The impact of frailty on postoperative outcomes in individuals aged 65 and over undergoing elective surgery for colorectal cancer: A systematic review

Journal of Geriatric Oncology

Volumn 7, Issue 6, 2016, Pages 479-491

  Fagard, Katleen ^a   Leonard, Silke ^b   Deschodt, Mieke ^b   Devriendt, Els ^a,b   Wolthuis, Albert ^a   Prenen, Hans ^a   Flamaing, Johan ^a,b   Milisen, Koen ^a,b   Wildiers, Hans ^a,b   Kenis, Cindy ^a  

^a UNIVERSITY HOSPITALS LEUVEN   (Belgium)

^b UNIVERSITY OF LEUVEN   (Belgium)

Author keywords

Aged; Colorectal neoplasms; Frailty; Geriatric assessment; Postoperative complications; Postoperative outcomes

Indexed keywords

ADVERSE OUTCOME; AGED; CLINICAL FEATURE; COLORECTAL CANCER; ELECTIVE SURGERY; EVIDENCE BASED MEDICINE; FRAILTY; HIGH RISK POPULATION; HOSPITAL READMISSION; HUMAN; LENGTH OF STAY; LONG TERM SURVIVAL; MEDLINE; OUTCOME ASSESSMENT; PERIOPERATIVE PERIOD; POSTOPERATIVE CARE; POSTOPERATIVE COMPLICATION; PRIORITY JOURNAL; REVIEW; RISK BENEFIT ANALYSIS; RISK FACTOR; SEPSIS; SURVIVAL RATE; SYSTEMATIC REVIEW; COLORECTAL TUMOR; FRAIL ELDERLY; MORTALITY; STATISTICS AND NUMERICAL DATA;

AGED; COLORECTAL NEOPLASMS; ELECTIVE SURGICAL PROCEDURES; FRAIL ELDERLY; HUMANS; LENGTH OF STAY; POSTOPERATIVE COMPLICATIONS; RISK FACTORS;

EID: 85006698947     PISSN: 18794068     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jgo.2016.06.001     Document Type: Review

References (47)

1. Colorectal cancer, [cited 2015 June 23]. Available from: http://www.euro.who.int/en/health-topics/noncommunicable-diseases/cancer/news/news/2012/2/early-detection-of-common-cancers/colorectal-cancer.
2. Ferlay, J., Steliarova-Foucher, E., Lortet-Tieulent, J., Rosso, S., Coebergh, J.W., Comber, H., et al. Cancer incidence and mortality patterns in Europe: estimates for 40 countries in 2012. Eur J Cancer 49:6 (2013), 1374–1403.
3. Howlader, N., Noone, A.M., Krapcho, M., Garshell, J., Miller, D., Altekruse, S.F., et al. SEER Cancer Statistics Review, 1975–2012. 2015, National Cancer Institute, Bethesda, MD ([updated based on November 2014 SEER data submission, posted to the SEER web site, April 2015]. Available from: http://seer.cancer.gov/csr/1975_2012/).
4. Pallis, A.G., Papamichael, D., Audisio, R., Peeters, M., Folprecht, G., Lacombe, D., et al. EORTC Elderly Task Force experts’ opinion for the treatment of colon cancer in older patients. Cancer Treat Rev 36:1 (2010), 83–90.
5. Hamaker, M.E., Prins, M.C., Schiphorst, A.H., van Tuyl, S.A., Pronk, A., van den Bos, F., Long-term changes in physical capacity after colorectal cancer treatment. J Geriatr Oncol 6:2 (2015), 153–164.
6. Partridge, J.S., Harari, D., Dhesi, J.K., Frailty in the older surgical patient: a review. Age Ageing 41:2 (2012), 142–147.
7. Beggs, T., Sepehri, A., Szwajcer, A., Tangri, N., Arora, R.C., Frailty and perioperative outcomes: a narrative review. Can J Anaesth 62:2 (2015), 143–157.
8. Chen, X., Mao, G., Leng, S.X., Frailty syndrome: an overview. Clin Interv Aging 9 (2014), 433–441.
9. Dasgupta, M., Rolfson, D.B., Stolee, P., Borrie, M.J., Speechley, M., Frailty is associated with postoperative complications in older adults with medical problems. Arch Gerontol Geriatr 48:1 (2009), 78–83.
10. Makary, M.A., Segev, D.L., Pronovost, P.J., Syin, D., Bandeen-Roche, K., Patel, P., et al. Frailty as a predictor of surgical outcomes in older patients. J Am Coll Surg 210:6 (2010), 901–908.
11. Clegg, A., Rogers, L., Young, J., Diagnostic test accuracy of simple instruments for identifying frailty in community-dwelling older people: a systematic review. Age Ageing 44:1 (2015), 148–152.
12. Rockwood, K., Theou, O., Mitnitski, A., What are frailty instruments for?. Age Ageing, 2015.
13. Balducci, L., Colloca, G., Cesari, M., Gambassi, G., Assessment and treatment of elderly patients with cancer. Surg Oncol 19:3 (2010), 117–123.
14. Papamichael, D., Audisio, R.A., Glimelius, B., de Gramont, A., Glynne-Jones, R., Haller, D., et al. Treatment of colorectal cancer in older patients: International Society of Geriatric Oncology (SIOG) consensus recommendations 2013. Ann Oncol 26:3 (2015), 463–476.
15. van Vugt, J.L., Reisinger, K.W., Derikx, J.P., Boerma, D., Stoot, J.H., Improving the outcomes in oncological colorectal surgery. World J Gastroenterol 20:35 (2014), 12445–12457.
16. Clegg, A., Young, J., Iliffe, S., Rikkert, M.O., Rockwood, K., Frailty in elderly people. Lancet 381:9868 (2013), 752–762.
17. Fried, L.P., Tangen, C.M., Walston, J., Newman, A.B., Hirsch, C., Gottdiener, J., et al. Frailty in older adults: evidence for a phenotype. J Gerontol A Biol Sci Med Sci 56:3 (2001), M146–M156.
18. Searle, S.D., Mitnitski, A., Gahbauer, E.A., Gill, T.M., Rockwood, K., A standard procedure for creating a frailty index. BMC Geriatr, 8, 2008, 24.
19. Rockwood, K., Mitnitski, A., Frailty in relation to the accumulation of deficits. J Gerontol A Biol Sci Med Sci 62:7 (2007), 722–727.
20. Sternberg, S.A., Wershof Schwartz, A., Karunananthan, S., Bergman, H., Mark, C.A., The identification of frailty: a systematic literature review. J Am Geriatr Soc 59:11 (2011), 2129–2138.
21. Ellis, G., Langhorne, P., Comprehensive geriatric assessment for older hospital patients. Br Med Bull 71 (2004), 45–59.
22. Rubenstein, L.Z., Stuck, A.E., Siu, A.L., Wieland, D., Impacts of geriatric evaluation and management programs on defined outcomes: overview of the evidence. J Am Geriatr Soc 39:9 Pt 2 (1991), 8S–16S (discussion 7S–8S).
23. Wildiers, H., Heeren, P., Puts, M., Topinkova, E., Janssen-Heijnen, M.L., Extermann, M., et al. International Society of Geriatric Oncology consensus on geriatric assessment in older patients with cancer. J Clin Oncol 32:24 (2014), 2595–2603.
24. Extermann, M., Hurria, A., Comprehensive geriatric assessment for older patients with cancer. J Clin Oncol 25:14 (2007), 1824–1831.
25. Puts, M.T., Hardt, J., Monette, J., Girre, V., Springall, E., Alibhai, S.M., Use of geriatric assessment for older adults in the oncology setting: a systematic review. J Natl Cancer Inst 104:15 (2012), 1133–1163.
26. Extermann, M., Aapro, M., Bernabei, R., Cohen, H.J., Droz, J.P., Lichtman, S., et al. Use of comprehensive geriatric assessment in older cancer patients: recommendations from the task force on CGA of the International Society of Geriatric Oncology (SIOG). Crit Rev Oncol Hematol 55:3 (2005), 241–252.
27. Audisio, R.A., Pope, D., Ramesh, H.S., Gennari, R., van Leeuwen, B.L., West, C., et al. Shall we operate? Preoperative assessment in elderly cancer patients (PACE) can help. A SIOG surgical task force prospective study. Crit Rev Oncol Hematol 65:2 (2008), 156–163.
28. Ugolini, G., Ghignone, F., Zattoni, D., Veronese, G., Montroni, I., Personalized surgical management of colorectal cancer in elderly population. World J Gastroenterol 20:14 (2014), 3762–3777.
29. Slim, K., Nini, E., Forestier, D., Kwiatkowski, F., Panis, Y., Chipponi, J., Methodological index for non-randomized studies (minors): development and validation of a new instrument. ANZ J Surg 73:9 (2003), 712–716.
30. Robinson, T.N., Wu, D.S., Pointer, L., Dunn, C.L., Cleveland, J.C. Jr., Moss, M., Simple frailty score predicts postoperative complications across surgical specialties. Am J Surg 206:4 (2013), 544–550.
31. Kristjansson, S.R., Nesbakken, A., Jordhoy, M.S., Skovlund, E., Audisio, R.A., Johannessen, H.O., et al. Comprehensive geriatric assessment can predict complications in elderly patients after elective surgery for colorectal cancer: a prospective observational cohort study. Crit Rev Oncol Hematol 76:3 (2010), 208–217.
32. Ommundsen, N., Wyller, T.B., Nesbakken, A., Jordhoy, M.S., Bakka, A., Skovlund, E., et al. Frailty is an independent predictor of survival in older patients with colorectal cancer. Oncologist 19:12 (2014), 1268–1275.
33. Reisinger, K.W., van Vugt, J.L., Tegels, J.J., Snijders, C., Hulsewe, K.W., Hoofwijk, A.G., et al. Functional compromise reflected by sarcopenia, frailty, and nutritional depletion predicts adverse postoperative outcome after colorectal cancer surgery. Ann Surg 261:2 (2015), 345–352.
34. Tan, K.Y., Kawamura, Y.J., Tokomitsu, A., Tang, T., Assessment for frailty is useful for predicting morbidity in elderly patients undergoing colorectal cancer resection whose comorbidities are already optimized. Am J Surg 204:2 (2012), 139–143.
35. Schuurmans, H., Steverink, N., Lindenberg, S., Frieswijk, N., Slaets, J.P., Old or frail: what tells us more?. J Gerontol A Biol Sci Med Sci 59:9 (2004), M962–M965.
36. Clavien, P.A., Sanabria, J.R., Strasberg, S.M., Proposed classification of complications of surgery with examples of utility in cholecystectomy. Surgery 111:5 (1992), 518–526.
37. Dindo, D., Demartines, N., Clavien, P.A., Classification of surgical complications: a new proposal with evaluation in a cohort of 6336 patients and results of a survey. Ann Surg 240:2 (2004), 205–213.
38. Strasberg, S.M., Linehan, D.C., Hawkins, W.G., The Accordion Severity Grading System of Surgical Complications. Ann Surg 250:2 (2009), 177–186.
39. Handforth, C., Clegg, A., Young, C., Simpkins, S., Seymour, M.T., Selby, P.J., et al. The prevalence and outcomes of frailty in older cancer patients: a systematic review. Ann Oncol 26:6 (2015), 1091–1101.
40. Decoster, L., Van Puyvelde, K., Mohile, S., Wedding, U., Basso, U., Colloca, G., et al. Screening tools for multidimensional health problems warranting a geriatric assessment in older cancer patients: an update on SIOG recommendationsdagger. Ann Oncol 26:2 (2015), 288–300.
41. Kenis, C., Bron, D., Libert, Y., Decoster, L., Van Puyvelde, K., Scalliet, P., et al. Relevance of a systematic geriatric screening and assessment in older patients with cancer: results of a prospective multicentric study. Ann Oncol 24:5 (2013), 1306–1312.
42. Kenig, J., Zychiewicz, B., Olszewska, U., Richter, P., Screening for frailty among older patients with cancer that qualify for abdominal surgery. J Geriatr Oncol 6:1 (2015), 52–59.
43. Wieland, D., The effectiveness and costs of comprehensive geriatric evaluation and management. Crit Rev Oncol Hematol 48:2 (2003), 227–237.
44. Hamaker, M.E., Jonker, J.M., de Rooij, S.E., Vos, A.G., Smorenburg, C.H., van Munster, B.C., Frailty screening methods for predicting outcome of a comprehensive geriatric assessment in elderly patients with cancer: a systematic review. Lancet Oncol 13:10 (2012), e437–e444.
45. Wildiers, H., Mauer, M., Pallis, A., Hurria, A., Mohile, S.G., Luciani, A., et al. End points and trial design in geriatric oncology research: a joint European organisation for research and treatment of cancer—Alliance for Clinical Trials in Oncology—International Society Of Geriatric Oncology position article. J Clin Oncol 31:29 (2013), 3711–3718.
46. Surgery for colorectal cancer in elderly patients: a systematic review. Colorectal Cancer Collaborative Group. Lancet, 356(9234), 2000, 968–974.
47. Hurria, A., Dale, W., Mooney, M., Rowland, J.H., Ballman, K.V., Cohen, H.J., et al. Designing therapeutic clinical trials for older and frail adults with cancer: U13 conference recommendations. J Clin Oncol 32:24 (2014), 2587–2594.