Bone mineral density and fracture risk with long-term use of inhaled corticosteroids in patients with asthma: systematic review and meta-analysis

BMJ Open

Volumn 5, Issue 11, 2015, Pages

  Loke, Yoon K ^a   Gilbert, Daniel ^a   Thavarajah, Menaka ^a   Blanco, Patricia ^a   Wilson, Andrew M ^a  

^a UNIVERSITY OF EAST ANGLIA   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIASTHMATIC AGENT; CORTICOSTEROID;

ADULT; ASTHMA; BONE DENSITY; CHILD; DRUG EFFECTS; FRACTURES, BONE; HUMAN; INHALATIONAL DRUG ADMINISTRATION; META ANALYSIS; OBSERVATIONAL STUDY; RANDOMIZED CONTROLLED TRIAL (TOPIC); RISK ASSESSMENT;

ADMINISTRATION, INHALATION; ADRENAL CORTEX HORMONES; ADULT; ANTI-ASTHMATIC AGENTS; ASTHMA; BONE DENSITY; CHILD; FRACTURES, BONE; HUMANS; OBSERVATIONAL STUDIES AS TOPIC; RANDOMIZED CONTROLLED TRIALS AS TOPIC; RISK ASSESSMENT;

EID: 85006385959     PISSN: None     EISSN: 20446055     Source Type: Journal    
DOI: 10.1136/BMJOPEN-2015-008554     Document Type: Article

References (33)

1. Ricciardolo FLM. The treatment of asthma in children: inhaled corticosteroids. Pulm Pharmacol Ther 2007;20:473-82.
2. British-Thoracic-Society/Scottish-Intercollegiate-Guidelines-Network. British Guideline on the Management of Asthma. Thorax 2008;63 (Suppl 4):iv1-121.
3. National-Asthma-Education-and-Prevention-Program. Expert Panel Report 3 (EPR-3): guidelines for the Diagnosis and Management of Asthma-Summary Report 2007. J Allergy Clin Immunol 2007;120(5 Suppl):S94-138.
4. Rossi GA, Cerasoli F, Cazzola M. Safety of inhaled corticosteroids: room for improvement. Pulm Pharmacol Ther 2007;20:23-35.
5. Jones A, Fay JK, Burr M, et al. Inhaled corticosteroid effects on bone metabolism in asthma and mild chronic obstructive pulmonary disease. Cochrane Database Syst Rev 2002;(1):CD003537.
6. Loke YK, Cavallazzi R, Singh S. Risk of fractures with inhaled corticosteroids in COPD: systematic review and meta-analysis of randomised controlled trials and observational studies. Thorax 2011;66:699-708.
7. Weatherall M, James K, Clay J, et al. Dose-response relationship for risk of non-vertebral fracture with inhaled corticosteroids. Clin Exp Allergy 2008;38:1451-8.
8. Law MR, Hackshaw AK. A meta-analysis of cigarette smoking, bone mineral density and risk of hip fracture: recognition of a major effect. BMJ 1997;315:841-6.
9. Vanfleteren LE, Spruit MA, Groenen M, et al. Clusters of comorbidities based on validated objective measurements and systemic inflammation in patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2013;187:728-35.
10. Loke YK, Golder SP, Vandenbroucke JP. Comprehensive evaluations of the adverse effects of drugs: importance of appropriate study selection and data sources. Ther Adv Drug Saf 2011;2:59-68.
11. Ioannidis JP, Trikalinos TA. The appropriateness of asymmetry tests for publication bias in meta-analyses: a large survey. CMAJ 2007;176:1091-6.
12. Higgins JPT, Deeks JJ, Altman DG. Special topics in statistics. In: Higgins JPT, Green S, eds. Cochrane handbook for systematic reviews of interventions. Chichester, UK: John Wiley & Sons, 2008. Chapter 16, pp 481-529.
13. Higgins JPT, Deeks JJ, Altman DG. Analysing data and undertaking meta-analyses. In: Higgins JPT, Green S, eds. Cochrane handbook for systematic reviews of interventions. Chichester, UK: John Wiley & Sons, 2008. Chapter 9, pp 243-296.
14. Ferguson AC, Van Bever HP, Teper AM, et al. A comparison of the relative growth velocities with budesonide and fluticasone propionate in children with asthma. Respir Med 2007;101:118-29.
15. Kelly HW, Van Natta ML, Covar RA, et al. Effect of long-term corticosteroid use on bone mineral density in children: a prospective longitudinal assessment in the childhood Asthma Management Program (CAMP) study. Pediatrics 2008;122:e53-61.
16. Kemp JP, Osur S, Shrewsbury SB, et al. Potential effects of fluticasone propionate on bone mineral density in patients with asthma: a 2-year randomized, double-blind, placebo-controlled trial. Mayo Clin Proc 2004;79:458-66.
17. Li JTC, Ford LB, Chervinsky P, et al. Fluticasone propionate powder and lack of clinically significant effects on hypothalamic-pituitary-adrenal axis and bone mineral density over 2 years in adults with mild asthma. J Allergy Clin Immunol 1999;103:1062-8.
18. Maspero J, Backer V, Yao R, et al. Effects of mometasone, fluticasone, and montelukast on bone mineral density in adults with asthma. J Allergy Clin Immunol Pract 2013;1:649-55.e1.
19. Roux C, Kolta S, Desfougeres JL, et al. Long-term safety of fluticasone propionate and nedocromil sodium on bone in children with asthma. Pediatrics 2003;111(6 Pt 1):e706-13.
20. Turpeinen M, Pelkonen AS, Nikander K, et al. Bone mineral density in children treated with daily or periodical inhaled budesonide: the Helsinki early intervention childhood asthma study. Pediatr Res 2010;68:169-73.
21. Agertoft L, Pedersen S. Bone mineral density in children with asthma receiving long-term treatment with inhaled budesonide. Am J Respir Crit Care Med 1998;157:178-83.
22. Allen HDW, Thong IG, Clifton-Bligh P, et al. Effects of high-dose inhaled corticosteroids on bone metabolism in prepubertal children with asthma. Pediatr Pulmonol 2000;29:188-93.
23. Bahceciler NN, Sezgin G, Nursoy MA, et al. Inhaled corticosteroids and bone density of children with asthma. J Asthma 2002;39:151-7.
24. El O, Gulbahar S, Ceylan E, et al. Bone mineral density in asthmatic patients using low dose inhaled glucocorticosteroids. J Investig Allergol Clin Immunol 2005;15:57-62.
25. Harris M, Hauser S, Nguyen TV, et al. Bone mineral density in prepubertal asthmatics receiving corticosteroid treatment. J Paediatr Child Health 2001;37:67-71.
26. Johannes CB, Schneider GA, Dube TJ, et al. The risk of nonvertebral fracture related to inhaled corticosteroid exposure among adults with chronic respiratory disease. Chest 2005;127:89-97.
27. Schlienger RG, Jick SS, Meier CR. Inhaled corticosteroids and the risk of fractures in children and adolescents. Pediatrics 2004;114:469-73.
28. Sosa M, Saavedra P, Valero C, et al. Inhaled steroids do not decrease bone mineral density but increase risk of fractures: data from the GIUMO study group. J Clin Densitom 2006;9:154-8.
29. Van Staa TP, Bishop N, Leufkens HGM, et al. Are inhaled corticosteroids associated with an increased risk of fracture in children? Osteoporos Int 2004;15:785-91.
30. Wisniewski AF, Lewis SA, Green DJ, et al. Cross sectional investigation of the effects of inhaled corticosteroids on bone density and bone metabolism in patients with asthma. Thorax 1997;52:853-60.
31. Yanik B, Ayrim A, Ozol D, et al. Influence of obesity on bone mineral density in postmenopausal asthma patients undergoing treatment with inhaled corticosteroids. Clinics 2009;64: 313-18.
32. The Childhood Asthma Management Program Research Group. Long-term effects of budesonide or nedocromil in children with asthma. N Engl J Med 2000;343:1054-63.
33. Richy F, Bousquet J, Ehrlich GE, et al. Inhaled corticosteroids effects on bone in asthmatic and COPD patients: a quantitative systematic review. Osteoporos Int 2003;14:179-90.