Effects of mometasone, fluticasone, and montelukast on bone mineral density in adults with asthma

Journal of Allergy and Clinical Immunology: In Practice

Volumn 1, Issue 6, 2013, Pages 649-655.e1

  Maspero, Jorge ^a   Backer, Vibeke ^b   Yao, Ruji ^c   Staudinger, Heribert ^c   Teper, Ariel ^c  

^a CABA   (Argentina)

^b BISPEBJERG HOSPITAL   (Denmark)

^c MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Asthma; Bone mineral density; Inhaled corticosteroids; Lumbar spine

Indexed keywords

25 HYDROXYVITAMIN D; CALCIUM; FLUTICASONE PROPIONATE; MOMETASONE FUROATE; MONTELUKAST; PLACEBO; VITAMIN D; ACETIC ACID DERIVATIVE; ANDROSTANE DERIVATIVE; ANTIASTHMATIC AGENT; FLUTICASONE; PREGNANE DERIVATIVE; QUINOLINE DERIVATIVE; TABLET;

ADULT; ARTICLE; ASTHMA; BONE DENSITOMETRY; BONE DENSITY; CALCIUM DEFICIENCY; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFECT; DRUG WITHDRAWAL; DRY POWDER INHALER; EVENING DOSAGE; FEMALE; FEMUR NECK; HUMAN; LUMBAR SPINE; MAJOR CLINICAL STUDY; MALE; METERED DOSE INHALER; MILD PERSISTENT ASTHMA; MODERATE PERSISTENT ASTHMA; MULTICENTER STUDY; PARALLEL DESIGN; RANDOMIZED CONTROLLED TRIAL; SIDE EFFECT; TREATMENT DURATION; VITAMIN D DEFICIENCY; VITAMIN SUPPLEMENTATION; CLINICAL TRIAL; COMPARATIVE STUDY; DRUG EFFECTS; FEMUR; INHALATIONAL DRUG ADMINISTRATION; ORAL DRUG ADMINISTRATION; PHASE 4 CLINICAL TRIAL; TABLET;

ACETATES; ADMINISTRATION, INHALATION; ADMINISTRATION, ORAL; ADULT; ANDROSTADIENES; ANTI-ASTHMATIC AGENTS; ASTHMA; BONE DENSITY; DOUBLE-BLIND METHOD; DRY POWDER INHALERS; FEMALE; FEMUR; HUMANS; MALE; PREGNADIENEDIOLS; QUINOLINES; TABLETS;

EID: 84887019464     PISSN: 22132198     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jaip.2013.07.011     Document Type: Article

References (24)

1. Lanes S.F., Garcia Rodriguez L.A., Huerta C. Respiratory medications and risk of asthma death. Thorax 2002, 57:683-686.
2. Suissa S., Ernst P., Benayoun S., Baltzan M., Cai B. Low-dose inhaled corticosteroids and the prevention of death from asthma. NEngl J Med 2000, 343:332-336.
3. Suissa S., Ernst P. Inhaled corticosteroids: impact on asthma morbidity and mortality. JAllergy Clin Immunol 2001, 107:937-944.
4. Bonala S.B., Reddy B.M., Silverman B.A., Bassett C.W., Rao Y.A., Amara S., et al. Bone mineral density in women with asthma on long-term inhaled corticosteroid therapy. Ann Allergy Asthma Immunol 2000, 85:495-500.
5. Israel E., Banerjee T.R., Fitzmaurice G.M., Kotlov T.V., LaHive K., LeBoff M.S. Effects of inhaled glucocorticoids on bone density in premenopausal women. NEngl J Med 2001, 345:941-947.
6. Wisniewski A.F., Lewis S.A., Green D.J., Maslanka W., Burrell H., Tattersfield A.E. Cross sectional investigation of the effects of inhaled corticosteroids on bone density and bone metabolism in patients with asthma. Thorax 1997, 52:853-860.
7. Ip M., Lam K., Yam L., Kung A., Ng M. Decreased bone mineral density in premenopausal asthma patients receiving long-term inhaled steroids. Chest 1994, 105:1722-1727.
8. Marystone J.F., Barrett-Connor E.L., Morton D.J. Inhaled and oral corticosteroids: their effects on bone mineral density in older adults. Am J Public Health 1995, 85:1693-1695.
9. Laatikainen A.K., Kroger H.P., Tukiainen H.O., Honkanen R.J., Saarikoski S.V. Bone mineral density in perimenopausal women with asthma: a population-based cross-sectional study. Am J Respir Crit Care Med 1999, 159:1179-1185.
10. Wong C.A., Walsh L.J., Smith C.J., Wisniewski A.F., Lewis S.A., Hubbard R., et al. Inhaled corticosteroid use and bone-mineral density in patients with asthma. Lancet 2000, 355:1399-1403.
11. National Osteoporosis Foundation Clinician's Guide to Prevention and Treatment of Osteoporosis. 2010 2010, National Osteoporosis Foundation, Washington, DC.
12. Barnes N.C. The properties of inhaled corticosteroids: similarities and differences. Prim Care Respir J 2007, 16:149-154.
13. Efthimiou J., Barnes P.J. Effect of inhaled corticosteroids on bones and growth. Eur Respir J 1998, 11:1167-1177.
14. Asmanex Twisthaler (mometasone furoate inhalation powder) [package insert]. Full prescribing information 2008, Merck & Co, Whitehouse Station, NJ.
15. Kemp J.P., Osur S., Shrewsbury S.B., Herje N.E., Duke S.P., Harding S.M., et al. Potential effects of fluticasone propionate on bone mineral density in patients with asthma: a 2-year randomized, double-blind, placebo-controlled trial. Mayo Clin Proc 2004, 79:458-466.
16. Li J.T., Ford L.B., Chervinsky P., Weisberg S.C., Kellerman D.J., Faulkner K.G., et al. Fluticasone propionate powder and lack of clinically significant effects on hypothalamic-pituitary-adrenal axis and bone mineral density over 2 years in adults with mild asthma. JAllergy Clin Immunol 1999, 103:1062-1068.
17. Tattersfield A.E., Town G.I., Johnell O., Picado C., Aubier M., Braillon P., et al. Bone mineral density in subjects with mild asthma randomised to treatment with inhaled corticosteroids or non-corticosteroid treatment for two years. Thorax 2001, 56:272-278.
18. Medici T.C., Grebski E., Hacki M., Ruegsegger P., Maden C., Efthimiou J. Effect of one year treatment with inhaled fluticasone propionate or beclomethasone dipropionate on bone density and bone metabolism: a randomised parallel group study in adult asthmatic subjects. Thorax 2000, 55:375-382.
19. Hughes J.A., Conry B.G., Male S.M., Eastell R. One year prospective open study of the effect of high dose inhaled steroids, fluticasone propionate, and budesonide on bone markers and bone mineral density. Thorax 1999, 54:223-229.
20. Egan J.J., Maden C., Kalra S., Adams J.E., Eastell R., Woodcock A.A. Arandomized, double-blind study comparing the effects of beclomethasone and fluticasone on bone density over two years. Eur Respir J 1999, 13:1267-1275.
21. Boulet L.P., Milot J., Gagnon L., Poubelle P.E., Brown J. Long-term influence of inhaled corticosteroids on bone metabolism and density. Are biological markers predictors of bone loss?. Am J Respir Crit Care Med 1999, 159:838-844.
22. Lewiecki E.M., Kendler D.L., Kiebzak G.M., Schmeer P., Prince R.L., El-Hajj Fuleihan G., et al. Special report on the official positions of the International Society for Clinical Densitometry. Osteoporos Int 2004, 15:779-784.
23. Jones A., Fay J.K., Burr M., Stone M., Hood K., Roberts G. Inhaled corticosteroid effects on bone metabolism in asthma and mild chronic obstructive pulmonary disease. Cochrane Database Syst Rev 2002, (1). CD003537.
24. Lekamwasam S., Trivedi D.P., Khaw K.T. An association between respiratory function and bone mineral density in women from the general community: a cross sectional study. Osteoporos Int 2002, 13:710-715.