Pseudomonas aeruginosa Airway infection recruits and modulates neutrophilic myeloid-derived suppressor cells

Frontiers in Cellular and Infection Microbiology

Volumn 6, Issue NOV, 2016, Pages

  öz, Hasan H ^a   Zhou, Benyuan ^a   Voss, Pina ^a   Carevic, Melanie ^a   Schroth, Carolin ^a   Frey, Nina ^a   Rieber, Nikolaus ^a,b   Hector, Andreas ^a   Hartl, Dominik ^a,c  

^a UNIVERSITY OF TÜBINGEN   (Germany)

^b TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^c F HOFFMANN LA ROCHE LTD   (Switzerland)

Author keywords

Bacteria; CFTR; Cystic fibrosis; Lung; MDSCs; Pseudomonas; T cells

Indexed keywords

CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR;

ADOPTIVE TRANSFER; ANIMAL CELL; ANIMAL MODEL; ARTICLE; BONE MARROW CELL; BONE MARROW SUPPRESSION; CELL ISOLATION; CELL PROLIFERATION; COLONY FORMING UNIT; CONTROLLED STUDY; FEMALE; FLOW CYTOMETRY; IMMUNOMODULATION; LUNG LAVAGE; MOUSE; NEUTROPHIL; NEUTROPHILIC MYELOID DERIVED SUPPRESSOR CELL; NONHUMAN; PSEUDOMONAS AERUGINOSA; PSEUDOMONAS INFECTION; RESPIRATORY TRACT INFECTION; SPLEEN CELL; ANIMAL; C57BL MOUSE; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR MOUSE; IMMUNE EVASION; IMMUNOLOGICAL TOLERANCE; IMMUNOLOGY; METABOLISM; MYELOID-DERIVED SUPPRESSOR CELL; T LYMPHOCYTE;

ANIMALS; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; IMMUNE EVASION; IMMUNE TOLERANCE; MICE, INBRED C57BL; MICE, INBRED CFTR; MYELOID-DERIVED SUPPRESSOR CELLS; NEUTROPHILS; PSEUDOMONAS AERUGINOSA; PSEUDOMONAS INFECTIONS; RESPIRATORY TRACT INFECTIONS; T-LYMPHOCYTES;

EID: 85006399789     PISSN: None     EISSN: 22352988     Source Type: Journal    
DOI: 10.3389/fcimb.2016.00167     Document Type: Article

References (25)

1. Ballbach, M., Hall, T., Brand, A., Neri, D., Singh, A., Schaefer, I., et al. (2016). Induction of myeloid-derived suppressor cells in cryopyrin-associated periodic syndromes. J. Innate Immun. 8, 493-506. doi: 10.1159/000446615
2. Bruchard, M., Mignot, G., Derangere, V., Chalmin, F., Chevriaux, A., Vegran, F., et al. (2013). Chemotherapy-triggered cathepsin B release in myeloid-derived suppressor cells activates the Nlrp3 inflammasome and promotes tumor growth. Nat. Med. 19, 57-64. doi: 10.1038/nm.2999
3. Corvol, H., Fitting, C., Chadelat, K., Jacquot, J., Tabary, O., Boule, M., et al. (2003). Distinct cytokine production by lung and blood neutrophils from children with cystic fibrosis. Am. J. Physiol. Lung Cell. Mol. Physiol. 284, L997-L1003. doi: 10.1152/ajplung.00156.2002
4. Diaz-Montero, C. M., Finke, J., and Montero, A. J. (2014). Myeloid-derived suppressor cells in cancer: therapeutic, predictive, and prognostic implications. Semin. Oncol. 41, 174-184. doi: 10.1053/j.seminoncol.2014.02.003
5. Draghiciu, O., Lubbers, J., Nijman, H. W., and Daemen, T. (2015). Myeloid derived suppressor cells-An overview of combat strategies to increase immunotherapy efficacy. Oncoimmunology 4:e954829. doi: 10.4161/21624011.2014.954829
6. Filipazzi, P., Huber, V., and Rivoltini, L. (2012). Phenotype, function and clinical implications of myeloid-derived suppressor cells in cancer patients. Cancer Immunol. Immunother. 61, 255-263. doi: 10.1007/s00262-011-1161-9
7. Gabrilovich, D. I., and Nagaraj, S. (2009). Myeloid-derived suppressor cells as regulators of the immune system. Nat. Rev. Immunol. 9, 162-174. doi: 10.1038/nri2506
8. Gantt, S., Gervassi, A., Jaspan, H., and Horton, H. (2014). The role of myeloid-derived suppressor cells in immune ontogeny. Front. Immunol. 5:387. doi: 10.3389/fimmu.2014.00387
9. Hartl, D., Gaggar, A., Bruscia, E., Hector, A., Marcos, V., Jung, A., et al. (2012). Innate immunity in cystic fibrosis lung disease. J. Cyst. Fibros. 11, 363-382. doi: 10.1016/j.jcf.2012.07.003
10. Hector, A., Schäfer, H., Pöschel, S., Fischer, A., Fritzsching, B., Ralhan, A., et al. (2015). Regulatory T-cell impairment in cystic fibrosis patients with chronic pseudomonas infection. Am. J. Respir. Crit. Care Med. 191, 914-923. doi: 10.1164/rccm.201407-1381OC
11. Hogardt, M., and Heesemann, J. (2010). Adaptation of Pseudomonas aeruginosa during persistence in the cystic fibrosis lung. Int. J. Med. Microbiol. 300, 557-562. doi: 10.1016/j.ijmm.2010.08.008
12. Jensen, P. Ø., Givskov, M., Bjarnsholt, T., and Moser, C. (2010). The immune system vs. Pseudomonas aeruginosa biofilms. FEMS Immunol. Med. Microbiol. 59, 292-305. doi: 10.1111/j.1574-695X.2010.00706.x
13. Koehn, B. H., Apostolova, P., Haverkamp, J. M., Miller, J. S., McCullar, V., Tolar, J., et al. (2015). GVHD-associated, inflammasome-mediated loss of function in adoptively transferred myeloid-derived suppressor cells. Blood 126, 1621-1628. doi: 10.1182/blood-2015-03-634691
14. Livraghi-Butrico, A., Kelly, E. J., Klem, E. R., Dang, H., Wolfgang, M. C., Boucher, R. C., et al. (2012). Mucus clearance, MyD88-dependent and MyD88-independent immunity modulate lung susceptibility to spontaneous bacterial infection and inflammation. Mucosal Immunol. 5, 397-408. doi: 10.1038/mi.2012.17
15. Mall, M. A., and Hartl, D. (2014). CFTR: cystic fibrosis and beyond. Eur. Respir. J. 44, 1042-1054. doi: 10.1183/09031936.00228013
16. Marigo, I., Bosio, E., Solito, S., Mesa, C., Fernandez, A., Dolcetti, L., et al. (2010). Tumor-induced tolerance and immune suppression depend on the C/EBPβ transcription factor. Immunity 32, 790-802. doi: 10.1016/j.immuni.2010.05.010
17. Marvel, D., and Gabrilovich, D. I. (2015). Myeloid-derived suppressor cells in the tumor microenvironment: expect the unexpected. J. Clin. Invest. 125, 3356-3364. doi: 10.1172/JCI80005
18. Munder, A., and Tummler, B. (2014). Assessing Pseudomonas virulence using mammalian models: acute infection model. Methods Mol. Biol. 1149, 773-791. doi: 10.1007/978-1-4939-0473-0_59
19. Pillarisetti, N., Williamson, E., Linnane, B., Skoric, B., Robertson, C. F., Robinson, P., et al. (2011). Infection, inflammation, and lung function decline in infants with cystic fibrosis. Am. J. Respir. Crit. Care Med. 184, 75-81. doi: 10.1164/rccm.201011-1892OC
20. Rieber, N., Brand, A., Hector, A., Graepler-Mainka, U., Ost, M., Schafer, I., et al. (2013). Flagellin induces myeloid-derived suppressor cells: implications for Pseudomonas aeruginosa infection in cystic fibrosis lung disease. J. Immunol. 190, 1276-1284. doi: 10.4049/jimmunol.1202144
21. Rieber, N., Singh, A., Öz, H., Carevic, M., Bouzani, M., Amich, J., et al. (2015). Pathogenic fungi regulate immunity by inducing neutrophilic myeloid-derived suppressor cells. Cell Host Microbe 17, 507-514. doi: 10.1016/j.chom.2015.02.007
22. Wesolowski, R., Markowitz, J., and Carson, W. E. III. (2013). Myeloid derived suppressor cells-a new therapeutic target in the treatment of cancer. J. Immunother. Cancer 1:10. doi: 10.1186/2051-1426-1-10
23. Williams, B. J., Dehnbostel, J., and Blackwell, T. S. (2010). Pseudomonas aeruginosa: host defence in lung diseases. Respirology 15, 1037-1056. doi: 10.1111/j.1440-1843.2010.01819.x
24. Yonker, L. M., Cigana, C., Hurley, B. P., and Bragonzi, A. (2015). Host-pathogen interplay in the respiratory environment of cystic fibrosis. J. Cyst. Fibros. 14, 431-439. doi: 10.1016/j.jcf.2015.02.008
25. Youn, J. I., Kumar, V., Collazo, M., Nefedova, Y., Condamine, T., Cheng, P., et al. (2013). Epigenetic silencing of retinoblastoma gene regulates pathologic differentiation of myeloid cells in cancer. Nat. Immunol. 14, 211-220. doi: 10.1038/ni.2526