneumoniae subsp. nov. and Klebsiella quasipneumoniae subsp. similipneumoniae subsp. nov., and demonstration that Klebsiella singaporensis is a junior heterotypic synonym of Klebsiella variicola. Int. J. Syst. Evol. Microbiol. 64, 3146-3152.
6. Brisse, S., Van Himbergen, T., Kusters, K., and Verhoef, J. (2004). Development of a rapid identification method for Klebsiella pneumoniae phylogenetic groups and analysis of 420 clinical isolates. Clin. Microbiol. Infect. 10, 942-945. doi: 10.1111/j.1469-0691.2004.00973.x
7. Brisse, S., and Verhoef, J. (2001). Phylogenetic diversity of Klebsiella pneumoniae and Klebsiella oxytoca clinical isolates revealed by randomly amplified polymorphic DNA, gyrA and parC genes sequencing and automated ribotyping. Int. J. Syst. Evol. Microbiol. 51, 915-924. doi: 10.1099/00207713-51-3-915
8. Calbo, E., and Garau, J. (2015). The changing epidemiology of hospital outbreaks due to ESBL-producing Klebsiella pneumoniae: the CTX-M-15 type consolidation. Future Microbiol. 10, 1063-1075. doi: 10.2217/fmb.15.22
9. CLSI (2016). Performance Standards for Antimicrobial Susceptibility Testing: Twenty-Six Informational Supplement M100-S26. Wayne, PA: Clinical and Laboratory Standards Institute.
10. Cubero, M., Grau, I., Tubau, F., Pallares, R., Dominguez, M. A., Linares, J., et al. (2016). Hypervirulent Klebsiella pneumoniae clones causing bacteraemia in adults in a teaching hospital in Barcelona, Spain (2007-2013). Clin. Microbiol. Infect. 22, 154-160. doi: 10.1016/j.cmi.2015.09.025
11. de Melo, M. E., Cabral, A. B., Maciel, M. A., Da Silveira, V. M., and De Souza Lopes, A. C. (2011). Phylogenetic groups among Klebsiella pneumoniae isolates from Brazil: relationship with antimicrobial resistance and origin. Curr. Microbiol. 62, 1596-1601. doi: 10.1007/s00284-011-9903-7
12. Denisuik, A. J., Lagace-Wiens, P. R., Pitout, J. D., Mulvey, M. R., Simner, P. J., Tailor, F., et al. (2013). Molecular epidemiology of extended-spectrum beta-lactamase-, AmpC beta-lactamase-and carbapenemase-producing Escherichia coli and Klebsiella pneumoniae isolated from Canadian hospitals over a 5 year period: CANWARD 2007-11. J. Antimicrob. Chemother. 68(Suppl. 1), i57-i65.
13. Diancourt, L., Passet, V., Verhoef, J., Grimont, P. A., and Brisse, S. (2005). Multilocus sequence typing of Klebsiella pneumoniae nosocomial isolates. J. Clin. Microbiol. 43, 4178-4182. doi: 10.1128/JCM.43.8.4178-4182.2005
14. Feil, E. J., Li, B. C., Aanensen, D. M., Hanage, W. P., and Spratt, B. G. (2004). eBURST: inferring patterns of evolutionary descent among clusters of related bacterial genotypes from multilocus sequence typing data. J. Bacteriol. 186, 1518-1530. doi: 10.1128/JB.186.5.1518-1530.2004
15. Holt, K. E., Wertheim, H., Zadoks, R. N., Baker, S., Whitehouse, C. A., Dance, D., et al. (2015). Genomic analysis of diversity, population structure, virulence, and antimicrobial resistance in Klebsiella pneumoniae, an urgent threat to public health. Proc. Natl. Acad. Sci. U.S.A. 112, E3574-E3581. doi: 10.1073/pnas.1501049112
16. Jung, S. W., Chae, H. J., Park, Y. J., Yu, J. K., Kim, S. Y., Lee, H. K., et al. (2013). Microbiological and clinical characteristics of bacteraemia caused by the hypermucoviscosity phenotype of Klebsiella pneumoniae in Korea. Epidemiol. Infect. 141, 334-340. doi: 10.1017/S0950268812000933
17. Kassakian, S. Z., and Mermel, L. A. (2014). Changing epidemiology of infections due to extended spectrum beta-lactamase producing bacteria. Antimicrob. Resist. Infect. Control 3, 9. doi: 10.1186/2047-2994-3-9
18. Kazmierczak, K. M., Lob, S. H., Hoban, D. J., Hackel, M. A., Badal, R. E., and Bouchillon, S. K. (2015). Characterization of extended-spectrum beta-lactamases and antimicrobial resistance of Klebsiella pneumoniae in intra-abdominal infection isolates in Latin America, 2008-2012. Results of the study for monitoring antimicrobial resistance trends. Diagn. Microbiol. Infect. Dis. 82, 209-214. doi: 10.1016/j.diagmicrobio.2015.03.025
19. Kumarasamy, K. K., Toleman, M. A., Walsh, T. R., Bagaria, J., Butt, F., Balakrishnan, R., et al. (2010). Emergence of a new antibiotic resistance mechanism in India, Pakistan, and the UK: a molecular, biological, and epidemiological study. Lancet Infect. Dis. 10, 597-602.
20. Li, W., Sun, G., Yu, Y., Li, N., Chen, M., Jin, R., et al. (2014). Increasing occurrence of antimicrobial-resistant hypervirulent (hypermucoviscous) Klebsiella pneumoniae isolates in China. Clin. Infect. Dis. 58, 225-232. doi: 10.1093/cid/cit675
21. Liao, C. H., Huang, Y. T., Chang, C. Y., Hsu, H. S., and Hsueh, P. R. (2014). Capsular serotypes and multilocus sequence types of bacteremic Klebsiella pneumoniae isolates associated with different types of infections. Eur. J. Clin. Microbiol. Infect. Dis. 33, 365-369. doi: 10.1007/s10096-013-1964-z
22. Lohiya, A., Kant, S., Kapil, A., Gupta, S. K., Misra, P., and Rai, S. K. (2015). Pattern of antibiotic resistance among community derived isolates of Enterobacteriaceae using urine sample: a study from Northern India. J. Clin. Diagn. Res. 9, LC15-LC19.
23. Maatallah, M., Vading, M., Kabir, M. H., Bakhrouf, A., Kalin, M., Naucler, P., et al. (2014). Klebsiella variicola is a frequent cause of bloodstream infection in the stockholm area, and associated with higher mortality compared to K. pneumoniae. PLoS ONE 9:e113539. doi: 10.1371/journal.pone.0113539
24. Maina, D., Revathi, G., Kariuki, S., and Ozwara, H. (2012). Genotypes and cephalosporin susceptibility in extended-spectrum beta-lactamase producing Enterobacteriaceae in the community. J. Infect. Dev. Ctries. 6, 470-477. doi: 10.3855/jidc.1456
25. Passet, V., and Brisse, S. (2015). Association of tellurite resistance with hypervirulent clonal groups of Klebsiella pneumoniae. J. Clin. Microbiol. 53, 1380-1382. doi: 10.1128/JCM.03053-14
26. Peirano, G., Sang, J. H., Pitondo-Silva, A., Laupland, K. B., and Pitout, J. D. (2012). Molecular epidemiology of extended-spectrum-beta-lactamase-producing Klebsiella pneumoniae over a 10 year period in Calgary. Can. J. Antimicrob. Chemother. 67, 1114-1120. doi: 10.1093/jac/dks026
27. Pitout, J. D. (2013). Enterobacteriaceae that produce extended-spectrum beta-lactamases and AmpC beta-lactamases in the community: the tip of the iceberg? Curr. Pharm. Des. 19, 257-263. doi: 10.2174/1381612811306020257
28. Rosenblueth, M., Martinez, L., Silva, J., and Martinez-Romero, E. (2004). Klebsiella variicola, a novel species with clinical and plant-associated isolates. Syst. Appl. Microbiol. 27, 27-35. doi: 10.1078/0723-2020-00261
29. Shahid, M., Sobia, F., Singh, A., and Khan, H. M. (2012). Concurrent occurrence of blaampC families and blaCTX-M genogroups and association with mobile genetic elements ISEcp1, IS26, ISCR1, and sul1-type class 1 integrons in Escherichia coli and Klebsiella pneumoniae isolates originating from India. J. Clin. Microbiol. 50, 1779-1782.
30. Tamura, K., Peterson, D., Peterson, N., Stecher, G., Nei, M., and Kumar, S. (2011). MEGA5: molecular evolutionary genetics analysis using maximum likelihood, evolutionary distance, and maximum parsimony methods. Mol. Biol. Evol. 28, 2731-2739. doi: 10.1093/molbev/msr121
31. Toubiana, J., Timsit, S., Ferroni, A., Grasseau, M., Nassif, X., Lortholary, O., et al. (2016). Community-onset extended-spectrum beta-lactamase-producing Enterobacteriaceae invasive infections in children in a university hospital in France. Medicine (Baltimore) 95:e3163. doi: 10.1097/MD.0000000000003163
32. Valverde, A., Coque, T. M., Garcia-San Miguel, L., Baquero, F., and Canton, R. (2008). Complex molecular epidemiology of extended-spectrum beta-lactamases in Klebsiella pneumoniae: a long-term perspective from a single institution in Madrid. J. Antimicrob. Chemother. 61, 64-72. doi: 10.1093/jac/dkm403
33. Wang, G., Huang, T., Surendraiah, P. K., Wang, K., Komal, R., Zhuge, J., et al. (2013). CTX-M beta-lactamase-producing Klebsiella pneumoniae in suburban New York City, New York, USA. Emerg. Infect. Dis. 19, 1803-1810. doi: 10.3201/eid1911.121470
34. Wang, Q., Li, B., Tsang, A. K., Yi, Y., Woo, P. C., and Liu, C. H. (2013). Genotypic analysis of Klebsiella pneumoniae isolates in a Beijing Hospital reveals high genetic diversity and clonal population structure of drug-resistant isolates. PLoS ONE 8:e57091. doi: 10.1371/journal.pone.0057091
35. Yang, Q., Zhang, H., Cheng, J., Xu, Z., Xu, Y., Cao, B., et al. (2015). In vitro activity of flomoxef and comparators against Escherichia coli. Klebsiella pneumoniae and Proteus mirabilis producing extended-spectrum beta-lactamases in China. Int. J. Antimicrob. Agents 45, 485-490.
36. Yang, Q., Zhang, H., Wang, Y., Xu, Y., Chen, M., Badal, R. E., et al. (2013). A 10 year surveillance for antimicrobial susceptibility of Escherichia coli and Klebsiella pneumoniae in community-and hospital-associated intra-abdominal infections in China. J. Med. Microbiol. 62, 1343-1349. doi: 10.1099/jmm.0.059816-0
37. Zhang, J., Zheng, B. W., Zhao, L. N., Wei, Z. Q., Ji, J. R., Li, L. J., et al. (2014). Nationwide high prevalence of CTX-M and an increase of CTX-M-55 in Escherichia coli isolated from patients with community-onset infections in Chinese county hospitals. BMC Infect. Dis. 14:659. doi: 10.1186/s12879-014-0659-0.
38. Zhao, W. H., and Hu, Z. Q. (2013). Epidemiology and genetics of CTX-M extended-spectrum beta-lactamases in gram-negative bacteria. Crit. Rev. Microbiol. 39, 79-101. doi: 10.3109/1040841X.2012.691460
39. Zhou, K., Ferdous, M., De Boer, R. F., Kooistra-Smid, A. M., Grundmann, H., Friedrich, A. W., et al. (2015). The mosaic genome structure and phylogeny of Shiga toxin-producing Escherichia coli O104:H4 is driven by short-term adaptation. Clin. Microbiol. Infect. 21, e7-e18. doi: 10.1016/j.cmi.2014.12.009