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Volumn 7, Issue 5-6, 2016, Pages 212-228

The renal effects of SGLT2 inhibitors and a mini-review of the literature

Author keywords

albuminuria; glucosuria; hyperfiltration; renal impairment; renoprotection; SGLT transporters; SGLT2 inhibitors; tubulointerstitial fibrosis; type 2 diabetes

Indexed keywords

CANAGLIFLOZIN; DAPAGLIFLOZIN; EMPAGLIFLOZIN; ERTUGLIFLOZIN; GLUCOSE TRANSPORTER; HEMOGLOBIN A1C; IPRAGLIFLOZIN; LOSARTAN; LUSEOGLIFLOZIN; PHLORIZIN; PLACEBO; REMOGLIFLOZIN ETABONATE; SODIUM GLUCOSE COTRANSPORTER 1; SODIUM GLUCOSE COTRANSPORTER 2; SODIUM GLUCOSE COTRANSPORTER 2 INHIBITOR; TOFOGLIFLOZIN;

EID: 85006446501     PISSN: 20420188     EISSN: 20420196     Source Type: Journal    
DOI: 10.1177/2042018816676239     Document Type: Review
Times cited : (40)

References (120)
  • 1
    • 64749089393 scopus 로고    scopus 로고
    • Inhibition of renal glucose reabsorption: a novel strategy for achieving glucose control in type 2 diabetes mellitus
    • Abdul-Ghani M., DeFronzo R., (2008) Inhibition of renal glucose reabsorption: a novel strategy for achieving glucose control in type 2 diabetes mellitus. Endocr Pract 14: 782–790.
    • (2008) Endocr Pract , vol.14 , pp. 782-790
    • Abdul-Ghani, M.1    DeFronzo, R.2
  • 2
    • 84914173984 scopus 로고    scopus 로고
    • Lowering plasma glucose concentration by inhibiting renal sodium-glucose co-transport
    • Abdul-Ghani M., DeFronzo R., (2014) Lowering plasma glucose concentration by inhibiting renal sodium-glucose co-transport. J Intern Med 276: 352–363. DOI:10.1111/joim.12244.
    • (2014) J Intern Med , vol.276 , pp. 352-363
    • Abdul-Ghani, M.1    DeFronzo, R.2
  • 3
    • 85081773894 scopus 로고    scopus 로고
    • accessed 28 October 2016,. :
    • ™ (dapagliflozin) now approved in European Union for treatment of type 2 diabetes. Available at: https://www.astrazeneca.com/media-centre/press-releases/2012/FORXIGA-dapagliflozin-now-approved-in-European-Union-for-treatment-of-type-2-diabetes-14112012.html#! (accessed 28 October 2016).
    • (2012) ™ (dapagliflozin) now approved in European Union for treatment of type 2 diabetes
  • 4
    • 77953598589 scopus 로고    scopus 로고
    • The protein family of glucose transport facilitators: it’s not only about glucose after all: critical review
    • Augustin R., (2010) The protein family of glucose transport facilitators: it’s not only about glucose after all: critical review. IUBMB Life 62: 315–333.
    • (2010) IUBMB Life , vol.62 , pp. 315-333
    • Augustin, R.1
  • 5
    • 77953857048 scopus 로고    scopus 로고
    • Effect of dapagliflozin in patients with type 2 diabetes who have inadequate glycaemic control with metformin: a randomised, double-blind, placebo-controlled trial
    • Bailey C., Gross J., Pieters A., Bastien A., List J., (2010) Effect of dapagliflozin in patients with type 2 diabetes who have inadequate glycaemic control with metformin: a randomised, double-blind, placebo-controlled trial. Lancet 375: 2223–2233.
    • (2010) Lancet , vol.375 , pp. 2223-2233
    • Bailey, C.1    Gross, J.2    Pieters, A.3    Bastien, A.4    List, J.5
  • 6
    • 0019614958 scopus 로고
    • Differences in active and passive glucose transport along the proximal nephron
    • Barfuss D., Schafer J., (1981) Differences in active and passive glucose transport along the proximal nephron. Am J Physiol 240: F322–F332.
    • (1981) Am J Physiol , vol.240 , pp. F322-F332
    • Barfuss, D.1    Schafer, J.2
  • 7
    • 84899961819 scopus 로고    scopus 로고
    • Efficacy and safety of empagliflozin added to existing antidiabetes treatment in patients with type 2 diabetes and chronic kidney disease: a randomised, double-blind, placebo-controlled trial
    • Barnett A., Mithal A., Manassie J., Jones R., Rattunde H., Woerle H.. (2014) Efficacy and safety of empagliflozin added to existing antidiabetes treatment in patients with type 2 diabetes and chronic kidney disease: a randomised, double-blind, placebo-controlled trial. Lancet Diabetes Endocrinol 2: 369–384.
    • (2014) Lancet Diabetes Endocrinol , vol.2 , pp. 369-384
    • Barnett, A.1    Mithal, A.2    Manassie, J.3    Jones, R.4    Rattunde, H.5    Woerle, H.6
  • 8
    • 84890285675 scopus 로고    scopus 로고
    • Sodium glucose co-transport 2 inhibitors in the treatment of type 2 diabetes mellitus: a meta-analysis of randomized double-blind controlled trials
    • Berhan A., Barker A., (2013) Sodium glucose co-transport 2 inhibitors in the treatment of type 2 diabetes mellitus: a meta-analysis of randomized double-blind controlled trials. BMC Endocrine Disorders 13: 1–11.
    • (2013) BMC Endocrine Disorders , vol.13 , pp. 1-11
    • Berhan, A.1    Barker, A.2
  • 9
    • 84858020943 scopus 로고    scopus 로고
    • Effects of dapagliflozin on body weight, total fat mass, and regional adipose tissue distribution in patients with type 2 diabetes mellitus with inadequate glycemic control on metformin
    • Bolinder J., Ljunggren Ö., Kullberg J., Johansson L., Wilding J., Langkilde A.. (2012) Effects of dapagliflozin on body weight, total fat mass, and regional adipose tissue distribution in patients with type 2 diabetes mellitus with inadequate glycemic control on metformin. J Clin Endocrinol Metab 97: 1020–1031.
    • (2012) J Clin Endocrinol Metab , vol.97 , pp. 1020-1031
    • Bolinder, J.1    Ljunggren, Ö.2    Kullberg, J.3    Johansson, L.4    Wilding, J.5    Langkilde, A.6
  • 10
    • 84937763347 scopus 로고    scopus 로고
    • Inhibition of the glucose transporter SGLT2 with dapagliflozin in pancreatic alpha cells triggers glucagon secretion
    • Bonner C., Kerr-Conte J., Gmyr V., Queniat G., Moerman E., Thévenet J.. (2015) Inhibition of the glucose transporter SGLT2 with dapagliflozin in pancreatic alpha cells triggers glucagon secretion. Nat Med 21: 512–517.
    • (2015) Nat Med , vol.21 , pp. 512-517
    • Bonner, C.1    Kerr-Conte, J.2    Gmyr, V.3    Queniat, G.4    Moerman, E.5    Thévenet, J.6
  • 12
    • 64549129226 scopus 로고    scopus 로고
    • Effect of protein kinase Cbeta inhibition on renal hemodynamic function and urinary biomarkers in humans with type 1 diabetes: a pilot study
    • Cherney D., Konvalinka A., Zinman B., Diamandis E., Soosaipillai A., Reich H.. (2009) Effect of protein kinase Cbeta inhibition on renal hemodynamic function and urinary biomarkers in humans with type 1 diabetes: a pilot study. Diabetes Care 32: 91–93.
    • (2009) Diabetes Care , vol.32 , pp. 91-93
    • Cherney, D.1    Konvalinka, A.2    Zinman, B.3    Diamandis, E.4    Soosaipillai, A.5    Reich, H.6
  • 13
    • 40949103146 scopus 로고    scopus 로고
    • The effect of cyclooxygenase-2 inhibition on renal hemodynamic function in humans with type 1 diabetes
    • Cherney D., Miller J., Scholey J., Bradley T., Slorach C., Curtis J.. (2008) The effect of cyclooxygenase-2 inhibition on renal hemodynamic function in humans with type 1 diabetes. Diabetes 57: 688–695.
    • (2008) Diabetes , vol.57 , pp. 688-695
    • Cherney, D.1    Miller, J.2    Scholey, J.3    Bradley, T.4    Slorach, C.5    Curtis, J.6
  • 14
    • 84893214045 scopus 로고    scopus 로고
    • The renal hemodynamic effect of SGLT2 inhibition in patients with type 1 diabetes
    • Cherney D., Perkins B., Soleymanlou N., Maione M., Lai V., Lee A.. (2014) The renal hemodynamic effect of SGLT2 inhibition in patients with type 1 diabetes. Circulation 129: 587–597. DOI:10.1161/CIRCULATIONAHA.113.005081.
    • (2014) Circulation , vol.129 , pp. 587-597
    • Cherney, D.1    Perkins, B.2    Soleymanlou, N.3    Maione, M.4    Lai, V.5    Lee, A.6
  • 15
    • 84867242387 scopus 로고    scopus 로고
    • Hyperfiltration and the effect of nitric oxide inhibition on renal and endothelial function in humans with uncomplicated type 1 diabetes mellitus
    • Cherney D., Reich H., Jiang S., Har R., Nasrallah R., Hebert R.. (2012) Hyperfiltration and the effect of nitric oxide inhibition on renal and endothelial function in humans with uncomplicated type 1 diabetes mellitus. Am J Physiol Regul Integr Comp Physiol 303: R710–R718.
    • (2012) Am J Physiol Regul Integr Comp Physiol , vol.303 , pp. R710-R718
    • Cherney, D.1    Reich, H.2    Jiang, S.3    Har, R.4    Nasrallah, R.5    Hebert, R.6
  • 17
    • 64649104158 scopus 로고    scopus 로고
    • From the triumvirate to the ominous octet: a new paradigm for the treatment of type 2 diabetes mellitus
    • DeFronzo R., (2009) From the triumvirate to the ominous octet: a new paradigm for the treatment of type 2 diabetes mellitus. Diabetes 58: 273–295.
    • (2009) Diabetes , vol.58 , pp. 273-295
    • DeFronzo, R.1
  • 18
    • 83655193529 scopus 로고    scopus 로고
    • The role of the kidneys in glucose homeostasis: a new path towards normalizing glycaemia
    • DeFronzo R., Davidson J., Del Prato S., (2012) The role of the kidneys in glucose homeostasis: a new path towards normalizing glycaemia. Diabetes Obes Metab 14: 5–14.
    • (2012) Diabetes Obes Metab , vol.14 , pp. 5-14
    • DeFronzo, R.1    Davidson, J.2    Del Prato, S.3
  • 19
    • 84860252876 scopus 로고    scopus 로고
    • Canagliflozin improves glycemic control over 28 days in subjects with type 2 diabetes not optimally controlled on insulin
    • Devineni D., Morrow L., Hompesch M., Skee D., Vandebosch A., (2012) Canagliflozin improves glycemic control over 28 days in subjects with type 2 diabetes not optimally controlled on insulin. Diabetes Obes Metab 14: 539–545.
    • (2012) Diabetes Obes Metab , vol.14 , pp. 539-545
    • Devineni, D.1    Morrow, L.2    Hompesch, M.3    Skee, D.4    Vandebosch, A.5
  • 21
    • 64749094872 scopus 로고
    • Effect of diabetes and insulin of the maximum capacity of the renal tubules to reabsorb glucose
    • Farber S., Berger E., Earle D., (1951) Effect of diabetes and insulin of the maximum capacity of the renal tubules to reabsorb glucose. J Clin Invest 30: 125–129.
    • (1951) J Clin Invest , vol.30 , pp. 125-129
    • Farber, S.1    Berger, E.2    Earle, D.3
  • 22
    • 84891851923 scopus 로고    scopus 로고
    • Long-term safety and efficacy of empagliflozin, sitagliptin, and metformin: an active-controlled, parallel-group, randomized, 78-week open-label extension study in patients with type 2 diabetes
    • Ferrannini E., Berk A., Hantel S., Pinnetti S., Hach T., Woerle H.. (2013a) Long-term safety and efficacy of empagliflozin, sitagliptin, and metformin: an active-controlled, parallel-group, randomized, 78-week open-label extension study in patients with type 2 diabetes. Diabetes Care 36: 4015–4021.
    • (2013) Diabetes Care , vol.36 , pp. 4015-4021
    • Ferrannini, E.1    Berk, A.2    Hantel, S.3    Pinnetti, S.4    Hach, T.5    Woerle, H.6
  • 23
    • 84893872877 scopus 로고    scopus 로고
    • Metabolic response to sodium-glucose cotransporter 2 inhibition in type 2 diabetic patients
    • Ferrannini E., Muscelli E., Frascerra S., Baldi S., Mari A., Heise T.. (2014) Metabolic response to sodium-glucose cotransporter 2 inhibition in type 2 diabetic patients. J Clin Invest 124: 499–508.
    • (2014) J Clin Invest , vol.124 , pp. 499-508
    • Ferrannini, E.1    Muscelli, E.2    Frascerra, S.3    Baldi, S.4    Mari, A.5    Heise, T.6
  • 24
    • 77956921439 scopus 로고    scopus 로고
    • Dapagliflozin monotherapy in type 2 diabetic patients with inadequate glycemic control by diet and exercise: a randomized, double- blind, placebo-controlled, phase III trial
    • Ferrannini E., Ramos S., Salsali A., Tang W., List J., (2010) Dapagliflozin monotherapy in type 2 diabetic patients with inadequate glycemic control by diet and exercise: a randomized, double- blind, placebo-controlled, phase III trial. Diabetes Care 33: 2217–2224.
    • (2010) Diabetes Care , vol.33 , pp. 2217-2224
    • Ferrannini, E.1    Ramos, S.2    Salsali, A.3    Tang, W.4    List, J.5
  • 25
    • 84876803427 scopus 로고    scopus 로고
    • Impact of chronic kidney disease and sodium-glucose cotransporter 2 inhibition in patients with type 2 diabetes
    • Ferrannini E., Veltkamp S., Smulders R., Kadokura T., (2013b) Impact of chronic kidney disease and sodium-glucose cotransporter 2 inhibition in patients with type 2 diabetes. Diabetes Care 36: 1260–1265.
    • (2013) Diabetes Care , vol.36 , pp. 1260-1265
    • Ferrannini, E.1    Veltkamp, S.2    Smulders, R.3    Kadokura, T.4
  • 26
    • 84975698839 scopus 로고    scopus 로고
    • Heart failure outcomes with empagliflozin in patients with type 2 diabetes at high cardiovascular risk: results of the EMPA-REG OUTCOME® trial
    • pii: ehv728
    • Fitchett D., Zinman B., Wanner C., Lachin J., Hantel S., Salsali A.. (2016) Heart failure outcomes with empagliflozin in patients with type 2 diabetes at high cardiovascular risk: results of the EMPA-REG OUTCOME® trial. Eur Heart J 26. pii: ehv728.
    • (2016) Eur Heart J , vol.26
    • Fitchett, D.1    Zinman, B.2    Wanner, C.3    Lachin, J.4    Hantel, S.5    Salsali, A.6
  • 27
    • 84876899238 scopus 로고    scopus 로고
    • Active- and placebo-controlled dose-finding study to assess the efficacy, safety, and tolerability of multiple doses of ipragliflozin in patients with type 2 diabetes mellitus
    • Fonseca V., Ferrannini E., Wilding J., Wilpshaar W., Dhanjal P., Ball G.. (2013) Active- and placebo-controlled dose-finding study to assess the efficacy, safety, and tolerability of multiple doses of ipragliflozin in patients with type 2 diabetes mellitus. J Diabetes Complications 27: 268–267.
    • (2013) J Diabetes Complications , vol.27 , pp. 267-268
    • Fonseca, V.1    Ferrannini, E.2    Wilding, J.3    Wilpshaar, W.4    Dhanjal, P.5    Ball, G.6
  • 28
    • 76249133903 scopus 로고    scopus 로고
    • Role of the kidney in normal glucose homeostasis and in the hyperglycaemia of diabetes mellitus: therapeutic implications
    • Gerich J., (2010) Role of the kidney in normal glucose homeostasis and in the hyperglycaemia of diabetes mellitus: therapeutic implications. Diabet Med 27: 136–142.
    • (2010) Diabet Med , vol.27 , pp. 136-142
    • Gerich, J.1
  • 29
    • 0032731318 scopus 로고    scopus 로고
    • The tubulointerstitium in progressive diabetic kidney disease: more than an aftermath of glomerular injury?
    • Gilbert R., Cooper M., (1999) The tubulointerstitium in progressive diabetic kidney disease: more than an aftermath of glomerular injury? Kidney Int 56: 1627–1637.
    • (1999) Kidney Int , vol.56 , pp. 1627-1637
    • Gilbert, R.1    Cooper, M.2
  • 30
    • 77949483458 scopus 로고    scopus 로고
    • Chapter 27: Urine formation by the kidneys: II tubular processing of the glomerular filtrate
    • Guyton, Hall, (eds), 11th ed., Philadelphia, Pennsylvania, Elsevier Saunders,. In, (Ed.), ;
    • Guyton A., Hall J., (2006) Chapter 27: Urine formation by the kidneys: II tubular processing of the glomerular filtrate. In Guyton A, Hall J, (Ed.), Textbook of Medical Physiology (11th ed.; pp. 327–347). Philadelphia, Pennsylvania: Elsevier Saunders.
    • (2006) Textbook of Medical Physiology , pp. 327-347
    • Guyton, A.1    Hall, J.2
  • 31
    • 84907291903 scopus 로고    scopus 로고
    • The sodium glucose cotransporter type 2 inhibitor empagliflozin preserves beta-cell mass and restores glucose homeostasis in the male Zucker diabetic fatty rat
    • Hansen H., Jelsing J., Hansen C., Hansen G., Vrang N., Mark M.. (2014) The sodium glucose cotransporter type 2 inhibitor empagliflozin preserves beta-cell mass and restores glucose homeostasis in the male Zucker diabetic fatty rat. J Pharmacol Exp Ther 350: 657–664.
    • (2014) J Pharmacol Exp Ther , vol.350 , pp. 657-664
    • Hansen, H.1    Jelsing, J.2    Hansen, C.3    Hansen, G.4    Vrang, N.5    Mark, M.6
  • 32
    • 0027948971 scopus 로고
    • Molecular physiology of sodium-glucose cotransporters
    • Hediger M., Rhoads D., (1994) Molecular physiology of sodium-glucose cotransporters. Physiol Rev 74: 993–1026.
    • (1994) Physiol Rev , vol.74 , pp. 993-1026
    • Hediger, M.1    Rhoads, D.2
  • 33
    • 84878947970 scopus 로고    scopus 로고
    • Safety, tolerability, pharmacokinetics and pharmacodynamics following 4 weeks’ treatment with empagliflozin once daily in patients with type 2 diabetes
    • Heise T., Seewaldt-Becker E., Macha S., Hantel S., Pinnetti S., Seman L.. (2013) Safety, tolerability, pharmacokinetics and pharmacodynamics following 4 weeks’ treatment with empagliflozin once daily in patients with type 2 diabetes. Diabetes Obes Metab 15: 613–621.
    • (2013) Diabetes Obes Metab , vol.15 , pp. 613-621
    • Heise, T.1    Seewaldt-Becker, E.2    Macha, S.3    Hantel, S.4    Pinnetti, S.5    Seman, L.6
  • 34
    • 84934442921 scopus 로고    scopus 로고
    • Exploring the potential of the SGLT2 inhibitor dapagliflozin in type 1 diabetes: a randomized, double- blind, placebo-controlled pilot study
    • Henry R., Rosenstock J., Edelman S., Mudaliar S., Chalamandaris A., Kasichayanula S.. (2015) Exploring the potential of the SGLT2 inhibitor dapagliflozin in type 1 diabetes: a randomized, double- blind, placebo-controlled pilot study. Diabetes Care 38(3): 412–419.
    • (2015) Diabetes Care , vol.38 , Issue.3 , pp. 412-419
    • Henry, R.1    Rosenstock, J.2    Edelman, S.3    Mudaliar, S.4    Chalamandaris, A.5    Kasichayanula, S.6
  • 35
    • 57349116972 scopus 로고    scopus 로고
    • Role of Kruppel-like factor 6 in transforming growth factor-beta1-induced epithelial-mesenchymal transition of proximal tubule cells
    • Holian J., Qi W., Kelly D., Zhang Y., Mreich E., Pollock C.. (2008) Role of Kruppel-like factor 6 in transforming growth factor-beta1-induced epithelial-mesenchymal transition of proximal tubule cells. Am J Physiol Renal Physiol 295: F1388–F1396.
    • (2008) Am J Physiol Renal Physiol , vol.295 , pp. F1388-F1396
    • Holian, J.1    Qi, W.2    Kelly, D.3    Zhang, Y.4    Mreich, E.5    Pollock, C.6
  • 36
    • 0020041880 scopus 로고
    • The case for intrarenal hypertension in the initiation and progression of diabetic and other glomerulopathies
    • Hostetter T., Rennke H., Brenner B., (1982) The case for intrarenal hypertension in the initiation and progression of diabetic and other glomerulopathies. Am J Med 72: 375–380.
    • (1982) Am J Med , vol.72 , pp. 375-380
    • Hostetter, T.1    Rennke, H.2    Brenner, B.3
  • 37
    • 0019460233 scopus 로고
    • Glomerular hemodynamics in experimental diabetes mellitus
    • Hostetter T., Troy J., Brenner B., (1981) Glomerular hemodynamics in experimental diabetes mellitus. Kidney Int 19: 410–415.
    • (1981) Kidney Int , vol.19 , pp. 410-415
    • Hostetter, T.1    Troy, J.2    Brenner, B.3
  • 38
    • 77953734934 scopus 로고    scopus 로고
    • Single-dose pharmacokinetics and pharmacodynamics of sergliflozin etabonate, a novel inhibitor of glucose reabsorption, in healthy volunteers and patients with type 2 diabetes mellitus
    • Hussey E., Clark R., Amin D., Kipnes M., O’Connor-Semmes R., O’Driscoll E.. (2010) Single-dose pharmacokinetics and pharmacodynamics of sergliflozin etabonate, a novel inhibitor of glucose reabsorption, in healthy volunteers and patients with type 2 diabetes mellitus. J Clin Pharmacol 50: 623–635.
    • (2010) J Clin Pharmacol , vol.50 , pp. 623-635
    • Hussey, E.1    Clark, R.2    Amin, D.3    Kipnes, M.4    O’Connor-Semmes, R.5    O’Driscoll, E.6
  • 39
    • 42449113420 scopus 로고    scopus 로고
    • The fundamental drivers of the obesity epidemic
    • James W., (2008) The fundamental drivers of the obesity epidemic. Obes Rev 9(Suppl. 1): 6–13.
    • (2008) Obes Rev , vol.9 , pp. 6-13
    • James, W.1
  • 42
    • 0031780198 scopus 로고    scopus 로고
    • TGFbeta 1 dissociates human proximal tubule cell growth and Na(+)-H+ exchange activity
    • Johnson D., Saunders H., Brew B., Poronnik P., Cook D., Field M.. (1998) TGFbeta 1 dissociates human proximal tubule cell growth and Na(+)-H+ exchange activity. Kidney Int 53: 1601–1607.
    • (1998) Kidney Int , vol.53 , pp. 1601-1607
    • Johnson, D.1    Saunders, H.2    Brew, B.3    Poronnik, P.4    Cook, D.5    Field, M.6
  • 43
    • 84899558137 scopus 로고    scopus 로고
    • Efficacy and safety of monotherapy with the novel sodium/glucose cotransporter-2 inhibitor tofogliflozin in Japanese patients with type 2 diabetes mellitus: a combined phase 2 and 3 randomized, placebo-controlled, double-blind, parallel-group comparative study
    • Kaku K., Watada H., Iwamoto Y., Utsunomiya K., Terauchi Y., Tobe K.. (2014) Efficacy and safety of monotherapy with the novel sodium/glucose cotransporter-2 inhibitor tofogliflozin in Japanese patients with type 2 diabetes mellitus: a combined phase 2 and 3 randomized, placebo-controlled, double-blind, parallel-group comparative study. Cardiovasc Diabetol 13: 1–15.
    • (2014) Cardiovasc Diabetol , vol.13 , pp. 1-15
    • Kaku, K.1    Watada, H.2    Iwamoto, Y.3    Utsunomiya, K.4    Terauchi, Y.5    Tobe, K.6
  • 44
    • 84897394040 scopus 로고    scopus 로고
    • Long-term study of patients with type 2 diabetesT2DM and moderate renal impairment shows that dapagliflozin reduces weigh and blood pressure but does not improve glycemic control
    • Kohan D., Fioretto P., Tang W., List J., (2014) Long-term study of patients with type 2 diabetesT2DM and moderate renal impairment shows that dapagliflozin reduces weigh and blood pressure but does not improve glycemic control. Kidney Int 85: 962–971.
    • (2014) Kidney Int , vol.85 , pp. 962-971
    • Kohan, D.1    Fioretto, P.2    Tang, W.3    List, J.4
  • 45
    • 84892477577 scopus 로고    scopus 로고
    • Empagliflozin improves glycaemic and weight control as add-on therapy to pioglitazone or pioglitazone plus metformin in patients with type 2 diabetes: a 24-week, randomized, placebo-controlled trial
    • Kovacs C., Seshiah V., Swallow R., Jones R., Rattunde H., Woerle H.. (2013) Empagliflozin improves glycaemic and weight control as add-on therapy to pioglitazone or pioglitazone plus metformin in patients with type 2 diabetes: a 24-week, randomized, placebo-controlled trial. Diabetes Obes Metab 16(2): 147–158.
    • (2013) Diabetes Obes Metab , vol.16 , Issue.2 , pp. 147-158
    • Kovacs, C.1    Seshiah, V.2    Swallow, R.3    Jones, R.4    Rattunde, H.5    Woerle, H.6
  • 46
    • 21544458635 scopus 로고    scopus 로고
    • Screening for kidney disease in adults with diabetes
    • Kramer H., Molitch M., (2005) Screening for kidney disease in adults with diabetes. Diabetes Care 28: 1813–1816.
    • (2005) Diabetes Care , vol.28 , pp. 1813-1816
    • Kramer, H.1    Molitch, M.2
  • 47
    • 84900812229 scopus 로고    scopus 로고
    • Empagliflozin, a sodium glucose co-transporter 2 inhibitor, in the treatment of type 1 diabetes
    • Lamos E., Younk L., Davis S., (2014) Empagliflozin, a sodium glucose co-transporter 2 inhibitor, in the treatment of type 1 diabetes. Expert Opin Investig Drugs 23: 875–882.
    • (2014) Expert Opin Investig Drugs , vol.23 , pp. 875-882
    • Lamos, E.1    Younk, L.2    Davis, S.3
  • 48
    • 84857099986 scopus 로고    scopus 로고
    • Effect of canagliflozin on renal threshold for glucose, glycemia, and body weight in normal and diabetic animal models
    • Liang Y., Arakawa K., Ueta K., Matsushita Y., Kuriyama C., Martin T.. (2012) Effect of canagliflozin on renal threshold for glucose, glycemia, and body weight in normal and diabetic animal models. PLoS One 7: e30555.
    • (2012) PLoS One , vol.7 , pp. e30555
    • Liang, Y.1    Arakawa, K.2    Ueta, K.3    Matsushita, Y.4    Kuriyama, C.5    Martin, T.6
  • 49
    • 84921480876 scopus 로고    scopus 로고
    • A review on the relationship between SGLT2 inhibitors and cancer
    • Lin H., Tseng C., (2014) A review on the relationship between SGLT2 inhibitors and cancer. Int J Endocrin 2014: 719578.
    • (2014) Int J Endocrin , vol.2014 , pp. 719578
    • Lin, H.1    Tseng, C.2
  • 50
    • 85006343609 scopus 로고    scopus 로고
    • Ipragliflozin (Suglat) first of new diabetes drug class in Japan
    • accessed 7 July 2014,. :
    • Nainggolan L., (2014) Ipragliflozin (Suglat) first of new diabetes drug class in Japan. Medscape Medical News. Available at: http://www.medscape.com/viewarticle/819447 (accessed 7 July 2014).
    • (2014) Medscape Medical News
    • Nainggolan, L.1
  • 51
    • 65349196064 scopus 로고    scopus 로고
    • Sodium-glucose cotransport inhibition with dapagliflozin in type 2 diabetes
    • List J., Woo V., Morales E., Tang W., Fiedorek F., (2009) Sodium-glucose cotransport inhibition with dapagliflozin in type 2 diabetes. Diabetes Care 32: 650–657.
    • (2009) Diabetes Care , vol.32 , pp. 650-657
    • List, J.1    Woo, V.2    Morales, E.3    Tang, W.4    Fiedorek, F.5
  • 52
    • 84893727925 scopus 로고    scopus 로고
    • Pharmacokinetics, pharmacodynamics and safety of empagliflozin, a sodium glucose cotransporter 2 (SGLT2) inhibitor, in subjects with renal impairment
    • Macha S., Mattheus M., Halabi A., Pinnetti S., Woerle H., Broedl U., (2014) Pharmacokinetics, pharmacodynamics and safety of empagliflozin, a sodium glucose cotransporter 2 (SGLT2) inhibitor, in subjects with renal impairment. Diabetes Obes Metab 16: 215–222.
    • (2014) Diabetes Obes Metab , vol.16 , pp. 215-222
    • Macha, S.1    Mattheus, M.2    Halabi, A.3    Pinnetti, S.4    Woerle, H.5    Broedl, U.6
  • 53
    • 61449183458 scopus 로고    scopus 로고
    • Is hyperfiltration associated with the future risk of developing diabetic nephropathy? A meta-analysis
    • Magee G., Bilous R., Cardwell C., Hunter S., Kee F., Fogarty D., (2009) Is hyperfiltration associated with the future risk of developing diabetic nephropathy? A meta-analysis. Diabetologia 52: 691–697.
    • (2009) Diabetologia , vol.52 , pp. 691-697
    • Magee, G.1    Bilous, R.2    Cardwell, C.3    Hunter, S.4    Kee, F.5    Fogarty, D.6
  • 54
    • 84962360678 scopus 로고    scopus 로고
    • Blood pressure reduction: an added benefit of sodium glucose cotransporter 2 inhibitors in patients with type 2 diabetes
    • Majewski C., Bakris G., (2015) Blood pressure reduction: an added benefit of sodium glucose cotransporter 2 inhibitors in patients with type 2 diabetes. Diabetes Care 38: 429–430.
    • (2015) Diabetes Care , vol.38 , pp. 429-430
    • Majewski, C.1    Bakris, G.2
  • 55
    • 85006492998 scopus 로고    scopus 로고
    • Albuminuria, the sentinel marker of renal failure, is consistently decreased with empagliflozin in several preclinical models of diabetic nephropathy
    • ePoster #824
    • Mark M., Vallon V., Hugo C., Roman R., Mayoux E., (2014) Albuminuria, the sentinel marker of renal failure, is consistently decreased with empagliflozin in several preclinical models of diabetic nephropathy. EASD Virtual Meeting. ePoster #824.
    • (2014) EASD Virtual Meeting
    • Mark, M.1    Vallon, V.2    Hugo, C.3    Roman, R.4    Mayoux, E.5
  • 56
    • 84902240389 scopus 로고    scopus 로고
    • Luseogliflozin: first global approval
    • Markaham A., Elkinson S., (2014) Luseogliflozin: first global approval. Drugs 74: 945–950. doi:10.1007/s40265-014-0230-8.
    • (2014) Drugs , vol.74 , pp. 945-950
    • Markaham, A.1    Elkinson, S.2
  • 57
    • 85006477095 scopus 로고    scopus 로고
    • FDA approves empagliflozin for adults with type 2 diabetes
    • accessed 2 March 2016,. :
    • Mechcatie E., (2014) FDA approves empagliflozin for adults with type 2 diabetes. Clinical Endocrinology News. Available at: http://www.clinicalendocrinologynews.com/home/article/fda-approves-empagliflozin-for-adults-with-type-2-diabetes/e8e500442424cf39148f889d6fe6b16c.html (accessed 2 March 2016).
    • (2014) Clinical Endocrinology News
    • Mechcatie, E.1
  • 58
    • 85006510353 scopus 로고    scopus 로고
    • accessed 2 March 2016, 31, October, 2015,. :, updated
    • Merck. (2015) Merck pipeline. Available at: http://www.merck.com/research/pipeline/home.html (accessed 2 March 2016, updated 31 October 2015).
    • (2015) Merck pipeline
  • 59
    • 84873079417 scopus 로고    scopus 로고
    • SGLT2 inhibitors: a promising new therapeutic option for treatment of type 2 diabetes mellitus: review
    • Misra M., (2012) SGLT2 inhibitors: a promising new therapeutic option for treatment of type 2 diabetes mellitus: review. J Pharm Pharmacol 65: 317–327.
    • (2012) J Pharm Pharmacol , vol.65 , pp. 317-327
    • Misra, M.1
  • 60
    • 84884554260 scopus 로고    scopus 로고
    • Tofogliflozin, a novel sodium-glucose co-transporter 2 inhibitor, improves renal and pancreatic function in db/db mice
    • Nagata T., Fukuzawa T., Takeda M., Fukazawa M., Mori T., Nihei T.. (2013) Tofogliflozin, a novel sodium-glucose co-transporter 2 inhibitor, improves renal and pancreatic function in db/db mice. Br J Pharmacol 170: 519–531.
    • (2013) Br J Pharmacol , vol.170 , pp. 519-531
    • Nagata, T.1    Fukuzawa, T.2    Takeda, M.3    Fukazawa, M.4    Mori, T.5    Nihei, T.6
  • 61
    • 80155124676 scopus 로고    scopus 로고
    • Dapagliflozin versus glipizide as add-on therapy in patients with type 2 diabetes who have inadequate glycemic control with metformin: a randomized, 52-week, double-blind, active-controlled noninferiority trial
    • Nauck M., Del Prato S., Meier J., Duran- Garcia S., Rohwedder K., Elze M.. (2011) Dapagliflozin versus glipizide as add-on therapy in patients with type 2 diabetes who have inadequate glycemic control with metformin: a randomized, 52-week, double-blind, active-controlled noninferiority trial. Diabetes Care 34: 2015–2022.
    • (2011) Diabetes Care , vol.34 , pp. 2015-2022
    • Nauck, M.1    Del Prato, S.2    Meier, J.3    Duran- Garcia, S.4    Rohwedder, K.5    Elze, M.6
  • 62
    • 85006439578 scopus 로고    scopus 로고
    • Sodium glucose cotransporter 2 inhibition in the diabetic kidney: an update
    • Novikov A., Vallon V., (2015) Sodium glucose cotransporter 2 inhibition in the diabetic kidney: an update. Curr Opin Nephrol Hypertens 24: 1–9.
    • (2015) Curr Opin Nephrol Hypertens , vol.24 , pp. 1-9
    • Novikov, A.1    Vallon, V.2
  • 63
    • 84863617006 scopus 로고    scopus 로고
    • Evaluation of vulvovaginal symptoms and Candida colonization in women with type 2 diabetes mellitus treated with canagliflozin, a sodium glucose co-transporter 2 inhibitor
    • Nyirjesy P., Zhao Y., Ways K., Usiskin K., (2012) Evaluation of vulvovaginal symptoms and Candida colonization in women with type 2 diabetes mellitus treated with canagliflozin, a sodium glucose co-transporter 2 inhibitor. Curr Med Res Opin 28: 1173–1178.
    • (2012) Curr Med Res Opin , vol.28 , pp. 1173-1178
    • Nyirjesy, P.1    Zhao, Y.2    Ways, K.3    Usiskin, K.4
  • 64
    • 0023130568 scopus 로고
    • Complete absence of tubular glucose reabsorption: a new type of renal glucosuria (type 0)
    • Oemar B., Byrd D., Brodehl J., (1987) Complete absence of tubular glucose reabsorption: a new type of renal glucosuria (type 0). Clin Nephrol 27: 156–160.
    • (1987) Clin Nephrol , vol.27 , pp. 156-160
    • Oemar, B.1    Byrd, D.2    Brodehl, J.3
  • 65
    • 0032850016 scopus 로고    scopus 로고
    • T-1095, an inhibitor of renal Na+-glucose cotransporters, may provide a novel approach to treating diabetes
    • Oku A., Ueta K., Arakawa K., Ishihara T., Nawano M., Kuronuma Y.. (1999) T-1095, an inhibitor of renal Na+-glucose cotransporters, may provide a novel approach to treating diabetes. Diabetes 48: 1794–1800.
    • (1999) Diabetes , vol.48 , pp. 1794-1800
    • Oku, A.1    Ueta, K.2    Arakawa, K.3    Ishihara, T.4    Nawano, M.5    Kuronuma, Y.6
  • 66
    • 84901198078 scopus 로고    scopus 로고
    • Blood pressure effects of sodium-glucose co-transport 2 (SGLT2) inhibitors
    • Oliva R., Bakris G., (2014) Blood pressure effects of sodium-glucose co-transport 2 (SGLT2) inhibitors. J Am Soc Hypertens 8: 330–339.
    • (2014) J Am Soc Hypertens , vol.8 , pp. 330-339
    • Oliva, R.1    Bakris, G.2
  • 67
    • 84873497173 scopus 로고    scopus 로고
    • Effects of SGLT2 inhibition in human kidney proximal tubular cells renoprotection in diabetic nephropathy?
    • Panchapakesan U., Pegg K., Gross S., Komala M., Mudaliar H., Forbes J.. (2013) Effects of SGLT2 inhibition in human kidney proximal tubular cells renoprotection in diabetic nephropathy? Plos One 8: e54442.
    • (2013) Plos One , vol.8 , pp. e54442
    • Panchapakesan, U.1    Pegg, K.2    Gross, S.3    Komala, M.4    Mudaliar, H.5    Forbes, J.6
  • 68
    • 4143099046 scopus 로고    scopus 로고
    • The effect of high glucose and PPAR-gamma agonists on PPAR-gamma expression and function in HK-2 cells
    • Panchapakesan U., Pollock C., Chen X, (2004) The effect of high glucose and PPAR-gamma agonists on PPAR-gamma expression and function in HK-2 cells. Am J Physiol Renal Physiol 287: F528–F534.
    • (2004) Am J Physiol Renal Physiol , vol.287 , pp. F528-F534
    • Panchapakesan, U.1    Pollock, C.2    Chen, X.3
  • 69
    • 26844496791 scopus 로고    scopus 로고
    • PPAR-gamma agonists exert antifibrotic effects in renal tubular cells exposed to high glucose
    • Panchapakesan U., Sumual S., Pollock C., Chen X., (2005) PPAR-gamma agonists exert antifibrotic effects in renal tubular cells exposed to high glucose. Am J Physiol Renal Physiol 289: F1153–F1158.
    • (2005) Am J Physiol Renal Physiol , vol.289 , pp. F1153-F1158
    • Panchapakesan, U.1    Sumual, S.2    Pollock, C.3    Chen, X.4
  • 70
    • 84902296808 scopus 로고    scopus 로고
    • Tofogliflozin: first global approval
    • Poole R., Prossler J., (2014) Tofogliflozin: first global approval. Drugs 74: 939–944.
    • (2014) Drugs , vol.74 , pp. 939-944
    • Poole, R.1    Prossler, J.2
  • 71
    • 84942312400 scopus 로고    scopus 로고
    • Assessing bladder cancer risk in type 2 diabetes clinical trials: the dapagliflozin drug development program as a ‘case study’
    • Ptaszynska A., Cohen S., Messing E., Reilly T., Johnsson E., Johnsson K., (2015) Assessing bladder cancer risk in type 2 diabetes clinical trials: the dapagliflozin drug development program as a ‘case study’. Diabetes Ther 6: 357–375.
    • (2015) Diabetes Ther , vol.6 , pp. 357-375
    • Ptaszynska, A.1    Cohen, S.2    Messing, E.3    Reilly, T.4    Johnsson, E.5    Johnsson, K.6
  • 72
    • 33750938708 scopus 로고    scopus 로고
    • Transforming growth factor-beta1 differentially mediates fibronectin and inflammatory cytokine expression in kidney tubular cells
    • Qi W., Chen X., Holian J., Mreich E., Twigg S., Gilbert R.. (2006) Transforming growth factor-beta1 differentially mediates fibronectin and inflammatory cytokine expression in kidney tubular cells. Am J Physiol Renal Physiol 291: F1070–F1077.
    • (2006) Am J Physiol Renal Physiol , vol.291 , pp. F1070-F1077
    • Qi, W.1    Chen, X.2    Holian, J.3    Mreich, E.4    Twigg, S.5    Gilbert, R.6
  • 73
    • 15044359781 scopus 로고    scopus 로고
    • Integrated actions of transforming growth factor-beta1 and connective tissue growth factor in renal fibrosis
    • Qi W., Twigg S., Chen X., Polhill T., Poronnik P., Gilbert R.. (2005) Integrated actions of transforming growth factor-beta1 and connective tissue growth factor in renal fibrosis. Am J Physiol Renal Physiol 288: F800–F809.
    • (2005) Am J Physiol Renal Physiol , vol.288 , pp. F800-F809
    • Qi, W.1    Twigg, S.2    Chen, X.3    Polhill, T.4    Poronnik, P.5    Gilbert, R.6
  • 74
    • 33644688031 scopus 로고    scopus 로고
    • Glucose transporters in human renal proximal tubular cells isolated from the urine of patients with non–insulin-dependent diabetes
    • Rahmoune H., Thompson P., Ward J., Smith C., Hong G., Brown J., (2005) Glucose transporters in human renal proximal tubular cells isolated from the urine of patients with non–insulin-dependent diabetes. Diabetes 54: 3427–3434.
    • (2005) Diabetes , vol.54 , pp. 3427-3434
    • Rahmoune, H.1    Thompson, P.2    Ward, J.3    Smith, C.4    Hong, G.5    Brown, J.6
  • 75
    • 84898954869 scopus 로고    scopus 로고
    • Carcinogenicity risk assessment supports the chronic safety of dapagliflozin, an inhibitor of sodium-glucose co-transporter 2, in the treatment of type 2 diabetes mellitus
    • Reilly T., Graziano M., Janovitz E., Dorr T., Fairchild C., Lee F.. (2014) Carcinogenicity risk assessment supports the chronic safety of dapagliflozin, an inhibitor of sodium-glucose co-transporter 2, in the treatment of type 2 diabetes mellitus. Diabetes Ther 5: 73–96.
    • (2014) Diabetes Ther , vol.5 , pp. 73-96
    • Reilly, T.1    Graziano, M.2    Janovitz, E.3    Dorr, T.4    Fairchild, C.5    Lee, F.6
  • 76
    • 84861781220 scopus 로고    scopus 로고
    • Dose-ranging effects of canagliflozin, a sodium-glucose cotransporter 2 inhibitor, as add-on to metformin in subjects with type 2 diabetes
    • Rosenstock J., Aggarwal N., Polidori D., Zhao Y., Arbit D., Usiskin K.. (2012) Dose-ranging effects of canagliflozin, a sodium-glucose cotransporter 2 inhibitor, as add-on to metformin in subjects with type 2 diabetes. Diabetes Care 35: 1232–1238.
    • (2012) Diabetes Care , vol.35 , pp. 1232-1238
    • Rosenstock, J.1    Aggarwal, N.2    Polidori, D.3    Zhao, Y.4    Arbit, D.5    Usiskin, K.6
  • 77
    • 84887191925 scopus 로고    scopus 로고
    • Efficacy and safety of empagliflozin, a sodium glucose cotransporter 2 (SGLT2) inhibitor, as add-on to metformin in type 2 diabetes with mild hyperglycaemia
    • Rosenstock J., Seman L., Jelaska A., Hantel S., Pinnetti S., Hach T.. (2013) Efficacy and safety of empagliflozin, a sodium glucose cotransporter 2 (SGLT2) inhibitor, as add-on to metformin in type 2 diabetes with mild hyperglycaemia. Diabetes Obes Metab 15: 1154–1160.
    • (2013) Diabetes Obes Metab , vol.15 , pp. 1154-1160
    • Rosenstock, J.1    Seman, L.2    Jelaska, A.3    Hantel, S.4    Pinnetti, S.5    Hach, T.6
  • 78
    • 0023571397 scopus 로고
    • Effect of chronic hyperglycemia on in vivo insulin secretion in partially pancreatectomized rats
    • Rossetti L., Shulman G., Zawalich W., DeFronzo R., (1987a) Effect of chronic hyperglycemia on in vivo insulin secretion in partially pancreatectomized rats. J Clin Invest 80: 1037–1044.
    • (1987) J Clin Invest , vol.80 , pp. 1037-1044
    • Rossetti, L.1    Shulman, G.2    Zawalich, W.3    DeFronzo, R.4
  • 79
    • 0023275573 scopus 로고
    • Correction of hyperglycemia with phlorizin normalizes tissue sensitivity to insulin in diabetic rats
    • Rossetti L., Smith D., Shulman G., Papachristou D., DeFronzo R., (1987b) Correction of hyperglycemia with phlorizin normalizes tissue sensitivity to insulin in diabetic rats. J Clin Invest 79: 1510–1515.
    • (1987) J Clin Invest , vol.79 , pp. 1510-1515
    • Rossetti, L.1    Smith, D.2    Shulman, G.3    Papachristou, D.4    DeFronzo, R.5
  • 81
    • 75749094398 scopus 로고    scopus 로고
    • Familial renal glucosuria and SGLT2: from a Mendelian trait to a therapeutic target: In-depth review
    • Santer R., Calado J., (2010) Familial renal glucosuria and SGLT2: from a Mendelian trait to a therapeutic target: In-depth review. Clin J Am Soc Nephrol 5: 133–141.
    • (2010) Clin J Am Soc Nephrol , vol.5 , pp. 133-141
    • Santer, R.1    Calado, J.2
  • 82
    • 84879384843 scopus 로고    scopus 로고
    • Safety, tolerability, pharmacokinetics and pharmacodynamics of single doses of empagliflozin, a sodium glucose cotransporter 2 (SGLT2) inhibitor, in healthy Japanese subjects
    • Sarashina A., Koiwai K., Seman L., Yamamura N., Tanigughi A., Negishi T.. (2013) Safety, tolerability, pharmacokinetics and pharmacodynamics of single doses of empagliflozin, a sodium glucose cotransporter 2 (SGLT2) inhibitor, in healthy Japanese subjects. Drug Metab Pharmacokinet 28: 213–219.
    • (2013) Drug Metab Pharmacokinet , vol.28 , pp. 213-219
    • Sarashina, A.1    Koiwai, K.2    Seman, L.3    Yamamura, N.4    Tanigughi, A.5    Negishi, T.6
  • 83
    • 84871213936 scopus 로고    scopus 로고
    • Renal hyperfiltration related to diabetes mellitus and obesity in human disease
    • Sasson A., Cherney D., (2012) Renal hyperfiltration related to diabetes mellitus and obesity in human disease. World J Diabetes 3: 1–6.
    • (2012) World J Diabetes , vol.3 , pp. 1-6
    • Sasson, A.1    Cherney, D.2
  • 84
    • 84896826460 scopus 로고    scopus 로고
    • Pharmacokinetic and pharmacodynamic profile of empagliflozin, a sodium glucose co-transporter 2 inhibitor
    • Scheen A., (2014) Pharmacokinetic and pharmacodynamic profile of empagliflozin, a sodium glucose co-transporter 2 inhibitor. Clin Pharmacokinet 53: 213–225.
    • (2014) Clin Pharmacokinet , vol.53 , pp. 213-225
    • Scheen, A.1
  • 85
    • 4544284779 scopus 로고    scopus 로고
    • Long-term outcome of renal glucosuria type 0: The original patient and his natural history
    • Scholl-Burgi S., Santer R., Ehrich J., (2004) Long-term outcome of renal glucosuria type 0: The original patient and his natural history. Nephrol Dial Transplant 19: 2394–2396.
    • (2004) Nephrol Dial Transplant , vol.19 , pp. 2394-2396
    • Scholl-Burgi, S.1    Santer, R.2    Ehrich, J.3
  • 86
    • 84933523949 scopus 로고    scopus 로고
    • Characterisation of glomerular haemodynamic responses to SGLT2 inhibition in patients with type 1 diabetes and renal hyperfiltration
    • Škrtić M., Yang G., Perkins B., Soleymanlou N., Lytvyn Y., Eynatten M.. (2014) Characterisation of glomerular haemodynamic responses to SGLT2 inhibition in patients with type 1 diabetes and renal hyperfiltration. Diabetologia 57: 2599–2602.
    • (2014) Diabetologia , vol.57 , pp. 2599-2602
    • Škrtić, M.1    Yang, G.2    Perkins, B.3    Soleymanlou, N.4    Lytvyn, Y.5    Eynatten, M.6
  • 87
    • 33646920858 scopus 로고    scopus 로고
    • Impact of rennin angiotensin system modulation on the hyperfiltration state in type 1 diabetes
    • Sochett E., Cherney D., Curtis J., Dekker M., Scholey J., Miller J., (2006) Impact of rennin angiotensin system modulation on the hyperfiltration state in type 1 diabetes. J Am Soc Nephrol 17: 1703–1709.
    • (2006) J Am Soc Nephrol , vol.17 , pp. 1703-1709
    • Sochett, E.1    Cherney, D.2    Curtis, J.3    Dekker, M.4    Scholey, J.5    Miller, J.6
  • 88
    • 0021911168 scopus 로고
    • Correction of hyperglycemia with phloridzin restores the glucagon response to glucose in insulin deficient dogs: implications for human diabetes
    • Starke A., Grundy S., McGarry J., Unger R., (1985) Correction of hyperglycemia with phloridzin restores the glucagon response to glucose in insulin deficient dogs: implications for human diabetes. Proc Natl Acad Sci USA 82: 1544–1546.
    • (1985) Proc Natl Acad Sci USA , vol.82 , pp. 1544-1546
    • Starke, A.1    Grundy, S.2    McGarry, J.3    Unger, R.4
  • 89
    • 84874291673 scopus 로고    scopus 로고
    • Efficacy and safety of canagliflozin monotherapy in subjects with type 2 diabetes mellitus inadequately controlled with diet and exercise
    • Stenlof K., Cefalu W., Kim K., Alba M., Usiskin K., Tong C.. (2013) Efficacy and safety of canagliflozin monotherapy in subjects with type 2 diabetes mellitus inadequately controlled with diet and exercise. Diabetes Obes Metab 15: 372–382.
    • (2013) Diabetes Obes Metab , vol.15 , pp. 372-382
    • Stenlof, K.1    Cefalu, W.2    Kim, K.3    Alba, M.4    Usiskin, K.5    Tong, C.6
  • 90
    • 80052524011 scopus 로고    scopus 로고
    • Effect of dapagliflozin in patients with type 2 diabetes who have inadequate glycaemic control with glimepiride: a randomized, 24-week, double-blind, placebo-controlled trial
    • Strojek K., Yoon K., Hruba V., Elze M., Langkilde A., Parikh S., (2011) Effect of dapagliflozin in patients with type 2 diabetes who have inadequate glycaemic control with glimepiride: a randomized, 24-week, double-blind, placebo-controlled trial. Diabetes Obes Metab 13: 928–938.
    • (2011) Diabetes Obes Metab , vol.13 , pp. 928-938
    • Strojek, K.1    Yoon, K.2    Hruba, V.3    Elze, M.4    Langkilde, A.5    Parikh, S.6
  • 91
    • 84939142605 scopus 로고    scopus 로고
    • SGLT2 inhibitors may predispose to ketoacidosis
    • Taylor S., Blau J., Rother K., (2015) SGLT2 inhibitors may predispose to ketoacidosis. J Clin Endocrinol Metab 100: 2849–2852.
    • (2015) J Clin Endocrinol Metab , vol.100 , pp. 2849-2852
    • Taylor, S.1    Blau, J.2    Rother, K.3
  • 93
    • 84928196614 scopus 로고    scopus 로고
    • Empagliflozin reduces blood pressure in patients with type 2 diabetes and hypertension
    • Tikkanen I., Narko K., Zeller C., Green A., Salsali A., Broedl U.. (2015) Empagliflozin reduces blood pressure in patients with type 2 diabetes and hypertension. Diabetes Care 38: 420–428.
    • (2015) Diabetes Care , vol.38 , pp. 420-428
    • Tikkanen, I.1    Narko, K.2    Zeller, C.3    Green, A.4    Salsali, A.5    Broedl, U.6
  • 94
    • 84887844360 scopus 로고    scopus 로고
    • Nonclinical toxicology assessments support the chronic safety of dapagliflozin, a first-in-class sodium-glucose cotransporter 2 inhibitor
    • Tirmenstein M., Dorr T., Janovitz E., Hagan D., Abell L., Onorato J.. (2013) Nonclinical toxicology assessments support the chronic safety of dapagliflozin, a first-in-class sodium-glucose cotransporter 2 inhibitor. Int J Toxicol 32: 336–350.
    • (2013) Int J Toxicol , vol.32 , pp. 336-350
    • Tirmenstein, M.1    Dorr, T.2    Janovitz, E.3    Hagan, D.4    Abell, L.5    Onorato, J.6
  • 95
    • 0000920044 scopus 로고
    • Heterogeneity of sodium-dependent D-glucose transport sites along the proximal tubule: evidence from vesicle studies
    • Turner R., Moran A., (1982a) Heterogeneity of sodium-dependent D-glucose transport sites along the proximal tubule: evidence from vesicle studies. Am J Physiol Renal Fluid Electrolyte Physiol 242: F406–F414.
    • (1982) Am J Physiol Renal Fluid Electrolyte Physiol , vol.242 , pp. F406-F414
    • Turner, R.1    Moran, A.2
  • 96
    • 0020445298 scopus 로고
    • Further studies of proximal tubular brush border membrane D-glucose transport heterogeneity
    • Turner R., Moran A., (1982b) Further studies of proximal tubular brush border membrane D-glucose transport heterogeneity. J Membr Biol 70: 37–45.
    • (1982) J Membr Biol , vol.70 , pp. 37-45
    • Turner, R.1    Moran, A.2
  • 97
    • 85006366219 scopus 로고    scopus 로고
    • :
    • United Stated Food and Drug Administration (2011) Dapagliflozin. Background document [database on the Internet]. Available at: http://www.fda.gov/downloads/AdvisoryCommittees/CommitteesMeetingMaterials/Drugs/EndocrinologicandMetabolicDrugsAdvisoryCommittee/UCM449865.pdf.
    • (2011) Dapagliflozin. Background document [database on the Internet]
  • 98
    • 84884151646 scopus 로고    scopus 로고
    • accessed 7 July 2014,. :
    • United States Food and Drug Administration (2013) FDA approves Invokana to treat type 2 diabetes. Available at: http://www.fda.gov/newsevents/newsroom/pressannouncements/ucm345848.htm (accessed 7 July 2014).
    • (2013) FDA approves Invokana to treat type 2 diabetes
  • 99
    • 84937201108 scopus 로고    scopus 로고
    • accessed 7 July 2014,. :
    • United States Food and Drug Administration (2014) FDA approves Farxiga to treat type 2 diabetes. Available at: http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm380829.htm (accessed 7 July 2014).
    • (2014) FDA approves Farxiga to treat type 2 diabetes
  • 100
    • 84905383426 scopus 로고    scopus 로고
    • Alicant, Janssen Pharmaceuticals, Inc., accessed 5 May 2013, :
    • United States Food and Drug Administration Advisory Committee (2013) FDA briefing document. NDA 204042. Invokana (canagliflozin) Tablets. Applicant: Janssen Pharmaceuticals, Inc. Available at:www.fda.gov/downloads/AdvisoryCommittees/CommitteesMeetingMaterials/Drugs/EndocrinologicandMetabolicDrugsAdvisoryCommittee/UCM334550.pdf (accessed 5 May 2013).
    • (2013) FDA briefing document. NDA 204042. Invokana (canagliflozin) Tablets
  • 101
    • 84892588641 scopus 로고    scopus 로고
    • SGLT2 inhibitor empagliflozin reduces renal growth and albuminuria in proportion to hyperglycemia and prevents glomerular hyperfiltration in diabetic akita mice
    • Vallon V., Gerasimova M., Rose M., Masuda T., Satriano J., Mayoux E.. (2014) SGLT2 inhibitor empagliflozin reduces renal growth and albuminuria in proportion to hyperglycemia and prevents glomerular hyperfiltration in diabetic akita mice. Am J Physiol Renal Physiol 306: F194–F204.
    • (2014) Am J Physiol Renal Physiol , vol.306 , pp. F194-F204
    • Vallon, V.1    Gerasimova, M.2    Rose, M.3    Masuda, T.4    Satriano, J.5    Mayoux, E.6
  • 103
    • 0032707179 scopus 로고    scopus 로고
    • Glomerular hyperfiltration in experimental diabetes mellitus: potential role of tubular reabsorption
    • Vallon V., Richter K., Blantz R., Thomson S., Osswald H., (1999) Glomerular hyperfiltration in experimental diabetes mellitus: potential role of tubular reabsorption. J Am Soc Nephrol 10: 2569–2576.
    • (1999) J Am Soc Nephrol , vol.10 , pp. 2569-2576
    • Vallon, V.1    Richter, K.2    Blantz, R.3    Thomson, S.4    Osswald, H.5
  • 104
    • 80155181454 scopus 로고    scopus 로고
    • Effect of ipragliflozin (ASP1941), a novel selective sodium-dependent glucose co-transporter 2 inhibitor, on urinary glucose excretion in healthy subjects
    • Veltkamp S., Kadokura T., Krauwinkel W., Smulders R., (2011) Effect of ipragliflozin (ASP1941), a novel selective sodium-dependent glucose co-transporter 2 inhibitor, on urinary glucose excretion in healthy subjects. Clin Drug Investig 31: 839–851.
    • (2011) Clin Drug Investig , vol.31 , pp. 839-851
    • Veltkamp, S.1    Kadokura, T.2    Krauwinkel, W.3    Smulders, R.4
  • 105
    • 0015598718 scopus 로고
    • Reevaluation of renal tubular glucose transport inhibition by phlorizin analogs
    • Vick H., Diedrich D., Baumann K., (1973) Reevaluation of renal tubular glucose transport inhibition by phlorizin analogs. Am J Physiol 224: 552–557.
    • (1973) Am J Physiol , vol.224 , pp. 552-557
    • Vick, H.1    Diedrich, D.2    Baumann, K.3
  • 107
    • 75449091856 scopus 로고    scopus 로고
    • Apple trees to sodium glucose co-transporter inhibitors: a review of SGLT2 inhibition
    • White J., (2010) Apple trees to sodium glucose co-transporter inhibitors: a review of SGLT2 inhibition. Clin Diabetes 28: 5–10.
    • (2010) Clin Diabetes , vol.28 , pp. 5-10
    • White, J.1
  • 108
    • 84876344111 scopus 로고    scopus 로고
    • Efficacy and safety of ipragliflozin in patients with type 2 diabetes inadequately controlled on metformin: a dose-finding study
    • Wilding J., Ferrannini E., Fonseca V., Wilpshaar W., Dhanjal P., Houzer A., (2013) Efficacy and safety of ipragliflozin in patients with type 2 diabetes inadequately controlled on metformin: a dose-finding study. Diabetes Obes Metab 15: 403–409.
    • (2013) Diabetes Obes Metab , vol.15 , pp. 403-409
    • Wilding, J.1    Ferrannini, E.2    Fonseca, V.3    Wilpshaar, W.4    Dhanjal, P.5    Houzer, A.6
  • 109
    • 69549095914 scopus 로고    scopus 로고
    • A study of dapagliflozin in patients with type 2 diabetes receiving high doses of insulin plus insulin sensitizers: applicability of a novel insulin-independent treatment
    • Wilding J., Norwood P., T’joen C., Bastien A., List J., Fiedorek F., (2009) A study of dapagliflozin in patients with type 2 diabetes receiving high doses of insulin plus insulin sensitizers: applicability of a novel insulin-independent treatment. Diabetes Care 32: 1656–1662.
    • (2009) Diabetes Care , vol.32 , pp. 1656-1662
    • Wilding, J.1    Norwood, P.2    T’joen, C.3    Bastien, A.4    List, J.5    Fiedorek, F.6
  • 110
    • 65449117604 scopus 로고    scopus 로고
    • accessed 18 October 2016,. :
    • o 312. Available at: http://www.who.int/mediacentre/factsheets/fs312/en/ (accessed 18 October 2016).
    • (2016) o 312
  • 111
    • 65449117604 scopus 로고    scopus 로고
    • accessed 18 October 2016,. :
    • World Health Organization (2016) Diabetes fact sheet No 138. Available at: http://www.who.int/mediacentre/factsheets/fs138/en/ (accessed 18 October 2016).
    • (2016) Diabetes fact sheet No 138
  • 112
    • 33846023326 scopus 로고    scopus 로고
    • Active sugar transport in health and disease
    • Wright E., Hirayama B., Loo D., (2007) Active sugar transport in health and disease. J Int Med 261: 32–43.
    • (2007) J Int Med , vol.261 , pp. 32-43
    • Wright, E.1    Hirayama, B.2    Loo, D.3
  • 113
    • 0002525090 scopus 로고
    • Intestinal sugar transport
    • L. Johnson, (ed), 3rd ed., New York, NY, Raven Press,. In:, (Ed.), ;
    • Wright E., Hirayama B., Loo D., Turk E., Hager K., (1994) Intestinal sugar transport. In: L. Johnson (Ed.), Physiology of Gastrointestinal Tract (3rd ed.; pp. 1751–1772). New York, NY: Raven Press.
    • (1994) Physiology of Gastrointestinal Tract , pp. 1751-1772
    • Wright, E.1    Hirayama, B.2    Loo, D.3    Turk, E.4    Hager, K.5
  • 114
    • 1242272759 scopus 로고    scopus 로고
    • The sodium/glucose cotransport family SLC5
    • Wright E., Turc E., (2004) The sodium/glucose cotransport family SLC5. Pflugers Arch 447: 510–518.
    • (2004) Pflugers Arch , vol.447 , pp. 510-518
    • Wright, E.1    Turc, E.2
  • 115
    • 78651349221 scopus 로고    scopus 로고
    • Biology of human sodium glucose transporters
    • Wright E., Loo D., Hirayama B., (2011) Biology of human sodium glucose transporters. Physiol Rev 91: 733–794.
    • (2011) Physiol Rev , vol.91 , pp. 733-794
    • Wright, E.1    Loo, D.2    Hirayama, B.3
  • 116
    • 84962613532 scopus 로고    scopus 로고
    • Effects of sodium-glucose cotransporter-2 inhibitors on cardiovascular events, death, and major safety outcomes in adults with type 2 diabetes: a systematic review and meta-analysis
    • Wu J., Foote C., Blomster J., Toyama T., Perkovic V., Sundström J.. (2016) Effects of sodium-glucose cotransporter-2 inhibitors on cardiovascular events, death, and major safety outcomes in adults with type 2 diabetes: a systematic review and meta-analysis. Lancet Diabetes Endocrinol 4: 411–419. DOI:10.1016/S2213–8587(16)00052–8.
    • (2016) Lancet Diabetes Endocrinol , vol.4 , pp. 411-419
    • Wu, J.1    Foote, C.2    Blomster, J.3    Toyama, T.4    Perkovic, V.5    Sundström, J.6
  • 118
    • 84876311251 scopus 로고    scopus 로고
    • Efficacy and safety of canagliflozin in subjects with type 2 diabetes and chronic kidney disease
    • Yale J., Bakris G., Cariou B., Yue D., David- Neto E., Xi L.. (2013) Efficacy and safety of canagliflozin in subjects with type 2 diabetes and chronic kidney disease. Diabetes Obes Metab 15: 463–473.
    • (2013) Diabetes Obes Metab , vol.15 , pp. 463-473
    • Yale, J.1    Bakris, G.2    Cariou, B.3    Yue, D.4    David- Neto, E.5    Xi, L.6
  • 119
    • 85006352850 scopus 로고    scopus 로고
    • Empagliflozin, a selective SGLT2 inhibitor, ameliorated hyperglycaemia and insulin resistance, while preserving the integrity of pancreas and kidney in CRDH rats
    • Abstract #801
    • Younis F., Abassi Z., Mayoux E., Hollander K., Rath-Wolfson L., Rosenthal T., (2014) Empagliflozin, a selective SGLT2 inhibitor, ameliorated hyperglycaemia and insulin resistance, while preserving the integrity of pancreas and kidney in CRDH rats. EASD Virtual Meeting. Abstract #801.
    • (2014) EASD Virtual Meeting
    • Younis, F.1    Abassi, Z.2    Mayoux, E.3    Hollander, K.4    Rath-Wolfson, L.5    Rosenthal, T.6
  • 120
    • 84944800184 scopus 로고    scopus 로고
    • Empagliflozin, cardiovascular outcomes, and mortality in type 2 diabetes
    • Zinman B., Wanner C., Lachin J., Fitchett D., Bluhmki E., Hantel S.. (2015) Empagliflozin, cardiovascular outcomes, and mortality in type 2 diabetes. N Engl J Med 373: 2117–2128.
    • (2015) N Engl J Med , vol.373 , pp. 2117-2128
    • Zinman, B.1    Wanner, C.2    Lachin, J.3    Fitchett, D.4    Bluhmki, E.5    Hantel, S.6


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